Grover Bagby

Professor Emeritus

  • 5033 Citations
  • 42 h-Index
1966 …2021
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Research Output 1966 2015

  • 5033 Citations
  • 42 h-Index
  • 133 Article
  • 2 Chapter
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Article
2015
13 Citations (Scopus)

Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling

Zhang, Q-S., Benedetti, E., Deater, M., Schubert, K., Major, A., Pelz, C., Impey, S., Marquez-Loza, L., Rathbun, R. K., Kato, S., Bagby, G. C. & Grompe, M., Jan 13 2015, In : Stem Cell Reports. 4, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

Oxymetholone
Fanconi Anemia
Osteopontin
Transcription
Hematopoietic Stem Cells
6 Citations (Scopus)

P38 mitogen-activated protein kinase inhibition enhances invitro erythropoiesis of Fanconi anemia, complementation group A-deficient bonemarrow cells

Svahn, J., Lanza, T., Rathbun, K., Bagby, G., Ravera, S., Corsolini, F., Pistorio, A., Longoni, D., Farruggia, P., Dufour, C. & Cappelli, E., Apr 1 2015, In : Experimental Hematology. 43, 4, p. 295-299 5 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Erythropoiesis
p38 Mitogen-Activated Protein Kinases
Stem Cells
Monocytes
2013
18 Citations (Scopus)

FANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages.

Garbati, M. R., Hays, L. E., Keeble, W., Yates, J. E., Rathbun, R. K. & Bagby, G. C., Oct 31 2013, In : Blood. 122, 18, p. 3197-3205 9 p.

Research output: Contribution to journalArticle

Macrophages
Toll-Like Receptors
p38 Mitogen-Activated Protein Kinases
Interleukin-1
Fanconi Anemia
2 Citations (Scopus)

The PI3K/Akt1 pathway enhances steady-state levels of FANCL

Dao, K-H., Rotelli, M. D., Brown, B. R., Yates, J. E., Rantala, J., Tognon, C., Tyner, J., Druker, B. & Bagby, G. C., Aug 15 2013, In : Molecular Biology of the Cell. 24, 16, p. 2582-2592 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Fanconi Anemia
Fanconi Anemia Complementation Group L Protein
Hematopoietic Stem Cells
Phosphatidylinositol 3-Kinases
2012
25 Citations (Scopus)

FANCL ubiquitinates β-catenin and enhances its nuclear function

Dao, K-H., Rotelli, M. D., Petersen, C. L., Kaech-Petrie, S., Nelson, W. D., Yates, J. E., Hanlon Newell, A. E., Olson, S., Druker, B. & Bagby, G. C., Jul 12 2012, In : Blood. 120, 2, p. 323-334 12 p.

Research output: Contribution to journalArticle

Catenins
Hematopoietic Stem Cells
Stem cells
Fanconi Anemia
Ubiquitin-Protein Ligases
12 Citations (Scopus)

Immune response gene profiles in the term placenta depend upon maternal muscle mass

O'Tierney, P. F., Lewis, R. M., McWeeney, S., Hanson, M. A., Inskip, H. M., Morgan, T., Barker, D. J., Bagby, G., Cooper, C., Godfrey, K. M. & Thornburg, K., Oct 2012, In : Reproductive Sciences. 19, 10, p. 1041-1056 16 p.

Research output: Contribution to journalArticle

Placenta
Mothers
Muscles
Genes
Immune System Phenomena
25 Citations (Scopus)

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC and FANCA-deficient mononuclear phagocytes

Anur, P., Yates, J., Garbati, M. R., Vanderwerf, S., Keeble, W., Rathbun, K., Hays, L. E., Tyner, J., Svahn, J., Cappelli, E., Dufour, C. & Bagby, G. C., Mar 1 2012, In : Blood. 119, 9, p. 1992-2002 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
p38 Mitogen-Activated Protein Kinases
Phagocytes
Macrophages
Phenotype
8 Citations (Scopus)

The fate of granulosa cells following premature oocyte loss and the development of ovarian cancers

Pitman, J. L., McNeilly, A. S., McNeilly, J. R., Hays, L. E., Bagby, G. C., Sawyer, H. R. & McNatty, K. P., 2012, In : International Journal of Developmental Biology. 56, 10-12, p. 949-958 10 p.

Research output: Contribution to journalArticle

Granulosa Cells
Ovarian Neoplasms
Oocytes
Germ Cells
Phenotype
2011
14 Citations (Scopus)

The stem cell fitness landscape and pathways of molecular leukemogenesis

Bagby, G. C. & Fleischman, A. G., Jan 1 2011, In : Frontiers in Bioscience - Scholar. 3 S, 2, p. 487-500 14 p.

Research output: Contribution to journalArticle

Clonal Evolution
Stem cells
Bone
Stem Cells
Bone Marrow
108 Citations (Scopus)

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R., Loriaux, M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

Cells
Stem cells
Stem Cells
Assays
Neoplasms
2010
58 Citations (Scopus)

Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol

Zhang, Q-S., Marquez-Loza, L., Eaton, L., Duncan, A. W., Goldman, D., Anur, P., Watanabe-Smith, K., Rathbun, R. K., Fleming, W., Bagby, G. C. & Grompe, M., Dec 9 2010, In : Blood. 116, 24, p. 5140-5148 9 p.

Research output: Contribution to journalArticle

Bone
Bone Marrow
Cells
Fanconi Anemia
Defects
31 Citations (Scopus)

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia

Pulliam-Leath, A. C., Ciccone, S. L., Nalepa, G., Li, X., Si, Y., Miravalle, L., Smith, D., Yuan, J., Li, J., Anur, P., Orazi, A., Vance, G. H., Yang, F. C., Hanenberg, H., Bagby, G. C. & Clapp, D. W., Oct 21 2010, In : Blood. 116, 16, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Acute Myeloid Leukemia
Bone
Fanconi Anemia Complementation Group Proteins
Bone Marrow
7 Citations (Scopus)

Human FANCC is hypomorphic in murine Fancc-deficient cells

Hays, L. E., Keeble, W. W., Yates, J. E., Rathbun, R. K., Koretsky, T., Olson, S., Sun, Z., Clapp, D. W. & Bagby, G. C., Sep 23 2010, In : Blood. 116, 12, p. 2057-2060 4 p.

Research output: Contribution to journalArticle

Endotoxins
Hypersensitivity
Assays
Bone Marrow
Cytokines
2009
21 Citations (Scopus)

Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes

Pejovic, T., Pande, N. T., Mori, M. T., Mhawech-Fauceglia, P., Harrington, C. C., Mongoue-Tchokote, S., Dim, D., Andrews, C., Beck, A., Tarumi, Y., Djilas, J., Cappuccini, F., Caballero, O., Huang, J., Levy, S., Tsiamouri, A., Cain, J., Bagby, G. C., Strausberg, R. L., Simpson, A. J. & 1 others, Odunsi, K. O., 2009, In : Translational Oncology. 2, 4, p. 341-349 9 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Phosphotransferases
Epithelial Cells
Genes
Reverse Transcription

Introducing "e-Blood"

Bagby, G. C. & Dunbar, C. E., 2009, In : Blood. 113, 19, p. 4488 1 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
Paroxysmal Hemoglobinuria
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Leukemia
Bone Marrow
2 Citations (Scopus)

Preface

Bagby, G. C. & Meyers, G., Apr 2009, In : Hematology/Oncology Clinics of North America. 23, 2

Research output: Contribution to journalArticle

Bone Marrow Diseases
50 Citations (Scopus)

TLR8-dependent TNF-α overexpression in Fanconi anemia group C cells

Vanderwerf, S. M., Svahn, J., Olson, S., Rathbun, R. K., Harrington, C. C., Yates, J., Keeble, W., Anderson, D. C., Anur, P., Pereira, N. F., Pilonetto, D. V., Pasquini, R. & Bagby, G. C., Dec 17 2009, In : Blood. 114, 26, p. 5290-5298 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 8
Fanconi Anemia
Tumor Necrosis Factor-alpha
Interleukin-1 Receptor-Associated Kinases
Proteins
2008
13 Citations (Scopus)

Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression

Hays, L. E., Zodrow, D. M., Yates, J. E., Deffebach, M. E., Jacoby, D., Olson, S., Pankow, J. F. & Bagby, G. C., May 20 2008, In : British Journal of Cancer. 98, 10, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Chromosomal Instability
Epithelial Cells
Bronchogenic Carcinoma
10 Citations (Scopus)

Discovering early molecular determinants of leukemogenesis

Bagby, G. C., Mar 2008, In : Journal of Clinical Investigation. 118, 3, p. 847-850 4 p.

Research output: Contribution to journalArticle

Mutation
Stem Cells
Granulocyte Colony-Stimulating Factor Receptors
Neoplastic Processes
Granulocyte Colony-Stimulating Factor
37 Citations (Scopus)
Invariant Set
Microarrays
Microarray Data
Normalization
Gene expression
23 Citations (Scopus)

TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice

Zhou, Y., Du, W., Koretsky, T., Bagby, G. C. & Pang, Q., Sep 15 2008, In : Blood. 112, 6, p. 2474-2483 10 p.

Research output: Contribution to journalArticle

Apoptosis
Peptides
Stem cells
Tumors
Leukemia
2007
23 Citations (Scopus)
Clonal Evolution
Leukemia
Bone Marrow
Paroxysmal Hemoglobinuria
Aplastic Anemia

In response [6]

Bagby, G. C. & Pejovic, T., Mar 15 2007, In : Cancer Research. 67, 6, p. 2902-2903 2 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

TNF-α induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells

Li, J., Sejas, D. P., Zhang, X., Qiu, Y., Nattamai, K. J., Rani, R., Rathbun, K. R., Geiger, H., Williams, D. A., Bagby, G. C. & Pang, Q., Nov 1 2007, In : Journal of Clinical Investigation. 117, 11, p. 3283-3295 13 p.

Research output: Contribution to journalArticle

Clonal Evolution
Fanconi Anemia
Stem Cells
Clone Cells
Cytokines
2006
1 Citation (Scopus)

Constitutional Marrow Failure: Introduction

Bagby, G. C., Jul 2006, In : Seminars in Hematology. 43, 3, p. 145-146 2 p.

Research output: Contribution to journalArticle

Bone Marrow Diseases
Fanconi Anemia
Aplastic Anemia
Stem Cell Transplantation
Graft vs Host Disease
36 Citations (Scopus)

Cytogenetic instability in ovarian epithelial cells from women at risk of ovarian cancer

Pejovic, T., Yates, J. E., Liu, H. Y., Hays, L. E., Akkari, Y., Torimaru, Y., Keeble, W., Rathbun, R. K., Rodgers, W. H., Bale, A. E., Ameziane, N., Zwaan, C. M., Errami, A., Thuillier, P., Cappuccini, F., Olson, S., Cain, J. M. & Bagby, G. C., Sep 15 2006, In : Cancer Research. 66, 18, p. 9017-9025 9 p.

Research output: Contribution to journalArticle

Cytogenetics
Ovarian Neoplasms
Epithelial Cells
Mitomycin
Fanconi Anemia
69 Citations (Scopus)

Evaluation and lead optimization of anti-malarial acridones

Winter, R. W., Kelly, J. X., Smilkstein, M. J., Dodean, R., Bagby, G. C., Rathbun, R. K., Levin, J. I., Hinrichs, D. & Riscoe, M., Sep 2006, In : Experimental Parasitology. 114, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

Acridones
Antimalarials
Plasmodium
Electron Transport Complex III
Structure-Activity Relationship
117 Citations (Scopus)

Fanconi Anemia

Bagby, G. C. & Alter, B. P., Jul 2006, In : Seminars in Hematology. 43, 3, p. 147-156 10 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
Fanconi Anemia
Fanconi Anemia Complementation Group D2 Protein
Hypersensitivity
Bone Marrow
26 Citations (Scopus)

Immune defects in Fanconi anemia

Fagerlie, S. R. & Bagby, G. C., 2006, In : Critical Reviews in Immunology. 26, 1, p. 81-96 16 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Bone Marrow
Hematopoietic Stem Cells
Chromosomal Instability
Inborn Genetic Diseases
2 Citations (Scopus)

Novel inactivating mutations of FANCC in Brazilian patients with Fanconi anemia.

Yates, J., Keeble, W., Pals, G., Ameziane, N., van Spaendonk, R., Olson, S., Akkari, Y., Pasquini, R. & Bagby, G., Feb 2006, In : Human Mutation. 27, 2, p. 214 1 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Exons
Fanconi Anemia Complementation Group C Protein
Mutation
Heterozygote
37 Citations (Scopus)

Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitor cells

Li, J., Sejas, D. P., Rani, R., Koretsky, T., Bagby, G. C. & Pang, Q., Jun 16 2006, In : Journal of Biological Chemistry. 281, 24, p. 16536-16545 10 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Cell Cycle
Cells
DNA Damage
1 Citation (Scopus)

The less-traveled Fanconi road

Bagby, G. C., Jun 1 2006, In : Blood. 107, 11, p. 4196-4197 2 p.

Research output: Contribution to journalArticle

Genes
Fanconi Anemia
Acute Myeloid Leukemia
Genome
Bone
2005
56 Citations (Scopus)

Generation and molecular characterization of head and neck squamous cell lines of Fanconi anemia patients

Van Zeeburg, H. J. T., Snijders, P. J. F., Pals, G., Hermsen, M. A. J. A., Rooimans, M. A., Bagby, G., Soulier, J., Gluckman, E., Wennerberg, J., Leemans, C. R., Joenje, H. & Brakenhoff, R. H., Feb 15 2005, In : Cancer Research. 65, 4, p. 1271-1276 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Neck
Epithelial Cells
Head
Cell Line
2004
113 Citations (Scopus)

Hypoxia-induced nucleophosmin protects cell death through inhibition of p53

Li, J., Zhang, X., Sejas, D. P., Bagby, G. C. & Pang, Q., Oct 1 2004, In : Journal of Biological Chemistry. 279, 40, p. 41275-41279 5 p.

Research output: Contribution to journalArticle

Cell death
Cell Death
Hypoxia-Inducible Factor 1
Cells
Null Lymphocytes
20 Citations (Scopus)

Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice

Fagerlie, S. R., Koretsky, T., Torok-Storb, B. & Bagby, G. C., Sep 15 2004, In : Journal of Immunology. 173, 6, p. 3863-3870 8 p.

Research output: Contribution to journalArticle

Fanconi Anemia
TYK2 Kinase
Fanconi Anemia Complementation Group C Protein
Mutation
Cell Differentiation
40 Citations (Scopus)

Marrow failure.

Bagby, G. C., Lipton, J. M., Sloand, E. M. & Schiffer, C. A., 2004, In : Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. p. 318-336 19 p.

Research output: Contribution to journalArticle

Bone Marrow
Dyskeratosis Congenita
Fanconi Anemia
Immunosuppressive Agents
Therapeutics
39 Citations (Scopus)

The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR)

Zhang, X., Li, J., Sejas, D. P., Rathbun, K. R., Bagby, G. C. & Pang, Q., Oct 15 2004, In : Journal of Biological Chemistry. 279, 42, p. 43910-43919 10 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
Fanconi Anemia
Protein Kinases
Bone
RNA
2003
39 Citations (Scopus)

Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia

Lensch, M. W., Tischkowitz, M., Christianson, T. A., Reifsteck, C. A., Speckhart, S. A., Jakobs, P. M., O'Dwyer, M. E., Olson, S., Le Beau, M. M., Hodgson, S. V., Mathew, C. G., Larson, R. A. & Bagby, G. C., Jul 1 2003, In : Blood. 102, 1, p. 7-16 10 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Mitomycin
Acute Myeloid Leukemia
Cytogenetics
Fanconi Anemia Complementation Group Proteins
8 Citations (Scopus)

Cisplatin and the sensitive cell

Bagby, G. C. & Olson, S., May 1 2003, In : Nature Medicine. 9, 5, p. 513-514 2 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Epigenomics
Ovarian Neoplasms
Cisplatin
Genes
126 Citations (Scopus)

Genetic basis of Fanconi anemia

Bagby, G. C., Jan 2003, In : Current Opinion in Hematology. 10, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Fanconi Anemia Complementation Group Proteins
DNA Damage
Bone Marrow Diseases
BRCA2 Gene
41 Citations (Scopus)

Nucleophosmin Interacts with and Inhibits the Catalytic Function of Eukaryotic Initiation Factor 2 Kinase PKR

Pang, Q., Christianson, T. A., Koretsky, T., Carlson, H., David, L., Keeble, W., Faulkner, G. R., Speckhart, A. & Bagby, G. C., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 41709-41717 9 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Phosphotransferases
Chemical activation
Cues
Fanconi Anemia
2002
72 Citations (Scopus)

Expression of apoptosis-related genes in chronic cyclosporine nephrotoxicity in mice

Yang, C. W., Faulkner, G. R., Wahba, I. M., Christianson, T. A., Bagby, G. C., Jin, D. C., Abboud, H. E., Andoh, T. F. & Bennett, W. M., May 2002, In : American Journal of Transplantation. 2, 5, p. 391-399 9 p.

Research output: Contribution to journalArticle

Cyclosporine
Apoptosis
Genes
Sodium-Restricted Diet
Caspase 1
46 Citations (Scopus)

Fanconi anemia group A and C double-mutant mice: Functional evidence for a multi-protein Fanconi anemia complex

Noll, M., Battaile, K. P., Bateman, R., Lax, T. P., Rathbun, K., Reifsteck, C., Bagby, G., Finegold, M., Olson, S. & Grompe, M., 2002, In : Experimental Hematology. 30, 7, p. 679-688 10 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
Fanconi Anemia
Germ Cells
DNA Damage
Phenotype
77 Citations (Scopus)

The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC

Pang, Q., Christianson, T. A., Keeble, W., Koretsky, T. & Bagby, G. C., Dec 20 2002, In : Journal of Biological Chemistry. 277, 51, p. 49638-49643 6 p.

Research output: Contribution to journalArticle

Fanconi Anemia Complementation Group Proteins
eIF-2 Kinase
Fanconi Anemia
Double-Stranded RNA
Interferons

The Fanconi anemia cell line HSC536N is not sensitive to interferon-γ and does not cleave PARP in response to Fas-mediated cell killing [5] (multiple letters)

Rutherford, T. R., Myatt, N. E., Gibson, F. M., Clarke, A. A. & Bagby, G. C., Apr 1 2002, In : Blood. 99, 7, p. 2627-2630 4 p.

Research output: Contribution to journalArticle

CD95 Antigens
Caspases
Caspase 3
Interferon-gamma
Cells
2001
109 Citations (Scopus)

FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-γ/TNF-α-mediated cytotoxicity

Pang, Q., Keeble, W., Christianson, T. A., Faulkner, G. R. & Bagby, G. C., Aug 15 2001, In : EMBO Journal. 20, 16, p. 4478-4489 12 p.

Research output: Contribution to journalArticle

Cytotoxicity
eIF-2 Kinase
Interferons
Tumor Necrosis Factor-alpha
Fanconi Anemia
40 Citations (Scopus)

Functional correction of FA-C cells with FANCC suppresses the expression of interferon γ-inducible genes

Fagerlie, S. R., Diaz, J., Christianson, T. A., McCartan, K., Keeble, W., Faulkner, G. R. & Bagby, G. C., May 15 2001, In : Blood. 97, 10, p. 3017-3024 8 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Interferons
Genes
Gamma Subunit Interferon-Stimulated Gene Factor 3
Fanconi Anemia Complementation Group C Protein
140 Citations (Scopus)

Hidradenitis suppurativa and Crohn's disease: Response to treatment with infliximab

Kempton, C. L., Bagby, G. & Collins, J. J., 2001, In : Inflammatory Bowel Diseases. 7, 4, p. 323-326 4 p.

Research output: Contribution to journalArticle

Hidradenitis Suppurativa
Crohn Disease
Skin Manifestations
Inflammatory Bowel Diseases
Infliximab
52 Citations (Scopus)

Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of fanconi anemia complementation group C cells to interferon γ, tumor necrosis factor-α, and double-stranded RNA

Pang, Q., Keeble, W., Diaz, J., Christianson, T. A., Fagerlie, S., Rathbun, K., Faulkner, G. R., O'Dwyer, M. & Bagby, G. C., Mar 15 2001, In : Blood. 97, 6, p. 1644-1652 9 p.

Research output: Contribution to journalArticle

eIF-2 Kinase
Fanconi Anemia
Double-Stranded RNA
Interferons
Hypersensitivity