Francis Valiyaveetil

Associate Professor

  • 1313 Citations
  • 17 h-Index
19972019

Research output per year

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Research Output

  • 1313 Citations
  • 17 h-Index
  • 27 Article
  • 3 Chapter
  • 1 Comment/debate
  • 1 Review article
Article

A facile approach for the in vitro assembly of multimeric membrane transport proteins

Riederer, E. A., Focke, P. J., Georgieva, E. R., Akyuz, N., Matulef, K., Borbat, P. P., Freed, J. H., Blanchard, S. C., Boudker, O. & Valiyaveetil, F., Jun 11 2018, In : eLife. 7, e36478.

Research output: Contribution to journalArticle

6 Scopus citations

A Shared Mechanism for the Folding of Voltage-Gated K + Channels

McDonald, S. K., Levitz, T. S. & Valiyaveetil, F. I., Mar 26 2019, In : Biochemistry. 58, 12, p. 1660-1671 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression

Focke, P. J., Hein, C., Hoffmann, B., Matulef, K., Bernhard, F., Dötsch, V. & Valiyaveetil, F. I., Aug 2 2016, In : Biochemistry. 55, 30, p. 4212-4219 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Engineering the glutamate transporter homologue GltPh using protein semisynthesis

Focke, P. J., Annen, A. W. & Valiyaveetil, F. I., Mar 3 2015, In : Biochemistry. 54, 8, p. 1694-1702 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Glycine as a D-amino acid surrogate in the K+-selectivity filter

Valiyaveetil, F. I., Sekedat, M., MacKinnon, R. & Muir, T. W., Dec 7 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 49, p. 17045-17049 5 p.

Research output: Contribution to journalArticle

76 Scopus citations

Individual Ion Binding Sites in the K+ Channel Play Distinct Roles in C-type Inactivation and in Recovery from Inactivation

Matulef, K., Annen, A. W., Nix, J. C. & Valiyaveetil, F. I., May 3 2016, In : Structure. 24, 5, p. 750-761 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Instantaneous ion configurations in the K+ion channel selectivity filter revealed by 2D IR spectroscopy

Kratochvil, H. T., Carr, J. K., Matulef, K., Annen, A. W., Li, H., Maj, M., Ostmeyer, J., Serrano, A. L., Raghuraman, H., Moran, S. D., Skinner, J. L., Perozo, E., Roux, B., Valiyaveetil, F. I. & Zanni, M. T., Sep 2 2016, In : Science. 353, 6303, p. 1040-1044 5 p.

Research output: Contribution to journalArticle

86 Scopus citations
Open Access

In vitro folding of K vAP, a voltage-gated K + channel

Devaraneni, P. K., Devereaux, J. J. & Valiyaveetil, F. I., Dec 6 2011, In : Biochemistry. 50, 48, p. 10442-10450 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ion-binding properties of a K+ channel selectivity filter in different conformations

Liu, S., Focke, P. J., Matulef, K., Bian, X., Moënne-Loccoz, P., Valiyaveetil, F. I. & Lockless, S. W., Dec 8 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 49, p. 15096-15100 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation

Valiyaveetil, F. I., Leonetti, M., Muir, T. W. & MacKinnon, R., Nov 10 2006, In : Science. 314, 5801, p. 1004-1007 4 p.

Research output: Contribution to journalArticle

108 Scopus citations

Lipids in the structure, folding, and function of the KcsA K+ channel

Valiyaveetil, F. I., Zhou, Y. & MacKinnon, R., Sep 3 2002, In : Biochemistry. 41, 35, p. 10771-10777 7 p.

Research output: Contribution to journalArticle

277 Scopus citations

Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

Infield, D. T., Matulef, K., Galpin, J. D., Lam, K., Tajkhorshid, E., Ahern, C. A. & Valiyaveetil, F. I., Dec 1 2018, In : Nature communications. 9, 1, 5055.

Research output: Contribution to journalArticle

3 Scopus citations

Modular strategy for the semisynthesis of a K+ channel: Investigating interactions of the pore helix

Komarov, A. G., Linn, K. M., Devereaux, J. J. & Valiyaveetil, F. I., Dec 18 2009, In : ACS chemical biology. 4, 12, p. 1029-1038 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

On the role of Arg-210 and Glu-219 of subunit α in proton translocation by the Escherichia coli F0F1-ATP synthase

Valiyaveetil, F. I. & Fillingame, R. H., Dec 19 1997, In : Journal of Biological Chemistry. 272, 51, p. 32635-32641 7 p.

Research output: Contribution to journalArticle

100 Scopus citations
20 Scopus citations

Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy

Kratochvil, H. T., Maj, M., Matulef, K., Annen, A. W., Ostmeyer, J., Perozo, E., Roux, B., Valiyaveetil, F. I. & Zanni, M. T., Jul 5 2017, In : Journal of the American Chemical Society. 139, 26, p. 8837-8845 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Semisynthesis and folding of the potassium channel KcsA

Valiyaveetil, F. I., MacKinnon, R. & Muir, T. W., Aug 7 2002, In : Journal of the American Chemical Society. 124, 31, p. 9113-9120 8 p.

Research output: Contribution to journalArticle

132 Scopus citations

Semisynthesis of a functional K+ channel

Valiyaveetil, F. I., Sekedat, M., Muir, T. W. & MacKinnon, R., May 3 2004, In : Angewandte Chemie - International Edition. 43, 19, p. 2504-2507 4 p.

Research output: Contribution to journalArticle

46 Scopus citations

Semisynthesis of NaK, a Na+ and K+ conducting ion channel

Linn, K. M., Derebe, M. G., Jiang, Y. & Valiyaveetil, F. I., Jun 1 2010, In : Biochemistry. 49, 21, p. 4450-4456 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Semisynthetic K+ channels show that the constricted conformation of the selectivity filter is not the C-type inactivated state

Devaraneni, P. K., Komarov, A. G., Costantino, C. A., Devereaux, J. J., Matulef, K. & Valiyaveetil, F. I., Sep 24 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 39, p. 15698-15703 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel

Valiyaveetil, F. I., Sekedat, M., MacKinnon, R. & Muir, T. W., Sep 6 2006, In : Journal of the American Chemical Society. 128, 35, p. 11591-11599 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Studies of ion channels using expressed protein ligation

Focke, P. J. & Valiyaveetil, F. I., Dec 1 2010, In : Current Opinion in Chemical Biology. 14, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Subunit interactions coupling H+ transport and ATP synthesis in F1F0 ATP synthase

Fillingame, R. H., Girvin, M. E., Jiang, W., Valiyaveetil, F. & Hermolin, J., 1998, In : Acta Physiologica Scandinavica, Supplement. 163, 643, p. 163-168 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Subunit organization and structure in the F0 sector of Escherichia coli F1F0 ATP synthase

Fillingame, R. H., Jones, P. C., Jiang, W., Valiyaveetil, F. I. & Dmitriev, O. Y., Jun 10 1998, In : Biochimica et Biophysica Acta - Bioenergetics. 1365, 1-2, p. 135-142 8 p.

Research output: Contribution to journalArticle

52 Scopus citations

Transmembrane topography of subunit a in the Escherichia coli F1F0 ATP synthase

Valiyaveetil, F. I. & Fillingame, R. H., Jun 26 1998, In : Journal of Biological Chemistry. 273, 26, p. 16241-16247 7 p.

Research output: Contribution to journalArticle

123 Scopus citations

Using protein backbone mutagenesis to dissect the link between ion occupancy and C-Type inactivation in K+ channels

Matulef, K., Komarov, A. G., Costantino, C. A. & Valiyaveetil, F. I., Oct 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 44, p. 17886-17891 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
Chapter

Chapter 7 Semisynthesis of K+ Channels

Komarov, A. G., Linn, K. M., Devereaux, J. J. & Valiyaveetil, F. I., Jul 24 2009, Methods in Enzymology. Muir, T. & Abelson, J. (eds.). p. 135-150 16 p. (Methods in Enzymology; vol. 462).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Engineering K+ channels using semisynthesis

Komarov, A. G., Costantino, C. A. & Valiyaveetil, F. I., 2013, Chemical Neurobiology: Methods and Protocols. Banghart, M. (ed.). p. 3-17 15 p. (Methods in Molecular Biology; vol. 995).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Patch-clamp recordings of the KcsA K+ channel in unilamellar blisters

Matulef, K. & Valiyaveetil, F. I., 2018, Methods in Molecular Biology. Humana Press Inc., p. 181-191 11 p. (Methods in Molecular Biology; vol. 1684).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
Comment/debate

A glimpse into the C-type-inactivated state for a potassium channel

Valiyaveetil, F. I., Oct 5 2017, In : Nature Structural and Molecular Biology. 24, 10, p. 787-788 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
Review article

Incorporation of Non-Canonical Amino Acids

Leisle, L., Valiyaveetil, F., Mehl, R. A. & Ahern, C. A., 2015, In : Advances in experimental medicine and biology. 869, p. 119-151 33 p.

Research output: Contribution to journalReview article

11 Scopus citations