Erik Tucker

Research Assistant Professor

  • 1292 Citations
  • 20 h-Index
20072020

Research output per year

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Research Output

  • 1292 Citations
  • 20 h-Index
  • 37 Article
  • 2 Letter
  • 1 Chapter
  • 1 Comment/debate
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Article
2020

Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate

Wallisch, M., Olson, S. R., Crosby, J., Johnson, J., Murray, S. F., Shatzel, J. J., Tucker, E., McCarty, O., Hinds, M. T., Monia, B. P. & Gruber, A., Jun 1 2020, In : Cellular and Molecular Bioengineering. 13, 3, p. 179-187 9 p.

Research output: Contribution to journalArticle

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Tucker, E. I., Verbout, N. G., Markway, B. D., Wallisch, M., Lorentz, C. U., Hinds, M. T., Shatzel, J. J., Pelc, L. A., Wood, D. C., McCarty, O. J. T., Di Cera, E. & Gruber, A., Feb 27 2020, In : Blood. 135, 9, p. 689-699 11 p.

Research output: Contribution to journalArticle

Open Access
2019

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Lorentz, C. U., Verbout, N. G., Wallisch, M., Hagen, M. W., Shatzel, J. J., Olson, S. R., Puy, C., Hinds, M., McCarty, O., Gailani, D., Gruber, A. & Tucker, E., Apr 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Shirai, T., Revenko, A. S., Tibbitts, J., Ngo, A. T. P., Mitrugno, A., Healy, L. D., Johnson, J., Tucker, E. I., Hinds, M. T., Coussens, L. M., McCarty, O. J. T., Monia, B. P. & Gruber, A., Oct 22 2019, In : Blood Advances. 3, 20, p. 3080-3091 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus–induced organ damage and death

Silasi, R., Keshari, R. S., Lupu, C., Van Rensburg, W. J., Chaaban, H., Regmi, G., Shamanaev, A., Shatzel, J. J., Puy, C., Lorentz, C. U., Tucker, E. I., Gailani, D., Gruber, A., McCarty, O. J. T. & Lupu, F., Feb 26 2019, In : Blood Advances. 3, 4, p. 658-669 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

Factor XI contributes to myocardial ischemia-reperfusion injury in mice

Lorentz, C. U., Verbout, N. G., Cao, Z., Liu, L., Hinds, M. T., McCarty, O. J. T., Ivanov, I., Tucker, E. I., Gailani, D. & Gruber, A., Jan 23 2018, In : Blood Advances. 2, 2, p. 85-88 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Factor XII activation promotes platelet consumption in the presence of bacterial-type long-chain polyphosphate in vitro and in vivo

Zilberman-Rudenko, J., Reitsma, S. E., Puy, C., Rigg, R. A., Smith, S. A., Tucker, E. I., Silasi, R., Merkulova, A., McCrae, K. R., Maas, C., Urbanus, R. T., Gailani, D., Morrissey, J. H., Gruber, A., Lupu, F., Schmaier, A. H. & McCarty, O. J. T., 2018, In : Arteriosclerosis, thrombosis, and vascular biology. 38, 8, p. 1748-1760 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin

Sylman, J. L., Daalkhaijav, U., Zhang, Y., Gray, E. M., Farhang, P. A., Chu, T. T., Zilberman-Rudenko, J., Puy, C., Tucker, E. I., Smith, S. A., Morrissey, J. H., Walker, T. W., Nan, X. L., Gruber, A. & McCarty, O. J. T., May 1 2017, In : Annals of Biomedical Engineering. 45, 5, p. 1328-1340 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions

Garland, K. S., Reitsma, S. E., Shirai, T., Zilberman-Rudenko, J., Tucker, E. I., Gailani, D., Gruber, A., McCarty, O. J. T. & Puy, C., 2017, In : Frontiers in Medicine. 4, DEC, 232.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

Biorheology of Platelet Activation in the Bloodstream Distal to Thrombus Formation

Zilberman-Rudenko, J., Itakura, A., Maddala, J., Baker-Groberg, S. M., Vetter, R., Tucker, E. I., Gruber, A., Gerdes, C. & McCarty, O. J. T., Dec 1 2016, In : Cellular and Molecular Bioengineering. 9, 4, p. 496-508 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Coagulation Factor XI promotes distal platelet activation and single platelet consumption in the bloodstream under shear flow

Zilberman-Rudenko, J., Itakura, A., Wiesenekker, C. P., Vetter, R., Maas, C., Gailani, D., Tucker, E. I., Gruber, A., Gerdes, C. & McCarty, O. J. T., Mar 1 2016, In : Arteriosclerosis, thrombosis, and vascular biology. 36, 3, p. 510-517 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice

Bane, C. E., Ivanov, I., Matafonov, A., Boyd, K. L., Cheng, Q., Sherwood, E. R., Tucker, E. I., Smiley, S. T., McCarty, O. J. T., Gruber, A. & Gailani, D., Apr 2016, In : PloS one. 11, 4, e0152968.

Research output: Contribution to journalArticle

25 Scopus citations

Platelet-derived short-chain polyphosphates enhance the inactivation of tissue factor pathway inhibitor by activated coagulation factor XI

Puy, C., Tucker, E. I., Ivanov, I. S., Gailani, D., Smith, S. A., Morrissey, J. H., Gruber, A. & McCarty, O. J. T., Oct 2016, In : PloS one. 11, 10, e0165172.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Puy, C., Tucker, E. I., Matafonov, A., Cheng, Q., Zientek, K. D., Gailani, D., Gruber, A. & McCarty, O. J. T., 2015, In : Blood. 125, 9, p. 1488-1496 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

WEDGE: An anticoagulant thrombin mutant produced by autoactivation

Wood, D. C., Pelc, L. A., Pozzi, N., Wallisch, M., Verbout, N. G., Tucker, E. I., Gruber, A. & Di Cera, E., Jan 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 1, p. 111-114 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Matafonov, A., Leung, P. Y., Gailani, A. E., Grach, S. L., Puy, C., Cheng, Q., Sun, M. F., McCarty, O. J. T., Tucker, E. I., Kataoka, H., Renné, T., Morrissey, J. H., Gruber, A. & Gailani, D., Mar 13 2014, In : Blood. 123, 11, p. 1739-1746 8 p.

Research output: Contribution to journalArticle

122 Scopus citations
9 Scopus citations
2013

Antithrombotic effect of antisense factor xi oligonucleotide treatment in primates

Crosby, J. R., Marzec, U., Revenko, A. S., Zhao, C., Gao, D., Matafonov, A., Gailani, D., MacLeod, A. R., Tucker, E. I., Gruber, A., Hanson, S. R. & Monia, B. P., Jul 2013, In : Arteriosclerosis, thrombosis, and vascular biology. 33, 7, p. 1670-1678 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

Evidence for factor IX-independent roles for factor XIa in blood coagulation

Matafonov, A., Cheng, Q., Geng, Y., Verhamme, I. M., Umunakwe, O., Tucker, E. I., Sun, M. F., Serebrov, V., Gruber, A. & Gailani, D., Dec 2013, In : Journal of Thrombosis and Haemostasis. 11, 12, p. 2118-2127 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates

Puy, C., Tucker, E. I., Wong, Z. C., Gailani, D., Smith, S. A., Choi, S. H., Morrissey, J. H., Gruber, A. & Mccarty, O. J. T., Jul 2013, In : Journal of Thrombosis and Haemostasis. 11, 7, p. 1341-1352 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Red blood cell-derived microparticles isolated from blood units initiate and propagate thrombin generation

Rubin, O., Delobel, J., Prudent, M., Lion, N., Kohl, K., Tucker, E. I., Tissot, J. D. & Angelillo-Scherrer, A., Aug 1 2013, In : Transfusion. 53, 8, p. 1744-1754 11 p.

Research output: Contribution to journalArticle

89 Scopus citations
2012

Factor xi-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis

Luo, D., Szaba, F. M., Kummer, L. W., Johnson, L. L., Tucker, E. I., Gruber, A., Gailani, D. & Smiley, S. T., Jan 2012, In : Infection and Immunity. 80, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Tucker, E. I., Verbout, N. G., Leung, P. Y., Hurst, S., McCarty, O. J. T., Gailani, D. & Gruber, A., May 17 2012, In : Blood. 119, 20, p. 4762-4768 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

Leung, P. Y., Hurst, S., Berny-Lang, M. A., Verbout, N. G., Gailani, D., Tucker, E. I., Wang, R. K., McCarty, O. J. T. & Gruber, A., Sep 2012, In : Translational Stroke Research. 3, 3, p. 381-389 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2011

Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes

Itakura, A., Verbout, N. G., Phillips, K. G., Insall, R. H., Gailani, D., Tucker, E. I., Gruber, A. & McCarty, O. J. T., Nov 2011, In : Journal of Leukocyte Biology. 90, 5, p. 923-927 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Thrombin mutant W215A/E217A treatment improves neurological outcome and reduces cerebral infarct size in a mouse model of ischemic stroke

Berny-Lang, M. A., Hurst, S., Tucker, E. I., Pelc, L. A., Wang, R. K., Hurn, P. D., Di Cera, E., McCarty, O. J. T. & Gruber, A., Jun 2011, In : Stroke. 42, 6, p. 1736-1741 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

Cheng, Q., Tucker, E. I., Pine, M. S., Sisler, I., Matafonov, A., Sun, M. F., White-Adams, T. C., Smith, S. A., Hanson, S. R., McCarty, O. J. T., Renné, T., Gruber, A. & Gailani, D., Nov 11 2010, In : Blood. 116, 19, p. 3981-3989 9 p.

Research output: Contribution to journalArticle

160 Scopus citations

Laminin promotes coagulation and thrombus formation in a factor XII-dependent manner

White-Adams, T. C., Berny, M. A., Patel, I. A., Tucker, E. I., Gailani, D., Gruber, A. & McCarty, O. J. T., Jun 2010, In : Journal of Thrombosis and Haemostasis. 8, 6, p. 1295-1301 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates

Tucker, E. I., Marzec, U. M., Berny, M. A., Hurst, S., Bunting, S., McCarty, O. J. T., Gruber, A. & Hanson, S. R., Jun 23 2010, In : Science translational medicine. 2, 37, 37ra45.

Research output: Contribution to journalArticle

17 Scopus citations
2 Scopus citations
2009

Factor XI contributes to thrombin generation in the absence of factor XII

Kravtsov, D. V., Matafonov, A., Tucker, E. I., Sun, M. F., Walsh, P. N., Gruber, A. & Gailani, D., 2009, In : Blood. 114, 2, p. 452-458 7 p.

Research output: Contribution to journalArticle

90 Scopus citations

Identification of coagulation factor XI as a ligand for platelet apolipoprotein e receptor 2 (ApoER2)

White-Adams, T. C., Berny, M. A., Tucker, E. I., Gertz, J. M., Gailani, D., Urbanus, R. T., De Groot, P. G., Gruber, A. & McCarty, O. J. T., Oct 2009, In : Arteriosclerosis, thrombosis, and vascular biology. 29, 10, p. 1602-1607 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

Tucker, E. I., Marzec, U. M., White, T. C., Hurst, S., Rugonyi, S., McCarty, O. J. T., Gailani, D., Gruber, A. & Hanson, S. R., Jan 22 2009, In : Blood. 113, 4, p. 936-944 9 p.

Research output: Contribution to journalArticle

126 Scopus citations
2008

Protein C supports platelet binding and activation under flow: Role of glycoprotein Ib and apolipoprotein E receptor 2

White, T. C., Berny, M. A., Tucker, E. I., Urbanus, R. T., De Groot, P. G., Fernández, J. A., Griffin, J. H., Gruber, A. & Mccarty, O. J. T., Jun 2008, In : Journal of Thrombosis and Haemostasis. 6, 6, p. 995-1002 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis

Tucker, E. I., Gailani, D., Hurst, S., Cheng, Q., Hanson, S. R. & Gruber, A., Jul 15 2008, In : Journal of Infectious Diseases. 198, 2, p. 271-274 4 p.

Research output: Contribution to journalArticle

37 Scopus citations

Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist

Berny, M. A., White, T. C., Tucker, E. I., Bush-Pelc, L. A., Di Cera, E., Gruber, A. & McCarty, O. J. T., Feb 1 2008, In : Arteriosclerosis, thrombosis, and vascular biology. 28, 2, p. 329-334 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
2007

Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates

Gruber, A., Marzec, U. M., Bush, L., Di Cera, E., Fernández, J. A., Berny, M. A., Tucker, E. I., McCarty, O. J. T., Griffin, J. H. & Hanson, S. R., May 1 2007, In : Blood. 109, 9, p. 3733-3740 8 p.

Research output: Contribution to journalArticle

41 Scopus citations