Eric Gouaux

Senior Scientist

  • 21174 Citations
  • 72 h-Index
1987 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2019

Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM

Zhao, Y., Chen, S., Swensen, A. C., Qian, W. J. & Gouaux, E., Apr 26 2019, In : Science. 364, 6438, p. 355-362 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Autoimmune receptor encephalitis in mice induced by active immunization with conformationally stabilized holoreceptors

Jones, B. E., Tovar, K. R., Goehring, A., Jalali-Yazdi, F., Okada, N. J., Gouaux, E. & Westbrook, G., Jul 10 2019, In : Science Translational Medicine. 11, 500, eaaw0044.

Research output: Contribution to journalArticle

4 Scopus citations

Insights into the mechanism and pharmacology of neurotransmitter sodium symporters

Navratna, V. & Gouaux, E., Feb 2019, In : Current Opinion in Structural Biology. 54, p. 161-170 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Coleman, J. A., Yang, D., Zhao, Z., Wen, P. C., Yoshioka, C., Tajkhorshid, E. & Gouaux, E., May 2 2019, In : Nature. 569, 7754, p. 141-145 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3

Campbell, N. G., Shekar, A., Aguilar, J. I., Peng, D., Navratna, V., Yang, D., Morley, A. N., Duran, A. M., Galli, G., O’Grady, B., Ramachandran, R., Sutcliffe, J. S., Sitte, H. H., Erreger, K., Meiler, J., Stockner, T., Bellan, L. M., Matthies, H. J. G., Gouaux, E., Mchaourab, H. S. & 1 others, Galli, A., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3853-3862 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structure and mechanism of AMPA receptor — auxiliary protein complexes

Chen, S. & Gouaux, E., Feb 1 2019, In : Current Opinion in Structural Biology. 54, p. 104-111 8 p.

Research output: Contribution to journalReview article

6 Scopus citations
2018

Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Phulera, S., Zhu, H., Yu, J., Claxton, D. P., Yoder, N., Yoshioka, C. & Gouaux, E., Jul 25 2018, In : eLife. 7, e39383.

Research output: Contribution to journalArticle

37 Scopus citations

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography

Yoder, N. & Gouaux, E., Aug 2018, In : PloS one. 13, 8, e0202134.

Research output: Contribution to journalArticle

6 Scopus citations

Expression and purification of a functional heteromeric GABAA receptor for structural studies

Claxton, D. P. & Gouaux, E., Jul 1 2018, In : PLoS One. 13, 7, e0201210.

Research output: Contribution to journalArticle

1 Scopus citations

Gating mechanisms of acid-sensing ion channels

Yoder, N., Yoshioka, C. & Gouaux, E., Mar 15 2018, In : Nature. 555, 7696, p. 397-401 5 p.

Research output: Contribution to journalArticle

43 Scopus citations

Mechanism of NMDA receptor channel block by MK-801 and memantine

Song, X., Jensen, M. O., Jogini, V., Stein, R. A., Lee, C. H., McHaourab, H. S., Shaw, D. E. & Gouaux, E., Apr 26 2018, In : Nature. 556, 7702, p. 515-519 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

Jalali-Yazdi, F., Chowdhury, S., Yoshioka, C. & Gouaux, E., Nov 29 2018, In : Cell. 175, 6, p. 1520-1532.e15

Research output: Contribution to journalArticle

18 Scopus citations

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Coleman, J. A. & Gouaux, E., Feb 1 2018, In : Nature Structural and Molecular Biology. 25, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

Ge, J., Elferich, J., Goehring, A., Zhao, H., Schuck, P. & Gouaux, E., Aug 2 2018, In : eLife. 7, e38770.

Research output: Contribution to journalArticle

10 Scopus citations

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

Navratna, V., Tosh, D. K., Jacobson, K. A. & Gouaux, E., Jul 1 2018, In : PLoS One. 13, 7, e0200085.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM

Chen, S., Zhao, Y., Wang, Y., Shekhar, M., Tajkhorshid, E. & Gouaux, E., 2017, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

46 Scopus citations

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

Lü, W., Du, J., Goehring, A. & Gouaux, E., Mar 24 2017, In : Science. 355, 6331, eaal3729.

Research output: Contribution to journalArticle

57 Scopus citations

Structure and symmetry inform gating principles of ionotropic glutamate receptors

Zhu, S. & Gouaux, E., Jan 1 2017, In : Neuropharmacology. 112, p. 11-15 5 p.

Research output: Contribution to journalReview article

27 Scopus citations
2016

Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM

Zhao, Y., Chen, S., Yoshioka, C., Baconguis, I. & Gouaux, E., Jul 1 2016, In : Nature. 536, 7614, p. 108-111 4 p.

Research output: Contribution to journalArticle

56 Scopus citations

Mechanism of NMDA Receptor Inhibition and Activation

Zhu, S., Stein, R. A., Yoshioka, C., Lee, C. H., Goehring, A., McHaourab, H. S. & Gouaux, E., Apr 21 2016, In : Cell. 165, 3, p. 704-714 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Thermostabilization, expression, purification, and crystallization of the human serotonin transporter bound to S-citalopram

Coleman, J. A., Green, E. M. & Gouaux, E., Nov 27 2016, In : Journal of Visualized Experiments. 2016, 117, e54792.

Research output: Contribution to journalArticle

8 Scopus citations

X-ray structures and mechanism of the human serotonin transporter

Coleman, J. A., Green, E. M. & Gouaux, E., Apr 21 2016, In : Nature. 532, 7599, p. 334-339 6 p.

Research output: Contribution to journalArticle

230 Scopus citations

X-ray structures define human P2X 3 receptor gating cycle and antagonist action

Mansoor, S. E., Lü, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E. & Gouaux, E., Sep 14 2016, In : Nature. 538, 7623, p. 66-71 6 p.

Research output: Contribution to journalArticle

83 Scopus citations
2015

Glycine receptor mechanism elucidated by electron cryo-microscopy

Du, J., Lü, W., Wu, S., Cheng, Y. & Gouaux, E., Oct 8 2015, In : Nature. 526, 7572, p. 224-229 6 p.

Research output: Contribution to journalArticle

203 Scopus citations

Neurotransmitter and psychostimulant recognition by the dopamine transporter

Wang, K. H., Penmatsa, A. & Gouaux, E., May 21 2015, In : Nature. 521, 7552, p. 322-327 6 p.

Research output: Contribution to journalArticle

177 Scopus citations

Thermostabilization of the human serotonin transporter in an antidepressant-bound conformation

Green, E. M., Coleman, J. A. & Gouaux, E., Dec 1 2015, In : PLoS One. 10, 12, e0145688.

Research output: Contribution to journalArticle

13 Scopus citations

X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine

Penmatsa, A., Wang, K. H. & Gouaux, E., Jun 3 2015, In : Nature Structural and Molecular Biology. 22, 6, p. 506-508 3 p.

Research output: Contribution to journalArticle

87 Scopus citations
2014

How LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transporters

Penmatsa, A. & Gouaux, E., Mar 1 2014, In : Journal of Physiology. 592, 5, p. 863-869 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

NMDA receptor structures reveal subunit arrangement and pore architecture

Lee, C. H., Lü, W., Michel, J. C., Goehring, A., Du, J., Song, X. & Gouaux, E., Jan 1 2014, In : Nature. 511, 7508, p. 191-197 7 p.

Research output: Contribution to journalArticle

279 Scopus citations

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

Goehring, A., Lee, C. H., Wang, K. H., Michel, J. C., Claxton, D. P., Baconguis, I., Althoff, T., Fischer, S., Garcia, K. C. & Gouaux, E., Nov 27 2014, In : Nature protocols. 9, 11, p. 2574-2585 12 p.

Research output: Contribution to journalArticle

156 Scopus citations

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states

Dürr, K. L., Chen, L., Stein, R. A., De Zorzi, R., Folea, I. M., Walz, T., McHaourab, H. S. & Gouaux, E., Aug 14 2014, In : Cell. 158, 4, p. 778-792 15 p.

Research output: Contribution to journalArticle

130 Scopus citations

X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na+-selective channel

Baconguis, I., Bohlen, C. J., Goehring, A., Julius, D. & Gouaux, E., Feb 13 2014, In : Cell. 156, 4, p. 717-729 13 p.

Research output: Contribution to journalArticle

149 Scopus citations

X-ray structures of AMPA receptor-cone snail toxin complexes illuminate activation mechanism.

Chen, L., Dürr, K. L. & Gouaux, E., Aug 29 2014, In : Science (New York, N.Y.). 345, 6200, p. 1021-1026 6 p.

Research output: Contribution to journalArticle

79 Scopus citations

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

Althoff, T., Hibbs, R. E., Banerjee, S. & Gouaux, E., Aug 21 2014, In : Nature. 512, 7514, p. 333-337 5 p.

Research output: Contribution to journalArticle

157 Scopus citations
2013

Novel Dicarboxylate Selectivity in an Insect Glutamate Transporter Homolog

Wang, H., Rascoe, A. M., Holley, D. C., Gouaux, E. & Kavanaugh, M. P., Aug 7 2013, In : PloS one. 8, 8, e70947.

Research output: Contribution to journalArticle

4 Scopus citations

Structural basis for action by diverse antidepressants on biogenic amine transporters

Wang, H., Goehring, A., Wang, K. H., Penmatsa, A., Ressler, R. & Gouaux, E., Oct 14 2013, In : Nature. 503, 7474, p. 141-145 5 p.

Research output: Contribution to journalArticle

85 Scopus citations
29 Scopus citations

X-ray structure of dopamine transporter elucidates antidepressant mechanism

Penmatsa, A., Wang, K. H. & Gouaux, E., Sep 16 2013, In : Nature. 503, 7474, p. 85-90 6 p.

Research output: Contribution to journalArticle

344 Scopus citations
2012

A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening

Hattori, M., Hibbs, R. E. & Gouaux, E., Aug 8 2012, In : Structure. 20, 8, p. 1293-1299 7 p.

Research output: Contribution to journalArticle

126 Scopus citations

Insights into transport mechanism from LeuT engineered to transport tryptophan

Piscitelli, C. L. & Gouaux, E., Jan 4 2012, In : EMBO Journal. 31, 1, p. 228-235 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Hattori, M. & Gouaux, E., May 9 2012, In : Nature. 485, 7397, p. 207-212 6 p.

Research output: Contribution to journalArticle

311 Scopus citations

Structural plasticity and dynamic selectivity of acid-sensing ion channelspider toxin complexes

Baconguis, I. & Gouaux, E., Sep 20 2012, In : Nature. 489, 7416, p. 400-405 6 p.

Research output: Contribution to journalArticle

171 Scopus citations

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

Wang, H., Elferich, J. & Gouaux, E., Feb 1 2012, In : Nature Structural and Molecular Biology. 19, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue

Wang, H. & Gouaux, E., Sep 1 2012, In : EMBO Reports. 13, 9, p. 861-866 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

Krishnamurthy, H. & Gouaux, E., Jan 26 2012, In : Nature. 481, 7382, p. 469-474 6 p.

Research output: Contribution to journalArticle

327 Scopus citations
2011

Amino terminal domains of the NMDA receptor are organized as local heterodimers

Lee, C. H. & Gouaux, E., May 4 2011, In : PloS one. 6, 4, e19180.

Research output: Contribution to journalArticle

29 Scopus citations

Principles of activation and permeation in an anion-selective Cys-loop receptor

Hibbs, R. E. & Gouaux, E., Jun 2 2011, In : Nature. 474, 7349, p. 54-60 7 p.

Research output: Contribution to journalArticle

683 Scopus citations
2010

Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density

Giannone, G., Hosy, E., Levet, F., Constals, A., Schulze, K., Sobolevsky, A. I., Rosconi, M. P., Gouaux, E., Tampe, R., Choquet, D. & Cognet, L., Aug 9 2010, In : Biophysical Journal. 99, 4, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

226 Scopus citations

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

Banerjee, A., Mikhailova, E., Cheley, S., Gu, L. Q., Montoya, M., Nagaoka, Y., Gouaux, E. & Bayley, H., May 4 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8165-8170 6 p.

Research output: Contribution to journalArticle

74 Scopus citations