Elaine Johnson

Associate Professor

  • 2733 Citations
  • 28 h-Index
19942018

Research Output 1994 2018

  • 2733 Citations
  • 28 h-Index
  • 52 Article
  • 1 Letter
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Article
2018

The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography

Jiang, X., Johnson, E., Cepurna, W., Lozano, D., Men, S., Wang, R. K. & Morrison, J. Jan 1 2018 In : Microvascular Research. 115, p. 12-19 8 p.

Research output: Research - peer-reviewArticle

Optical Coherence Tomography
Intraocular Pressure
Angiography
Optical tomography
Animals
2017
3 Citations

Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: A pilot study

Jayaram, H., Phillips, J. I., Lozano, D. C., Choe, T. E., Cepurna, W. O., Johnson, E. C., Morrison, J. C., Gattey, D. M., Saugstad, J. A. & Keller, K. E. Jun 1 2017 In : Investigative Ophthalmology and Visual Science. 58, 7, p. 2884-2890 7 p.

Research output: Research - peer-reviewArticle

Aqueous Humor
MicroRNAs
Polymerase Chain Reaction
Primary Open Angle Glaucoma
Encyclopedias
2 Citations

The challenge of regenerative therapies for the optic nerve in glaucoma

Calkins, D. J., Pekny, M., Cooper, M. L., Benowitz, L., Calkins, D., Benowitz, L., Cooper, M., Crowston, J., Huberman, A., Johnson, E., Lu, R., Pekny, M., Sappington, R., Zack, D. & The Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants Apr 1 2017 In : Experimental Eye Research. 157, p. 28-33 6 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Glaucoma
Regeneration
Therapeutics
Retinal Ganglion Cells
2016
1 Citations

A period of controlled elevation of IOP (CEI) produces the specific gene expression responses and focal injury pattern of experimental rat glaucoma

Morrison, J. C., Cepurna, W. O., Tehrani, S., Choe, T. E., Jayaram, H., Lozano, D. C., Fortune, B. & Johnson, E. C. Dec 1 2016 In : Investigative Ophthalmology and Visual Science. 57, 15, p. 6700-6711 12 p.

Research output: Research - peer-reviewArticle

Optic Disk
Glaucoma
Gene Expression
Wounds and Injuries
Optic Nerve
2 Citations

Astrocyte structural and molecular response to elevated intraocular pressure occurs rapidly and precedes axonal tubulin rearrangement within the optic nerve head in a rat model

Tehrani, S., Davis, L., Cepurna, W. O., Choe, T. E., Lozano, D. C., Monfared, A., Cooper, L., Cheng, J., Johnson, E. C. & Morrison, J. C. Nov 1 2016 In : PLoS One. 11, 11, e0167364

Research output: Research - peer-reviewArticle

astrocytes
optics
tubulin
nerve tissue
animal models
6 Citations

Expansions of the neurovascular scleral canal and contained optic nerve occur early in the hypertonic saline rat experimental glaucoma model

Pazos, M., Yang, H., Gardiner, S. K., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Burgoyne, C. F. Apr 1 2016 In : Experimental Eye Research. 145, p. 173-186 14 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Glaucoma
Theoretical Models
Optic Disk
Nerve Expansion
2015
6 Citations
Optical Coherence Tomography
Intraocular Pressure
Perfusion
Pressure
Optical tomography
11 Citations

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

Ying, H. H., Turturro, S. S., Nguyen, T. T., Shen, X. X., Zelkha, R. R., Johnson, E. E. C., Morrison, J. J. C. & Yue, B. B. Y. J. T. May 6 2015 In : BMC Cell Biology. 16, 1, 14

Research output: Research - peer-reviewArticle

Autophagy
Proteasome Endopeptidase Complex
Genes
Ubiquitin
Proteins
7 Citations

MicroRNA expression in the glaucomatous retina

Jayaram, H., Cepurna, W. O., Johnson, E. C. & Morrison, J. C. Dec 1 2015 In : Investigative Ophthalmology and Visual Science. 56, 13, p. 7971-7982 12 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Retina
Intraocular Pressure
Central Nervous System
Gene Expression
8 Citations

Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure

Morrison, J. C., Cepurna, W. O. & Johnson, E. C. Mar 28 2015 In : Experimental Eye Research. 141, p. 23-32 10 p.

Research output: Research - peer-reviewArticle

Intraocular Pressure
Glaucoma
Injections
Aqueous Humor
Optic Disk
12 Citations

Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye

Lu, W., Hu, H., Sévigny, J., Gabelt, B. T., Kaufman, P. L., Johnson, E. C., Morrison, J. C., Zode, G. S., Sheffield, V. C., Zhang, X., Laties, A. M. & Mitchell, C. H. 2015 In : Investigative Ophthalmology and Visual Science. 56, 5, p. 3075-3083 9 p.

Research output: Research - peer-reviewArticle

Glaucoma
Primates
Adenosine Triphosphate
CD39 antigen
Astrocytes
7 Citations

Rat optic nerve head anatomy within 3D histomorphometric reconstructions of normal control eyes

Pazos, M., Yang, H., Gardiner, S. K., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Burgoyne, C. F. Oct 1 2015 In : Experimental Eye Research. 139, p. 1-12 12 p.

Research output: Research - peer-reviewArticle

Optic Disk
Anatomy
Bruch Membrane
Retinal Vein
Sclera
2014
11 Citations
Optic Disk
Astrocytes
Glaucoma
Actins
Optic Nerve
10 Citations
Optic Nerve
Intraocular Pressure
Radiation
Wounds and Injuries
Glaucoma
2012
35 Citations
intraocular pressure
retina
nerves
blood flow
rats
2011
67 Citations

Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma

Johnson, E. C., Doser, T. A., Cepurna, W. O., Dyck, J. A., Jia, L., Guo, Y., Lambert, W. S. & Morrison, J. C. Jan 2011 In : Investigative Ophthalmology and Visual Science. 52, 1, p. 504-518 15 p.

Research output: Research - peer-reviewArticle

Optic Nerve Injuries
Optic Disk
Craniocerebral Trauma
Glaucoma
Interleukin-6
39 Citations

Early gene expression changes in the retinal ganglion cell layer of a rat glaucoma model

Guo, Y., Johnson, E. C., Cepurna, W. O., Dyck, J. A., Doser, T. & Morrison, J. C. Mar 2011 In : Investigative Ophthalmology and Visual Science. 52, 3, p. 1460-1473 14 p.

Research output: Research - peer-reviewArticle

Retinal Ganglion Cells
Glaucoma
Gene Expression
Genes
Wounds and Injuries
47 Citations

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

Morrison, J. C., Cepurna Ying Guo, W. O. & Johnson, E. C. Aug 2011 In : Experimental Eye Research. 93, 2, p. 156-164 9 p.

Research output: Research - peer-reviewArticle

Optic Disk
Optic Nerve
Intraocular Pressure
Glaucoma
Primates
54 Citations

Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography

Zhi, Z., Cepurna, W., Johnson, E., Shen, T., Morrison, J. & Wang, R. K. Mar 1 2011 In : Biomedical Optics Express. 2, 3, p. 579-591 13 p.

Research output: Research - peer-reviewArticle

angiography
blood flow
imaging techniques
rats
flow velocity
2010
28 Citations

Retinal cell responses to elevated intraocular pressure: A gene array comparison between the whole retina and retinal ganglion cell layer

Guo, Y., Cepurna, W. O., Dyck, J. A., Doser, T. A., Johnson, E. C. & Morrison, J. C. Jun 2010 In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3003-3018 16 p.

Research output: Research - peer-reviewArticle

Retinal Ganglion Cells
Intraocular Pressure
Retina
Genes
Down-Regulation
2009
27 Citations

Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?

Guo, Y., Johnson, E., Cepurna, W., Jia, L., Dyck, J. & Morrison, J. C. Dec 2009 In : Experimental Eye Research. 89, 6, p. 921-933 13 p.

Research output: Research - peer-reviewArticle

Intraocular Pressure
Glaucoma
Proteins
Wounds and Injuries
Messenger RNA
74 Citations

Friend or foe? Resolving the impact of glial responses in glaucoma

Johnson, E. C. & Morrison, J. C. Jun 2009 In : Journal of Glaucoma. 18, 5, p. 341-353 13 p.

Research output: Research - peer-reviewArticle

Neuroglia
Glaucoma
Optic Disk
Retina
Retinal Ganglion Cells
57 Citations

Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models

Johnson, E. C., Guo, Y., Cepurna, W. O. & Morrison, J. C. Apr 30 2009 In : Experimental Eye Research. 88, 4, p. 808-815 8 p.

Research output: Research - peer-reviewArticle

Retinal Ganglion Cells
Nerve Growth Factors
Glaucoma
Cell Survival
Pressure
28 Citations

Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats

Morrison, J. C., Jia, L., Cepurna, W., Guo, Y. & Johnson, E. 2009 In : Investigative Ophthalmology and Visual Science. 50, 6, p. 2802-2808 7 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Reading
Lighting
Transducers
Light
83 Citations

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G. , Ben-Hur, T. , Gibson, G. E. , Stevens, B. , Streit, W. J. , Wekerle, H. , Bhattacharya, S. K. , Borras, T. , Burgoyne, C. F. , Caspi, R. R. , Chauhan, B. C. , Clark, A. F. , Crowston, J. , Danias, J. , Dick, A. D. , Flammer, J. , Foster, C. S. , Grosskreutz, C. L. , Grus, F. H. , Guy, J. & 48 others Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. T., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D., Ju, W. K., Kang, K., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J. Mar 2009 In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Research - peer-reviewArticle

2008
25 Citations

Comparison of anterior segment structures in two rat glaucoma models: An ultrasound biomicroscopic study

Nissirios, N., Chanis, R., Johnson, E., Morrison, J., Cepurna, W. O., Jia, L., Mittag, T. & Danias, J. Jun 2008 In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2478-2482 5 p.

Research output: Research - peer-reviewArticle

Glaucoma
Veins
Anterior Chamber
Sclerosis
Cautery
51 Citations

Rat models for glaucoma research

Morrison, J. C., Johnson, E. & Cepurna, W. O. 2008 In : Progress in Brain Research. 173, p. 285-301 17 p.

Research output: Research - peer-reviewArticle

Glaucoma
Pressure
Research
Optic Disk
Optic Nerve
2007
143 Citations

Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model

Johnson, E. C., Jia, L., Cepurna, W. O., Doser, T. A. & Morrison, J. C. Jul 2007 In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3161-3177 17 p.

Research output: Research - peer-reviewArticle

Optic Disk
Intraocular Pressure
Glaucoma
Gene Expression
Wounds and Injuries
2006
20 Citations

The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models

Johnson, E. C., Cepurna, W. O., Jia, L. & Morrison, J. C. Jul 2006 In : Experimental Eye Research. 83, 1, p. 51-60 10 p.

Research output: Research - peer-reviewArticle

Intraocular Pressure
Glaucoma
Pressure
Therapeutics
Optic Nerve Injuries
2005
41 Citations

Age related optic nerve axonal loss in adult Brown Norway rats

Cepurna, W. O., Kayton, R. J., Johnson, E. C. & Morrison, J. C. Jun 2005 In : Experimental Eye Research. 80, 6, p. 877-884 8 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Axons
Transmission Electron Microscopy
73 Citations

Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage

Pang, I. H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F. & Morrison, J. C. Apr 2005 In : Investigative Ophthalmology and Visual Science. 46, 4, p. 1313-1321 9 p.

Research output: Research - peer-reviewArticle

Optic Nerve Diseases
Optic Disk
Nitric Oxide Synthase Type II
Optic Nerve
Pressure
168 Citations

Understanding mechanisms of pressure-induced optic nerve damage

Morrison, J. C., Johnson, E. C., Cepurna, W. & Jia, L. Mar 2005 In : Progress in Retinal and Eye Research. 24, 2, p. 217-240 24 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Intraocular Pressure
Pressure
Retina
Optic Disk
2004
145 Citations

Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure

Ahmed, F., Brown, K. M., Stephan, D. A., Morrison, J. C., Johnson, E. C. & Tomarev, S. I. Apr 2004 In : Investigative Ophthalmology and Visual Science. 45, 4, p. 1247-1258 12 p.

Research output: Research - peer-reviewArticle

Microarray Analysis
Intraocular Pressure
Retina
Messenger RNA
Optic Nerve Injuries
100 Citations

Selective ganglion cell functional loss in rats with experimental glaucoma

Fortune, B., Bui, B. V., Morrison, J. C., Johnson, E. C., Dong, J., Cepurna, W. O., Jia, L., Barber, S. & Cioffi, G. A. Jun 2004 In : Investigative Ophthalmology and Visual Science. 45, 6, p. 1854-1862 9 p.

Research output: Research - peer-reviewArticle

Intraocular Pressure
Ganglia
Glaucoma
Microscopy
Theoretical Models
2001
26 Citations
Optic Nerve Injuries
Intraocular Pressure
Messenger RNA
Genes
Retina
145 Citations

Changes in Thy1 gene expression associated with damaged retinal ganglion cells

Schlamp, C. L., Johnson, E. C., Li, Y., Morrison, J. C. & Nickells, R. W. 2001 In : Molecular Vision. 7, p. 192-201 10 p.

Research output: Research - peer-reviewArticle

Retinal Ganglion Cells
Gene Expression
Messenger RNA
Optic Nerve
Intraocular Pressure
2000
169 Citations

Chronology of optic nerve head and retinal responses to elevated intraocular pressure

Johnson, E. C., Deppmeier, L. M. H., Wentzien, S. K. F., Hsu, I. & Morrison, J. C. 2000 In : Investigative Ophthalmology and Visual Science. 41, 2, p. 431-442 12 p.

Research output: Research - peer-reviewArticle

Chronology
Optic Disk
Intraocular Pressure
Retinal Ganglion Cells
Nerve Growth Factors
104 Citations

Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction

Jia, L., Cepurna, W. O., Johnson, E. C. & Morrison, J. C. 2000 In : Investigative Ophthalmology and Visual Science. 41, 11, p. 3415-3419 5 p.

Research output: Research - peer-reviewArticle

General Anesthetics
Intraocular Pressure
Anesthesia
Anesthetics
Ketamine
71 Citations

Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats

Jia, L., Cepurna, W. O., Johnson, E. C. & Morrison, J. C. 2000 In : Investigative Ophthalmology and Visual Science. 41, 6, p. 1380-1385 6 p.

Research output: Research - peer-reviewArticle

Aqueous Humor
Optic Nerve
Intraocular Pressure
Light
Veins
1999
68 Citations

Microvasculature of the rat optic nerve head

Morrison, J. C., Johnson, E. C., Cepurna, W. O. & Funk, R. H. W. 1999 In : Investigative Ophthalmology and Visual Science. 40, 8, p. 1702-1709 8 p.

Research output: Research - peer-reviewArticle

Optic Disk
Microvessels
Veins
Ciliary Arteries
Optic Nerve
8 Citations

Modeling glaucomatous optic nerve damage

Morrison, J. C., Cepurna, W. O. & Johnson, E. C. Jun 1999 In : International Ophthalmology Clinics. 39, 3, p. 29-41 13 p.

Research output: Research - peer-reviewArticle

1998
62 Citations

Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma

Morrison, J. C., Nylander, K. B., Lauer, A. K., Cepurna, W. O. & Johnson, E. Mar 1998 In : Investigative Ophthalmology and Visual Science. 39, 3, p. 526-531 6 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Intraocular Pressure
Glaucoma
Lubricant Eye Drops
Betaxolol
1997
356 Citations

A rat model of chronic pressure-induced optic nerve damage

Morrison, J. C., Moore, C. G., Deppmeier, L. M. H., Gold, B. G., Meshul, C. K. & Johnson, E. C. Jan 1997 In : Experimental Eye Research. 64, 1, p. 85-96 12 p.

Research output: Research - peer-reviewArticle

Optic Nerve
Intraocular Pressure
Pressure
Injections
Trabecular Meshwork
4 Citations
Chronology
Retinal Ganglion Cells
Optic Disk
Optic Nerve
Intraocular Pressure
50 Citations

Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid

Vranka, J. A., Johnson, E., Zhu, X., Shepardson, A., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S. 1997 In : Current Eye Research. 16, 2, p. 102-110 9 p.

Research output: Research - peer-reviewArticle

Tissue Inhibitor of Metalloproteinase-3
Choroid
Retina
human TIMP3 protein
Tissue Inhibitor of Metalloproteinases
2 Citations

Microvasculature of the raf optic nerve head

Morrison, J. C., Johnson, E. G. & Funk, R. H. W. 1997 In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Research - peer-reviewArticle

Optic Disk
Microvessels
Veins
Ciliary Arteries
Optic Nerve
1996

Chronic therapy of unilateral IOP elevation in rats

Morrison, J. C., Johnson, E. C., Nylander, K. & Lauer, A. Feb 15 1996 In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Research - peer-reviewArticle

Therapeutics
Betaxolol
Lubricant Eye Drops
apraclonidine
Trabecular Meshwork
86 Citations

Circadian rhythm of intraocular pressure in the rat

Moore, C. G., Johnson, E. C. & Morrison, J. C. Feb 1996 In : Current Eye Research. 15, 2, p. 185-191 7 p.

Research output: Research - peer-reviewArticle

Circadian Rhythm
Intraocular Pressure
Light
Appointments and Schedules
Photoperiod
99 Citations

The effect of chronically elevated intraocular pressure on the rat optic nerve head extracellular matrix

Johnson, E. C., Morrison, J. C., Farrell, S., Deppmeier, L., Moore, C. G. & Mcginty, M. R. Jun 1996 In : Experimental Eye Research. 62, 6, p. 663-674 12 p.

Research output: Research - peer-reviewArticle

Optic Disk
Intraocular Pressure
Extracellular Matrix
Pressure
Collagen
4 Citations

TIMP3 expression in the human retina and choroid

Vranka, J. A., Shepardson, A., Johnson, E. C., Zhu, X. H., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S. Feb 15 1996 In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Research - peer-reviewArticle

Choroid
Retina
Messenger RNA
Proteins
Tissue Inhibitor of Metalloproteinase-3