Elaine Johnson

Associate Professor

  • 2939 Citations
  • 28 h-Index
19942018
If you made any changes in Pure these will be visible here soon.

Research Output 1994 2018

  • 2939 Citations
  • 28 h-Index
  • 54 Article
  • 3 Chapter
  • 1 Letter
Filter
Article
2018

A Methodology for Individual-Specific Modeling of Rat Optic Nerve Head Biomechanics in Glaucoma

Schwaner, S. A., Kight, A. M., Perry, R. N., Pazos, M., Yang, H., Johnson, E. C., Morrison, J. C., Burgoyne, C. F. & Ross Ethier, C., Aug 1 2018, In : Journal of Biomechanical Engineering. 140, 8, 084501

Research output: Contribution to journalArticle

Biomechanics
Optic Disk
Biomechanical Phenomena
Glaucoma
Rats

In Vivo Small Molecule Delivery to the Optic Nerve in a Rodent Model

Tehrani, S., Delf, R. K., Cepurna, W. O., Davis, L., Johnson, E. C. & Morrison, J. C., Dec 1 2018, In : Scientific Reports. 8, 1, 4453

Research output: Contribution to journalArticle

Optic Disk
Optic Nerve
Rodentia
Actins
Optic Nerve Diseases
3 Citations

The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography

Jiang, X., Johnson, E., Cepurna, W., Lozano, D., Men, S., Wang, R. K. & Morrison, J., Jan 1 2018, In : Microvascular Research. 115, p. 12-19 8 p.

Research output: Contribution to journalArticle

Angiography
Optical tomography
Optical Coherence Tomography
Intraocular Pressure
Animals
2017
6 Citations

Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: A pilot study

Jayaram, H., Phillips, J. I., Lozano, D. C., Choe, T. E., Cepurna, W. O., Johnson, E. C., Morrison, J. C., Gattey, D. M., Saugstad, J. A. & Keller, K. E., Jun 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 7, p. 2884-2890 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
MicroRNAs
Polymerase Chain Reaction
Primary Open Angle Glaucoma
Encyclopedias
7 Citations

The challenge of regenerative therapies for the optic nerve in glaucoma

The Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants, Apr 1 2017, In : Experimental Eye Research. 157, p. 28-33 6 p.

Research output: Contribution to journalArticle

Optic Nerve
Glaucoma
Regeneration
Retinal Ganglion Cells
Axons
2016
7 Citations

A period of controlled elevation of IOP (CEI) produces the specific gene expression responses and focal injury pattern of experimental rat glaucoma

Morrison, J. C., Cepurna, W. O., Tehrani, S., Choe, T. E., Jayaram, H., Lozano, D. C., Fortune, B. & Johnson, E. C., Dec 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 15, p. 6700-6711 12 p.

Research output: Contribution to journalArticle

Optic Disk
Glaucoma
Gene Expression
Optic Nerve
Wounds and Injuries
7 Citations

Astrocyte structural and molecular response to elevated intraocular pressure occurs rapidly and precedes axonal tubulin rearrangement within the optic nerve head in a rat model

Tehrani, S., Davis, L., Cepurna, W. O., Choe, T. E., Lozano, D. C., Monfared, A., Cooper, L., Cheng, J., Johnson, E. C. & Morrison, J. C., Nov 1 2016, In : PLoS One. 11, 11, e0167364

Research output: Contribution to journalArticle

astrocytes
Optic Disk
Tubulin
optics
tubulin
8 Citations

Expansions of the neurovascular scleral canal and contained optic nerve occur early in the hypertonic saline rat experimental glaucoma model

Pazos, M., Yang, H., Gardiner, S. K., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Burgoyne, C. F., Apr 1 2016, In : Experimental Eye Research. 145, p. 173-186 14 p.

Research output: Contribution to journalArticle

Optic Nerve
Glaucoma
Theoretical Models
Optic Disk
Nerve Expansion
2015
11 Citations
Optical tomography
Optical Coherence Tomography
Intraocular Pressure
Rats
Blood
15 Citations

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

Ying, H. H., Turturro, S. S., Nguyen, T. T., Shen, X. X., Zelkha, R. R., Johnson, E. E. C., Morrison, J. J. C. & Yue, B. B. Y. J. T., May 6 2015, In : BMC Cell Biology. 16, 1, 14

Research output: Contribution to journalArticle

Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Retinal Ganglion Cells
Fluorescence
13 Citations

MicroRNA expression in the glaucomatous retina

Jayaram, H., Cepurna, W. O., Johnson, E. C. & Morrison, J. C., Dec 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 13, p. 7971-7982 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Retina
Intraocular Pressure
Central Nervous System
Chemical Databases
16 Citations

Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure

Morrison, J. C., Cepurna, W. O. & Johnson, E. C., Mar 28 2015, In : Experimental Eye Research. 141, p. 23-32 10 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Aqueous Humor
Optic Disk
Injections
16 Citations

Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye

Lu, W., Hu, H., Sévigny, J., Gabelt, B. T., Kaufman, P. L., Johnson, E. C., Morrison, J. C., Zode, G. S., Sheffield, V. C., Zhang, X., Laties, A. M. & Mitchell, C. H., 2015, In : Investigative Ophthalmology and Visual Science. 56, 5, p. 3075-3083 9 p.

Research output: Contribution to journalArticle

Glaucoma
Primates
Adenosine Triphosphate
Astrocytes
Retinal Neurons
10 Citations

Rat optic nerve head anatomy within 3D histomorphometric reconstructions of normal control eyes

Pazos, M., Yang, H., Gardiner, S. K., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Burgoyne, C. F., Oct 1 2015, In : Experimental Eye Research. 139, p. 1-12 12 p.

Research output: Contribution to journalArticle

Bruch Membrane
Optic Disk
Anatomy
Retinal Vein
Sclera
2014
16 Citations
Optic Disk
Astrocytes
Glaucoma
Actins
Optic Nerve
10 Citations
Optic Nerve
Intraocular Pressure
Radiation
Wounds and Injuries
Glaucoma
2012
43 Citations

Impact of intraocular pressure on changes of blood flow in the retina, choroid, and optic nerve head in rats investigated by optical microangiography

Zhi, Z., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Wang, R. K., Sep 1 2012, In : Biomedical Optics Express. 3, 9, p. 2220-2233 14 p.

Research output: Contribution to journalArticle

intraocular pressure
Choroid
retina
Optic Disk
nerves
2011
70 Citations

Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma

Johnson, E. C., Doser, T. A., Cepurna, W. O., Dyck, J. A., Jia, L., Guo, Y., Lambert, W. S. & Morrison, J. C., Jan 2011, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 504-518 15 p.

Research output: Contribution to journalArticle

Optic Nerve Injuries
Optic Disk
Craniocerebral Trauma
Glaucoma
Interleukin-6
41 Citations

Early gene expression changes in the retinal ganglion cell layer of a rat glaucoma model

Guo, Y., Johnson, E. C., Cepurna, W. O., Dyck, J. A., Doser, T. & Morrison, J. C., Mar 2011, In : Investigative Ophthalmology and Visual Science. 52, 3, p. 1460-1473 14 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Glaucoma
Gene Expression
Ganglia
Genes
51 Citations

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

Morrison, J. C., Cepurna Ying Guo, W. O. & Johnson, E. C., Aug 2011, In : Experimental Eye Research. 93, 2, p. 156-164 9 p.

Research output: Contribution to journalArticle

Optic Disk
Optic Nerve
Intraocular Pressure
Glaucoma
Primates
61 Citations

Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography

Zhi, Z., Cepurna, W., Johnson, E., Shen, T., Morrison, J. & Wang, R. K., Mar 1 2011, In : Biomedical Optics Express. 2, 3, p. 579-591 13 p.

Research output: Contribution to journalArticle

angiography
blood flow
imaging techniques
rats
Angiography
2010
32 Citations

Retinal cell responses to elevated intraocular pressure: A gene array comparison between the whole retina and retinal ganglion cell layer

Guo, Y., Cepurna, W. O., Dyck, J. A., Doser, T. A., Johnson, E. C. & Morrison, J. C., Jun 2010, In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3003-3018 16 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Intraocular Pressure
Retina
Genes
Laser Capture Microdissection
2009
28 Citations

Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?

Guo, Y., Johnson, E., Cepurna, W., Jia, L., Dyck, J. & Morrison, J. C., Dec 2009, In : Experimental Eye Research. 89, 6, p. 921-933 13 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Messenger RNA
Wounds and Injuries
Retinal Ganglion Cells
80 Citations

Friend or foe? Resolving the impact of glial responses in glaucoma

Johnson, E. C. & Morrison, J. C., Jun 2009, In : Journal of Glaucoma. 18, 5, p. 341-353 13 p.

Research output: Contribution to journalArticle

Neuroglia
Glaucoma
Optic Disk
Retina
Retinal Ganglion Cells
61 Citations

Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models

Johnson, E. C., Guo, Y., Cepurna, W. O. & Morrison, J. C., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 808-815 8 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Nerve Growth Factors
Glaucoma
Cell Survival
Pressure
30 Citations

Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats

Morrison, J. C., Jia, L., Cepurna, W., Guo, Y. & Johnson, E., 2009, In : Investigative Ophthalmology and Visual Science. 50, 6, p. 2802-2808 7 p.

Research output: Contribution to journalArticle

Optic Nerve
Reading
Lighting
Transducers
Optic Nerve Injuries
88 Citations

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G. , Ben-Hur, T. , Gibson, G. E. , Stevens, B. , Streit, W. J. , Wekerle, H. , Bhattacharya, S. K. , Borras, T. , Burgoyne, C. F. , Caspi, R. R. , Chauhan, B. C. , Clark, A. F. , Crowston, J. , Danias, J. , Dick, A. D. , Flammer, J. , Foster, C. S. , Grosskreutz, C. L. , Grus, F. H. , Guy, J. & 48 others Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. T., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D., Ju, W. K., Kang, K., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J., Mar 2009, In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

2008
26 Citations

Comparison of anterior segment structures in two rat glaucoma models: An ultrasound biomicroscopic study

Nissirios, N., Chanis, R., Johnson, E., Morrison, J., Cepurna, W. O., Jia, L., Mittag, T. & Danias, J., Jun 2008, In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2478-2482 5 p.

Research output: Contribution to journalArticle

Glaucoma
Veins
Anterior Chamber
Sclerosis
Cautery
55 Citations

Rat models for glaucoma research

Morrison, J. C., Johnson, E. & Cepurna, W. O., 2008, In : Progress in Brain Research. 173, p. 285-301 17 p.

Research output: Contribution to journalArticle

Glaucoma
Pressure
Research
Optic Disk
Optic Nerve
2007
151 Citations

Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model

Johnson, E. C., Jia, L., Cepurna, W. O., Doser, T. A. & Morrison, J. C., Jul 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3161-3177 17 p.

Research output: Contribution to journalArticle

Optic Disk
Intraocular Pressure
Glaucoma
Gene Expression
Wounds and Injuries
2006
20 Citations

The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models

Johnson, E. C., Cepurna, W. O., Jia, L. & Morrison, J. C., Jul 2006, In : Experimental Eye Research. 83, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Optic Nerve Injuries
Pressure
Ciliary Body
2005
44 Citations

Age related optic nerve axonal loss in adult Brown Norway rats

Cepurna, W. O., Kayton, R. J., Johnson, E. C. & Morrison, J. C., Jun 2005, In : Experimental Eye Research. 80, 6, p. 877-884 8 p.

Research output: Contribution to journalArticle

Optic Nerve
Axons
Transmission Electron Microscopy
77 Citations

Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage

Pang, I. H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F. & Morrison, J. C., Apr 2005, In : Investigative Ophthalmology and Visual Science. 46, 4, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

Optic Nerve Diseases
Optic Disk
Nitric Oxide Synthase Type II
Optic Nerve
Pressure
177 Citations

Understanding mechanisms of pressure-induced optic nerve damage

Morrison, J. C., Johnson, E. C., Cepurna, W. & Jia, L., Mar 2005, In : Progress in Retinal and Eye Research. 24, 2, p. 217-240 24 p.

Research output: Contribution to journalArticle

Optic Nerve
Intraocular Pressure
Pressure
Optic Disk
Retina
2004
156 Citations

Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure

Ahmed, F., Brown, K. M., Stephan, D. A., Morrison, J. C., Johnson, E. C. & Tomarev, S. I., Apr 2004, In : Investigative Ophthalmology and Visual Science. 45, 4, p. 1247-1258 12 p.

Research output: Contribution to journalArticle

Microarray Analysis
Intraocular Pressure
Retina
Messenger RNA
Optic Nerve Injuries
109 Citations

Selective ganglion cell functional loss in rats with experimental glaucoma

Fortune, B., Bui, B. V., Morrison, J. C., Johnson, E. C., Dong, J., Cepurna, W. O., Jia, L., Barber, S. & Cioffi, G. A., Jun 2004, In : Investigative Ophthalmology and Visual Science. 45, 6, p. 1854-1862 9 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Ganglia
Glaucoma
Microscopy
Theoretical Models
2001
26 Citations
Optic Nerve Injuries
Intraocular Pressure
Retina
Messenger RNA
Genes
147 Citations

Changes in Thy1 gene expression associated with damaged retinal ganglion cells

Schlamp, C. L., Johnson, E. C., Li, Y., Morrison, J. C. & Nickells, R. W., 2001, In : Molecular Vision. 7, p. 192-201 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Gene Expression
Nerve Crush
Optic Nerve
Intraocular Pressure
2000
176 Citations

Chronology of optic nerve head and retinal responses to elevated intraocular pressure

Johnson, E. C., Deppmeier, L. M. H., Wentzien, S. K. F., Hsu, I. & Morrison, J. C., 2000, In : Investigative Ophthalmology and Visual Science. 41, 2, p. 431-442 12 p.

Research output: Contribution to journalArticle

Chronology
Optic Disk
Intraocular Pressure
Retinal Ganglion Cells
Nerve Growth Factors
108 Citations

Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction

Jia, L., Cepurna, W. O., Johnson, E. C. & Morrison, J. C., 2000, In : Investigative Ophthalmology and Visual Science. 41, 11, p. 3415-3419 5 p.

Research output: Contribution to journalArticle

General Anesthetics
Intraocular Pressure
Anesthesia
Anesthetics
Ketamine
75 Citations

Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats

Jia, L., Cepurna, W. O., Johnson, E. C. & Morrison, J. C., 2000, In : Investigative Ophthalmology and Visual Science. 41, 6, p. 1380-1385 6 p.

Research output: Contribution to journalArticle

Aqueous Humor
Optic Nerve
Intraocular Pressure
Light
Veins
1999
72 Citations

Microvasculature of the rat optic nerve head

Morrison, J. C., Johnson, E. C., Cepurna, W. O. & Funk, R. H. W., 1999, In : Investigative Ophthalmology and Visual Science. 40, 8, p. 1702-1709 8 p.

Research output: Contribution to journalArticle

Optic Disk
Microvessels
Ciliary Arteries
Veins
Optic Nerve
8 Citations

Modeling glaucomatous optic nerve damage

Morrison, J. C., Cepurna, W. O. & Johnson, E. C., Jun 1999, In : International Ophthalmology Clinics. 39, 3, p. 29-41 13 p.

Research output: Contribution to journalArticle

Animal Disease Models
Optic Nerve Diseases
Optic Disk
Optic Nerve
Intraocular Pressure
1998
63 Citations

Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma

Morrison, J. C., Nylander, K. B., Lauer, A. K., Cepurna, W. O. & Johnson, E., Mar 1998, In : Investigative Ophthalmology and Visual Science. 39, 3, p. 526-531 6 p.

Research output: Contribution to journalArticle

Optic Nerve
Intraocular Pressure
Glaucoma
Betaxolol
Nerve Fibers
1997
371 Citations

A rat model of chronic pressure-induced optic nerve damage

Morrison, J. C., Moore, C. G., Deppmeier, L. M. H., Gold, B. G., Meshul, C. K. & Johnson, E. C., Jan 1997, In : Experimental Eye Research. 64, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

Optic Nerve
Intraocular Pressure
Pressure
Trabecular Meshwork
Injections
4 Citations
Chronology
Retinal Ganglion Cells
Optic Disk
Optic Nerve
Intraocular Pressure
52 Citations

Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid

Vranka, J. A., Johnson, E., Zhu, X., Shepardson, A., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S., 1997, In : Current Eye Research. 16, 2, p. 102-110 9 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Choroid
Retina
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-2
2 Citations

Microvasculature of the raf optic nerve head

Morrison, J. C., Johnson, E. G. & Funk, R. H. W., 1997, In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Optic Disk
Microvessels
Veins
Ciliary Arteries
Optic Nerve
1996

Chronic therapy of unilateral IOP elevation in rats

Morrison, J. C., Johnson, E. C., Nylander, K. & Lauer, A., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Betaxolol
Trabecular Meshwork
Aqueous Humor
Sclerosis
Therapeutics
91 Citations

Circadian rhythm of intraocular pressure in the rat

Moore, C. G., Johnson, E. C. & Morrison, J. C., Feb 1996, In : Current Eye Research. 15, 2, p. 185-191 7 p.

Research output: Contribution to journalArticle

Circadian Rhythm
Intraocular Pressure
Light
Appointments and Schedules
Photoperiod