Elaine Johnson

Associate Professor

  • 2887 Citations
  • 28 h-Index
19942018
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Research Output 1994 2018

  • 2887 Citations
  • 28 h-Index
  • 53 Article
  • 3 Chapter
  • 1 Letter
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Article
2018

In Vivo Small Molecule Delivery to the Optic Nerve in a Rodent Model

Tehrani, S., Delf, R. K., Cepurna, W. O., Davis, L., Johnson, E. C. & Morrison, J. C. Dec 1 2018 In : Scientific Reports. 8, 1, 4453

Research output: Contribution to journalArticle

Optic Disk
Optic Nerve
Rodentia
Actins
Optic Nerve Diseases
1 Citations

The effect of age on the response of retinal capillary filling to changes in intraocular pressure measured by optical coherence tomography angiography

Jiang, X., Johnson, E., Cepurna, W., Lozano, D., Men, S., Wang, R. K. & Morrison, J. Jan 1 2018 In : Microvascular Research. 115, p. 12-19 8 p.

Research output: Contribution to journalArticle

Angiography
Optical tomography
Optical Coherence Tomography
Intraocular Pressure
Animals
2017
5 Citations

Comparison of microRNA expression in aqueous humor of normal and primary open-angle glaucoma patients using PCR arrays: A pilot study

Jayaram, H., Phillips, J. I., Lozano, D. C., Choe, T. E., Cepurna, W. O., Johnson, E. C., Morrison, J. C., Gattey, D. M., Saugstad, J. A. & Keller, K. E. Jun 1 2017 In : Investigative Ophthalmology and Visual Science. 58, 7, p. 2884-2890 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
MicroRNAs
Polymerase Chain Reaction
Primary Open Angle Glaucoma
Encyclopedias
7 Citations

The challenge of regenerative therapies for the optic nerve in glaucoma

Calkins, D. J., Pekny, M., Cooper, M. L., Benowitz, L., Calkins, D., Benowitz, L., Cooper, M., Crowston, J., Huberman, A., Johnson, E., Lu, R., Pekny, M., Sappington, R., Zack, D. & The Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants Apr 1 2017 In : Experimental Eye Research. 157, p. 28-33 6 p.

Research output: Contribution to journalArticle

Optic Nerve
Glaucoma
Regeneration
Retinal Ganglion Cells
Axons
2016
5 Citations

A period of controlled elevation of IOP (CEI) produces the specific gene expression responses and focal injury pattern of experimental rat glaucoma

Morrison, J. C., Cepurna, W. O., Tehrani, S., Choe, T. E., Jayaram, H., Lozano, D. C., Fortune, B. & Johnson, E. C. Dec 1 2016 In : Investigative Ophthalmology and Visual Science. 57, 15, p. 6700-6711 12 p.

Research output: Contribution to journalArticle

Optic Disk
Glaucoma
Gene Expression
Optic Nerve
Wounds and Injuries
4 Citations

Astrocyte structural and molecular response to elevated intraocular pressure occurs rapidly and precedes axonal tubulin rearrangement within the optic nerve head in a rat model

Tehrani, S., Davis, L., Cepurna, W. O., Choe, T. E., Lozano, D. C., Monfared, A., Cooper, L., Cheng, J., Johnson, E. C. & Morrison, J. C. Nov 1 2016 In : PLoS One. 11, 11, e0167364

Research output: Contribution to journalArticle

astrocytes
Optic Disk
Tubulin
optics
tubulin
7 Citations

Expansions of the neurovascular scleral canal and contained optic nerve occur early in the hypertonic saline rat experimental glaucoma model

Pazos, M., Yang, H., Gardiner, S. K., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Burgoyne, C. F. Apr 1 2016 In : Experimental Eye Research. 145, p. 173-186 14 p.

Research output: Contribution to journalArticle

Optic Nerve
Glaucoma
Theoretical Models
Optic Disk
Nerve Expansion
2015
11 Citations
Optical tomography
Optical Coherence Tomography
Intraocular Pressure
Rats
Blood
13 Citations

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene

Ying, H. H., Turturro, S. S., Nguyen, T. T., Shen, X. X., Zelkha, R. R., Johnson, E. E. C., Morrison, J. J. C. & Yue, B. B. Y. J. T. May 6 2015 In : BMC Cell Biology. 16, 1, 14

Research output: Contribution to journalArticle

Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Retinal Ganglion Cells
Fluorescence
12 Citations

MicroRNA expression in the glaucomatous retina

Jayaram, H., Cepurna, W. O., Johnson, E. C. & Morrison, J. C. Dec 1 2015 In : Investigative Ophthalmology and Visual Science. 56, 13, p. 7971-7982 12 p.

Research output: Contribution to journalArticle

MicroRNAs
Retina
Intraocular Pressure
Central Nervous System
Chemical Databases
15 Citations

Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure

Morrison, J. C., Cepurna, W. O. & Johnson, E. C. Mar 28 2015 In : Experimental Eye Research. 141, p. 23-32 10 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Aqueous Humor
Optic Disk
Injections
15 Citations

Rat, mouse, and primate models of chronic glaucoma show sustained elevation of extracellular ATP and altered purinergic signaling in the posterior eye

Lu, W., Hu, H., Sévigny, J., Gabelt, B. T., Kaufman, P. L., Johnson, E. C., Morrison, J. C., Zode, G. S., Sheffield, V. C., Zhang, X., Laties, A. M. & Mitchell, C. H. 2015 In : Investigative Ophthalmology and Visual Science. 56, 5, p. 3075-3083 9 p.

Research output: Contribution to journalArticle

Glaucoma
Primates
Adenosine Triphosphate
Astrocytes
Retinal Neurons
9 Citations

Rat optic nerve head anatomy within 3D histomorphometric reconstructions of normal control eyes

Pazos, M., Yang, H., Gardiner, S. K., Cepurna, W. O., Johnson, E. C., Morrison, J. C. & Burgoyne, C. F. Oct 1 2015 In : Experimental Eye Research. 139, p. 1-12 12 p.

Research output: Contribution to journalArticle

Bruch Membrane
Optic Disk
Anatomy
Retinal Vein
Sclera
2014
14 Citations
Optic Disk
Astrocytes
Glaucoma
Actins
Optic Nerve
10 Citations
Optic Nerve
Intraocular Pressure
Radiation
Wounds and Injuries
Glaucoma
2012
39 Citations
intraocular pressure
Choroid
retina
Optic Disk
nerves
2011
69 Citations

Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma

Johnson, E. C., Doser, T. A., Cepurna, W. O., Dyck, J. A., Jia, L., Guo, Y., Lambert, W. S. & Morrison, J. C. Jan 2011 In : Investigative Ophthalmology and Visual Science. 52, 1, p. 504-518 15 p.

Research output: Contribution to journalArticle

Optic Nerve Injuries
Optic Disk
Craniocerebral Trauma
Glaucoma
Interleukin-6
41 Citations

Early gene expression changes in the retinal ganglion cell layer of a rat glaucoma model

Guo, Y., Johnson, E. C., Cepurna, W. O., Dyck, J. A., Doser, T. & Morrison, J. C. Mar 2011 In : Investigative Ophthalmology and Visual Science. 52, 3, p. 1460-1473 14 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Glaucoma
Gene Expression
Ganglia
Genes
50 Citations

Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma

Morrison, J. C., Cepurna Ying Guo, W. O. & Johnson, E. C. Aug 2011 In : Experimental Eye Research. 93, 2, p. 156-164 9 p.

Research output: Contribution to journalArticle

Optic Disk
Optic Nerve
Intraocular Pressure
Glaucoma
Primates
58 Citations

Volumetric and quantitative imaging of retinal blood flow in rats with optical microangiography

Zhi, Z., Cepurna, W., Johnson, E., Shen, T., Morrison, J. & Wang, R. K. Mar 1 2011 In : Biomedical Optics Express. 2, 3, p. 579-591 13 p.

Research output: Contribution to journalArticle

angiography
blood flow
imaging techniques
rats
Angiography
2010
32 Citations

Retinal cell responses to elevated intraocular pressure: A gene array comparison between the whole retina and retinal ganglion cell layer

Guo, Y., Cepurna, W. O., Dyck, J. A., Doser, T. A., Johnson, E. C. & Morrison, J. C. Jun 2010 In : Investigative Ophthalmology and Visual Science. 51, 6, p. 3003-3018 16 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Intraocular Pressure
Retina
Genes
Laser Capture Microdissection
2009
28 Citations

Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?

Guo, Y., Johnson, E., Cepurna, W., Jia, L., Dyck, J. & Morrison, J. C. Dec 2009 In : Experimental Eye Research. 89, 6, p. 921-933 13 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Messenger RNA
Wounds and Injuries
Retinal Ganglion Cells
77 Citations

Friend or foe? Resolving the impact of glial responses in glaucoma

Johnson, E. C. & Morrison, J. C. Jun 2009 In : Journal of Glaucoma. 18, 5, p. 341-353 13 p.

Research output: Contribution to journalArticle

Neuroglia
Glaucoma
Optic Disk
Retina
Retinal Ganglion Cells
60 Citations

Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models

Johnson, E. C., Guo, Y., Cepurna, W. O. & Morrison, J. C. Apr 30 2009 In : Experimental Eye Research. 88, 4, p. 808-815 8 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Nerve Growth Factors
Glaucoma
Cell Survival
Pressure
29 Citations

Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats

Morrison, J. C., Jia, L., Cepurna, W., Guo, Y. & Johnson, E. 2009 In : Investigative Ophthalmology and Visual Science. 50, 6, p. 2802-2808 7 p.

Research output: Contribution to journalArticle

Optic Nerve
Reading
Lighting
Transducers
Optic Nerve Injuries
88 Citations

The role of glia, mitochondria, and the immune system in glaucoma

Tezel, G. , Ben-Hur, T. , Gibson, G. E. , Stevens, B. , Streit, W. J. , Wekerle, H. , Bhattacharya, S. K. , Borras, T. , Burgoyne, C. F. , Caspi, R. R. , Chauhan, B. C. , Clark, A. F. , Crowston, J. , Danias, J. , Dick, A. D. , Flammer, J. , Foster, C. S. , Grosskreutz, C. L. , Grus, F. H. , Guy, J. & 48 others Hernandez, M. R., Johnson, E., Kaplan, H. J., Kuehn, M. H., Lenaers, G., Levin, L. A., Lindsey, J. D., Malina, H., Nickells, R. W., Osborne, N., Quigley, H. A., Rao, N., Rosenbaum, J. T., Sadun, A. A., Schwartz, M., Sun, D., Trounce, I., Wax, M. B., Yorio, T., Abrams, G. W., Atherton, S. S., Boatright, J. H., Chu, J., Dowling, J., Ferris, F. L., Garway-Heath, D., Gregory, M., Grzybowski, D. M., Gupta, N., Inman, D., Ju, W. K., Kang, K., Kaufman, H. E., Kaufman, P. L., Larssen, L. I., Liebmann, J., Lupien, C., Miller, R. F., Niesman, M., O'Brien, C., Petrash, J. M., Prasanna, G., Ritch, R., Shestopalov, V., Wirostko, B., WoldeMussie, E., Yue, B. & Zimmerman, T. J. Mar 2009 In : Investigative Ophthalmology and Visual Science. 50, 3, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

2008
25 Citations

Comparison of anterior segment structures in two rat glaucoma models: An ultrasound biomicroscopic study

Nissirios, N., Chanis, R., Johnson, E., Morrison, J., Cepurna, W. O., Jia, L., Mittag, T. & Danias, J. Jun 2008 In : Investigative Ophthalmology and Visual Science. 49, 6, p. 2478-2482 5 p.

Research output: Contribution to journalArticle

Glaucoma
Veins
Anterior Chamber
Sclerosis
Cautery
55 Citations

Rat models for glaucoma research

Morrison, J. C., Johnson, E. & Cepurna, W. O. 2008 In : Progress in Brain Research. 173, p. 285-301 17 p.

Research output: Contribution to journalArticle

Glaucoma
Pressure
Research
Optic Disk
Optic Nerve
2007
150 Citations

Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model

Johnson, E. C., Jia, L., Cepurna, W. O., Doser, T. A. & Morrison, J. C. Jul 2007 In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3161-3177 17 p.

Research output: Contribution to journalArticle

Optic Disk
Intraocular Pressure
Glaucoma
Gene Expression
Wounds and Injuries
2006
20 Citations

The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models

Johnson, E. C., Cepurna, W. O., Jia, L. & Morrison, J. C. Jul 2006 In : Experimental Eye Research. 83, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Glaucoma
Optic Nerve Injuries
Pressure
Ciliary Body
2005
43 Citations

Age related optic nerve axonal loss in adult Brown Norway rats

Cepurna, W. O., Kayton, R. J., Johnson, E. C. & Morrison, J. C. Jun 2005 In : Experimental Eye Research. 80, 6, p. 877-884 8 p.

Research output: Contribution to journalArticle

Optic Nerve
Axons
Transmission Electron Microscopy
77 Citations

Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage

Pang, I. H., Johnson, E. C., Jia, L., Cepurna, W. O., Shepard, A. R., Hellberg, M. R., Clark, A. F. & Morrison, J. C. Apr 2005 In : Investigative Ophthalmology and Visual Science. 46, 4, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

Optic Nerve Diseases
Optic Disk
Nitric Oxide Synthase Type II
Optic Nerve
Pressure
176 Citations

Understanding mechanisms of pressure-induced optic nerve damage

Morrison, J. C., Johnson, E. C., Cepurna, W. & Jia, L. Mar 2005 In : Progress in Retinal and Eye Research. 24, 2, p. 217-240 24 p.

Research output: Contribution to journalArticle

Optic Nerve
Intraocular Pressure
Pressure
Optic Disk
Retina
2004
153 Citations

Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure

Ahmed, F., Brown, K. M., Stephan, D. A., Morrison, J. C., Johnson, E. C. & Tomarev, S. I. Apr 2004 In : Investigative Ophthalmology and Visual Science. 45, 4, p. 1247-1258 12 p.

Research output: Contribution to journalArticle

Microarray Analysis
Intraocular Pressure
Retina
Messenger RNA
Optic Nerve Injuries
107 Citations

Selective ganglion cell functional loss in rats with experimental glaucoma

Fortune, B., Bui, B. V., Morrison, J. C., Johnson, E. C., Dong, J., Cepurna, W. O., Jia, L., Barber, S. & Cioffi, G. A. Jun 2004 In : Investigative Ophthalmology and Visual Science. 45, 6, p. 1854-1862 9 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Ganglia
Glaucoma
Microscopy
Theoretical Models
2001
26 Citations
Optic Nerve Injuries
Intraocular Pressure
Retina
Messenger RNA
Genes
147 Citations

Changes in Thy1 gene expression associated with damaged retinal ganglion cells

Schlamp, C. L., Johnson, E. C., Li, Y., Morrison, J. C. & Nickells, R. W. 2001 In : Molecular Vision. 7, p. 192-201 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Gene Expression
Nerve Crush
Optic Nerve
Intraocular Pressure
2000
173 Citations

Chronology of optic nerve head and retinal responses to elevated intraocular pressure

Johnson, E. C., Deppmeier, L. M. H., Wentzien, S. K. F., Hsu, I. & Morrison, J. C. 2000 In : Investigative Ophthalmology and Visual Science. 41, 2, p. 431-442 12 p.

Research output: Contribution to journalArticle

Chronology
Optic Disk
Intraocular Pressure
Retinal Ganglion Cells
Nerve Growth Factors
107 Citations

Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction

Jia, L., Cepurna, W. O., Johnson, E. C. & Morrison, J. C. 2000 In : Investigative Ophthalmology and Visual Science. 41, 11, p. 3415-3419 5 p.

Research output: Contribution to journalArticle

General Anesthetics
Intraocular Pressure
Anesthesia
Anesthetics
Ketamine
74 Citations

Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats

Jia, L., Cepurna, W. O., Johnson, E. C. & Morrison, J. C. 2000 In : Investigative Ophthalmology and Visual Science. 41, 6, p. 1380-1385 6 p.

Research output: Contribution to journalArticle

Aqueous Humor
Optic Nerve
Intraocular Pressure
Light
Veins
1999
71 Citations

Microvasculature of the rat optic nerve head

Morrison, J. C., Johnson, E. C., Cepurna, W. O. & Funk, R. H. W. 1999 In : Investigative Ophthalmology and Visual Science. 40, 8, p. 1702-1709 8 p.

Research output: Contribution to journalArticle

Optic Disk
Microvessels
Ciliary Arteries
Veins
Optic Nerve
8 Citations

Modeling glaucomatous optic nerve damage

Morrison, J. C., Cepurna, W. O. & Johnson, E. C. Jun 1999 In : International Ophthalmology Clinics. 39, 3, p. 29-41 13 p.

Research output: Contribution to journalArticle

Animal Disease Models
Optic Nerve Diseases
Optic Disk
Optic Nerve
Intraocular Pressure
1998
63 Citations

Glaucoma drops control intraocular pressure and protect optic nerves in a rat model of glaucoma

Morrison, J. C., Nylander, K. B., Lauer, A. K., Cepurna, W. O. & Johnson, E. Mar 1998 In : Investigative Ophthalmology and Visual Science. 39, 3, p. 526-531 6 p.

Research output: Contribution to journalArticle

Optic Nerve
Intraocular Pressure
Glaucoma
Betaxolol
Nerve Fibers
1997
368 Citations

A rat model of chronic pressure-induced optic nerve damage

Morrison, J. C., Moore, C. G., Deppmeier, L. M. H., Gold, B. G., Meshul, C. K. & Johnson, E. C. Jan 1997 In : Experimental Eye Research. 64, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

Optic Nerve
Intraocular Pressure
Pressure
Trabecular Meshwork
Injections
4 Citations
Chronology
Retinal Ganglion Cells
Optic Disk
Optic Nerve
Intraocular Pressure
52 Citations

Discrete expression and distribution pattern of TIMP-3 in the human retina and choroid

Vranka, J. A., Johnson, E., Zhu, X., Shepardson, A., Alexander, J. P., Bradley, J. M. B., Wirtz, M. K., Weleber, R. G., Klein, M. L. & Acott, T. S. 1997 In : Current Eye Research. 16, 2, p. 102-110 9 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Choroid
Retina
Tissue Inhibitor of Metalloproteinases
Tissue Inhibitor of Metalloproteinase-2
2 Citations

Microvasculature of the raf optic nerve head

Morrison, J. C., Johnson, E. G. & Funk, R. H. W. 1997 In : Investigative Ophthalmology and Visual Science. 38, 4

Research output: Contribution to journalArticle

Optic Disk
Microvessels
Veins
Ciliary Arteries
Optic Nerve
1996

Chronic therapy of unilateral IOP elevation in rats

Morrison, J. C., Johnson, E. C., Nylander, K. & Lauer, A. Feb 15 1996 In : Investigative Ophthalmology and Visual Science. 37, 3

Research output: Contribution to journalArticle

Betaxolol
Trabecular Meshwork
Aqueous Humor
Sclerosis
Therapeutics
91 Citations

Circadian rhythm of intraocular pressure in the rat

Moore, C. G., Johnson, E. C. & Morrison, J. C. Feb 1996 In : Current Eye Research. 15, 2, p. 185-191 7 p.

Research output: Contribution to journalArticle

Circadian Rhythm
Intraocular Pressure
Light
Appointments and Schedules
Photoperiod
100 Citations

The effect of chronically elevated intraocular pressure on the rat optic nerve head extracellular matrix

Johnson, E. C., Morrison, J. C., Farrell, S., Deppmeier, L., Moore, C. G. & Mcginty, M. R. Jun 1996 In : Experimental Eye Research. 62, 6, p. 663-674 12 p.

Research output: Contribution to journalArticle

Optic Disk
Intraocular Pressure
Extracellular Matrix
Collagen
Pressure