Edward Neuwelt

Professor

  • 14690 Citations
  • 63 h-Index
1971 …2021
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Research Output 1971 2019

  • 14690 Citations
  • 63 h-Index
  • 307 Article
  • 9 Chapter
  • 3 Review article
  • 1 Conference contribution
2019

Combined iron oxide nanoparticle ferumoxytol and gadolinium contrast enhanced MRI define glioblastoma pseudoprogression

Barajas, R., Hamilton, B., Schwartz, D., Mcconnell, H. L., Pettersson, D., Horvath, A., Szidonya, L., Varallyay, C. G., Firkins, J., Jaboin, J., Kubicky, C. D., Raslan, A., Dogan, A., Cetas, J., Ciporen, J., Han, S. J., Ambady, P., Muldoon, L., Woltjer, R. R., Rooney, W. & 1 others, Neuwelt, E., Mar 18 2019, In : Neuro-Oncology. 21, 4, p. 517-526 10 p.

Research output: Contribution to journalArticle

Open Access
Ferrosoferric Oxide
Gadolinium
Glioblastoma
Nanoparticles
Isocitrate Dehydrogenase
2018

Blood-Brain Barrier Disruption Chemotherapy

McGregor, J. M., Bell, S. D., Doolittle, N., Murillo, T. P. & Neuwelt, E., Apr 24 2018, Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy: Second Edition. Elsevier Inc., p. 145-153 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood-Brain Barrier
Drug Therapy
Central Nervous System
Oligodendroglioma
Brain Neoplasms
1 Citation (Scopus)

Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI: Comparison to standard of care

Varallyay, C. G., Nesbit, E., Horvath, A., Varallyay, P., Fu, R. R., Gahramanov, S., Muldoon, L., Li, X., Rooney, W. & Neuwelt, E., Jan 1 2018, (Accepted/In press) In : Journal of Magnetic Resonance Imaging.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Standard of Care
Perfusion
Noise
Putamen

Combination immunotherapy as a non-chemotherapy alternative for refractory or recurrent CNS lymphoma

Ambady, P., Szidonya, L., Firkins, J., James, J., Johansson, K., White, T., Jezierski, C., Doolittle, N. & Neuwelt, E., Jan 1 2018, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

Immunotherapy
Lymphoma
3 Citations (Scopus)

Neurovascular unit: Basic and clinical imaging with emphasis on advantages of ferumoxytol

Netto, J. P., Iliff, J., Stanimirovic, D., Krohn, K. A., Hamilton, B., Varallyay, C., Gahramanov, S., Daldrup-Link, H., D'Esterre, C., Zlokovic, B., Sair, H., Lee, Y., Taheri, S., Jain, R., Panigrahy, A., Reich, D. S., Drewes, L. R., Castillo, M. & Neuwelt, E., Jan 1 2018, In : Neurosurgery. 82, 6, p. 770-780 11 p.

Research output: Contribution to journalReview article

Open Access
Nervous System Physiological Phenomena
Ferrosoferric Oxide
Physiological Phenomena
Pericytes
Tight Junctions
25 Citations (Scopus)

Sodium thiosulfate for protection from cisplatin-induced hearing loss

Brock, P. R., Maibach, R., Childs, M., Rajput, K., Roebuck, D., Sullivan, M. J., Laithier, V., Ronghe, M., Dall'Igna, P., Hiyama, E., Brichard, B., Skeen, J., Mateos, M. E., Capra, M., Rangaswami, A. A., Ansari, M., Rechnitzer, C., Veal, G. J., Covezzoli, A., Brugières, L. & 4 others, Perilongo, G., Czauderna, P., Morland, B. & Neuwelt, E., Jun 21 2018, In : New England Journal of Medicine. 378, 25, p. 2376-2385 10 p.

Research output: Contribution to journalArticle

Hearing Loss
Cisplatin
Hepatoblastoma
Disease-Free Survival
Confidence Intervals
2017
1 Citation (Scopus)

Comprehensive review of the ThinkFirst injury prevention programs: A 30-Year success story for organized neurosurgery

Youngers, E. H., Zundel, K., Gerhardstein, D., Martínez, M., Bertrán, C., Proctor, M. R., Spatola, M. A. & Neuwelt, E. A., Sep 1 2017, In : Clinical Neurosurgery. 81, 3, p. 416-421 6 p.

Research output: Contribution to journalArticle

Neurosurgery
Wounds and Injuries
Young Adult
Nonprofit Organizations
Program Evaluation
40 Citations (Scopus)

Current and potential imaging applications of ferumoxytol for magnetic resonance imaging

Toth, G. B., Varallyay, C. G., Horvath, A., Bashir, M. R., Choyke, P. L., Daldrup-Link, H. E., Dosa, E., Finn, J. P., Gahramanov, S., Harisinghani, M., Macdougall, I., Neuwelt, A., Vasanawala, S. S., Ambady, P., Barajas, R., Cetas, J., Ciporen, J., Deloughery, T., Doolittle, N., Fu, R. R. & 13 others, Grinstead, J., Guimaraes, A., Hamilton, B., Li, X., McConnell, H. L., Muldoon, L., Nesbit, G., Netto, J. P., Petterson, D., Rooney, W., Schwartz, D., Szidonya, L. & Neuwelt, E., Jul 1 2017, In : Kidney International. 92, 1, p. 47-66 20 p.

Research output: Contribution to journalReview article

Ferrosoferric Oxide
Magnetic Resonance Imaging
Contrast Media
Central Nervous System
Atlases
5 Citations (Scopus)

Dose escalation study of intravenous and intra-arterial N-acetylcysteine for the prevention of oto- and nephrotoxicity of cisplatin with a contrast-induced nephropathy model in patients with renal insufficiency

Dósa, E., Heltai, K., Radovits, T., Molnár, G., Kapocsi, J., Merkely, B., Fu, R. R., Doolittle, N., Tóth, G. B., Urdang, Z. & Neuwelt, E., Oct 3 2017, In : Fluids and Barriers of the CNS. 14, 1, 26.

Research output: Contribution to journalArticle

Acetylcysteine
Cisplatin
Renal Insufficiency
Maximum Tolerated Dose
Auditory Hair Cells
37 Citations (Scopus)

Effects of sodium thiosulfate versus observation on development of cisplatin-induced hearing loss in children with cancer (ACCL0431): a multicentre, randomised, controlled, open-label, phase 3 trial

Freyer, D. R., Chen, L., Krailo, M. D., Knight, K., Villaluna, D., Bliss, B., Pollock, B. H., Ramdas, J., Lange, B., Van Hoff, D., VanSoelen, M. L., Wiernikowski, J., Neuwelt, E. & Sung, L., Jan 1 2017, In : The Lancet Oncology. 18, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Hearing Loss
Cisplatin
Neoplasms
Audiometry
Control Groups
1 Citation (Scopus)

Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors

Ambady, P., Wu, Y. J., Walker, J. M., Kersch, C., Pagel, M. A., Woltjer, R. R., Fu, R. R., Muldoon, L. & Neuwelt, E., Aug 1 2017, In : Cancer Gene Therapy. 24, 8, p. 348-357 10 p.

Research output: Contribution to journalArticle

Morpholinos
Methyltransferases
Radiation
DNA
temozolomide
17 Citations (Scopus)

Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children's Oncology Group

Knight, K., Chen, L., Freyer, D., Aplenc, R., Bancroft, M., Bliss, B., Dang, H., Gillmeister, B., Hendershot, E., Kraemer, D., Lindenfeld, L., Meza, J., Neuwelt, E., Pollock, B. H. & Sung, L., Feb 1 2017, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35, 4, p. 440-445 6 p.

Research output: Contribution to journalArticle

American Speech-Language-Hearing Association
Cisplatin
Terminology
Prospective Studies
Drug Therapy
6 Citations (Scopus)

High αv integrin level of cancer cells is associated with development of brain metastasis in athymic rats

Wu, Y. J., Pagel, M. A., Muldoon, L., Fu, R. R. & Neuwelt, E., Aug 1 2017, In : Anticancer Research. 37, 8, p. 4029-4040 12 p.

Research output: Contribution to journalArticle

Nude Rats
Integrins
Neoplasm Metastasis
Brain
Neoplasms
8 Citations (Scopus)
Central Nervous System Diseases
Blood Vessels
Lymphoma
Central Nervous System
Monoclonal Antibodies

Pseudo-extravasation rate constant of dynamic susceptibility contrast-MRI determined from pharmacokinetic first principles

Li, X., Varallyay, C. G., Gahramanov, S., Fu, R. R., Rooney, W. & Neuwelt, E., 2017, (Accepted/In press) In : NMR in Biomedicine.

Research output: Contribution to journalArticle

Pharmacokinetics
Magnetic resonance imaging
Rate constants
Magnetic resonance
Imaging techniques
2 Citations (Scopus)

Quantitative comparison of delayed ferumoxytol T1 enhancement with immediate gadoteridol enhancement in high grade gliomas

Horváth, A., Varallyay, C. G., Schwartz, D., Toth, G. B., Netto, J. P., Barajas, R., Várallyay, P., Szidonya, L., Firkins, J., Youngers, E., Fu, R. R., Ambady, P., Bogner, P. & Neuwelt, E., Jan 1 2017, (Accepted/In press) In : Magnetic Resonance in Medicine.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Glioma
Contrast Media
Steroids
Therapeutics
35 Citations (Scopus)

The translational significance of the neurovascular unit

McConnell, H. L., Kersch, C. N., Woltjer, R. R. & Neuwelt, E., Jan 20 2017, In : Journal of Biological Chemistry. 292, 3, p. 762-770 9 p.

Research output: Contribution to journalReview article

Blood-Brain Barrier
Blood
Neurons
Brain
Cerebrovascular Circulation
15 Citations (Scopus)

What does the boxed warning tell us? Safe practice of using ferumoxytol as an MRI CONTRAST AGENT

Varallyay, C. G., Toth, G. B., Fu, R. R., Netto, J. P., Firkins, J., Ambady, P. & Neuwelt, E., Jul 1 2017, In : American Journal of Neuroradiology. 38, 7, p. 1297-1302 6 p.

Research output: Contribution to journalArticle

Drug Labeling
Ferrosoferric Oxide
Safety
Research Ethics Committees
Gadolinium
2016
4 Citations (Scopus)

Ferumoxytol-enhanced MRI differentiation of meningioma from dural metastases: a pilot study with immunohistochemical observations

Hamilton, B., Woltjer, R. R., Prola-Netto, J., Nesbit, G., Gahramanov, S., Pham, T., Wagner, J. & Neuwelt, E., Jul 8 2016, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Meningioma
Magnetic Resonance Imaging
Gadolinium
Neoplasm Metastasis
12 Citations (Scopus)

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific

McConnell, H. L., Schwartz, D. L., Richardson, B. E., Woltjer, R. R., Muldoon, L. & Neuwelt, E., Aug 1 2016, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 12, 6, p. 1535-1542 8 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Nanoparticles
Magnetic resonance
Brain
Imaging techniques
7 Citations (Scopus)
temozolomide
Intra Arterial Infusions
Neoplasm Metastasis
Brain
Poisons
3 Citations (Scopus)
Ferrosoferric Oxide
Magnetic Resonance Angiography
Blood Volume
Neuroglia
Gadolinium
1 Citation (Scopus)

Outwitting the Blood-Brain Barrier

Neuwelt, E., Ambady, P., Muldoon, L., McConnell, H. & Doolittle, N., Nov 15 2016, In : Oncology (Williston Park, N.Y.). 30, 11

Research output: Contribution to journalArticle

Blood-Brain Barrier
3 Citations (Scopus)

Therapy for secondary CNS involvement inmalignant lymphomas: No standard yet!

Korfel, A., Chamberlain, M., Neuwelt, E., Thiel, E., Doolittle, N., Schlegel, U., Dreyling, M., Rubenstein, J., Fischer, L., Björkholm, M., Martus, P., Weller, M. & Glantz, M., May 20 2016, In : Journal of Clinical Oncology. 34, 15, p. 1829-1830 2 p.

Research output: Contribution to journalArticle

Lymphoma
Therapeutics
2015
5 Citations (Scopus)
Drug Dose Response Relationship
Gadolinium
Contrast Media
Seizures
Central Nervous System
9 Citations (Scopus)

Interactions between αv-Integrin and HER2 and their role in the invasive phenotype of breast cancer cells in vitro and in rat brain

Lal, S., Kersch, C., Beeson, K. A., Wu, Y. J., Muldoon, L. & Neuwelt, E., Jul 29 2015, In : PLoS One. 10, 7, e0131842.

Research output: Contribution to journalArticle

integrins
Integrins
breast neoplasms
Rats
Brain
20 Citations (Scopus)
Neuroimaging
Brain Mapping
Brain
Water
Multiple Sclerosis
13 Citations (Scopus)

N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models

Muldoon, L., Wu, Y. J., Pagel, M. A. & Neuwelt, E., 2015, In : Journal of Neuro-Oncology. 121, 3, p. 433-440 8 p.

Research output: Contribution to journalArticle

Acetylcysteine
Cisplatin
Pediatrics
Tumor Burden
Neoplasms
3 Citations (Scopus)

Primary CNS lymphoma

Neuwelt, E. & Schiff, D., Mar 24 2015, In : Neurology. 84, 12, p. 1194-1195 2 p.

Research output: Contribution to journalArticle

Antineoplastic Antimetabolites
Cranial Irradiation
Central Nervous System Neoplasms
Methotrexate
Lymphoma
35 Citations (Scopus)

Safety Report of Ferumoxytol for Magnetic Resonance Imaging in Children and Young Adults

Muehe, A. M., Feng, D., von Eyben, R., Luna-Fineman, S., Link, M. P., Muthig, T., Huddleston, A. E., Neuwelt, E. & Daldrup-Link, H. E., Dec 12 2015, (Accepted/In press) In : Investigative Radiology.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Young Adult
Magnetic Resonance Imaging
Safety
Injections
27 Citations (Scopus)

Unsanctifying the sanctuary: Challenges and opportunities with brain metastases

Puhalla, S., Elmquist, W., Freyer, D., Kleinberg, L., Adkins, C., Lockman, P., McGregor, J., Muldoon, L., Nesbit, G., Peereboom, D., Smith, Q., Walker, S. & Neuwelt, E., May 1 2015, In : Neuro-Oncology. 17, 5, p. 639-651 13 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Brain
Blood-Brain Barrier
Therapeutics
Neoplasms
20 Citations (Scopus)
Brain Neoplasms
Vascular Endothelial Growth Factor A
Aminoisobutyric Acids
Blood Vessels
Permeability
2014
31 Citations (Scopus)

Delivery of chemotherapeutics across the blood-brain barrier: Challenges and advances

Doolittle, N., Muldoon, L., Culp, A. Y. & Neuwelt, E., 2014, In : Advances in Pharmacology. 71, p. 203-243 41 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Brain Neoplasms
Central Nervous System
Drug Therapy
Nanoparticles
15 Citations (Scopus)

Diagnosis of pseudoprogression using MRI perfusion in patients with glioblastoma multiforme may predict improved survival

Gahramanov, S., Varallyay, C., Tyson, R. M. A., Lacy, C., Fu, R. R., Netto, J. P. R., Nasseri, M., White, T., Woltjer, R. R., Gultekin, S. & Neuwelt, E., Nov 1 2014, In : CNS oncology. 3, 6, p. 389-400 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Perfusion
Survival
Methylation
Ferrosoferric Oxide
52 Citations (Scopus)

Evaluation of pseudoprogression in patients with glioblastoma multiforme using dynamic magnetic resonance imaging with ferumoxytol calls RANO criteria into question

Nasseri, M., Gahramanov, S., Netto, J. P., Fu, R. R., Muldoon, L., Varallyay, C., Hamilton, B. & Neuwelt, E., 2014, In : Neuro-Oncology. 16, 8, p. 1146-1154 9 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Glioblastoma
Chemoradiotherapy
Magnetic Resonance Imaging
Magnetic Resonance Angiography
5 Citations (Scopus)

Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis

Neuwelt, A. J., Nguyen, T. M., Fu, R. R., Bubalo, J., Tyson, R. M. A., Lacy, C., Gahramanov, S., Nasseri, M., Barnes, P. D. & Neuwelt, E., Jul 1 2014, In : CNS oncology. 3, 4, p. 267-273 7 p.

Research output: Contribution to journalArticle

temozolomide
Pneumocystis carinii
Pneumocystis Pneumonia
Incidence
Neoplasms
7 Citations (Scopus)

Preclinical high-dose acetaminophen with N-acetylcysteine rescue enhances the efficacy of cisplatin chemotherapy in atypical teratoid rhabdoid tumors

Neuwelt, A. J., Nguyen, T., Wu, Y. J., Donson, A. M., Vibhakar, R., Venkatamaran, S., Amani, V., Neuwelt, E., Rapkin, L. B. & Foreman, N. K., 2014, In : Pediatric Blood and Cancer. 61, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

Acetylcysteine
Acetaminophen
Cisplatin
Drug Therapy
Peroxides
2013
1 Citation (Scopus)
Cognition Disorders
Antirheumatic Agents
X Ray Computed Tomography
Paresthesia
Neurologic Manifestations
9 Citations (Scopus)

Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma

Wu, Y. J. J., Neuwelt, A. J., Muldoon, L. & Neuwelt, E., Jun 2013, In : Anticancer Research. 33, 6, p. 2391-2400 10 p.

Research output: Contribution to journalArticle

Acetaminophen
Carcinoma
Glutathione
Ovarian Neoplasms
Neoplasms

Blood-tumor barrier normalization effects on cytotoxic drug delivery to brain tumors

Pishko, G. L., Nasseri, M., Gahramanov, S., Muldoon, L. & Neuwelt, E., 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. Vol. 1 A.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Drug delivery
Brain Neoplasms
Tumors
Brain
Blood
4 Citations (Scopus)

Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder

Nakamoto, B. K., Shikuma, C. M., Ogata-Arakaki, D., Umaki, T., Neuwelt, E., Shiramizu, B. T., Chow, D. C., Parikh, N. I., Kallianpur, K. J. & Hamilton, B., Dec 2013, In : Journal of NeuroVirology. 19, 6, p. 601-605 5 p.

Research output: Contribution to journalArticle

Ferrosoferric Oxide
Neuroimaging
HIV
Monocytes
Macrophages
58 Citations (Scopus)
Ferrosoferric Oxide
Central Nervous System Neoplasms
Nanoparticles
Central Nervous System
Pathology
122 Citations (Scopus)

Immunologic privilege in the central nervous system and the blood-brain barrier

Muldoon, L., Alvarez, J. I., Begley, D. J., Boado, R. J., Del Zoppo, G. J., Doolittle, N., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., Prat, A., Scarpa, M., Smeyne, R. J., Drewes, L. R. & Neuwelt, E., Jan 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Central Nervous System
Cerebrovascular Disorders
Brain
Neurosciences
29 Citations (Scopus)

Inhibition of SUR1 decreases the vascular permeability of cerebral metastases

Thompson, E. M., Pishko, G. L., Muldoon, L. & Neuwelt, E., 2013, In : Neoplasia (United States). 15, 5, p. 535-543 9 p.

Research output: Contribution to journalArticle

Sulfonylurea Receptors
Capillary Permeability
Glyburide
Neoplasm Metastasis
Zonula Occludens-1 Protein
66 Citations (Scopus)

Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma

Doolittle, N., Korfel, A., Lubow, M. A., Schorb, E., Schlegel, U., Rogowski, S., Fu, R. R., Dósa, E., Illerhaus, G., Kraemer, D., Muldoon, L., Calabrese, P., Hedrick, N., Tyson, R. M., Jahnke, K., Maron, L., Butler, R. W. & Neuwelt, E., Jul 2 2013, In : Neurology. 81, 1, p. 84-92 9 p.

Research output: Contribution to journalArticle

Neuroimaging
Cognition
Lymphoma
Quality of Life
Radiotherapy
12 Citations (Scopus)

Preservation of cognitive function in primary CNS lymphoma survivors a median of 12 years after enhanced chemotherapy delivery

Doolittle, N., Dósa, E., Fu, R. R., Muldoon, L., Maron, L., Lubow, M. A., Tyson, R. M., Lacy, C. A., Kraemer, D., Butler, R. W. & Neuwelt, E., Nov 1 2013, In : Journal of Clinical Oncology. 31, 31, p. 4026-4027 2 p.

Research output: Contribution to journalArticle

Cognition Disorders
Central Nervous System Neoplasms
Neuropsychological Tests
Antineoplastic Agents
Cognition
90 Citations (Scopus)
Ferrosoferric Oxide
Magnetic Resonance Angiography
Glioblastoma
Radiotherapy
Survival
5 Citations (Scopus)

The effect of alpha-v integrin inhibition on the malignant characteristics of medulloblastoma: Laboratory investigation

Thompson, E. M., Whitney, N. L., Wu, Y. J. & Neuwelt, E., Jan 2013, In : Journal of Neurosurgery: Pediatrics. 11, 1, p. 60-67 8 p.

Research output: Contribution to journalArticle

Integrin alpha Chains
Medulloblastoma
Integrins
Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
39 Citations (Scopus)

Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL

Farrell, B. T., Hamilton, B., Dosa, E., Rimely, E., Nasseri, M., Gahramanov, S., Lacy, C. A., Frenkel, E. P., Doolittle, N., Jacobs, P. M. & Neuwelt, E., Jul 16 2013, In : Neurology. 81, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Nanoparticles
Contrast Media
Gadolinium
Ferrosoferric Oxide
2012
12 Citations (Scopus)

Cerebrospinal fluid shunting and hearing loss in patients treated for medulloblastoma: Clinical article

Guillaume, D. J., Knight, K., Marquez, C., Kraemer, D., Bardo, D. M. E. & Neuwelt, E., Apr 2012, In : Journal of Neurosurgery: Pediatrics. 9, 4, p. 421-427 7 p.

Research output: Contribution to journalArticle

Medulloblastoma
Hearing Loss
Cerebrospinal Fluid
Cochlear Aqueduct
Radiation