Doris Kretzschmar

Associate Professor

  • 1710 Citations
  • 23 h-Index
1992 …2019
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Research Output 1992 2019

  • 1710 Citations
  • 23 h-Index
  • 48 Article
  • 2 Chapter
  • 1 Review article
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Article
2019

ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration

Sunderhaus, E. R., Law, A. D. & Kretzschmar, D., Oct 1 2019, In : Neurobiology of Disease. 130, 104520.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Cheese
Endoplasmic Reticulum
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Diptera
2018
2 Citations (Scopus)

Drosophila Full-Length Amyloid Precursor Protein Is Required for Visual Working Memory and Prevents Age-Related Memory Impairment

Rieche, F., Carmine-Simmen, K., Poeck, B., Kretzschmar, D. & Strauss, R., Mar 5 2018, In : Current Biology. 28, 5, p. 817-823.e3

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
amyloid
Short-Term Memory
Drosophila
2 Citations (Scopus)

The PKA-C3 catalytic subunit is required in two pairs of interneurons for successful mating of Drosophila

Cassar, M., Sunderhaus, E., Wentzell, J. S., Kuntz, S., Strauss, R. & Kretzschmar, D., Dec 1 2018, In : Scientific Reports. 8, 1, 2458.

Research output: Contribution to journalArticle

Interneurons
Cyclic AMP-Dependent Protein Kinases
Drosophila
Catalytic Domain
Copulation
2017
2 Citations (Scopus)

NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers

Mcferrin, J., Patton, B., Sunderhaus, E. R. & Kretzschmar, D., 2017, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

Phospholipases
Schwann Cells
Neuroglia
neurotoxic esterase
Organophosphate Poisoning
3 Citations (Scopus)

Reduced expression of foxpl as a contributing factor in huntington’s disease

Titus, A. S. C. L. S., Yusuff, T., Cassar, M., Thomas, E., Kretzschmar, D. & D’Mello, S. R., 2017, In : Journal of Neuroscience. 37, 27, p. 6575-6587 13 p.

Research output: Contribution to journalArticle

Huntington Disease
Neurons
Protein Isoforms
Mutant Proteins
Forkhead Transcription Factors
2016
9 Citations (Scopus)

Amyloid precursor proteins are dynamically trafficked and processed during neuronal development

Ramaker, J. M., Cargill, R. S., Swanson, T. L., Quirindongo, H., Cassar, M., Kretzschmar, D. & Copenhaver, P., Nov 25 2016, In : Frontiers in Molecular Neuroscience. 9, NOV2016, 130.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Neurons
Nervous System
Insects
Time-Lapse Imaging
19 Citations (Scopus)

Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function

Dutta, S., Rieche, F., Eckl, N., Duch, C. & Kretzschmar, D., Mar 1 2016, In : DMM Disease Models and Mechanisms. 9, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

Cheeses
Cheese
Neuroglia
Drosophila
Neurons
4 Citations (Scopus)

Mass histology to quantify neurodegeneration in drosophila

Sunderhaus, E. R. & Kretzschmar, D., Dec 15 2016, In : Journal of Visualized Experiments. 2016, 118, e54809.

Research output: Contribution to journalArticle

Histology
Diptera
Neurodegenerative diseases
Drosophila
Brain
29 Citations (Scopus)

The genetic basis of cerebral palsy

Fahey, M. C., Maclennan, A. H., Kretzschmar, D., Gecz, J. & Kruer, M. C., 2016, (Accepted/In press) In : Developmental Medicine and Child Neurology.

Research output: Contribution to journalArticle

Cerebral Palsy
Genetic Heterogeneity
Neurobiology
Validation Studies
Chromosome Mapping
2015
18 Citations (Scopus)

Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila

Blake, M. R., Holbrook, S. D., Kotwica-Rolinska, J., Chow, E. S., Kretzschmar, D. & Giebultowicz, J. M., May 1 2015, In : Neurobiology of Disease. 77, p. 117-126 10 p.

Research output: Contribution to journalArticle

Circadian Clocks
Amyloid beta-Protein Precursor
Drosophila
Alzheimer Disease
Activity Cycles
32 Citations (Scopus)

Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness

Kmoch, S., Majewski, J., Ramamurthy, V., Cao, S., Fahiminiya, S., Ren, H., Macdonald, I. M., Lopez, I., Sun, V., Keser, V., Khan, A., Stránecký, V., Hartmannová, H., På Istoupilová, A., HodaÅ ová, K., Piherová, L., KuchaÅ, L., Baxová, A., Chen, R., Barsottini, O. G. P. & 21 others, Pyle, A., Griffin, H., Splitt, M., Sallum, J., Tolmie, J. L., Sampson, J. R., Chinnery, P., Banin, E., Sharon, D., Dutta, S., Grebler, R., Helfrich-Foerster, C., Pedroso, J. L., Kretzschmar, D., Cayouette, M., Koenekoop, R. K., Boycott, K., MacKenzie, A., Brudno, M., Bulman, D. & Dyment, D., Jan 8 2015, In : Nature Communications. 6, 5614.

Research output: Contribution to journalArticle

blindness
photoreceptors
degeneration
Blindness
mutations
2014
4 Citations (Scopus)

Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant loechrig

Cook, M., Bolkan, B. J. & Kretzschmar, D., Feb 25 2014, In : PLoS One. 9, 2, e89847.

Research output: Contribution to journalArticle

AMP-activated protein kinase
AMP-Activated Protein Kinases
Polymerization
polymerization
actin
39 Citations (Scopus)

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome

Topaloglu, A. K., Lomniczi, A., Kretzschmar, D., Dissen, G., Kotan, L. D., McArdle, C. A., Koc, A. F., Hamel, B. C., Guclu, M., Papatya, E. D., Eren, E., Mengen, E., Gurbuz, F., Cook, M., Castellano, J. M., Kekil, M. B., Mungan, N. O., Yuksel, B. & Ojeda, S., Oct 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 10, p. E2067-E2075

Research output: Contribution to journalArticle

Hypogonadism
Gonadotropin-Releasing Hormone
Mutation
Phospholipids
Bearings (structural)
22 Citations (Scopus)

Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila

Bolkan, B. J. & Kretzschmar, D., Dec 1 2014, In : Developmental Neurobiology. 74, 12, p. 1210-1225 16 p.

Research output: Contribution to journalArticle

Diptera
Drosophila
Microtubule-Associated Proteins
Tauopathies
Phenotype
6 Citations (Scopus)

Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration

Wentzell, J. S., Cassar, M. & Kretzschmar, D., Feb 18 2014, In : PLoS One. 9, 2, e87526.

Research output: Contribution to journalArticle

Swiss cheese
Cheeses
peripheral nervous system diseases
Organophosphates
Cheese
18 Citations (Scopus)

Relationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila

Long, D. M., Blake, M. R., Dutta, S., Holbrook, S. D., Kotwica-Rolinska, J., Kretzschmar, D. & Giebultowicz, J. M., Aug 29 2014, In : PLoS One. 9, 8, e106068.

Research output: Contribution to journalArticle

Alzheimer disease
Diptera
signs and symptoms (animals and humans)
Drosophila
Clocks
2013
22 Citations (Scopus)

Mutations in gamma adducin are associated with inherited cerebral palsy

Kruer, M. C., Jepperson, T., Dutta, S., Steiner, R. D., Cottenie, E., Sanford, L., Merkens, M., Russman, B. S., Blasco, P., Fan, G., Pollock, J., Green, S., Woltjer, R. R., Mooney, C., Kretzschmar, D., Paisán-Ruiz, C. & Houlden, H., Dec 2013, In : Annals of Neurology. 74, 6, p. 805-814 10 p.

Research output: Contribution to journalArticle

Cerebral Palsy
Mutation
Fibroblasts
Adaptor Protein Complex 4
Cytoskeleton
2012
30 Citations (Scopus)

Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

Wentzell, J. S., Bolkan, B. J., Carmine-Simmen, K., Swanson, T. L., Musashe, D. T. & Kretzschmar, D., Apr 2012, In : Neurobiology of Disease. 46, 1, p. 78-87 10 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Drosophila
Diptera
Amyloid Precursor Protein Secretases
AMP-Activated Protein Kinases
19 Citations (Scopus)

Analysis of amyloid precursor protein function in Drosophila melanogaster

Poeck, B., Strauss, R. & Kretzschmar, D., Apr 2012, In : Experimental Brain Research. 217, 3-4, p. 413-421 9 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Drosophila melanogaster
Diptera
Proteins
Long-Term Memory
11 Citations (Scopus)

Increased RhoA Prenylation in the loechrig (loe) Mutant Leads to Progressive Neurodegeneration

Cook, M., Mani, P., Wentzell, J. S. & Kretzschmar, D., Sep 6 2012, In : PLoS One. 7, 9, e44440.

Research output: Contribution to journalArticle

Prenylation
AMP-activated protein kinase
AMP-Activated Protein Kinases
isoprenoids
Terpenes
51 Citations (Scopus)

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

Krishnan, N., Rakshit, K., Chow, E. S., Wentzell, J. S., Kretzschmar, D. & Giebultowicz, J. M., Mar 2012, In : Neurobiology of Disease. 45, 3, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

Circadian Clocks
Circadian Rhythm
Mutation
Diptera
Genes
1 Citation (Scopus)

Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin

Kassa, R., Monterroso, V., Wentzell, J., Ramos, A. L., Couchi, E., Lecomte, M. C., Iordanov, M., Kretzschmar, D., Nicolas, G. & Tshala-Katumbay, D., Jul 2012, In : Journal of Molecular Neuroscience. 47, 3, p. 631-638 8 p.

Research output: Contribution to journalArticle

Spectrin
Calpain
Caspases
Maintenance
Molecular Probes
19 Citations (Scopus)

β-secretase cleavage of the fly amyloid precursor protein is required for glial survival

Bolkan, B. J., Triphan, T. & Kretzschmar, D., Nov 14 2012, In : Journal of Neuroscience. 32, 46, p. 16181-16192 12 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Neuroglia
Diptera
Neuregulins
2011
20 Citations (Scopus)

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug

Copenhaver, P., Anekonda, T. S., Musashe, D., Robinson, K. M., Ramaker, J. M., Swanson, T. L., Wadsworth, T. L., Kretzschmar, D., Woltjer, R. R. & Quinn, J., Sep 2011, In : DMM Disease Models and Mechanisms. 4, 5, p. 634-648 15 p.

Research output: Contribution to journalArticle

Isradipine
Alzheimer Disease
Amyloid
Biological Assay
Pharmaceutical Preparations
5 Citations (Scopus)

Drosophila GGA Model: An Ultimate Gateway to GGA Analysis

Eissenberg, J. C., Ilvarsonn, A. M., Sly, W. S., Waheed, A., Krzyzanek, V., Pohlmann, R., Waschkau, D., Kretzschmar, D. & Dennes, A. C., Dec 2011, In : Traffic. 12, 12, p. 1821-1838 18 p.

Research output: Contribution to journalArticle

Sorting
Drosophila
Protein Transport
Enzymes
ADP-Ribosylation Factors
2010
23 Citations (Scopus)

Alzheimer's Disease and tauopathy studies in flies and worms

Wentzell, J. & Kretzschmar, D., Oct 2010, In : Neurobiology of Disease. 40, 1, p. 21-28 8 p.

Research output: Contribution to journalArticle

Tauopathies
Diptera
Alzheimer Disease
Invertebrates
Amyloid beta-Protein Precursor
23 Citations (Scopus)

Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration

Wang, L., Ankati, H., Akubathini, S. K., Balderamos, M., Storey, C. A., Patel, A. V., Price, V., Kretzschmar, D., Biehl, E. R. & D'Mello, S. R., Jul 2010, In : Journal of Neuroscience Research. 88, 9, p. 1970-1984 15 p.

Research output: Contribution to journalArticle

Benzoxazines
Cyclin-Dependent Kinases
Neurons
Huntington Disease
p38 Mitogen-Activated Protein Kinases
2009
74 Citations (Scopus)

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

Carmine-Simmen, K., Proctor, T., Tschäpe, J., Poeck, B., Triphan, T., Strauss, R. & Kretzschmar, D., Feb 2009, In : Neurobiology of Disease. 33, 2, p. 274-281 8 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Poisons
Amyloid Plaques
Amyloid
Drosophila
10 Citations (Scopus)

Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila

Kretzschmar, D., Mar 2009, In : Journal of Neurogenetics. 23, 1-2, p. 34-41 8 p.

Research output: Contribution to journalArticle

Cheese
Diptera
Drosophila
Genes
74 Citations (Scopus)

The circadian clock gene period extends healthspan in aging Drosophila melanogaster.

Krishnan, N., Kretzschmar, D., Rakshit, K., Chow, E. & Giebultowicz, J. M., Nov 2009, In : Aging. 1, 11, p. 937-948 12 p.

Research output: Contribution to journalArticle

Circadian Clocks
Drosophila melanogaster
Diptera
Genes
Hyperoxia
2008
12 Citations (Scopus)

Optomotor-blind expression in glial cells is required for correct axonal projection across the Drosophila inner optic chiasm

Hofmeyer, K., Kretzschmar, D. & Pflugfelder, G. O., Mar 1 2008, In : Developmental Biology. 315, 1, p. 28-41 14 p.

Research output: Contribution to journalArticle

Optic Chiasm
Neuroglia
Drosophila
Neuropil
Axons
29 Citations (Scopus)

Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3

Da Cruz, A. B., Wentzell, J. & Kretzschmar, D., Oct 22 2008, In : Journal of Neuroscience. 28, 43, p. 10885-10892 8 p.

Research output: Contribution to journalArticle

Cheese
Proteins
Catalytic Domain
Hereditary Spastic Paraplegia
Membranes
2005
63 Citations (Scopus)

Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila

Da Cruz, A. B., Schwärzel, M., Schulze, S., Niyyati, M., Heisenberg, M. & Kretzschmar, D., May 2005, In : Molecular Biology of the Cell. 16, 5, p. 2433-2442 10 p.

Research output: Contribution to journalArticle

Axonal Transport
Microtubule-Associated Proteins
Cytoskeleton
Drosophila
Diptera
38 Citations (Scopus)

Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila

Kretzschmar, D., Tschäpe, J., Da Cruz, A. B., Asan, E., Poeck, B., Strauss, R. & Pflugfelder, G. O., Jan 1 2005, In : GLIA. 49, 1, p. 59-72 14 p.

Research output: Contribution to journalArticle

Neuroglia
Drosophila
Proteins
Cell Death
Behavioral Symptoms
100 Citations (Scopus)

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila

Mühlig-Versen, M., Da Cruz, A. B., Tschäpe, J. A., Moser, M., Büttner, R., Athenstaedt, K., Glynn, P. & Kretzschmar, D., Mar 16 2005, In : Journal of Neuroscience. 25, 11, p. 2865-2873 9 p.

Research output: Contribution to journalArticle

Cheese
Phosphatidylcholines
Neuroglia
Drosophila
Homeostasis
21 Citations (Scopus)
Drosophila
Neurodegenerative Diseases
Genes
RNA Editing
Caenorhabditis elegans
2004
181 Citations (Scopus)

Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila

Greeve, I., Kretzschmar, D., Tschäpe, J. A., Beyn, A., Brellinger, C., Schweizer, M., Nitsch, R. M. & Reifegerste, R., Apr 21 2004, In : Journal of Neuroscience. 24, 16, p. 3899-3906 8 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid Plaques
Drosophila
Alzheimer Disease
Presenilins
88 Citations (Scopus)

Placental Failure and Impaired Vasculogenesis Result in Embryonic Lethality for Neuropathy Target Esterase-Deficient Mice

Moser, M., Li, Y., Vaupel, K., Kretzschmar, D., Kluge, R., Glynn, P. & Buettner, R., Feb 2004, In : Molecular and Cellular Biology. 24, 4, p. 1667-1679 13 p.

Research output: Contribution to journalArticle

Embryonic Structures
Cheese
Apoptosis
Neurons
Placentation
60 Citations (Scopus)

The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration

Botella, J. A., Ulschmid, J. K., Gruenewald, C., Moehle, C., Kretzschmar, D., Becker, K. & Schneuwly, S., May 4 2004, In : Current Biology. 14, 9, p. 782-786 5 p.

Research output: Contribution to journalArticle

Alcohol Oxidoreductases
Oxidative stress
Drosophila
Oxidative Stress
oxidative stress
2003
25 Citations (Scopus)

Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap

Botella, J. A., Kretzschmar, D., Kiermayer, C., Feldmann, P., Hughes, D. A. & Schneuwly, S., Jan 1 2003, In : Molecular Biology of the Cell. 14, 1, p. 241-250 10 p.

Research output: Contribution to journalArticle

Drosophila
Neurons
Brain
Cell Death
ras GTPase-Activating Proteins
12 Citations (Scopus)

Progressive neurodegeneration in Drosophila: A model system

Tschäpe, J. A., Bettencourt Da Cruz, A. & Kretzschmar, D., 2003, In : Journal of Neural Transmission, Supplement. 65, p. 51-62 12 p.

Research output: Contribution to journalArticle

Diptera
Drosophila
Brain
Genes
Neurodegenerative Diseases
2002
38 Citations (Scopus)

Glia in development, function, and neurodegeneration of the adult insect brain

Kretzschmar, D. & Pflugfelder, G. O., Jan 1 2002, In : Brain Research Bulletin. 57, 1, p. 121-131 11 p.

Research output: Contribution to journalArticle

Neuroglia
Insects
Brain
Neurons
Brain Diseases
96 Citations (Scopus)

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

Tschäpe, J. A., Hammerschmied, C., Mühlig-Versen, M., Athenstaedt, K., Daum, G. & Kretzschmar, D., Dec 2 2002, In : EMBO Journal. 21, 23, p. 6367-6376 10 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl CoA Reductases
Amyloid beta-Protein Precursor
AMP-Activated Protein Kinases
Homeostasis
Cholesterol
2000
38 Citations (Scopus)

Cloning and expression of the murine sws/NTE gene

Moser, M., Stempfl, T., Li, Y., Glynn, P., Büttner, R. & Kretzschmar, D., Feb 1 2000, In : Mechanisms of Development. 90, 2, p. 279-282 4 p.

Research output: Contribution to journalArticle

Organism Cloning
Neurons
Cerebellar Nuclei
Medulla Oblongata
Pons
46 Citations (Scopus)

Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3β adaptin gene ruby

Kretzschmar, D., Poeck, B., Roth, H., Ernst, R., Keller, A., Porsch, M., Strauss, R. & Pflugfelder, G. O., May 2000, In : Genetics. 155, 1, p. 213-223 11 p.

Research output: Contribution to journalArticle

Eye Color
Drosophila
Lysosomes
Organelles
Mutation
1997
180 Citations (Scopus)

The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila

Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M. & Benzer, S., 1997, In : Journal of Neuroscience. 17, 19, p. 7425-7432 8 p.

Research output: Contribution to journalArticle

Cheese
Neuroglia
Drosophila
Pupa
Brain
1995
27 Citations (Scopus)

Avian cellular homolog of the qin oncogene

Chang, H. W., Li, J., Kretzschmar, D. & Vogt, P. K., Jan 17 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 2, p. 447-451 5 p.

Research output: Contribution to journalArticle

Oncogenes
Chickens
Embryonic Structures
Avian Sarcoma Viruses
Telencephalon
1992
46 Citations (Scopus)

Giant lens, a gene involved in cell determination and axon guidance in the visual system of Drosophila melanogaster

Kretzschmar, D., Brunner, A., Wiersdorff, V., Pflugfelder, G. O., Heisenberg, M. & Schneuwly, S., 1992, In : EMBO Journal. 11, 7, p. 2531-2539 9 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Lenses
Genes
Axons
Optics