Doris Kretzschmar

Associate Professor

  • 1812 Citations
  • 24 h-Index
1992 …2019

Research output per year

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Research Output

  • 1812 Citations
  • 24 h-Index
  • 44 Article
  • 6 Review article
  • 2 Chapter
2019

Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila

Nash, T. R., Chow, E. S., Law, A. D., Fu, S. D., Fuszara, E., Bilska, A., Bebas, P., Kretzschmar, D. & Giebultowicz, J. M., Dec 1 2019, In : npj Aging and Mechanisms of Disease. 5, 1, 8.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration

Sunderhaus, E. R., Law, A. D. & Kretzschmar, D., Oct 1 2019, In : Neurobiology of Disease. 130, 104520.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Drosophila Full-Length Amyloid Precursor Protein Is Required for Visual Working Memory and Prevents Age-Related Memory Impairment

Rieche, F., Carmine-Simmen, K., Poeck, B., Kretzschmar, D. & Strauss, R., Mar 5 2018, In : Current Biology. 28, 5, p. 817-823.e3

Research output: Contribution to journalArticle

3 Scopus citations

The PKA-C3 catalytic subunit is required in two pairs of interneurons for successful mating of Drosophila

Cassar, M., Sunderhaus, E., Wentzell, J. S., Kuntz, S., Strauss, R. & Kretzschmar, D., Dec 1 2018, In : Scientific Reports. 8, 1, 2458.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Animal Models of Alzheimer's Disease

Newman, M., Kretzschmar, D., Khan, I., Chen, M., Verdile, G. & Lardelli, M., Jun 28 2017, Animal Models for the Study of Human Disease: Second Edition. Elsevier Inc., p. 1031-1085 55 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

NTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers

Mcferrin, J., Patton, B., Sunderhaus, E. R. & Kretzschmar, D., 2017, (Accepted/In press) In : GLIA.

Research output: Contribution to journalArticle

4 Scopus citations

Reduced expression of foxpl as a contributing factor in huntington’s disease

Titus, A. S. C. L. S., Yusuff, T., Cassar, M., Thomas, E., Kretzschmar, D. & D’Mello, S. R., 2017, In : Journal of Neuroscience. 37, 27, p. 6575-6587 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Amyloid precursor proteins are dynamically trafficked and processed during neuronal development

Ramaker, J. M., Cargill, R. S., Swanson, T. L., Quirindongo, H., Cassar, M., Kretzschmar, D. & Copenhaver, P., Nov 25 2016, In : Frontiers in Molecular Neuroscience. 9, NOV2016, 130.

Research output: Contribution to journalArticle

9 Scopus citations

Analysis of amyloid precursor protein function in Drosophila melanogaster

Cassar, M. & Kretzschmar, D., Jul 26 2016, In : Frontiers in Molecular Neuroscience. 9, JUL, 61.

Research output: Contribution to journalReview article

15 Scopus citations

Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and function

Dutta, S., Rieche, F., Eckl, N., Duch, C. & Kretzschmar, D., Mar 1 2016, In : DMM Disease Models and Mechanisms. 9, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mass histology to quantify neurodegeneration in drosophila

Sunderhaus, E. R. & Kretzschmar, D., Dec 15 2016, In : Journal of Visualized Experiments. 2016, 118, e54809.

Research output: Contribution to journalArticle

7 Scopus citations

The genetic basis of cerebral palsy

Fahey, M. C., Maclennan, A. H., Kretzschmar, D., Gecz, J. & Kruer, M. C., 2016, (Accepted/In press) In : Developmental Medicine and Child Neurology.

Research output: Contribution to journalArticle

41 Scopus citations
2015

Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila

Blake, M. R., Holbrook, S. D., Kotwica-Rolinska, J., Chow, E. S., Kretzschmar, D. & Giebultowicz, J. M., May 1 2015, In : Neurobiology of Disease. 77, p. 117-126 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness

Kmoch, S., Majewski, J., Ramamurthy, V., Cao, S., Fahiminiya, S., Ren, H., Macdonald, I. M., Lopez, I., Sun, V., Keser, V., Khan, A., Stránecký, V., Hartmannová, H., På Istoupilová, A., HodaÅ ová, K., Piherová, L., KuchaÅ, L., Baxová, A., Chen, R., Barsottini, O. G. P. & 21 others, Pyle, A., Griffin, H., Splitt, M., Sallum, J., Tolmie, J. L., Sampson, J. R., Chinnery, P., Banin, E., Sharon, D., Dutta, S., Grebler, R., Helfrich-Foerster, C., Pedroso, J. L., Kretzschmar, D., Cayouette, M., Koenekoop, R. K., Boycott, K., MacKenzie, A., Brudno, M., Bulman, D. & Dyment, D., Jan 8 2015, In : Nature communications. 6, 5614.

Research output: Contribution to journalArticle

34 Scopus citations
2014

Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant loechrig

Cook, M., Bolkan, B. J. & Kretzschmar, D., Feb 25 2014, In : PloS one. 9, 2, e89847.

Research output: Contribution to journalArticle

4 Scopus citations

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome

Topaloglu, A. K., Lomniczi, A., Kretzschmar, D., Dissen, G. A., Kotan, L. D., McArdle, C. A., Koc, A. F., Hamel, B. C., Guclu, M., Papatya, E. D., Eren, E., Mengen, E., Gurbuz, F., Cook, M., Castellano, J. M., Kekil, M. B., Mungan, N. O., Yuksel, B. & Ojeda, S. R., Oct 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 10, p. E2067-E2075

Research output: Contribution to journalArticle

45 Scopus citations

Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila

Bolkan, B. J. & Kretzschmar, D., Dec 1 2014, In : Developmental Neurobiology. 74, 12, p. 1210-1225 16 p.

Research output: Contribution to journalArticle

23 Scopus citations

Organophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegeneration

Wentzell, J. S., Cassar, M. & Kretzschmar, D., Feb 18 2014, In : PloS one. 9, 2, e87526.

Research output: Contribution to journalArticle

7 Scopus citations

Relationships between the circadian system and Alzheimer's disease-like symptoms in Drosophila

Long, D. M., Blake, M. R., Dutta, S., Holbrook, S. D., Kotwica-Rolinska, J., Kretzschmar, D. & Giebultowicz, J. M., Aug 29 2014, In : PloS one. 9, 8, e106068.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Models of Alzheimer's Disease

Chen, M., Kretzschmar, D., Verdile, G. & Lardelli, M., Jul 2013, Animal Models for the Study of Human Disease. Elsevier Inc., p. 595-632 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Mutations in gamma adducin are associated with inherited cerebral palsy

Kruer, M. C., Jepperson, T., Dutta, S., Steiner, R. D., Cottenie, E., Sanford, L., Merkens, M., Russman, B. S., Blasco, P. A., Fan, G., Pollock, J., Green, S., Woltjer, R. L., Mooney, C., Kretzschmar, D., Paisán-Ruiz, C. & Houlden, H., Dec 1 2013, In : Annals of Neurology. 74, 6, p. 805-814 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

Wentzell, J. S., Bolkan, B. J., Carmine-Simmen, K., Swanson, T. L., Musashe, D. T. & Kretzschmar, D., Apr 1 2012, In : Neurobiology of Disease. 46, 1, p. 78-87 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Analysis of amyloid precursor protein function in Drosophila melanogaster

Poeck, B., Strauss, R. & Kretzschmar, D., Apr 1 2012, In : Experimental Brain Research. 217, 3-4, p. 413-421 9 p.

Research output: Contribution to journalReview article

20 Scopus citations

Increased RhoA Prenylation in the loechrig (loe) Mutant Leads to Progressive Neurodegeneration

Cook, M., Mani, P., Wentzell, J. S. & Kretzschmar, D., Sep 6 2012, In : PloS one. 7, 9, e44440.

Research output: Contribution to journalArticle

12 Scopus citations

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants

Krishnan, N., Rakshit, K., Chow, E. S., Wentzell, J. S., Kretzschmar, D. & Giebultowicz, J. M., Mar 1 2012, In : Neurobiology of Disease. 45, 3, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

Proximal giant neurofilamentous axonopathy in mice genetically engineered to resist calpain and caspase cleavage of α-II spectrin

Kassa, R., Monterroso, V., Wentzell, J., Ramos, A. L., Couchi, E., Lecomte, M. C., Iordanov, M., Kretzschmar, D., Nicolas, G. & Tshala-Katumbay, D., Jul 1 2012, In : Journal of Molecular Neuroscience. 47, 3, p. 631-638 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

β-secretase cleavage of the fly amyloid precursor protein is required for glial survival

Bolkan, B. J., Triphan, T. & Kretzschmar, D., Nov 14 2012, In : Journal of Neuroscience. 32, 46, p. 16181-16192 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: Isradipine as a candidate drug

Copenhaver, P. F., Anekonda, T. S., Musashe, D., Robinson, K. M., Ramaker, J. M., Swanson, T. L., Wadsworth, T. L., Kretzschmar, D., Woltjer, R. L. & Quinn, J. F., Sep 1 2011, In : DMM Disease Models and Mechanisms. 4, 5, p. 634-648 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Drosophila GGA Model: An Ultimate Gateway to GGA Analysis

Eissenberg, J. C., Ilvarsonn, A. M., Sly, W. S., Waheed, A., Krzyzanek, V., Pohlmann, R., Waschkau, D., Kretzschmar, D. & Dennes, A. C., Dec 1 2011, In : Traffic. 12, 12, p. 1821-1838 18 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Alzheimer's Disease and tauopathy studies in flies and worms

Wentzell, J. & Kretzschmar, D., Oct 1 2010, In : Neurobiology of Disease. 40, 1, p. 21-28 8 p.

Research output: Contribution to journalReview article

24 Scopus citations

Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration

Wang, L., Ankati, H., Akubathini, S. K., Balderamos, M., Storey, C. A., Patel, A. V., Price, V., Kretzschmar, D., Biehl, E. R. & D'Mello, S. R., Jul 1 2010, In : Journal of Neuroscience Research. 88, 9, p. 1970-1984 15 p.

Research output: Contribution to journalArticle

24 Scopus citations
2009

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

Carmine-Simmen, K., Proctor, T., Tschäpe, J., Poeck, B., Triphan, T., Strauss, R. & Kretzschmar, D., Feb 1 2009, In : Neurobiology of Disease. 33, 2, p. 274-281 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila

Kretzschmar, D., Mar 1 2009, In : Journal of Neurogenetics. 23, 1-2, p. 34-41 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

The circadian clock gene period extends healthspan in aging Drosophila melanogaster.

Krishnan, N., Kretzschmar, D., Rakshit, K., Chow, E. & Giebultowicz, J. M., Nov 1 2009, In : Aging. 1, 11, p. 937-948 12 p.

Research output: Contribution to journalArticle

80 Scopus citations
2008

Optomotor-blind expression in glial cells is required for correct axonal projection across the Drosophila inner optic chiasm

Hofmeyer, K., Kretzschmar, D. & Pflugfelder, G. O., Mar 1 2008, In : Developmental Biology. 315, 1, p. 28-41 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Swiss cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3

Da Cruz, A. B., Wentzell, J. & Kretzschmar, D., Oct 22 2008, In : Journal of Neuroscience. 28, 43, p. 10885-10892 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
2005

Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila

Da Cruz, A. B., Schwärzel, M., Schulze, S., Niyyati, M., Heisenberg, M. & Kretzschmar, D., May 1 2005, In : Molecular biology of the cell. 16, 5, p. 2433-2442 10 p.

Research output: Contribution to journalArticle

67 Scopus citations

Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila

Kretzschmar, D., Tschäpe, J., Da Cruz, A. B., Asan, E., Poeck, B., Strauss, R. & Pflugfelder, G. O., Jan 1 2005, In : GLIA. 49, 1, p. 59-72 14 p.

Research output: Contribution to journalArticle

38 Scopus citations

Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila

Mühlig-Versen, M., Da Cruz, A. B., Tschäpe, J. A., Moser, M., Büttner, R., Athenstaedt, K., Glynn, P. & Kretzschmar, D., Mar 16 2005, In : Journal of Neuroscience. 25, 11, p. 2865-2873 9 p.

Research output: Contribution to journalArticle

102 Scopus citations

Neurodegenerative mutants in Drosophila: A means to identify genes and mechanisms involved in human diseases?

Kretzschmar, D., Nov 1 2005, In : Invertebrate Neuroscience. 5, 3-4, p. 97-109 13 p.

Research output: Contribution to journalReview article

21 Scopus citations
2004

Age-Dependent Neurodegeneration and Alzheimer-Amyloid Plaque Formation in Transgenic Drosophila

Greeve, I., Kretzschmar, D., Tschäpe, J. A., Beyn, A., Brellinger, C., Schweizer, M., Nitsch, R. M. & Reifegerste, R., Apr 21 2004, In : Journal of Neuroscience. 24, 16, p. 3899-3906 8 p.

Research output: Contribution to journalReview article

187 Scopus citations

Placental Failure and Impaired Vasculogenesis Result in Embryonic Lethality for Neuropathy Target Esterase-Deficient Mice

Moser, M., Li, Y., Vaupel, K., Kretzschmar, D., Kluge, R., Glynn, P. & Buettner, R., Feb 1 2004, In : Molecular and cellular biology. 24, 4, p. 1667-1679 13 p.

Research output: Contribution to journalArticle

90 Scopus citations

The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration

Botella, J. A., Ulschmid, J. K., Gruenewald, C., Moehle, C., Kretzschmar, D., Becker, K. & Schneuwly, S., May 4 2004, In : Current Biology. 14, 9, p. 782-786 5 p.

Research output: Contribution to journalArticle

62 Scopus citations
2003

Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap

Botella, J. A., Kretzschmar, D., Kiermayer, C., Feldmann, P., Hughes, D. A. & Schneuwly, S., Jan 1 2003, In : Molecular biology of the cell. 14, 1, p. 241-250 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Progressive neurodegeneration in Drosophila: A model system

Tschäpe, J. A., Bettencourt Da Cruz, A. & Kretzschmar, D., Jan 1 2003, In : Journal of Neural Transmission, Supplement. 65, p. 51-62 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2002

Glia in development, function, and neurodegeneration of the adult insect brain

Kretzschmar, D. & Pflugfelder, G. O., Jan 1 2002, In : Brain Research Bulletin. 57, 1, p. 121-131 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

Tschäpe, J. A., Hammerschmied, C., Mühlig-Versen, M., Athenstaedt, K., Daum, G. & Kretzschmar, D., Dec 2 2002, In : EMBO Journal. 21, 23, p. 6367-6376 10 p.

Research output: Contribution to journalArticle

97 Scopus citations
2000

Cloning and expression of the murine sws/NTE gene

Moser, M., Stempfl, T., Li, Y., Glynn, P., Büttner, R. & Kretzschmar, D., Feb 1 2000, In : Mechanisms of Development. 90, 2, p. 279-282 4 p.

Research output: Contribution to journalArticle

39 Scopus citations

Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3β adaptin gene ruby

Kretzschmar, D., Poeck, B., Roth, H., Ernst, R., Keller, A., Porsch, M., Strauss, R. & Pflugfelder, G. O., May 2000, In : Genetics. 155, 1, p. 213-223 11 p.

Research output: Contribution to journalArticle

49 Scopus citations
1997

The Swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila

Kretzschmar, D., Hasan, G., Sharma, S., Heisenberg, M. & Benzer, S., Oct 9 1997, In : Journal of Neuroscience. 17, 19, p. 7425-7432 8 p.

Research output: Contribution to journalArticle

184 Scopus citations