Dennis Koop

Professor

  • 8840 Citations
  • 51 h-Index
1978 …2020

Research output per year

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Research Output

  • 8840 Citations
  • 51 h-Index
  • 131 Article
  • 4 Review article
  • 1 Editorial
  • 1 Short survey
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Article
2020

Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial

Cameron, M., Taylor, C., Lapidus, J., Ramsey, K., Koop, D. & Spain, R., Jan 1 2020, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

2019

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

Smilkstein, M. J., Pou, S., Krollenbrock, A., Bleyle, L. A., Dodean, R. A., Frueh, L., Hinrichs, D. J., Li, Y., Martinson, T., Munar, M. Y., Winter, R. W., Bruzual, I., Whiteside, S., Nilsen, A., Koop, D. R., Kelly, J. X., Kappe, S. H. I., Wilder, B. K. & Riscoe, M. K., Aug 27 2019, In : Malaria Journal. 18, 1, 291.

Research output: Contribution to journalArticle

Open Access
2017

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis

Asquith, M., Davin, S., Stauffer, P., Michell, C., Janowitz, C., Lin, P., Ensign-Lewis, J., Kinchen, J. M., Koop, D. & Rosenbaum, J. J., Oct 1 2017, In : Arthritis & rheumatology (Hoboken, N.J.). 69, 10, p. 1984-1995 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation

Al-Uzri, A., Freeman, K., Wade, J., Clark, K., Bleyle, L. A., Munar, M. & Koop, D., 2017, (Accepted/In press) In : Pediatric Transplantation.

Research output: Contribution to journalArticle

10 Scopus citations
2016

A comparison of salivary testosterone measurement using immunoassays and tandem mass spectrometry

Welker, K. M., Lassetter, B., Brandes, C. M., Prasad, S., Koop, D. & Mehta, P. H., Sep 1 2016, In : Psychoneuroendocrinology. 71, p. 180-188 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani

Martin, J. L., Yates, P., Boitz, J. M., Koop, D., Fulwiler, A. L., Cassera, M. B., Ullman, B. & Carter, N., Jul 1 2016, In : Molecular Microbiology. 101, 2, p. 299-313 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

Foss, M. H., Pou, S., Davidson, P. M., Dunaj, J. L., Winter, R. W., Pou, S., Licon, M. H., Doh, J. K., Li, Y., Kelly, J. X., Dodean, R. A., Koop, D., Riscoe, M. & Purdy, G., Jul 8 2016, In : ACS Infectious Diseases. 2, 7, p. 500-508 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2015

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

Alumkal, J. J., Slottke, R., Schwartzman, J., Cherala, G., Munar, M., Graff, J. N., Beer, T. M., Ryan, C. W., Koop, D. R., Gibbs, A., Gao, L., Flamiatos, J. F., Tucker, E., Kleinschmidt, R. & Mori, M., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Lovera, J., Ramos, A., Devier, D., Garrison, V., Kovner, B., Reza, T., Koop, D., Rooney, W., Foundas, A. & Bourdette, D., Nov 15 2015, In : Journal of the Neurological Sciences. 358, 1-2, p. 46-52 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013
47 Scopus citations

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

O'Hare, T., Eide, C. A., Agarwal, A., Adrian, L. T., Zabriskie, M. S., MacKenzie, R. J., La Tocha, D. H., Johnson, K. J., You, H., Luo, J., Riddle, S. M., Marks, B. D., Vogel, K. W., Koop, D. R., Apgar, J., Tyner, J. W., Deininger, M. W. & Druker, B. J., Jun 1 2013, In : Cancer Research. 73, 11, p. 3356-3370 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Effect of the ethinylestradiol/levonorgestrel combined oral contraceptive on the activity of cytochrome P4503A in obese women

Edelman, A., Munar, M., Elman, M. R., Koop, D. & Cherala, G., Sep 1 2012, In : British Journal of Clinical Pharmacology. 74, 3, p. 510-514 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats

Wallisch, M., El Rody, N. M., Huang, B., Koop, D. R., Baker, J. R. & Olsen, G. D., Jan 15 2012, In : Respiratory Physiology and Neurobiology. 180, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice

Bradford, B. U., Lock, E. F., Kosyk, O., Kim, S., Uehara, T., Harbourt, D., DeSimone, M., Threadgill, D. W., Tryndyak, V., Pogribny, I. P., Bleyle, L., Koop, D. R. & Rusyn, I., Mar 4 2011, In : Toxicological Sciences. 120, 1, p. 206-217 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Optimization of endochin-like quinolones for antimalarial activity

Winter, R., Kelly, J. X., Smilkstein, M. J., Hinrichs, D., Koop, D. R. & Riscoe, M. K., Feb 1 2011, In : Experimental Parasitology. 127, 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1

Jones, J. P., Joswig-Jones, C. A., Hebner, M., Chu, Y. & Koop, D. R., Aug 15 2011, In : Chemico-Biological Interactions. 193, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: Identification of sites targeted for phosphorylation and ubiquitination

Wang, Y. Q., Guan, S., Acharya, P., Koop, D. R., Liu, Y., Liao, M., Burlingame, A. L. & Correia, M. A., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9443-9456 14 p.

Research output: Contribution to journalArticle

30 Scopus citations
2010

Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors

Powell, C. L., Bradford, B. U., Craig, C. P., Tsuchiya, M., Uehara, T., O'Connell, T. M., Pogribny, I. P., Melnyk, S., Koop, D. R., Bleyle, L., Threadgill, D. W. & Rusyn, I., May 1 2010, In : Toxicological Sciences. 115, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pharmacokinetic study of acid in multiple sclerosis: Comparing mice and human pharmacokinetic parameters

Yadav, V., Marracci, G. H., Munar, M. Y., Cherala, G., Stuber, L. E., Alvarez, L., Shinto, L., Koop, D. R. & Bourdette, D. N., Apr 1 2010, In : Multiple Sclerosis. 16, 4, p. 387-397 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2008

Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus

Peters, J. H., McDougall, S. J., Mendelowitz, D., Koop, D. R. & Andresen, M. C., Apr 2008, In : Anesthesiology. 108, 4, p. 675-683 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Paired assessment of volatile anesthetic voncentrations with synaptic actions recorded in vitro

McDougall, S. J., Peters, J. H., LaBrant, L., Wang, X., Koop, D. R. & Andresen, M. C., Oct 8 2008, In : PloS one. 3, 10, e3372.

Research output: Contribution to journalArticle

12 Scopus citations

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang, W., Otsuka, T., Sugo, N., Ardeshiri, A., Alhadid, Y. K., Iliff, J. J., DeBarber, A. E., Koop, D. R. & Alkayed, N. J., Jul 2008, In : Stroke; a journal of cerebral circulation. 39, 7, p. 2073-2078 6 p.

Research output: Contribution to journalArticle

142 Scopus citations
2007

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

Koerner, I. P., Jacks, R., DeBarber, A. E., Koop, D., Mao, P., Grant, D. F. & Alkayed, N. J., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4642-4649 8 p.

Research output: Contribution to journalArticle

92 Scopus citations
2006

Effect of pregnancy on the pharmacokinetics of paclitaxel: A case report

Lycette, J. L., Dul, C. L., Munar, M., Belle, D., Chui, S. Y., Koop, D. R. & Nichols, C. R., Oct 2006, In : Clinical Breast Cancer. 7, 4, p. 342-344 3 p.

Research output: Contribution to journalArticle

25 Scopus citations
2 Scopus citations
2005
16 Scopus citations
89 Scopus citations

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

Bradford, B. U., Kono, H., Isayama, F., Kosyk, O., Wheeler, M. D., Akiyama, T. E., Bleye, L., Krausz, K. W., Gonzalez, F. J., Koop, D. R. & Rusyn, I., Feb 1 2005, In : Hepatology. 41, 2, p. 336-344 9 p.

Research output: Contribution to journalArticle

120 Scopus citations

Hepatoprotective mechanisms of Yan-gan-wan

Yang, M. D., Deng, Q. G., Chen, S., Xiong, S., Koop, D. & Tsukamoto, H., Aug 1 2005, In : Hepatology Research. 32, 4, p. 202-212 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Steatohepatitis induced by intragastric overfeeding in mice

Deng, Q. G., She, H., Cheng, J. H., French, S. W., Koop, D. R., Xiong, S. & Tsukamoto, H., Oct 1 2005, In : Hepatology. 42, 4, p. 905-914 10 p.

Research output: Contribution to journalArticle

176 Scopus citations

Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol

Lakshman, R., Cederbaum, A. I., Hoek, J. B., Konishi, M., Koop, D. & Donohue, T. M., Sep 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1726-1734 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2004

CYP2E1 Overexpression Alters Hepatocyte Death from Menadione and Fatty Acids by Activation of ERK1/2 Signaling

Schattenberg, J. M., Wang, Y., Rigoli, R. M., Koop, D. R. & Czaja, M. J., Feb 1 2004, In : Hepatology. 39, 2, p. 444-455 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells

Huan, J. Y., Streicher, J. M., Bleyle, L. A. & Koop, D. R., Sep 15 2004, In : Toxicology and Applied Pharmacology. 199, 3, p. 332-343 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

ω-Hydroxylation of farnesol by mammalian cytochromes P450

DeBarber, A. E., Bleyle, L. A., Roullet, J. B. O. & Koop, D. R., Jun 1 2004, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1682, 1-3, p. 18-27 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2003

Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling

Spatzenegger, M., Liu, H., Wang, Q., Debarber, A., Koop, D. R. & Halpert, J. R., Jan 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 1, p. 477-487 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

In vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in rats

Wadsworth, T., Poonyagariyagorn, H., Sullivan, E., Koop, D. & Roselli, C. E., Jul 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 1, p. 187-194 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rat hepatic CYP2E1 is induced by very low nicotine doses: An investigation of induction, time course, dose response, and mechanism

Micu, A. L., Miksys, S., Sellers, E. M., Koop, D. R. & Tyndale, R. F., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 941-947 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice

Isayama, F., Froh, M., Bradford, B. U., McKim, S. E., Kadiiska, M. B., Connor, H. D., Mason, R. P., Koop, D. R., Wheeler, M. D. & Arteel, G. E., Dec 15 2003, In : Free Radical Biology and Medicine. 35, 12, p. 1568-1581 14 p.

Research output: Contribution to journalArticle

24 Scopus citations
2002

Forum original research communication: Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress

Jones, B. E., Liu, H., Lo, C. R., Koop, D. R. & Czaja, M. J., Jan 1 2002, In : Antioxidants and Redox Signaling. 4, 5, p. 701-709 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2001

Attenuation of CCl4-induced hepatic fibrosis by GdCl3 treatment or dietary glycine

Rivera, C. A., Bradford, B. U., Hunt, K. J., Adachi, Y., Schrum, L. W., Koop, D. R., Burchardt, E. R., Rippe, R. A. & Thurman, R. G., Oct 14 2001, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 281, 1 44-1, p. G200-G207

Research output: Contribution to journalArticle

139 Scopus citations

Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide

Wadsworth, T. L. & Koop, D. R., Jul 31 2001, In : Chemico-Biological Interactions. 137, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

103 Scopus citations

Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α

Wadsworth, T. L., McDonald, T. L. & Koop, D. R., Oct 1 2001, In : Biochemical Pharmacology. 62, 7, p. 963-974 12 p.

Research output: Contribution to journalArticle

121 Scopus citations
1999

Cyp2e1 is not involved in early alcohol-induced liver injury

Kono, H., Bradford, B. U., Yin, M., Sulik, K. K., Koop, D. R., Peters, J. M., Gonzalez, F. J., McDonald, T., Dikalova, A., Kadiiska, M. B., Mason, R. P. & Thurman, R. G., Dec 1 1999, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 6 40-6, p. G1259-G1267

Research output: Contribution to journalArticle

155 Scopus citations

Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages

Wadsworth, T. L. & Koop, D. R., Apr 15 1999, In : Biochemical Pharmacology. 57, 8, p. 941-949 9 p.

Research output: Contribution to journalArticle

279 Scopus citations

Enzymatic determinants of the substrate specificity of CYP2C9: Role of B'-C loop residues in providing the π-stacking anchor site for warfarin binding

Haining, R. L., Jones, J. P., Henne, K. R., Fisher, M. B., Koop, D. R., Trager, W. F. & Rettie, A. E., Mar 16 1999, In : Biochemistry. 38, 11, p. 3285-3292 8 p.

Research output: Contribution to journalArticle

88 Scopus citations
7 Scopus citations

Tightly regulated and inducible expression of rabbit CYP2E1 using a tetracycline-controlled expression system

Huan, J. Y. & Koop, D. R., Apr 24 1999, In : Drug Metabolism and Disposition. 27, 4, p. 549-554 6 p.

Research output: Contribution to journalArticle

15 Scopus citations
1998

Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner

Brunner, L. J., Bennett, W. M. & Koop, D. R., Jan 1 1998, In : Kidney International. 54, 1, p. 216-223 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Cytochrome P450-dependent desaturation of lauric acid: Isoform selectivity and mechanism of formation of 11-dodecenoic acid

Guan, X., Fisher, M. B., Lang, D. H., Zheng, Y. M., Koop, D. R. & Rettie, A. E., Mar 12 1998, In : Chemico-Biological Interactions. 110, 1-2, p. 103-121 19 p.

Research output: Contribution to journalArticle

48 Scopus citations