Dennis Koop

Professor

  • 8665 Citations
  • 51 h-Index
1978 …2017
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Research Output 1978 2017

  • 8665 Citations
  • 51 h-Index
  • 136 Article
  • 1 Short survey
2017
6 Citations (Scopus)

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.

Research output: Contribution to journalArticle

Prodrugs
Malaria
Esters
Pharmaceutical Preparations
Plasmodium yoelii
11 Citations (Scopus)

Intestinal Metabolites Are Profoundly Altered in the Context of HLA-B27 Expression and Functionally Modulate Disease in a Rat Model of Spondyloarthritis

Asquith, M., Davin, S., Stauffer, P., Michell, C., Janowitz, C., Lin, P., Ensign-Lewis, J., Kinchen, J. M., Koop, D. & Rosenbaum, J. J., Oct 1 2017, In : Arthritis & rheumatology (Hoboken, N.J.). 69, 10, p. 1984-1995 12 p.

Research output: Contribution to journalArticle

HLA-B27 Antigen
Transgenic Rats
Propionates
Microbiota
Inflammation
3 Citations (Scopus)

Lipoic acid pharmacokinetics at baseline and 1 year in secondary progressive MS

Bittner, F., Murchison, C., Koop, D., Bourdette, D. & Spain, R., 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 5, 380.

Research output: Contribution to journalShort survey

Thioctic Acid
Pharmacokinetics
2 Citations (Scopus)

Longitudinal study on the use of dried blood spots for home monitoring in children after kidney transplantation

Al-Uzri, A., Freeman, K., Wade, J., Clark, K., Bleyle, L. A., Munar, M. & Koop, D., 2017, (Accepted/In press) In : Pediatric Transplantation.

Research output: Contribution to journalArticle

Kidney Transplantation
Longitudinal Studies
Caregivers
Parents
Pediatrics
2016
30 Citations (Scopus)

A comparison of salivary testosterone measurement using immunoassays and tandem mass spectrometry

Welker, K. M., Lassetter, B., Brandes, C. M., Prasad, S., Koop, D. & Mehta, P. H., Sep 1 2016, In : Psychoneuroendocrinology. 71, p. 180-188 9 p.

Research output: Contribution to journalArticle

Tandem Mass Spectrometry
Immunoenzyme Techniques
Immunoassay
Testosterone
Diagnosis-Related Groups
6 Citations (Scopus)

A role for adenine nucleotides in the sensing mechanism to purine starvation in Leishmania donovani

Martin, J. L., Yates, P., Boitz, J. M., Koop, D., Fulwiler, A. L., Cassera, M. B., Ullman, B. & Carter, N., Jul 1 2016, In : Molecular Microbiology. 101, 2, p. 299-313 15 p.

Research output: Contribution to journalArticle

Leishmania donovani
Adenine Nucleotides
Starvation
Purines
Leishmania
13 Citations (Scopus)

Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis

Foss, M. H., Pou, S., Davidson, P. M., Dunaj, J. L., Winter, R. W., Pou, S., Licon, M. H., Doh, J. K., Li, Y., Kelly, J. X., Dodean, R. A., Koop, D., Riscoe, M. & Purdy, G., Jul 8 2016, In : ACS Infectious Diseases. 2, 7, p. 500-508 9 p.

Research output: Contribution to journalArticle

Diamines
Mycobacterium tuberculosis
Pharmaceutical Preparations
Infection
Extensively Drug-Resistant Tuberculosis
2015
63 Citations (Scopus)

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

Alumkal, J., Slottke, R., Schwartzman, J., Cherala, G., Munar, M., Graff, J., Beer, T. T., Ryan, C., Koop, D., Gibbs, A., Gao, L., Flamiatos, J. F., Tucker, E., Kleinschmidt, R. & Mori, M. T., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

Brassica
Prostatic Neoplasms
Vegetables
Diet
Prostate
20 Citations (Scopus)

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Lovera, J., Ramos, A., Devier, D., Garrison, V., Kovner, B., Reza, T., Koop, D., Rooney, W., Foundas, A. & Bourdette, D., Nov 15 2015, In : Journal of the Neurological Sciences. 358, 1-2, p. 46-52 7 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Placebos
Creatine
Medical Futility
Neuroprotective Agents
2013
44 Citations (Scopus)
Liquid chromatography
Tacrolimus
Tandem Mass Spectrometry
Liquid Chromatography
Mass spectrometry
17 Citations (Scopus)

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

O'Hare, T., Eide, C. A., Agarwal, A., Adrian, L. T., Zabriskie, M. S., MacKenzie, R. J., La Tocha, D. H., Johnson, K. J., You, H., Luo, J., Riddle, S. M., Marks, B. D., Vogel, K. W., Koop, D., Apgar, J., Tyner, J., Deininger, M. W. & Druker, B., Jun 1 2013, In : Cancer Research. 73, 11, p. 3356-3370 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Apoptosis
Phosphotransferases
2012
7 Citations (Scopus)

Effect of the ethinylestradiol/levonorgestrel combined oral contraceptive on the activity of cytochrome P4503A in obese women

Edelman, A., Munar, M., Elman, M. R., Koop, D. & Cherala, G., Sep 2012, In : British Journal of Clinical Pharmacology. 74, 3, p. 510-514 5 p.

Research output: Contribution to journalArticle

Contraceptives, Oral, Combined
Levonorgestrel
Ethinyl Estradiol
Cytochromes
Cytochrome P-450 CYP3A
2 Citations (Scopus)

Naloxone pro-drug rescues morphine induced respiratory depression in Sprague-Dawley rats

Wallisch, M., El Rody, N. M., Huang, B., Koop, D., Baker, J. R. & Olsen, G. D., Jan 15 2012, In : Respiratory Physiology and Neurobiology. 180, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Drug Repositioning
Prodrugs
Naloxone
Respiratory Insufficiency
Morphine
2011
40 Citations (Scopus)

Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice

Bradford, B. U., Lock, E. F., Kosyk, O., Kim, S., Uehara, T., Harbourt, D., DeSimone, M., Threadgill, D. W., Tryndyak, V., Pogribny, I. P., Bleyle, L., Koop, D. & Rusyn, I., 2011, In : Toxicological Sciences. 120, 1, p. 206-217 12 p.

Research output: Contribution to journalArticle

Trichloroethylene
Liver
Metabolism
Inbred Strains Mice
Metabolites
46 Citations (Scopus)

Optimization of endochin-like quinolones for antimalarial activity

Winter, R., Kelly, J. X., Smilkstein, M. J., Hinrichs, D., Koop, D. & Riscoe, M., Feb 2011, In : Experimental Parasitology. 127, 2, p. 545-551 7 p.

Research output: Contribution to journalArticle

Quinolones
Antimalarials
Acridones
Atovaquone
Plasmodium falciparum
11 Citations (Scopus)

The effects of nitrogen-heme-iron coordination on substrate affinities for cytochrome P450 2E1

Jones, J. P., Joswig-Jones, C. A., Hebner, M., Chu, Y. & Koop, D., Aug 15 2011, In : Chemico-Biological Interactions. 193, 1, p. 50-56 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Heme
Nitrogen
Iron
Chlorzoxazone
28 Citations (Scopus)

Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: Identification of sites targeted for phosphorylation and ubiquitination

Wang, Y., Guan, S., Acharya, P., Koop, D., Liu, Y., Liao, M., Burlingame, A. L. & Correia, M. A., Mar 18 2011, In : Journal of Biological Chemistry. 286, 11, p. 9443-9456 14 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Phosphorylation
Ubiquitination
Ubiquitin
Liver
2010
21 Citations (Scopus)

Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors

Powell, C. L., Bradford, B. U., Craig, C. P., Tsuchiya, M., Uehara, T., O'Connell, T. M., Pogribny, I. P., Melnyk, S., Koop, D., Bleyle, L., Threadgill, D. W. & Rusyn, I., May 2010, In : Toxicological Sciences. 115, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

Liver
Alcohols
Wounds and Injuries
Metabolism
S-Adenosylmethionine
34 Citations (Scopus)

Pharmacokinetic study of acid in multiple sclerosis: Comparing mice and human pharmacokinetic parameters

Yadav, V., Marracci, G., Munar, M. Y., Cherala, G., Stuber, L. E., Alvarez, L., Shinto, L., Koop, D. & Bourdette, D., Apr 2010, In : Multiple Sclerosis. 16, 4, p. 387-397 11 p.

Research output: Contribution to journalArticle

Thioctic Acid
Multiple Sclerosis
Pharmacokinetics
Acids
Serum
2008
16 Citations (Scopus)

Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus

Peters, J. H., McDougall, S. J., Mendelowitz, D., Koop, D. & Andresen, M., Apr 2008, In : Anesthesiology. 108, 4, p. 675-683 9 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Isoflurane
Synaptic Transmission
Visceral Afferents
Rhombencephalon
12 Citations (Scopus)

Paired assessment of volatile anesthetic voncentrations with synaptic actions recorded in vitro

McDougall, S. J., Peters, J. H., LaBrant, L., Wang, X., Koop, D. & Andresen, M., Oct 8 2008, In : PLoS One. 3, 10, e3372.

Research output: Contribution to journalArticle

Isoflurane
isoflurane
anesthetics
Anesthetics
Baths
137 Citations (Scopus)

Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang, W., Otsuka, T., Sugo, N., Ardeshiri, A., Alhadid, Y. K., Iliff, J., De Barber, A., Koop, D. & Alkayed, N., Jul 2008, In : Stroke. 39, 7, p. 2073-2078 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Gene Deletion
Brain Ischemia
Knockout Mice
Middle Cerebral Artery Infarction
2007
92 Citations (Scopus)

Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury

Koerner, I., Jacks, R., De Barber, A., Koop, D., Mao, P., Grant, D. F. & Alkayed, N., Apr 25 2007, In : Journal of Neuroscience. 27, 17, p. 4642-4649 8 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Wounds and Injuries
Genes
Cell Death
Enzymes
2006
61 Citations (Scopus)
Cytochrome P-450 CYP2E1
Oxidative Stress
Alcohols
Oxygen
Enzymes
24 Citations (Scopus)

Effect of pregnancy on the pharmacokinetics of paclitaxel: A case report

Lycette, J., Dul, C. L., Munar, M., Belle, D., Chui, S. S., Koop, D. & Nichols, C. R., 2006, In : Clinical Breast Cancer. 7, 4, p. 342-344 3 p.

Research output: Contribution to journalArticle

Paclitaxel
Pharmacokinetics
Pregnancy
Adjuvant Chemotherapy
Breast Neoplasms
2 Citations (Scopus)
Epoxide Hydrolases
Wounds and Injuries
Genes
2005
16 Citations (Scopus)
Celecoxib
Leucovorin
Fluorouracil
Colorectal Neoplasms
Chemotherapy
80 Citations (Scopus)
Centella
Nerve Regeneration
Neurites
Oral Administration
Axons
113 Citations (Scopus)

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

Bradford, B. U., Kono, H., Isayama, F., Kosyk, O., Wheeler, M. D., Akiyama, T. E., Bleye, L., Krausz, K. W., Gonzalez, F. J., Koop, D. & Rusyn, I., Feb 2005, In : Hepatology. 41, 2, p. 336-344 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
NADP
Cytochrome P-450 Enzyme System
DNA Damage
Rodentia
8 Citations (Scopus)

Hepatoprotective mechanisms of Yan-gan-wan

Yang, M. D., Deng, Q. G., Chen, S., Xiong, S., Koop, D. & Tsukamoto, H., Aug 2005, In : Hepatology Research. 32, 4, p. 202-212 11 p.

Research output: Contribution to journalArticle

Kupffer Cells
Microarray Analysis
Isoenzymes
Hepatocytes
Liver
170 Citations (Scopus)

Steatohepatitis induced by intragastric overfeeding in mice

Deng, Q. G., She, H., Cheng, J. H., French, S. W., Koop, D., Xiong, S. & Tsukamoto, H., Oct 2005, In : Hepatology. 42, 4, p. 905-914 10 p.

Research output: Contribution to journalArticle

Fatty Liver
White Adipose Tissue
Insulin Resistance
Receptors, Tumor Necrosis Factor, Type I
Peroxisome Proliferator-Activated Receptors
8 Citations (Scopus)

Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol

Lakshman, R., Cederbaum, A. I., Hoek, J. B., Konishi, M., Koop, D. & Donohue, T. M., Sep 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1726-1734 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Liver
Hep G2 Cells
Ethanol
Cells
2004
44 Citations (Scopus)

CYP2E1 Overexpression Alters Hepatocyte Death from Menadione and Fatty Acids by Activation of ERK1/2 Signaling

Schattenberg, J. M., Wang, Y., Rigoli, R. M., Koop, D. & Czaja, M. J., Feb 2004, In : Hepatology. 39, 2, p. 444-455 12 p.

Research output: Contribution to journalArticle

Vitamin K 3
Cytochrome P-450 CYP2E1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Hepatocytes
32 Citations (Scopus)

Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells

Huan, J., Streicher, J. M., Bleyle, L. A. & Koop, D., Sep 15 2004, In : Toxicology and Applied Pharmacology. 199, 3, p. 332-343 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2B1
Cytochrome P-450 CYP2E1
Proteasome Endopeptidase Complex
Tetracycline
HeLa Cells
29 Citations (Scopus)

ω-Hydroxylation of farnesol by mammalian cytochromes P450

De Barber, A., Bleyle, L. A., Roullet, J-B. & Koop, D., Jun 1 2004, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1682, 1-3, p. 18-27 10 p.

Research output: Contribution to journalArticle

Farnesol
Cytochrome P-450 CYP2E1
Hydroxylation
Cytochrome P-450 Enzyme System
Microsomes
2003
56 Citations (Scopus)

Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling

Spatzenegger, M., Liu, H., Wang, Q., De Barber, A., Koop, D. & Halpert, J. R., Jan 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 304, 1, p. 477-487 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Site-Directed Mutagenesis
Catalytic Domain
Arachidonic Acid
Cytochrome P-450 Enzyme System
6 Citations (Scopus)

In vivo effect of PC-SPES on prostate growth and hepatic CYP3A expression in rats

Wadsworth, T., Poonyagariyagorn, H., Sullivan, E., Koop, D. & Roselli, C., Jul 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 1, p. 187-194 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Diethylstilbestrol
Prostate
Liver
Growth
41 Citations (Scopus)

Rat hepatic CYP2E1 is induced by very low nicotine doses: An investigation of induction, time course, dose response, and mechanism

Micu, A. L., Miksys, S., Sellers, E. M., Koop, D. & Tyndale, R. F., Sep 1 2003, In : Journal of Pharmacology and Experimental Therapeutics. 306, 3, p. 941-947 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Nicotine
Liver
Cotinine
Smoke
24 Citations (Scopus)

The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice

Isayama, F., Froh, M., Bradford, B. U., McKim, S. E., Kadiiska, M. B., Connor, H. D., Mason, R. P., Koop, D., Wheeler, M. D. & Arteel, G. E., Dec 15 2003, In : Free Radical Biology and Medicine. 35, 12, p. 1568-1581 14 p.

Research output: Contribution to journalArticle

Oxidative stress
Liver
Cytochrome P-450 Enzyme System
Rats
Oxidative Stress
2002
25 Citations (Scopus)

Forum original research communication: Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress

Jones, B. E., Liu, H., Lo, C. R., Koop, D. & Czaja, M. J., Oct 2002, In : Antioxidants and Redox Signaling. 4, 5, p. 701-709 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
2001
136 Citations (Scopus)

Attenuation of CCl4-induced hepatic fibrosis by GdCl3 treatment or dietary glycine

Rivera, C. A., Bradford, B. U., Hunt, K. J., Adachi, Y., Schrum, L. W., Koop, D., Burchardt, E. R., Rippe, R. A. & Thurman, R. G., 2001, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 281, 1 44-1

Research output: Contribution to journalArticle

Glycine
Fibrosis
Kupffer Cells
Liver
Staining and Labeling
101 Citations (Scopus)

Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide

Wadsworth, T. L. & Koop, D., Jul 31 2001, In : Chemico-Biological Interactions. 137, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

Quercetin
Lipopolysaccharides
Nitric Oxide
Nitric Oxide Synthase Type II
Macrophages
118 Citations (Scopus)

Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α

Wadsworth, T. L., McDonald, T. L. & Koop, D., Oct 1 2001, In : Biochemical Pharmacology. 62, 7, p. 963-974 12 p.

Research output: Contribution to journalArticle

Quercetin
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Phosphorylation
Electrophoretic mobility
1999
152 Citations (Scopus)

Cyp2e1 is not involved in early alcohol-induced liver injury

Kono, H., Bradford, B. U., Yin, M., Sulik, K. K., Koop, D., Peters, J. M., Gonzalez, F. J., McDonald, T., Dikalova, A., Kadiiska, M. B., Mason, R. P. & Thurman, R. G., Dec 1999, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 6 40-6

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2E1
Alcohols
Liver
Wounds and Injuries
Ethanol
273 Citations (Scopus)

Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages

Wadsworth, T. L. & Koop, D., Apr 15 1999, In : Biochemical Pharmacology. 57, 8, p. 941-949 9 p.

Research output: Contribution to journalArticle

Wine
Macrophages
Quercetin
Lipopolysaccharides
Cytokines
87 Citations (Scopus)

Enzymatic determinants of the substrate specificity of CYP2C9: Role of B'-C loop residues in providing the π-stacking anchor site for warfarin binding

Haining, R. L., Jones, J. P., Henne, K. R., Fisher, M. B., Koop, D., Trager, W. F. & Rettie, A. E., Mar 16 1999, In : Biochemistry. 38, 11, p. 3285-3292 8 p.

Research output: Contribution to journalArticle

Warfarin
Substrate Specificity
Anchors
Binding Sites
lauric acid
6 Citations (Scopus)
Nociceptors
Anura
Rana catesbeiana
Anesthesia
Righting Reflex
15 Citations (Scopus)
Tetracycline
Cytochrome P-450 Enzyme System
Rabbits
Cells
Enzymes
1998
31 Citations (Scopus)

Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner

Brunner, L. J., Bennett, W. M. & Koop, D., 1998, In : Kidney International. 54, 1, p. 216-223 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Cyclosporine
Liver
Protein Isoforms
Hydroxylation
46 Citations (Scopus)

Cytochrome P450-dependent desaturation of lauric acid: Isoform selectivity and mechanism of formation of 11-dodecenoic acid

Guan, X., Fisher, M. B., Lang, D. H., Zheng, Y. M., Koop, D. & Rettie, A. E., Mar 12 1998, In : Chemico-Biological Interactions. 110, 1-2, p. 103-121 19 p.

Research output: Contribution to journalArticle

lauric acid
Cytochrome P-450 Enzyme System
Protein Isoforms
Metabolites
Rabbits