Dennis Bourdette

Professor

  • 9924 Citations
  • 48 h-Index
1976 …2018
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Research Output 1979 2018

2018
Multiple Sclerosis
Fatigue
Randomized Controlled Trials
Education
Confidence Intervals
Thioctic Acid
Relapsing-Remitting Multiple Sclerosis
Monocytes
Blood Cells
B-Lymphocytes

Elephant in the room

Hartung, D. M., Johnston, K., Cohen, D. M., Nguyen, T., Deodhar, A. A. & Bourdette, D. N., Jan 23 2018, (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Impact of mindfulness-based stress reduction for people with multiple sclerosis at 8 weeks and 12 months: A randomized clinical trial

Senders, A., Hanes, D., Bourdette, D., Carson, K., Marshall, L. M. & Shinto, L., Jul 1 2018, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Mindfulness
Multiple Sclerosis
Randomized Controlled Trials
Education
Outcome Assessment (Health Care)

In reply

Hartung, D. M., Bourdette, D. N. & Cohen, D. M., Apr 1 2018, In : JAMA Internal Medicine. 178, 4, p. 583-584 2 p.

Research output: Contribution to journalLetter

Meals, Mindfulness, & Moving Forward: A feasibility study to a multi-modal lifestyle approach in early psychosis

Usher, C., Thompson, A., Griebeler, M., Senders, A., Seibel, C., Ly, R., Murchison, C., Hagen, K., Afong, K. A., Bourdette, D., Ross, R., Borgatti, A. & Shinto, L., Jan 1 2018, (Accepted/In press) In : Early Intervention in Psychiatry.

Research output: Contribution to journalArticle

Mindfulness
Feasibility Studies
Psychotic Disorders
Meals
Life Style
3 Citations
Optical Coherence Tomography
Optic Nerve
Optic Neuritis
Multiple Sclerosis
Angiography
2017

About multiple sclerosis and hematopoietic stem cells in the treatment of multiple sclerosis

Frederick, M. C. & Bourdette, D., May 30 2017, In : Neurology. 88, 22, p. e220

Research output: Contribution to journalComment/debate

Hematopoietic Stem Cells
Multiple Sclerosis

A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Short- and medium-term benefits

On Behalf of the VA MS Fatigue Study Group, Dec 1 2017, (Accepted/In press) In : Multiple Sclerosis Journal.

Research output: Contribution to journalArticle

Self Care
Multiple Sclerosis
Fatigue
Rehabilitation
Randomized Controlled Trials

Author response: Neurologists and the economics of MS treatment: Lighting candles, not cursing the darkness

Bourdette, D. N., Aug 1 2017, In : Neurology. 89, 5, p. 520-521 2 p.

Research output: Contribution to journalLetter

Darkness
Lighting
Economics
Therapeutics
Neurologists
2 Citations

Can immune reprogramming with alemtuzumab induce permanent remission in multiple sclerosis?

Wiendl, H., Bourdette, D. & Ciccarelli, O., Sep 1 2017, In : Neurology. 89, 11, p. 1098-1100 3 p.

Research output: Contribution to journalEditorial

Multiple Sclerosis
alemtuzumab
3 Citations

Early Fever As a Predictor of Paroxysmal Sympathetic Hyperactivity in Traumatic Brain Injury

Hinson, H. E., Schreiber, M. A., Laurie, A. L., Baguley, I. J., Bourdette, D. & Ling, G. S. F., Jan 5 2017, (Accepted/In press) In : Journal of Head Trauma Rehabilitation.

Research output: Contribution to journalArticle

Fever
Vital Signs
Decerebrate State
Tachypnea
Glasgow Coma Scale
4 Citations

Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration

Ferrara, S. J., Meinig, J. M., Placzek, A. T., Banerji, T., McTigue, P., Hartley, M. D., Sanford-Crane, H. S., Banerji, T., Bourdette, D. & Scanlan, T. S., May 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 10, p. 2743-2753 11 p.

Research output: Contribution to journalArticle

Ethanolamine
Prodrugs
Blood-Brain Barrier
Amides
Esters
10 Citations

Lipoic acid in secondary progressive MS

Spain, R., Powers, K., Murchison, C., Heriza, E., Winges, K., Yadav, V., Cameron, M., Kim, E., Horak, F., Simon, J. & Bourdette, D., 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 5, 374

Research output: Contribution to journalArticle

Thioctic Acid
Brain
Atrophy
Placebos
Compliance
1 Citations

Lipoic acid pharmacokinetics at baseline and 1 year in secondary progressive MS

Bittner, F., Murchison, C., Koop, D., Bourdette, D. & Spain, R., 2017, In : Neurology: Neuroimmunology and NeuroInflammation. 4, 5, 380

Research output: Contribution to journalShort survey

Thioctic Acid
Pharmacokinetics

Lipoic Acid Stimulates cAMP Production in Healthy Control and Secondary Progressive MS Subjects

Fiedler, S. E., Yadav, V., Kerns, A. R., Tsang, C., Markwardt, S., Kim, E., Spain, R., Bourdette, D. & Salinthone, S., Nov 15 2017, (Accepted/In press) In : Molecular Neurobiology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Chronic Progressive Multiple Sclerosis
Thioctic Acid
Cyclic AMP
Multiple Sclerosis
Anti-Inflammatory Agents
1 Citations
Chronic Progressive Multiple Sclerosis
Optic Atrophy
Optical Coherence Tomography
Multiple Sclerosis
Atrophy
6 Citations

MIF and D-DT are potential disease severity modifiers in male MS subjects

Benedek, G. , Meza-Romero, R. , Jordan, K. , Zhang, Y. , Nguyen, H. , Kent, G. , Li, J. , Siu, E. , Frazer, J. , Piecychna, M. , Du, X. , Sreih, A. , Leng, L. , Wiedrick, J. , Caillier, S. J. , Offner, H. , Oksenberg, J. R. , Yadav, V. , Bourdette, D. , Bucala, R. & 1 others Vandenbark, A. A., Oct 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. E8421-E8429

Research output: Contribution to journalArticle

Multiple Sclerosis
Macrophage Migration-Inhibitory Factors
Sex Factors
Autoimmune Experimental Encephalomyelitis
dopachrome isomerase

MS and bone marrow transplant: Not for most patients

Frederick, M. C. & Bourdette, D., May 30 2017, In : Neurology. 88, 22, p. e219

Research output: Contribution to journalComment/debate

Bone Marrow
Transplants
2 Citations

Sex-dependent treatment of chronic EAE with partial MHC class II constructs

Benedek, G., Chaudhary, P., Meza-Romero, R., Calkins, E., Kent, G., Offner, H., Bourdette, D. & Vandenbark, A. A., May 6 2017, In : Journal of Neuroinflammation. 14, 1, 100

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Central Nervous System
Relapsing-Remitting Multiple Sclerosis
Estrogen Receptor alpha
5 Citations

Sleep and its associations with perceived and objective cognitive impairment in individuals with multiple sclerosis

Hughes, A. J., Parmenter, B. A., Haselkorn, J. K., Lovera, J. F., Bourdette, D., Boudreau, E., Cameron, M. H. & Turner, A. P., Aug 1 2017, In : Journal of Sleep Research. 26, 4, p. 428-435 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Sleep
Cognition
Cognitive Dysfunction
Sex Education
3 Citations

Targeting Fatty-Acid Amide Hydrolase with Prodrugs for CNS-Selective Therapy

Meinig, J. M., Ferrara, S. J., Banerji, T., Banerji, T., Sanford-Crane, H. S., Bourdette, D. & Scanlan, T. S., Nov 15 2017, In : ACS Chemical Neuroscience. 8, 11, p. 2468-2476 9 p.

Research output: Contribution to journalArticle

Prodrugs
Brain
Pharmaceutical Preparations
Carboxylic Acids
Blood-Brain Barrier
4 Citations

Trends and characteristics of US Medicare spending on repository corticotropin

Hartung, D. M., Johnston, K., Van Leuven, S., Deodhar, A., Cohen, D. M. & Bourdette, D. N., Nov 1 2017, In : JAMA Internal Medicine. 177, 11, p. 1680-1682 3 p.

Research output: Contribution to journalArticle

Medicare
Adrenocorticotropic Hormone

Using the Anterior Visual System to Assess Neuroprotection and Remyelination in Multiple Sclerosis Trials

Silbermann, E., Wooliscroft, L. & Bourdette, D., Aug 1 2017, In : Current Neurology and Neuroscience Reports. 18, 8, 49

Research output: Contribution to journalReview article

Multiple Sclerosis
Optic Neuritis
Optic Nerve
Clinical Trials
Diffusion Tensor Imaging
2016
6 Citations

Dimethyl fumarate activates the prostaglandin EP2 receptor and stimulates cAMP signaling in human peripheral blood mononuclear cells

Fiedler, S. E., Kerns, A. R., Tsang, C., Tsang, V., Bourdette, D. & Salinthone, S., Jun 17 2016, In : Biochemical and Biophysical Research Communications. 475, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

Prostaglandin Receptors
Cyclic AMP
Prostaglandins
Blood Cells
Blood
3 Citations

Immunopathology of Japanese macaque encephalomyelitis is similar to multiple sclerosis

Blair, T. C., Manoharan, M., Rawlings-Rhea, S. D., Tagge, I., Kohama, S. G., Hollister-Smith, J., Ferguson, B., Woltjer, R. L., Frederick, M. C., Pollaro, J., Rooney, W. D., Sherman, L. S., Bourdette, D. N. & Wong, S. W., Feb 15 2016, In : Journal of Neuroimmunology. 291, p. 1-10 10 p.

Research output: Contribution to journalArticle

Encephalomyelitis
Macaca
Multiple Sclerosis
Central Nervous System
T-Lymphocytes
11 Citations

Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial

Yadav, V., Marracci, G., Kim, E., Spain, R., Cameron, M., Overs, S., Riddehough, A., Li, D. K. B., McDougall, J., Lovera, J., Murchison, C. & Bourdette, D., Sep 1 2016, In : Multiple Sclerosis and Related Disorders. 9, p. 80-90 11 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Randomized Controlled Trials
Fats
Diet
Fatigue
4 Citations

Neurologists and the economics of MS treatment: Lighting candles, not cursing the darkness

Bourdette, D. & Whitham, R., Oct 11 2016, In : Neurology. 87, 15, p. 1532-1533 2 p.

Research output: Contribution to journalEditorial

Darkness
Lighting
Economics
Therapeutics
Neurologists
5 Citations

Omega-3 fatty acids for depression in multiple sclerosis: A randomized pilot study

Shinto, L., Marracci, G., Mohr, D. C., Bumgarner, L., Murchison, C., Senders, A. & Bourdette, D., Jan 1 2016, In : PLoS One. 11, 1, e0147195

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
sclerosis
omega-3 fatty acids
Multiple Sclerosis
Depression
5 Citations
Patient Harm
Health Insurance
Multiple Sclerosis
Decision Making
Insurance
2 Citations

Rituximab for treating multiple sclerosis

Bourdette, D., Nov 15 2016, In : Neurology. 87, 20, p. 2070-2071 2 p.

Research output: Contribution to journalEditorial

Multiple Sclerosis
Rituximab
9 Citations

Spatio-temporal patterns of demyelination and remyelination in the cuprizone mouse model

Tagge, I., O'Connor, A., Chaudhary, P., Pollaro, J., Berlow, Y., Chalupsky, M., Bourdette, D., Woltjer, R., Johnson, M. & Rooney, W., Apr 1 2016, In : PLoS One. 11, 4, e0152480

Research output: Contribution to journalArticle

Cuprizone
Demyelinating Diseases
animal models
brain
Corpus Callosum
40 Citations

The contemporary spectrum of multiple sclerosis misdiagnosis

Solomon, A. J. , Bourdette, D. N. , Cross, A. H. , Applebee, A. , Skidd, P. M. , Howard, D. B. , Spain, R. I. , Cameron, M. H. , Kim, E. , Mass, M. K. , Yadav, V. , Whitham, R. H. , Longbrake, E. E. , Naismith, R. T. , Wu, G. F. , Parks, B. J. , Wingerchuk, D. M. , Rabin, B. L. , Toledano, M. , Tobin, W. O. & 4 others Kantarci, O. H., Carter, J. L., Keegan, B. M. & Weinshenker, B. G., Sep 27 2016, In : Neurology. 87, 13, p. 1393-1399 7 p.

Research output: Contribution to journalArticle

Diagnostic Errors
Multiple Sclerosis
Neurologic Manifestations
Neuromyelitis Optica
Fibromyalgia

US health insurance is an obstacle to disease-modifying treatments in MS

Bourdette, D. & Patti, F., Jul 26 2016, In : Neurology. 87, 4, p. 346-347 2 p.

Research output: Contribution to journalReview article

Relapsing-Remitting Multiple Sclerosis
Health Insurance
United States Food and Drug Administration
Therapeutics
Neurologists
2015

Author response

Hartung, D. M., Bourdette, D. N. & Whitham, R. H., Nov 10 2015, In : Neurology. 85, 19, p. 1727 1 p.

Research output: Contribution to journalArticle

Drug Industry
Immunologic Factors
Immunosuppressive Agents
Multiple Sclerosis
Tumor Necrosis Factor-alpha

Author response

Hartung, D. M., Bourdette, D. N., Ahmed, S. & Whitham, R. H., Nov 10 2015, In : Neurology. 85, 19, p. 1728 1 p.

Research output: Contribution to journalArticle

Drug Industry
Immunologic Factors
Immunosuppressive Agents
Multiple Sclerosis
Tumor Necrosis Factor-alpha
7 Citations

Cognitive Impairment and Community Integration Outcomes in Individuals Living With Multiple Sclerosis

Hughes, A. J., Hartoonian, N., Parmenter, B., Haselkorn, J. K., Lovera, J. F., Bourdette, D. & Turner, A. P., Nov 1 2015, In : Archives of Physical Medicine and Rehabilitation. 96, 11, p. 1973-1979 7 p.

Research output: Contribution to journalArticle

Community Integration
Multiple Sclerosis
Cognitive Dysfunction
Ginkgo biloba
Veterans
7 Citations

Equivalence of glatiramer acetate generics with branded glatiramer acetate in efficacy and cost for the treatment of multiple sclerosis

Bourdette, D. & Hartung, D., Dec 1 2015, In : JAMA Neurology. 72, 12, p. 1411-1413 3 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Health Care Costs
Multiple Sclerosis
Glatiramer Acetate
Health Care Costs
Multiple Sclerosis
Glatiramer Acetate
12 Citations
Multiple Sclerosis
Fear
Statistical Factor Analysis
Logistic Models
Odds Ratio
7 Citations

Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

Chaudhary, P., Marracci, G., Galipeau, D., Pocius, E., Morris, B. & Bourdette, D., Dec 15 2015, In : Journal of Neuroimmunology. 289, p. 68-74 7 p.

Research output: Contribution to journalArticle

Thioctic Acid
Autoimmune Experimental Encephalomyelitis
Galectin 3
Inflammation
Brain
15 Citations
Neuroimaging
Brain Mapping
Brain
Water
Multiple Sclerosis
2 Citations

Medications are associated with falls in people with multiple sclerosis

Cameron, M. H., Karstens, L., Hoang, P., Bourdette, D. & Lord, S., 2015, In : International Journal of MS Care. 17, 5, p. 207-214 8 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Accidental Falls
Comorbidity
Logistic Models
Odds Ratio

Natalizumab to fingolimod: Questions answered, unanswered, and unasked

Stüve, O. & Bourdette, D., Jul 7 2015, In : Neurology. 85, 1, p. 14-15 2 p.

Research output: Contribution to journalArticle

Propylene Glycols
Drug Substitution
Antibodies, Monoclonal, Humanized
Relapsing-Remitting Multiple Sclerosis
Sphingosine
16 Citations

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Lovera, J., Ramos, A., Devier, D., Garrison, V., Kovner, B., Reza, T., Koop, D., Rooney, W., Foundas, A. & Bourdette, D., Nov 15 2015, In : Journal of the Neurological Sciences. 358, 1-2, p. 46-52 7 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Placebos
Creatine
Medical Futility
Capsules
2 Citations

The cost of multiple sclerosis drugs in the US and the pharmaceutical industry: Too big to fail?

Tischner, J. R., Hartung, D. M., Bourdette, D. N., Whitham, R. H., Rittenhouse, B. E. & Ahmed, S., Nov 10 2015, In : Neurology. 85, 19, p. 1727-1728 2 p.

Research output: Contribution to journalArticle

Drug Industry
Immunologic Factors
Immunosuppressive Agents
Multiple Sclerosis
Tumor Necrosis Factor-alpha
84 Citations

The cost of multiple sclerosis drugs in the US and the pharmaceutical industry

Hartung, D. M., Bourdette, D. N., Ahmed, S. M. & Whitham, R. H., May 26 2015, In : Neurology. 84, 21, p. 2185-2192 8 p.

Research output: Contribution to journalArticle

Drug Industry
Multiple Sclerosis
Costs and Cost Analysis
Pharmaceutical Preparations
Economic Inflation

The use of flow cytometry to assess a novel drug efficacy in multiple sclerosis

Benedek, G., Meza-Romero, R., Bourdette, D. & Vandenbark, A. A., 2015, In : Metabolic Brain Disease. 30, 4, p. 877-884 8 p., A002

Research output: Contribution to journalArticle

Flow cytometry
Multiple Sclerosis
Flow Cytometry
Disease Progression
Biomarkers
2014
2 Citations

Alemtuzumab and multiple sclerosis: Is it safe?

Bourdette, D., Jul 1 2014, In : Neurology. 83, 1, p. 17-18 2 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
82 Citations

A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease

Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L. & Kaye, J., 2014, In : Journal of Alzheimer's Disease. 38, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Thioctic Acid
Omega-3 Fatty Acids
Alzheimer Disease
Placebos
Activities of Daily Living