• 5268 Citations
  • 39 h-Index
1986 …2021
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Research Output 1986 2018

  • 5268 Citations
  • 39 h-Index
  • 116 Article
  • 2 Chapter
  • 2 Review article
  • 1 Letter
2018
7 Citations (Scopus)

Eosinophil and airway nerve interactions in asthma

Drake, M., Lebold, K. M., Roth-Carter, Q. R., Pincus, A. B., Blum, E. D., Proskocil, B. J., Jacoby, D., Fryer, A. & Nie, Z. J., Jul 1 2018, In : Journal of Leukocyte Biology. 104, 1, p. 61-67 7 p.

Research output: Contribution to journalReview article

Eosinophils
Asthma
Bronchoconstriction
Eosinophil Major Basic Protein
Muscarinic M2 Receptors
1 Citation (Scopus)

Eosinophils increase airway sensory nerve density in mice and in human asthma

Drake, M., Scott, G. D., Blum, E. D., Lebold, K. M., Nie, Z. J., Lee, J. J., Fryer, A., Costello, R. W. & Jacoby, D., Sep 5 2018, In : Science Translational Medicine. 10, 457, aar8477.

Research output: Contribution to journalArticle

Eosinophils
Asthma
Irritants
Airway Remodeling
Bronchoconstriction
2017
17 Citations (Scopus)

An official American thoracic society research statement: Current challenges facing research and therapeutic advances in airway remodeling

ATS Assembly on Respiratory Structure and Function, Jan 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 2, p. e4-e19

Research output: Contribution to journalReview article

Therapeutic Human Experimentation
Airway Remodeling
Thorax
Research
Obstructive Lung Diseases

In Memory and Celebration: Dr. James J. Lee

Rosenberg, H. F., Fryer, A., Munitz, A., Bochner, B. S., Jacoby, D., Levi-Schaffer, F., Gleich, G. J., Furuta, G. T., Rothenberg, M. E., Lacy, P., Fulkerson, P. C., Hogan, S. P., Ackerman, S. J. & Foster, P. S., Jul 1 2017, In : Clinical and Experimental Allergy. 47, 7, p. 980-981 2 p.

Research output: Contribution to journalLetter

5 Citations (Scopus)
Ozone
Eosinophils
Guinea Pigs
Hematopoiesis
Bronchoconstriction
3 Citations (Scopus)

Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-α blockade

Wicher, S. A., Lawson, K. L., Jacoby, D., Fryer, A. & Drake, M., Dec 1 2017, In : Physiological Reports. 5, 24, e13538.

Research output: Contribution to journalArticle

Ozone
Eosinophils
Tumor Necrosis Factor-alpha
Antigens
Bronchoalveolar Lavage
2016
20 Citations (Scopus)

Human and mouse eosinophils have antiviral activity against parainfluenza virus

Drake, M., Bivins-Smith, E. R., Proskocil, B. J., Nie, Z. J., Scott, G. D., Lee, J. J., Lee, N. A., Fryer, A. & Jacoby, D., Sep 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

Paramyxoviridae Infections
Viruses
Eosinophils
Antiviral Agents
Nitric Oxide
3 Citations (Scopus)

Toll-Like Receptor 7-Targeted Therapy in Respiratory Disease

Lebold, K. M., Jacoby, D. & Drake, M., Mar 1 2016, In : Transfusion Medicine and Hemotherapy. 43, 2, p. 114-119 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Respiratory Therapy
Airway Remodeling
Respiratory Tract Diseases
Th2 Cells
2015
12 Citations (Scopus)

Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

Lee, J. J., Protheroe, C. A., Luo, H., Ochkur, S. I., Scott, G. D., Zellner, K. R., Raish, R. J., Dahl, M. V., Vega, M. L., Conley, O., Condjella, R. M., Kloeber, J. A., Neely, J. L., Patel, Y. S., Maizer, P., Mazzolini, A., Fryer, A., Jacoby, N. W., Jacoby, D. & Lee, N. A., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 477-487 11 p.

Research output: Contribution to journalArticle

Pruritus
Eosinophils
Skin
Substance P
Dinitrofluorobenzene
5 Citations (Scopus)

The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity

Proskocil, B. J., Bruun, D. A., Garg, J. A., Villagomez, C. C., Jacoby, D., Lein, P. J. & Fryer, A., Nov 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 5, p. 738-747 10 p.

Research output: Contribution to journalArticle

Chlorpyrifos
Pesticides
Diazinon
Parathion
Interleukin-5
2014
25 Citations (Scopus)
Hyperinsulinism
Muscarinic M2 Receptors
Vagus Nerve Stimulation
Rats
Obesity

Interactions of eosinophils with nerves

Roth-Carter, Q. R., Jacoby, D. & Nie, Z. J., 2014, Methods in Molecular Biology. Humana Press Inc., Vol. 1178. p. 215-229 15 p. (Methods in Molecular Biology; vol. 1178).

Research output: Chapter in Book/Report/Conference proceedingChapter

Parasympathetic Ganglia
Eosinophils
Spinal Ganglia
Coculture Techniques
12 Citations (Scopus)
Muscarinic M2 Receptors
Interleukin-1
Viruses
Interleukin 1 Receptor Antagonist Protein
Virus Diseases
19 Citations (Scopus)
Three-Dimensional Imaging
Tissue
Imaging techniques
Lung
Fluorescence microscopy
2013
5 Citations (Scopus)

Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs

Verhein, K. C., Salituro, F. G., Ledeboer, M. W., Fryer, A. & Jacoby, D., Sep 18 2013, In : PLoS One. 8, 9, e75351.

Research output: Contribution to journalArticle

mitogen-activated protein kinase kinase
JNK Mitogen-Activated Protein Kinases
Ozone
Protein Kinase Inhibitors
Mitogen-Activated Protein Kinases

Eosinophils in Human Disease

Gelfand, E. W., Simon, D., Simon, H. U., Thomas, A., Busse, W. W., Nair, P., Gauvreau, G. M., Denburg, J. A., Bivins-Smith, E. R., Jacoby, D., Davis, B. P., Rothenberg, M. E., Khoury, P., Klion, A. D., Lotfi, R., Spada, N., Lotze, M. T., Schleimer, R. P., Kato, A., Kern, R. & 10 others, Lavigne, M. C., Eppihimer, M. J., Roufosse, F., Massart, A., Benghiat, F. S., Lemaitre, P., Le Moine, A., Krahn, M., Bartoli, M. & Levy, N., 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 431-536 106 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils
19 Citations (Scopus)

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs

Proskocil, B. J., Bruun, D. A., Jacoby, D., van Rooijen, N., Lein, P. J. & Fryer, A., 2013, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 304, 8

Research output: Contribution to journalArticle

Parathion
Guinea Pigs
Macrophages
Pesticides
Alveolar Macrophages
8 Citations (Scopus)
Neuronal Plasticity
Surgical Instruments
Esophagus
Lung Diseases
Colon
8 Citations (Scopus)
Toll-Like Receptor 6
Toll-Like Receptor 9
Toll-Like Receptor 2
Viruses
Guinea Pigs
28 Citations (Scopus)

Toll-like receptor 7 rapidly relaxes human airways

Drake, M., Scott, G. D., Proskocil, B. J., Fryer, A., Jacoby, D. & Kaufman, E. H., Sep 15 2013, In : American Journal of Respiratory and Critical Care Medicine. 188, 6, p. 664-672 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Nitric Oxide
imiquimod
Guinea Pigs
Toll-Like Receptors
2012

Comment

Rynko, A. E. & Jacoby, D., Nov 2012, In : Neuromodulation. 15, 6, p. 535-536 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Muscarinic receptor agonists and antagonists: Effects on inflammation and immunity

Verbout, N. G. & Jacoby, D., 2012, In : Handbook of Experimental Pharmacology. 208, p. 403-427 25 p.

Research output: Contribution to journalArticle

Muscarinic Agonists
Muscarinic Antagonists
Muscarinic Receptors
Cholinergic Agents
Immunity
36 Citations (Scopus)

Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma

Buels, K. S., Jacoby, D. & Fryer, A., Mar 2012, In : British Journal of Pharmacology. 165, 5, p. 1501-1514 14 p.

Research output: Contribution to journalArticle

Bronchoconstriction
Guinea Pigs
Asthma
Muscarinic Receptors
Antigens
24 Citations (Scopus)

Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4 +8 - thymocytes and invariant NKT cells but not in Treg cells

Koguchi, Y., Buenafe, A. C., Thauland, T. J., Gardell, J. L., Bivins-Smith, E. R., Jacoby, D., Slifka, M. & Parker, D., Feb 21 2012, In : PLoS One. 7, 2, e31296.

Research output: Contribution to journalArticle

CD40 Ligand
Natural Killer T-Cells
thymocytes
Regulatory T-Lymphocytes
Thymocytes
26 Citations (Scopus)

The therapeutic potential of toll-like receptor 7 stimulation in Asthma

Drake, M., Kaufman, E. H., Fryer, A. & Jacoby, D., 2012, In : Inflammation and Allergy - Drug Targets. 11, 6, p. 484-491 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
imiquimod
resiquimod
Asthma
Airway Remodeling
5 Citations (Scopus)

Upping the antedrug: Is a novel anti-inflammatory Toll-like receptor 7 agonist also a bronchodilator?

Kaufman, E. H. & Jacoby, D., May 2012, In : British Journal of Pharmacology. 166, 2, p. 569-572 4 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
Bronchodilator Agents
Anti-Inflammatory Agents
Asthma
Lung Diseases
5 Citations (Scopus)

β2-Agonists Inhibit TNF-α-Induced ICAM-1 Expression in Human Airway Parasympathetic Neurons

Nie, Z. J., Fryer, A. & Jacoby, D., Sep 25 2012, In : PLoS One. 7, 9, e44780.

Research output: Contribution to journalArticle

Albuterol
agonists
Neurons
adhesion
Adhesion
2011
43 Citations (Scopus)

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. & Jacoby, D., 2011, In : PLoS One. 6, 7, e22029.

Research output: Contribution to journalArticle

eosinophils
Eosinophils
skin (animal)
Neurons
branching
19 Citations (Scopus)

Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M 2 muscarinic receptor dysfunction

Nie, Z. J., Scott, G. D., Weis, P. D., Itakura, A., Fryer, A. & Jacoby, D., Sep 2011, In : British Journal of Pharmacology. 164, 2 B, p. 444-452 9 p.

Research output: Contribution to journalArticle

Alphavirus
Muscarinic Receptors
Tumor Necrosis Factor-alpha
Bronchoconstriction
Viruses
8 Citations (Scopus)
Ozone
Nerve Growth Factor
Substance P
Tachykinins
Interleukin-1
30 Citations (Scopus)

Toll-like receptor 7 agonists are potent and rapid bronchodilators in guinea pigs

Kaufman, E. H., Fryer, A. & Jacoby, D., Feb 2011, In : Journal of Allergy and Clinical Immunology. 127, 2, p. 462-469 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
imiquimod
Bronchoconstriction
Bronchodilator Agents
Guinea Pigs
2010
316 Citations (Scopus)

Human mucosal associated invariant T cells detect bacterially infected cells

Gold, M., Cerri, S., Smyk-Pearson, S., Cansler, M. E., Vogt, T. M., Delepine, J., Winata, E., Swarbrick, G. M., Chua, W. J., Yu, Y. Y. L., Lantz, O., Cook, M. S., Null, M. D., Jacoby, D., Harriff, M., Lewinsohn, D., Hansen, T. H. & Lewinsohn, D., Jun 2010, In : PLoS Biology. 8, 6

Research output: Contribution to journalArticle

T-cells
Mycobacterium tuberculosis
T-lymphocytes
T-Lymphocytes
cells
2009
13 Citations (Scopus)
Nerve Growth Factor
Atropine
Eosinophils
Guinea Pigs
Antigens
23 Citations (Scopus)
Muscarinic Receptors
Guinea Pigs
Antigens
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptors
21 Citations (Scopus)

Neural control of airway inflammation

Verhein, K. C., Fryer, A. & Jacoby, D., 2009, In : Current Allergy and Asthma Reports. 9, 6, p. 484-490 7 p.

Research output: Contribution to journalArticle

Airway Management
Leukocytes
Inflammation
Neurotransmitter Agents
3 Citations (Scopus)
Tretinoin
Antiviral Agents
Anti-Inflammatory Agents
Viruses
Bronchoconstriction
2008
21 Citations (Scopus)

Antigen sensitization influences organophosphorus pesticide-induced airway hyperreactivity

Proskocil, B. J., Bruun, D. A., Lorton, J. K., Blensly, K. C., Jacoby, D., Lein, P. J. & Fryer, A., Mar 2008, In : Environmental Health Perspectives. 116, 3, p. 381-388 8 p.

Research output: Contribution to journalArticle

Parathion
antigen
Pesticides
Eosinophils
Antigens
94 Citations (Scopus)

Characterization of side population cells from human airway epithelium

Hackett, T. L., Shaheen, F., Johnson, A., Wadsworth, S., Pechkovsky, D. V., Jacoby, D., Kicic, A., Stick, S. M. & Knight, D. A., Oct 2008, In : Stem Cells. 26, 10, p. 2576-2585 10 p.

Research output: Contribution to journalArticle

Side-Population Cells
Epithelium
Population
Cadherins
Stem Cells
13 Citations (Scopus)

Cigarette smoke induces genetic instability in airway epithelial cells by suppressing FANCD2 expression

Hays, L. E., Zodrow, D. M., Yates, J. E., Deffebach, M. E., Jacoby, D., Olson, S., Pankow, J. F. & Bagby, G. C., May 20 2008, In : British Journal of Cancer. 98, 10, p. 1653-1661 9 p.

Research output: Contribution to journalArticle

Smoke
Tobacco Products
Chromosomal Instability
Epithelial Cells
Bronchogenic Carcinoma
21 Citations (Scopus)
Interleukin-1 Receptors
Ozone
Guinea Pigs
Interleukin-1
Eosinophils
2007
22 Citations (Scopus)
Atropine
Eosinophils
Guinea Pigs
Antigens
Acetylcholine
19 Citations (Scopus)

Expression and regulation of intercellular adhesion molecule-1 on airway parasympathetic nerves

Nie, Z. J., Nelson, C. S., Jacoby, D. & Fryer, A., Jun 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1415-1422 8 p.

Research output: Contribution to journalArticle

Intercellular Adhesion Molecule-1
Dexamethasone
Neuroblastoma
Guinea Pigs
Eosinophils
37 Citations (Scopus)

Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage

Wong, J., Korcheva, V., Jacoby, D. & Magun, B., May 2007, In : American Journal of Pathology. 170, 5, p. 1497-1510 14 p.

Research output: Contribution to journalArticle

Ricin
Kidney
Lung
Body Weight
RNA
33 Citations (Scopus)
Ricin
Proto-Oncogene Proteins c-akt
Heat-Shock Proteins
p38 Mitogen-Activated Protein Kinases
Lung
46 Citations (Scopus)

Role of apoptotic signaling pathways in regulation of inflammatory responses to ricin in primary murine macrophages

Korcheva, V., Wong, J., Lindauer, M., Jacoby, D., Iordanov, M. S. & Magun, B., Apr 2007, In : Molecular Immunology. 44, 10, p. 2761-2771 11 p.

Research output: Contribution to journalArticle

Ricin
Macrophages
Adult Respiratory Distress Syndrome
Cytokines
Lung
2006
100 Citations (Scopus)

Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction

Fryer, A., Stein, L. H., Nie, Z. J., Curtis, D. E., Evans, C. M., Hodgson, S. T., Jose, P. J., Belmonte, K. E., Fitch, E. & Jacoby, D., Jan 2006, In : Journal of Clinical Investigation. 116, 1, p. 228-236 9 p.

Research output: Contribution to journalArticle

Eosinophils
Eosinophil Major Basic Protein
Muscarinic M2 Receptors
Antigens
Ovalbumin
2005
25 Citations (Scopus)
Ozone
Eosinophils
Smooth Muscle
Dimercaprol
Lung
2004
12 Citations (Scopus)

Insulin Regulates Neuronal M2 Muscarinic Receptor Function in the Ileum of Diabetic Rats

Coulson, F. R., Jacoby, D. & Fryer, A., Feb 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 2, p. 760-766 7 p.

Research output: Contribution to journalArticle

Muscarinic M2 Receptors
Ileum
Insulin
Acetylcholine
Electric Stimulation
21 Citations (Scopus)

Pathophysiology of airway viral infections

Jacoby, D., Dec 2004, In : Pulmonary Pharmacology and Therapeutics. 17, 6 SPEC.ISS., p. 333-336 4 p.

Research output: Contribution to journalArticle

Tachykinins
Virus Diseases
Cough
Neprilysin
Nerve Growth Factors
90 Citations (Scopus)

Protein kinase Cδ mediates lysophosphatidic acid-induced NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

Cummings, R., Zhao, Y., Jacoby, D., Spannhake, E. W., Ohba, M., Garcia, J. G. N., Watkins, T., He, D., Saatian, B. & Natarajan, V., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 41085-41094 10 p.

Research output: Contribution to journalArticle

Interleukin-8
Protein Kinase C
Epithelial Cells
Chemical activation
G12-G13 GTP-Binding Protein alpha Subunits