David Ellison

Professor

  • 8406 Citations
  • 50 h-Index
1982 …2021
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1982 2020

Filter
Article
2014
37 Citations (Scopus)

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension

Picard, N., Trompf, K., Yang, C-L., Miller, R. L., Carrel, M., Loffing-Cueni, D., Fenton, R. A., Ellison, D. & Loffing, J., Mar 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 511-522 12 p.

Research output: Contribution to journalArticle

Hypotension
Phosphorylation
Kidney
Gitelman Syndrome
Distal Kidney Tubule
33 Citations (Scopus)

Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension

Terker, A. S., Yang, C-L., McCormick, J. J., Meermeier, N. P., Rogers, S. L., Grossmann, S., Trompf, K., Delpire, E., Loffing, J. & Ellison, D., 2014, In : Hypertension. 64, 1, p. 178-184 7 p.

Research output: Contribution to journalArticle

Thiazides
Sodium Chloride
Phosphotransferases
Salts
Hypertension
17 Citations (Scopus)

Training the next generation’s nephrology workforce

Berns, J. S., Ellison, D., Linas, S. L. & Rosner, M. H., 2014, In : Clinical Journal of the American Society of Nephrology. 9, 9, p. 1639-1644 6 p.

Research output: Contribution to journalArticle

Nephrology
Internal Medicine
Medical Students
Teaching
Education
47 Citations (Scopus)

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4

Chávez-Canales, M., Zhang, C., Soukaseum, C., Moreno, E., Pacheco-Alvarez, D., Vidal-Petiot, E., Castañeda-Bueno, M., Vázquez, N., Rojas-Vega, L., Meermeier, N. P., Rogers, S., Jeunemaitre, X., Yang, C-L., Ellison, D., Gamba, G. & Hadchouel, J., Nov 1 2014, In : Hypertension. 64, 5, p. 1047-1053 7 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Hypertension
Phosphotransferases
Proline
Alanine
2013
2 Citations (Scopus)

PharmGKB summary: Diuretics pathway, pharmacodynamics

Thorn, C. F., Ellison, D., Turner, S. T., Altman, R. B. & Klein, T. E., Aug 2013, In : Pharmacogenetics and Genomics. 23, 8, p. 449-453 5 p.

Research output: Contribution to journalArticle

Potassium Sparing Diuretics
Sodium Potassium Chloride Symporter Inhibitors
Sodium Chloride Symporter Inhibitors
Pharmacogenetics
Genetic Association Studies
34 Citations (Scopus)

Salt sensitivity: A review with a focus on non-Hispanic blacks and Hispanics

Richardson, S. I., Freedman, B. I., Ellison, D. & Rodriguez, C. J., Mar 2013, In : Journal of the American Society of Hypertension. 7, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

Hispanic Americans
Salts
Renin
Potassium
Tissue Kallikreins
60 Citations (Scopus)

SPAK differentially mediates vasopressin effects on sodium cotransporters

Saritas, T., Borschewski, A., McCormick, J. J., Paliege, A., Dathe, C., Uchida, S., Terker, A., Himmerkus, N., Bleich, M., Demaretz, S., Laghmani, K., Delpire, E., Ellison, D., Bachmann, S. & Mutig, K., Feb 28 2013, In : Journal of the American Society of Nephrology. 24, 3, p. 407-418 12 p.

Research output: Contribution to journalArticle

Vasopressins
Proline
Alanine
Phosphotransferases
Sodium
6 Citations (Scopus)

Ubiquitylation and the pathogenesis of hypertension

Ellison, D., Feb 1 2013, In : Journal of Clinical Investigation. 123, 2, p. 546-548 3 p.

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Ubiquitination
Liddle Syndrome
Hypertension
Sodium Chloride Symporters
2012
7 Citations (Scopus)

Adaptation in gitelman syndrome: "we just want to pump you up"

Ellison, D., Mar 1 2012, In : Clinical Journal of the American Society of Nephrology. 7, 3, p. 379-382 4 p.

Research output: Contribution to journalArticle

Gitelman Syndrome
Kidney Tubules
Symporters
Drug Receptors
Sodium
32 Citations (Scopus)

Enhanced phosphorylation of Na+ -Cl- co-transporter in experimental metabolic syndrome: Role of insulin

Komers, R., Rogers, S., Oyamat, T., Xu, B., Yang, C-L., McCormick, J. J. & Ellison, D., Dec 2012, In : Clinical Science. 123, 11, p. 635-647 13 p.

Research output: Contribution to journalArticle

Symporters
Phosphorylation
Insulin
Zucker Rats
Hydrochlorothiazide
8 Citations (Scopus)

Hypertension after kidney transplantation: Calcineurin inhibitors increase salt-sensitivity

Hoorn, E. J., Walsh, S. B., Unwin, R. J. & Ellison, D., Apr 2012, In : Journal of Hypertension. 30, 4, p. 832-833 2 p.

Research output: Contribution to journalArticle

Kidney Transplantation
Antihypertensive Agents
Salts
Hypertension
Calcineurin Inhibitors
81 Citations (Scopus)

Pathogenesis of calcineurin inhibitor-induced hypertension

Hoorn, E. J., Walsh, S. B., McCormick, J. J., Zietse, R., Unwin, R. J. & Ellison, D., Jun 2012, In : Journal of Nephrology. 25, 3, p. 269-275 7 p.

Research output: Contribution to journalArticle

Hypertension
Kidney
Member 3 Solute Carrier Family 12
Sodium
Endothelins
21 Citations (Scopus)

WNK kinases and the kidney

Hoorn, E. J. & Ellison, D., May 15 2012, In : Experimental Cell Research. 318, 9, p. 1020-1026 7 p.

Research output: Contribution to journalArticle

Phosphotransferases
Kidney
Water-Electrolyte Balance
Sodium
Hypertension
2011
118 Citations (Scopus)

A SPAK isoform switch modulates renal salt transport and blood pressure

McCormick, J. J., Mutig, K., Nelson, J. H., Saritas, T., Hoorn, E. J., Yang, C-L., Rogers, S., Curry, J., Delpire, E., Bachmann, S. & Ellison, D., Sep 7 2011, In : Cell Metabolism. 14, 3, p. 352-364 13 p.

Research output: Contribution to journalArticle

Protein Isoforms
Extremities
Salts
Blood Pressure
Kidney
6 Citations (Scopus)

Diuretics and salt transport along the nephron

Bernstein, P. L. & Ellison, D., Nov 2011, In : Seminars in Nephrology. 31, 6, p. 475-482 8 p.

Research output: Contribution to journalArticle

Nephrons
Diuretics
Salts
Sodium
Kidney
13 Citations (Scopus)

High tail-cuff blood pressure in mice 1 week after shipping: The need for longer acclimation

Hoorn, E. J., McCormick, J. J. & Ellison, D., May 2011, In : American Journal of Hypertension. 24, 5, p. 534-536 3 p.

Research output: Contribution to journalArticle

Acclimatization
Tail
Blood Pressure
Control Groups
Motor Vehicles
32 Citations (Scopus)

Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension

McCormick, J. J., Nelson, J. H., Yang, C-L., Curry, J. N. & Ellison, D., Nov 2011, In : Hypertension. 58, 5, p. 888-894 7 p.

Research output: Contribution to journalArticle

Sodium Chloride Symporters
Hypertension
Transgenic Mice
Blood Pressure
Fludrocortisone
10 Citations (Scopus)

Renal nerves, WNK4, glucocorticoids, and salt transport

Ellison, D. & Brooks, V., Jun 8 2011, In : Cell Metabolism. 13, 6, p. 619-620 2 p.

Research output: Contribution to journalArticle

Glucocorticoids
Salts
Hypertension
Kidney
Sympathetic Nervous System
165 Citations (Scopus)

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

Hoorn, E. J., Walsh, S. B., McCormick, J. J., Fürstenberg, A., Yang, C-L., Roeschel, T., Paliege, A., Howie, A. J., Conley, J., Bachmann, S., Unwin, R. J. & Ellison, D., Oct 2011, In : Nature Medicine. 17, 10, p. 1304-1309 6 p.

Research output: Contribution to journalArticle

Sodium Chloride Symporters
Tacrolimus
Hypertension
Kidney
Phosphotransferases
90 Citations (Scopus)

The WNK kinase network regulating sodium, potassium, and blood pressure

Hoorn, E. J., Nelson, J. H., McCormick, J. J. & Ellison, D., Apr 2011, In : Journal of the American Society of Nephrology. 22, 4, p. 605-614 10 p.

Research output: Contribution to journalArticle

Potassium
Phosphotransferases
Sodium
Blood Pressure
Hypertension
145 Citations (Scopus)

The WNKs: Atypical protein kinases with pleiotropic actions

McCormick, J. J. & Ellison, D., Jan 2011, In : Physiological Reviews. 91, 1, p. 177-219 43 p.

Research output: Contribution to journalArticle

Protein Kinases
Kidney
Pseudohypoaldosteronism
Hereditary Sensory and Autonomic Neuropathies
Genes
4 Citations (Scopus)

Through a glass darkly: Salt transport by the distal tubule

Ellison, D., Jan 2011, In : Kidney International. 79, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

Aldosterone
Angiotensin II
Glass
Potassium
Homeostasis
2010
37 Citations (Scopus)

Altered renal FGF23-mediated activity involving MAPK and Wnt: Effects of the Hyp mutation

Farrow, E. G., Summers, L. J., Schiavi, S. C., McCormick, J. J., Ellison, D. & White, K. E., 2010, In : Journal of Endocrinology. 207, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Kidney
Mutation
Familial Hypophosphatemic Rickets
Phosphates
Hypophosphatemia
31 Citations (Scopus)

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2

Reiche, J., Theilig, F., Rafiqi, F. H., Carlo, A. S., Militz, D., Mutig, K., Todiras, M., Christensen, E. I., Ellison, D., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. & Willnow, T. E., Jun 2010, In : Molecular and Cellular Biology. 30, 12, p. 3027-3037 11 p.

Research output: Contribution to journalArticle

Sodium-Potassium-Chloride Symporters
Proline
Alanine
Phosphotransferases
Kidney
8 Citations (Scopus)

Sorting out lysosomal trafficking of the thiazide-sensitive Na-Cl co-transporter

Subramanya, A. R. & Ellison, D., Jan 2010, In : Journal of the American Society of Nephrology. 21, 1, p. 7-9 3 p.

Research output: Contribution to journalArticle

Sodium Chloride Symporters
Distal Kidney Tubule
Vesicular Transport Adaptor Proteins
Symporters
Thiazides
2009
108 Citations (Scopus)

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

Rozansky, D., Cornwall, T., Subramanya, A. R., Rogers, S., Yang, Y. F., David, L., Zhu, X., Yang, C-L. & Ellison, D., Sep 1 2009, In : Journal of Clinical Investigation. 119, 9, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Aldosterone
Glucocorticoids
Phosphotransferases
Serum
9 Citations (Scopus)

The voltage-gated K+ channel subunit Kv1.1 links kidney and brain

Ellison, D., Apr 1 2009, In : Journal of Clinical Investigation. 119, 4, p. 763-766 4 p.

Research output: Contribution to journalArticle

Voltage-Gated Potassium Channels
Kidney
Mutation
Nephrons
Brain
73 Citations (Scopus)

Thiazide effects and adverse effects: Insights from molecular genetics

Ellison, D. & Loffing, J., Aug 2009, In : Hypertension. 54, 2, p. 196-202 7 p.

Research output: Contribution to journalArticle

Severity of Illness Index
Blood Pressure Determination
Thiazides
Hypokalemia
Kidney Diseases
83 Citations (Scopus)

WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction

Subramanya, A. R., Liu, J., Ellison, D., Wade, J. B. & Welling, P. A., Jul 3 2009, In : Journal of Biological Chemistry. 284, 27, p. 18471-18480 10 p.

Research output: Contribution to journalArticle

Thiazides
Lysosomes
Lysine
Phosphotransferases
thiazide receptor
2008
5 Citations (Scopus)

Renal magnification by EGF

Ellison, D., May 2008, In : Nephrology Dialysis Transplantation. 23, 5, p. 1497-1499 3 p.

Research output: Contribution to journalArticle

Inborn Errors Renal Tubular Transport
Magnesium Deficiency
Biological Models
Inborn Genetic Diseases
Ion Transport
52 Citations (Scopus)

WNK kinases and renal sodium transport in health and disease: an integrated view.

McCormick, J. J., Yang, C-L. & Ellison, D., Mar 2008, In : Hypertension. 51, 3, p. 588-596 9 p.

Research output: Contribution to journalArticle

Biological Transport
Animal Disease Models
Protein-Serine-Threonine Kinases
Transgenic Mice
Phosphotransferases
2007

The authors reply [12]

Ellison, D. & Berl, T., Aug 30 2007, In : New England Journal of Medicine. 357, 9, p. 942 1 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

The continous erythropoietin receptor activator (C.E.R.A.) corrects anemia at extended administration intervals in patients with chronic kidney disease not on dialysis: Results of a phase II study

Provenzano, R., Besarab, A., Macdougall, I. C., Ellison, D., Maxwell, A. P., Sulowicz, W., Klinger, M., Rutkowski, B., Correa-Rotter, R., Dougherty, F. C., Barre, P., Levin, A., McMahon, A., Tobe, S. W., Valdes, A., Fishbane, S., Lewis, J., Leiserowitz, M., Mehta, R. & Vicks, S., May 2007, In : Clinical Nephrology. 67, 5, p. 306-317 12 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Anemia
Dialysis
Hemoglobins
continuous erythropoietin receptor activator
578 Citations (Scopus)

The syndrome of inappropriate antidiuresis

Ellison, D. & Berl, T., May 17 2007, In : New England Journal of Medicine. 356, 20, p. 2064-2072 9 p.

Research output: Contribution to journalArticle

Hyponatremia
Osmolar Concentration
Dysgeusia
Sodium
Small Cell Carcinoma
106 Citations (Scopus)

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

Yang, C-L., Zhu, X. & Ellison, D., Nov 1 2007, In : Journal of Clinical Investigation. 117, 11, p. 3403-3411 9 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Phosphotransferases
Hypertension
Oocytes
Sodium Chloride Symporter Inhibitors
38 Citations (Scopus)

WNK1 and WNK4 modulate CFTR activity

Yang, C-L., Liu, X., Paliege, A., Zhu, X., Bachmann, S., Dawson, D. C. & Ellison, D., Feb 16 2007, In : Biochemical and Biophysical Research Communications. 353, 3, p. 535-540 6 p.

Research output: Contribution to journalArticle

Cystic Fibrosis Transmembrane Conductance Regulator
Phosphotransferases
Hypertension
Chloride Channels
Cystic Fibrosis
2006
88 Citations (Scopus)

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

Subramanya, A. R., Yang, C-L., Zhu, X. & Ellison, D., Mar 2006, In : American Journal of Physiology - Renal Physiology. 290, 3

Research output: Contribution to journalArticle

Lysine
Protein Isoforms
Phosphotransferases
Kidney
Oocytes
11 Citations (Scopus)

Management of cirrhotic ascites: Physiological basis of diuretic action

Rosner, M. H., Gupta, R., Ellison, D. & Okusa, M. D., Jan 2006, In : European Journal of Internal Medicine. 17, 1, p. 8-19 12 p.

Research output: Contribution to journalArticle

Diuretics
Ascites
Fibrosis
Peritoneovenous Shunt
Transjugular Intrahepatic Portasystemic Shunt
101 Citations (Scopus)

WNK1 kinase isoform switch regulates renal potassium excretion

Wade, J. B., Fang, L., Liu, J., Li, D., Yang, C-L., Subramanya, A. R., Maouyo, D., Mason, A., Ellison, D. & Welling, P. A., May 30 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 22, p. 8558-8563 6 p.

Research output: Contribution to journalArticle

Potassium
Protein Isoforms
Phosphotransferases
Kidney
L Forms
267 Citations (Scopus)

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

Lalioti, M. D., Zhang, J., Volkman, H. M., Kahle, K. T., Hoffmann, K. E., Toka, H. R., Nelson-Williams, C., Ellison, D., Flavell, R., Booth, C. J., Lu, Y., Geller, D. S. & Lifton, R. P., Oct 2006, In : Nature Genetics. 38, 10, p. 1124-1132 9 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Pseudohypoaldosteronism
Potassium
Hyperkalemia
Homeostasis
57 Citations (Scopus)

WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron

Subramanya, A. R., Yang, C-L., McCormick, J. J. & Ellison, D., Aug 28 2006, In : Kidney International. 70, 4, p. 630-634 5 p.

Research output: Contribution to journalArticle

Thiazides
Nephrons
Aldosterone
Sodium Chloride
Potassium
2005
4 Citations (Scopus)

A water deprivation test is not indicated in the evaluation of hypernatremia [3] (multiple letters)

Moritz, M. L. & Ellison, D., Dec 2005, In : American Journal of Kidney Diseases. 46, 6, p. 1150-1151 2 p.

Research output: Contribution to journalArticle

Nephrogenic Diabetes Insipidus
Hypernatremia
Water Deprivation
Polyuria
Vasopressins
4 Citations (Scopus)

Disorders of sodium and water.

Ellison, D., 2005, In : American Journal of Kidney Diseases. 46, 2, p. 356-361 6 p.

Research output: Contribution to journalArticle

Water-Electrolyte Imbalance
Hypernatremia
Natriuresis
Hyponatremia
Body Water
139 Citations (Scopus)

Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

Yang, C-L., Zhu, X., Wang, Z., Subramanya, A. R. & Ellison, D., May 2005, In : Journal of Clinical Investigation. 115, 5, p. 1379-1387 9 p.

Research output: Contribution to journalArticle

Thiazides
Phosphotransferases
Hypertension
Proteins
Nephrons
2004
28 Citations (Scopus)

Comparison of WNK4 and WNK1 kinase and inhibiting activities

Wang, Z., Yang, C-L. & Ellison, D., May 7 2004, In : Biochemical and Biophysical Research Communications. 317, 3, p. 939-944 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Glutathione Transferase
Member 3 Solute Carrier Family 12
HEK293 Cells
Protein-Serine-Threonine Kinases
63 Citations (Scopus)

Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease

Sabath, E., Meade, P., Berkman, J., De Los Heros, P., Moreno, E., Bobadilla, N. A., Vázqaez, N., Ellison, D. & Gamba, G., Aug 2004, In : American Journal of Physiology - Renal Physiology. 287, 2 56-2

Research output: Contribution to journalArticle

Mutation
Metolazone
Thiazides
Insertional Mutagenesis
Ion Transport
2003
50 Citations (Scopus)

Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats

Schmitt, R., Klussmann, E., Kahl, T., Ellison, D. & Bachmann, S., May 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

Aquaporin 2
Sodium
Kidney
Carrier Proteins
Hypothyroidism
23 Citations (Scopus)
Sodium Chloride Symporters
Benzothiadiazines
Symporters
Sodium Chloride Symporter Inhibitors
Drug Receptors
361 Citations (Scopus)

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

Yang, C-L., Angell, J., Mitchell, R. & Ellison, D., Apr 2003, In : Journal of Clinical Investigation. 111, 7, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Thiazides
Pseudohypoaldosteronism
Phosphotransferases
Mutation
2002
26 Citations (Scopus)
Oocytes
Kidney Cortex
Complementary RNA
thiazide receptor
glucose-regulated proteins