David Ellison

Professor

  • 8406 Citations
  • 50 h-Index
1982 …2021
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Research Output 1982 2020

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123 Citations (Scopus)

11β-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules

Bostonjoglo, M., Reeves, W. B., Reilly, R. F., Velázquez, H., Robertson, N., Litwack, G., Morsing, P., Dørup, J., Bachmann, S. & Ellison, D., Aug 1998, In : Journal of the American Society of Nephrology. 9, 8, p. 1347-1358 12 p.

Research output: Contribution to journalArticle

11-beta-Hydroxysteroid Dehydrogenases
Mineralocorticoid Receptors
Aldosterone
Member 3 Solute Carrier Family 12
Extremities
5 Citations (Scopus)

Acute renal failure in critically ill patients

Ellison, D. & Johnson Bia, M., 1987, In : Journal of Intensive Care Medicine. 2, 1, p. 8-24 17 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Critical Illness
Necrosis
Kidney
Serositis
7 Citations (Scopus)

Adaptation in gitelman syndrome: "we just want to pump you up"

Ellison, D., Mar 1 2012, In : Clinical Journal of the American Society of Nephrology. 7, 3, p. 379-382 4 p.

Research output: Contribution to journalArticle

Gitelman Syndrome
Kidney Tubules
Symporters
Drug Receptors
Sodium
43 Citations (Scopus)

Adaptation of distal convoluted tubule of rats II. Effects of chronic thiazide infusion

Morsing, P., Velázquez, H., Wright, F. S. & Ellison, D., 1991, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261, 1 30-1

Research output: Contribution to journalArticle

Thiazides
Hydrochlorothiazide
Membranes
Metolazone
Punctures
199 Citations (Scopus)
Furosemide
Diuretics
Salts
Hypertrophy
Distal Kidney Tubule
118 Citations (Scopus)

Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules

Velazquez, H., Bartiss, A., Bernstein, P. & Ellison, D., 1996, In : American Journal of Physiology. 270, 1 PART 2

Research output: Contribution to journalArticle

Distal Kidney Tubule
Thiazides
Aldosterone
Dexamethasone
Metolazone
108 Citations (Scopus)

Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway

Rozansky, D., Cornwall, T., Subramanya, A. R., Rogers, S., Yang, Y. F., David, L., Zhu, X., Yang, C-L. & Ellison, D., Sep 1 2009, In : Journal of Clinical Investigation. 119, 9, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Aldosterone
Glucocorticoids
Phosphotransferases
Serum
37 Citations (Scopus)

Altered renal FGF23-mediated activity involving MAPK and Wnt: Effects of the Hyp mutation

Farrow, E. G., Summers, L. J., Schiavi, S. C., McCormick, J. J., Ellison, D. & White, K. E., 2010, In : Journal of Endocrinology. 207, 1, p. 67-75 9 p.

Research output: Contribution to journalArticle

Kidney
Mutation
Familial Hypophosphatemic Rickets
Phosphates
Hypophosphatemia

Anaesthesia recommendations for patients suffering from Liddle's syndrome

McCaul, C., Caulfield, K., Sinha, R. & Ellison, D., Sep 1 2016, In : Anasthesiologie und Intensivmedizin. 57, 9, p. S500-S505

Research output: Contribution to journalArticle

Liddle Syndrome
Anesthesia
Hypertension
Epithelial Sodium Channel Blockers
Triamterene
4 Citations (Scopus)

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120

Research output: Contribution to journalArticle

Open Access
Animal Models
Hypertension
Comorbidity
Chronic Disease
Research Design
3 Citations (Scopus)

An integrated view of potassium homeostasis

Hoorn, E. J., Loffing, J. & Ellison, D., Oct 29 2015, In : New England Journal of Medicine. 373, 18, p. 1786 1 p.

Research output: Contribution to journalArticle

Potassium
Homeostasis

An Integrated View of Potassium Homeostasis

Hoorn, E. J., Loffing, J. & Ellison, D. H., Oct 29 2015, In : The New England journal of medicine. 373, 18, p. 1786 1 p.

Research output: Contribution to journalArticle

Circadian Clocks
Potassium
Homeostasis
10 Citations (Scopus)

A quest - Halting the progression of autosomal dominant polycystic kidney disease

Ellison, D. & Ingelfinger, J. R., Dec 11 2014, In : New England Journal of Medicine. 371, 24, p. 2329-2331 3 p.

Research output: Contribution to journalArticle

Benzimidazoles
Lisinopril
Angiotensin II Type 1 Receptor Blockers
Autosomal Dominant Polycystic Kidney
Benzoates
118 Citations (Scopus)

A SPAK isoform switch modulates renal salt transport and blood pressure

McCormick, J. J., Mutig, K., Nelson, J. H., Saritas, T., Hoorn, E. J., Yang, C-L., Rogers, S., Curry, J., Delpire, E., Bachmann, S. & Ellison, D., Sep 7 2011, In : Cell Metabolism. 14, 3, p. 352-364 13 p.

Research output: Contribution to journalArticle

Protein Isoforms
Extremities
Salts
Blood Pressure
Kidney
4 Citations (Scopus)

A water deprivation test is not indicated in the evaluation of hypernatremia [3] (multiple letters)

Moritz, M. L. & Ellison, D., Dec 2005, In : American Journal of Kidney Diseases. 46, 6, p. 1150-1151 2 p.

Research output: Contribution to journalArticle

Nephrogenic Diabetes Insipidus
Hypernatremia
Water Deprivation
Polyuria
Vasopressins
9 Citations (Scopus)

Bardoxolone methyl in type 2 diabetes and advanced chronic kidney disease

Ellison, D., 2014, In : New England Journal of Medicine. 370, 18, p. 1768 1 p.

Research output: Contribution to journalArticle

Oleanolic Acid
Diabetic Nephropathies
Chronic Renal Insufficiency
Type 2 Diabetes Mellitus
Chronic Kidney Failure
14 Citations (Scopus)

Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl- Cotransporter

Borschewski, A., Himmerkus, N., Boldt, C., Blankenstein, K. I., McCormick, J. J., Lazelle, R., Willnow, T. E., Jankowski, V., Plain, A., Bleich, M., Ellison, D., Bachmann, S. & Mutig, K., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

Calcineurin
Kidney
Extremities
Cyclosporine
Member 1 Solute Carrier Family 12
14 Citations (Scopus)

Calcineurin inhibitor cyclosporine A activates renal NA-K-CL cotransporters via local and systemic mechanisms

Blankenstein, K. I., Borschewski, A., Labes, R., Paliege, A., Boldt, C., McCormick, J. J., Ellison, D., Bader, M., Bachmann, S. & Mutig, K., Mar 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 3, p. F489-F501

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Arginine Vasopressin
Cyclosporine
Kidney
Calcineurin
17 Citations (Scopus)

Calcium Balance and Parathyroid Hormone Mediated Vasodilation in the Spontaneously Hypertensive Rat

Anderson, S., Grady, J. R., Ellison, D. & McCarron, D. A., 1983, In : Hypertension. 5, 2, p. I-59-I-63

Research output: Contribution to journalArticle

Inbred SHR Rats
Parathyroid Hormone
Vasodilation
Calcium
Teriparatide

Chapter 30 The physiologic basis of diuretic drug action and synergism

Ellison, D., 1997, In : Principles of Medical Biology. 8, C, p. 577-599 23 p.

Research output: Contribution to journalArticle

Drug Synergism
Diuretics
Pharmaceutical Preparations
Ion Transport
Ions
55 Citations (Scopus)
Biological Transport
Distal Kidney Tubule
Kidney Tubules
Potassium Chloride
Membrane Potentials
2 Citations (Scopus)

Clinical pharmacology in diuretic use

Ellison, D., Aug 7 2019, In : Clinical Journal of the American Society of Nephrology. 14, 8, p. 1248-1257 10 p.

Research output: Contribution to journalArticle

Open Access
Cardio-Renal Syndrome
Kidney Tubules
Clinical Pharmacology
Diuresis
Nephrotic Syndrome
28 Citations (Scopus)

Comparison of WNK4 and WNK1 kinase and inhibiting activities

Wang, Z., Yang, C-L. & Ellison, D., May 7 2004, In : Biochemical and Biophysical Research Communications. 317, 3, p. 939-944 6 p.

Research output: Contribution to journalArticle

Phosphotransferases
Glutathione Transferase
Member 3 Solute Carrier Family 12
HEK293 Cells
Protein-Serine-Threonine Kinases
16 Citations (Scopus)

Compensatory distal reabsorption drives diuretic resistance in human heart failure

Rao, V. S., Planavsky, N., Hanberg, J. S., Ahmad, T., Brisco-Bacik, M. A., Wilson, F. P., Jacoby, D., Chen, M., Tang, W. H. W., Cherney, D. Z. I., Ellison, D. & Testani, J. M., Nov 1 2017, In : Journal of the American Society of Nephrology. 28, 11, p. 3414-3424 11 p.

Research output: Contribution to journalArticle

Diuretics
Heart Failure
Sodium Potassium Chloride Symporter Inhibitors
Sodium
Lithium
1 Citation (Scopus)

C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity

Murillo-de-Ozores, A. R., Rodríguez-Gama, A., Bazúa-Valenti, S., Leyva-Ríos, K., Vázquez, N., Pacheco-Álvarez, D., De La Rosa-Velázquez, I. A., Wengi, A., Stone, K. L., Zhang, J., Loffing, J., Lifton, R. P., Yang, C-L., Ellison, D., Gamba, G. & Castañeda-Bueno, M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 31, p. 12209-12221 13 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Phosphotransferases
Kidney
Binding Sites
Member 3 Solute Carrier Family 12
121 Citations (Scopus)

Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome

Kunchaparty, S., Palcso, M., Berkman, J., Velázquez, H., Desir, G. V., Bernstein, P., Reilly, R. F. & Ellison, D., Oct 1999, In : American Journal of Physiology - Renal Physiology. 277, 4 46-4

Research output: Contribution to journalArticle

Gitelman Syndrome
Oocytes
Clone Cells
Staining and Labeling
Mutation
7 Citations (Scopus)

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension

Zhang, C., Meermeier, N. P., Terker, A. S., Blankenstein, K. I., Singer, J. D., Hadchouel, J., Ellison, D. & Yang, C-L., Jan 1 2016, In : Biochemical and Biophysical Research Communications. 469, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

Cullin Proteins
Phosphotransferases
Hypertension
Degradation
Mutation
117 Citations (Scopus)

Developmental expression of sodium entry pathways in rat nephron

Schmitt, R., Ellison, D., Farman, N., Rossier, B. C., Reilly, R. F., Reeves, W. B., Oberbäumer, I., Tapp, R. & Bachmann, S., Mar 1999, In : American Journal of Physiology - Renal Physiology. 276, 3 45-3

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Nephrons
11-beta-Hydroxysteroid Dehydrogenases
Sodium
Loop of Henle
41 Citations (Scopus)

Direct and indirect mineralocorticoid effects determine distal salt transport

Terker, A. S., Yarbrough, B., Ferdaus, M. Z., Lazelle, R. A., Erspamer, K. J., Meermeier, N. P., Park, H. J., McCormick, J. J., Yang, C-L. & Ellison, D., 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2436-2445 10 p.

Research output: Contribution to journalArticle

Mineralocorticoids
Aldosterone
Salts
Nephrons
Dietary Potassium
4 Citations (Scopus)

Disorders of sodium and water.

Ellison, D., 2005, In : American Journal of Kidney Diseases. 46, 2, p. 356-361 6 p.

Research output: Contribution to journalArticle

Water-Electrolyte Imbalance
Hypernatremia
Natriuresis
Hyponatremia
Body Water
80 Citations (Scopus)

Distal convoluted tubule

Subramanya, A. R. & Ellison, D., 2014, In : Clinical Journal of the American Society of Nephrology. 9, 12, p. 2147-2163 17 p.

Research output: Contribution to journalArticle

Nephrons
Divalent Cations
Potassium
Homeostasis
Sodium
38 Citations (Scopus)

Distal convoluted tubule

McCormick, J. J. & Ellison, D., Jan 1 2015, In : Comprehensive Physiology. 5, 1, p. 45-98 54 p.

Research output: Contribution to journalArticle

Nephrons
Member 3 Solute Carrier Family 12
Gitelman Syndrome
Wasting Syndrome
Transient Receptor Potential Channels
3 Citations (Scopus)

Diuretic combinations in the treatment of edema: Rationale and recommendations

Ellison, D., 1994, In : Drug Therapy. 24, 3

Research output: Contribution to journalArticle

Diuretics
Edema
Kidney
Therapeutics
Drug and Narcotic Control
54 Citations (Scopus)

Diuretic drugs and the treatment of edema: From clinic to bench and back again

Ellison, D., 1994, In : American Journal of Kidney Diseases. 23, 5, p. 623-643 21 p.

Research output: Contribution to journalArticle

Diuretics
Edema
Ion Transport
Extracellular Fluid
Pharmaceutical Preparations
76 Citations (Scopus)

Diuretic resistance: Physiology and therapeutics

Ellison, D., 1999, In : Seminars in Nephrology. 19, 6, p. 581-597 17 p.

Research output: Contribution to journalArticle

Diuretics
Therapeutics
Kidney Tubules
Sodium
Pharmaceutical Preparations
24 Citations (Scopus)

Diuretic Resistance

Hoorn, E. J. & Ellison, D., Feb 23 2016, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

Diuretics
Sodium Potassium Chloride Symporter Inhibitors
Edema
Nephrotic Syndrome
Epithelial Sodium Channel Blockers

Diuretic resistance versus adaptation [3]

Zatuchni, J. & Ellison, D., 1991, In : Annals of Internal Medicine. 115, 5, p. 408-409 2 p.

Research output: Contribution to journalArticle

Physiological Adaptation
Diuretics
Drug Resistance
Edema
6 Citations (Scopus)

Diuretics and salt transport along the nephron

Bernstein, P. L. & Ellison, D., Nov 2011, In : Seminars in Nephrology. 31, 6, p. 475-482 8 p.

Research output: Contribution to journalArticle

Nephrons
Diuretics
Salts
Sodium
Kidney
206 Citations (Scopus)

Diuretic therapy and resistance in congestive heart failure

Ellison, D., 2001, In : Cardiology. 96, 3-4, p. 132-143 12 p.

Research output: Contribution to journalArticle

Diuretics
Heart Failure
Therapeutics
Renin
Nephrons
87 Citations (Scopus)
Gitelman Syndrome
Bartter Syndrome
Nephrons
Ion Transport
Divalent Cations
88 Citations (Scopus)

Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform

Subramanya, A. R., Yang, C-L., Zhu, X. & Ellison, D., Mar 2006, In : American Journal of Physiology - Renal Physiology. 290, 3

Research output: Contribution to journalArticle

Lysine
Protein Isoforms
Phosphotransferases
Kidney
Oocytes
3 Citations (Scopus)

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension

Cornelius, R. J., Zhang, C., Erspamer, K. J., Agbor, L. N., Sigmund, C. D., Singer, J. D., Yang, C-L. & Ellison, D., Oct 1 2018, In : American journal of physiology. Renal physiology. 315, 4, p. F1006-F1018

Research output: Contribution to journalArticle

Cullin Proteins
Ligases
Ubiquitin
Hypertension
Mutation
21 Citations (Scopus)

Effects of calcium infusion on blood pressure in hypertensive and normotensive humans

Ellison, D., Shneidman, R., Morris, C. & McCarron, D. A., 1986, In : Hypertension. 8, 6, p. 497-505 9 p.

Research output: Contribution to journalArticle

Dietary Sodium
Blood Pressure
Calcium
Dietary Calcium
Parathyroid Hormone
4 Citations (Scopus)

Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension

Nelson, J. W., Ferdaus, M. Z., McCormick, J. J., Minnier, J., Kaul, S., Ellison, D. & Barnes, A., Feb 1 2018, In : Physiological Genomics. 50, 2, p. 104-116 13 p.

Research output: Contribution to journalArticle

Fibrosis
Hypertension
Endothelial Cells
Blood Pressure
RNA Sequence Analysis
32 Citations (Scopus)

Enhanced phosphorylation of Na+ -Cl- co-transporter in experimental metabolic syndrome: Role of insulin

Komers, R., Rogers, S., Oyamat, T., Xu, B., Yang, C-L., McCormick, J. J. & Ellison, D., Dec 2012, In : Clinical Science. 123, 11, p. 635-647 13 p.

Research output: Contribution to journalArticle

Symporters
Phosphorylation
Insulin
Zucker Rats
Hydrochlorothiazide
4 Citations (Scopus)

Evaluating hyponatremia

Cohen, D. & Ellison, D., Mar 24 2015, In : JAMA - Journal of the American Medical Association. 313, 12, p. 1260-1261 2 p.

Research output: Contribution to journalArticle

Inappropriate ADH Syndrome
Hyponatremia
Haloperidol
Sodium Chloride
Abdominal Pain
86 Citations (Scopus)

Expression of the Na-K-2Cl cotransporter by macula densa and thick ascending limb cells of rat and rabbit nephron

Obermüller, N., Kunchaparty, S., Ellison, D. & Bachmann, S., Aug 1 1996, In : Journal of Clinical Investigation. 98, 3, p. 635-640 6 p.

Research output: Contribution to journalArticle

Nephrons
Extremities
Rabbits
Messenger RNA
Uromodulin
69 Citations (Scopus)

Expression of the thiazide-sensitive Na-Cl cotransporter by rabbit distal convoluted tubule cells

Bachmann, S., Velazquez, H., Obermuller, N., Reilly, R. F., Moser, D. & Ellison, D., 1995, In : Journal of Clinical Investigation. 96, 5, p. 2510-2514 5 p.

Research output: Contribution to journalArticle

Rabbits
Nephrons
Messenger RNA
Thiazides
Antibodies
163 Citations (Scopus)

Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidney

Obermüller, N., Bernstein, P., Velazquez, H., Reilly, R., Moser, D., Ellison, D. & Bachmann, S., Dec 1995, In : American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 269, 6 38-6

Research output: Contribution to journalArticle

kidneys
Kidney
rats
cells
Uromodulin
919 Citations (Scopus)

Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter

Simon, D. B., Nelson-Williams, C., Bia, M. J., Ellison, D., Karet, F. E., Molina, A. M., Vaara, I., Iwata, F., Cushner, H. M., Koolen, M., Gainza, F. J., Gitelman, H. J. & Lifton, R. P., Jan 1996, In : Nature Genetics. 12, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

Gitelman Syndrome
Bartter Syndrome
Alkalosis
Mutation
Electrolytes