David Ellison

Professor

  • 8609 Citations
  • 51 h-Index
1982 …2021

Research output per year

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Research Output

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Article
2020

Effect of Angiotensin II on ENaC in the Distal Convoluted Tubule and in the Cortical Collecting Duct of Mineralocorticoid Receptor Deficient Mice

Wu, P., Gao, Z. X., Zhang, D. D., Duan, X. P., Terker, A. S., Lin, D. H., Ellison, D. H. & Wang, W. H., Apr 7 2020, In : Journal of the American Heart Association. 9, 7, p. e014996

Research output: Contribution to journalArticle

Open Access

Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Clase, C. M., Carrero, J. J., Ellison, D. H., Grams, M. E., Hemmelgarn, B. R., Jardine, M. J., Kovesdy, C. P., Kline, G. A., Lindner, G., Obrador, G. T., Palmer, B. F., Cheung, M., Wheeler, D. C., Winkelmayer, W. C., Pecoits-Filho, R., Ashuntantang, G. E., Bakker, S. J. L., Bakris, G. L., Bhandari, S., Burdmann, E. A. & 33 others, Campbell, K. L., Charytan, D. M., Clegg, D. J., Cuppari, L., Goldsmith, D., Hallan, S. I., He, J., Herzog, C. A., Hoenig, M. P., Hoorn, E. J., Leipziger, J. G., Leonberg-Yoo, A. K., Lerma, E. V., Lopez-Almaraz, J. E., Małyszko, J., Mann, J. F. E., Marklund, M., McDonough, A. A., Nagahama, M., Navaneethan, S. D., Pitt, B., Pochynyuk, O. M., Proença de Moraes, T., Rafique, Z., Robinson, B. M., Roger, S. D., Rossignol, P., Singer, A. J., Smyth, A., Sood, M. M., Walsh, M., Weir, M. R. & Wingo, C. S., Jan 2020, In : Kidney International. 97, 1, p. 42-61 20 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Tacrolimus-induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurin

Gratreak, B. D. K., Swanson, E. A., Lazelle, R. A., Jelen, S. K., Hoenderop, J., Bindels, R. J., Yang, C. L. & Ellison, D. H., Jan 1 2020, In : Physiological reports. 8, 1, e14316.

Research output: Contribution to journalArticle

Open Access

WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia

Thomson, M. N., Cuevas, C. A., Bewarder, T. M., Dittmayer, C., Miller, L. N., Si, J., Cornelius, R. J., Su, X. T., Yang, C. L., McCormick, J. A., Hadchouel, J., Ellison, D. H., Bachmann, S. & Mutig, K., Jan 1 2020, In : American Journal of Physiology - Renal Physiology. 318, 1, p. F216-F228

Research output: Contribution to journalArticle

2019

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120

Research output: Contribution to journalArticle

Open Access

Clinical pharmacology in diuretic use

Ellison, D., Aug 7 2019, In : Clinical Journal of the American Society of Nephrology. 14, 8, p. 1248-1257 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Kir4.1/Kir5.1 in the DCT plays a role in the regulation of renal K + excretion

Su, X. T., Ellison, D. & Wang, W. H., Mar 1 2019, In : American journal of physiology. Renal physiology. 316, 3, p. F582-F586

Research output: Contribution to journalArticle

6 Scopus citations

Optical clearing and imaging of immunolabeled kidney tissue

Saritas, T., Puelles, V. G., Su, X. T., Ellison, D. & Kramann, R., Jul 1 2019, In : Journal of Visualized Experiments. 2019, 149, e60002.

Research output: Contribution to journalArticle

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney

Thomson, M. N., Schneider, W., Mutig, K., Ellison, D., Kettritz, R. & Bachmann, S., Feb 1 2019, In : American journal of physiology. Renal physiology. 316, 2, p. F292-F300

Research output: Contribution to journalArticle

Renal-Tubule Epithelial Cell Nomenclature for Single-Cell RNA-Sequencing Studies

Chen, L., Clark, J. Z., Nelson, J. W., Kaissling, B., Ellison, D. & Knepper, M. A., Aug 1 2019, In : Journal of the American Society of Nephrology : JASN. 30, 8, p. 1358-1364 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Salt-sensitive transcriptome of isolated kidney distal tubule cells

Swanson, E. A., Nelson, J. W., Jeng, S., Erspamer, K. J., Yang, C. L., McWeeney, S. & Ellison, D. H., Apr 2019, In : Physiological genomics. 51, 4, p. 125-135 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans

Thosar, S. S., Rueda, J., Berman, A. M., Lasarev, M. R., Herzig, M. X., Clemons, N. A., Roberts, S. A., Bowles, N. P., Emens, J., Ellison, D. & Shea, S., Feb 1 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 2, p. R157-R164

Research output: Contribution to journalArticle

1 Scopus citations

Serum Bicarbonate as a Surrogate for pH in Hemodialysis: A Pilot Study

Woodell, T. B., Rifkin, D. E., Ellison, D. H., Negoianu, D. & Weiss, J. W., Jan 1 2019, (Accepted/In press) In : Kidney Medicine.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

WNK4 limits distal calcium losses following acute furosemide treatment

Ferdaus, M. Z., Gratreak, B. D. K., Miller, L., Si, J., McCormick, J. A., Yang, C. L., Ellison, D. H. & Terker, A. S., Sep 1 2019, In : Physiological reports. 7, 17, e14195.

Research output: Contribution to journalArticle

Open Access
2018

C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity

Murillo-de-Ozores, A. R., Rodríguez-Gama, A., Bazúa-Valenti, S., Leyva-Ríos, K., Vázquez, N., Pacheco-Álvarez, D., De La Rosa-Velázquez, I. A., Wengi, A., Stone, K. L., Zhang, J., Loffing, J., Lifton, R. P., Yang, C-L., Ellison, D., Gamba, G. & Castañeda-Bueno, M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 31, p. 12209-12221 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension

Cornelius, R. J., Zhang, C., Erspamer, K. J., Agbor, L. N., Sigmund, C. D., Singer, J. D., Yang, C. L. & Ellison, D. H., Oct 1 2018, In : American journal of physiology. Renal physiology. 315, 4, p. F1006-F1018

Research output: Contribution to journalArticle

5 Scopus citations

Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension

Nelson, J. W., Ferdaus, M. Z., McCormick, J. J., Minnier, J., Kaul, S., Ellison, D. & Barnes, A., Feb 1 2018, In : Physiological Genomics. 50, 2, p. 104-116 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC

Argaiz, E. R., Chavez-Canales, M., Ostrosky-Frid, M., Rodríguez-Gama, A., Vázquez, N., Gonzalez-Rodriguez, X., Garcia-Valdes, J., Hadchouel, J., Ellison, D. & Gamba, G., Sep 6 2018, In : American Journal of Physiology - Renal Physiology. 315, 3, p. F734-F745

Research output: Contribution to journalArticle

10 Scopus citations

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling

Saritas, T., Puelles, V. G., Su, X. T., McCormick, J. J., Welling, P. A. & Ellison, D., Dec 4 2018, In : Cell Reports. 25, 10, p. 2668-2675.e3

Research output: Contribution to journalArticle

8 Scopus citations

Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel

Wang, M. X., Cuevas, C. A., Su, X. T., Wu, P., Gao, Z. X., Lin, D. H., McCormick, J. J., Yang, C-L., Wang, W. H. & Ellison, D., Jan 1 2018, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

27 Scopus citations

Renal COP9 signalosome deficiency alters CUL3-KLHL3-WNK signaling pathway

Cornelius, R. J., Si, J., Cuevas, C. A., Nelson, J. W., Gratreak, B. D. K., Pardi, R., Yang, C-L. & Ellison, D., Nov 1 2018, In : Journal of the American Society of Nephrology. 29, 11, p. 2627-2640 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule

Wu, P., Gao, Z. X., Su, X. T., Ellison, D. H., Hadchouel, J., Teulon, J. & Wang, W. H., Aug 2018, In : American Journal of Physiology - Renal Physiology. 315, 2, p. F223-F230

Research output: Contribution to journalArticle

2 Scopus citations

The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway

Bazúa-Valenti, S., Rojas-Vega, L., Castañeda-Bueno, M., Barrera-Chimal, J., Bautista, R., Cervantes-Pérez, L. G., Vázquez, N., Plata, C., Murillo-de-Ozores, A. R., González-Mariscal, L., Ellison, D. H., Riccardi, D., Bobadilla, N. A. & Gamba, G., Jul 2018, In : Journal of the American Society of Nephrology. 29, 7, p. 1838-1848 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

With no lysine kinase 4 modulates sodium potassium 2 chloride cotransporter activity in vivo

Terker, A. S., Castañeda-Bueno, M., Ferdaus, M. Z., Cornelius, R. J., Erspamer, K. J., Su, X. T., Miller, L. N., McCormick, J. J., Wang, W. H., Gamba, G., Yang, C-L. & Ellison, D., Oct 1 2018, In : American Journal of Physiology - Renal Physiology. 315, 4, p. F781-F790

Research output: Contribution to journalArticle

8 Scopus citations
2017

Calcineurin inhibitor cyclosporine A activates renal NA-K-CL cotransporters via local and systemic mechanisms

Blankenstein, K. I., Borschewski, A., Labes, R., Paliege, A., Boldt, C., McCormick, J. J., Ellison, D., Bader, M., Bachmann, S. & Mutig, K., Mar 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 3, p. F489-F501

Research output: Contribution to journalArticle

17 Scopus citations

Compensatory distal reabsorption drives diuretic resistance in human heart failure

Rao, V. S., Planavsky, N., Hanberg, J. S., Ahmad, T., Brisco-Bacik, M. A., Wilson, F. P., Jacoby, D., Chen, M., Tang, W. H. W., Cherney, D. Z. I., Ellison, D. & Testani, J. M., Nov 1 2017, In : Journal of the American Society of Nephrology. 28, 11, p. 3414-3424 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Blanchard, A., Bockenhauer, D., Bolignano, D., Calò, L. A., Cosyns, E., Devuyst, O., Ellison, D. H., Karet Frankl, F. E., Knoers, N. V. A. M., Konrad, M., Lin, S. H. & Vargas-Poussou, R., Jan 1 2017, In : Kidney International. 91, 1, p. 24-33 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Potassium sensing by renal distal tubules requires Kir4.1

Cuevas, C. A., Su, X. T., Wang, M. X., Terker, A. S., Lin, D. H., McCormick, J. J., Yang, C-L., Ellison, D. & Wang, W. H., Jun 1 2017, In : Journal of the American Society of Nephrology. 28, 6, p. 1814-1825 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure

ter Maaten, J. M., Rao, V. S., Hanberg, J. S., Perry Wilson, F., Bellumkonda, L., Assefa, M., Sam Broughton, J., D'Ambrosi, J., Wilson Tang, W. H., Damman, K., Voors, A. A., Ellison, D. & Testani, J. M., 2017, (Accepted/In press) In : European Journal of Heart Failure.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Anaesthesia recommendations for patients suffering from Liddle's syndrome

McCaul, C., Caulfield, K., Sinha, R. & Ellison, D., Sep 1 2016, In : Anasthesiologie und Intensivmedizin. 57, 9, p. S500-S505

Research output: Contribution to journalArticle

Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl- Cotransporter

Borschewski, A., Himmerkus, N., Boldt, C., Blankenstein, K. I., McCormick, J. J., Lazelle, R., Willnow, T. E., Jankowski, V., Plain, A., Bleich, M., Ellison, D., Bachmann, S. & Mutig, K., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 1, p. 107-119 13 p.

Research output: Contribution to journalArticle

16 Scopus citations

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension

Zhang, C., Meermeier, N. P., Terker, A. S., Blankenstein, K. I., Singer, J. D., Hadchouel, J., Ellison, D. H. & Yang, C. L., Jan 1 2016, In : Biochemical and Biophysical Research Communications. 469, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Direct and indirect mineralocorticoid effects determine distal salt transport

Terker, A. S., Yarbrough, B., Ferdaus, M. Z., Lazelle, R. A., Erspamer, K. J., Meermeier, N. P., Park, H. J., McCormick, J. J., Yang, C-L. & Ellison, D., 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2436-2445 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Diuretic Resistance

Hoorn, E. J. & Ellison, D., Feb 23 2016, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

27 Scopus citations

Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases

Hadchouel, J., Ellison, D. & Gamba, G., Feb 10 2016, In : Annual Review of Physiology. 78, p. 367-389 23 p.

Research output: Contribution to journalArticle

84 Scopus citations

Renal deletion of 12 kDa FK506-binding protein attenuates tacrolimus-induced hypertension

Lazelle, R. A., McCully, B., Terker, A. S., Himmerkus, N., Blankenstein, K. I., Mutig, K., Bleich, M., Bachmann, S., Yang, C-L. & Ellison, D., May 1 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

Terker, A. S., Zhang, C., Erspamer, K. J., Gamba, G., Yang, C. L. & Ellison, D. H., Jan 1 2016, In : Kidney International. 89, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

99 Scopus citations
2015

An Integrated View of Potassium Homeostasis

Hoorn, E. J., Loffing, J. & Ellison, D. H., Oct 29 2015, In : The New England journal of medicine. 373, 18, p. 1786 1 p.

Research output: Contribution to journalArticle

Distal convoluted tubule

McCormick, J. A. & Ellison, D. H., Jan 1 2015, In : Comprehensive Physiology. 5, 1, p. 45-98 54 p.

Research output: Contribution to journalArticle

40 Scopus citations

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter

Wang, J., Sun, C., Gerdes, N., Liu, C., Liao, M., Liu, J., Shi, M. A., He, A., Zhou, Y., Sukhova, G. K., Chen, H., Cheng, X. W., Kuzuya, M., Murohara, T., Zhang, J., Cheng, X., Jiang, M., Shull, G. E., Rogers, S., Yang, C. L. & 7 others, Ke, Q., Jelen, S., Bindels, R., Ellison, D. H., Jarolim, P., Libby, P. & Shi, G. P., Jul 9 2015, In : Nature medicine. 21, 7, p. 820-826 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride

Terker, A. S., Zhang, C., McCormick, J. A., Lazelle, R. A., Zhang, C., Meermeier, N. P., Siler, D. A., Park, H. J., Fu, Y., Cohen, D. M., Weinstein, A. M., Wang, W. H., Yang, C. L. & Ellison, D. H., Jan 6 2015, In : Cell Metabolism. 21, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

173 Scopus citations

The effect of WNK4 on the Na+-Cl- cotransporter is modulated by intracellular chloride

Bazúa-Valenti, S., Chávez-Canales, M., Rojas-Vega, L., González-Rodríguez, X., Vázquez, N., Rodríguez-Gama, A., Argaiz, E. R., Melo, Z., Plata, C., Ellison, D. H., García-Valdés, J., Hadchouel, J. & Gamba, G., Aug 1 2015, In : Journal of the American Society of Nephrology. 26, 8, p. 1781-1786 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Why Your Mother Was Right: How Potassium Intake Reduces Blood Pressure

Ellison, D. & Terker, A. S., 2015, In : Transactions of the American Clinical and Climatological Association. 126, p. 46-55 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Distal convoluted tubule

Subramanya, A. R. & Ellison, D. H., Jan 1 2014, In : Clinical Journal of the American Society of Nephrology. 9, 12, p. 2147-2163 17 p.

Research output: Contribution to journalArticle

82 Scopus citations

Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3

McCormick, J. A., Yang, C. L., Zhang, C., Davidge, B., Blankenstein, K. I., Terker, A. S., Yarbrough, B., Meermeier, N. P., Park, H. J., McCully, B., West, M., Borschewski, A., Himmerkus, N., Bleich, M., Bachmann, S., Mutig, K., Argaiz, E. R., Gamba, G., Singer, J. D. & Ellison, D. H., Nov 3 2014, In : Journal of Clinical Investigation. 124, 11, p. 4723-4736 14 p.

Research output: Contribution to journalArticle

62 Scopus citations

Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension

Picard, N., Trompf, K., Yang, C. L., Miller, R. L., Carrel, M., Loffing-Cueni, D., Fenton, R. A., Ellison, D. H. & Loffing, J., Mar 1 2014, In : Journal of the American Society of Nephrology. 25, 3, p. 511-522 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension

Terker, A. S., Yang, C. L., McCormick, J. A., Meermeier, N. P., Rogers, S. L., Grossmann, S., Trompf, K., Delpire, E., Loffing, J. & Ellison, D. H., Jul 2014, In : Hypertension. 64, 1, p. 178-184 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4

Chávez-Canales, M., Zhang, C., Soukaseum, C., Moreno, E., Pacheco-Alvarez, D., Vidal-Petiot, E., Castañeda-Bueno, M., Vázquez, N., Rojas-Vega, L., Meermeier, N. P., Rogers, S., Jeunemaitre, X., Yang, C. L., Ellison, D. H., Gamba, G. & Hadchouel, J., Nov 1 2014, In : Hypertension. 64, 5, p. 1047-1053 7 p.

Research output: Contribution to journalArticle

49 Scopus citations
2013

PharmGKB summary: Diuretics pathway, pharmacodynamics

Thorn, C. F., Ellison, D. H., Turner, S. T., Altman, R. B. & Klein, T. E., Aug 1 2013, In : Pharmacogenetics and Genomics. 23, 8, p. 449-453 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

SPAK differentially mediates vasopressin effects on sodium cotransporters

Saritas, T., Borschewski, A., McCormick, J. A., Paliege, A., Dathe, C., Uchida, S., Terker, A., Himmerkus, N., Bleich, M., Demaretz, S., Laghmani, K., Delpire, E., Ellison, D. H., Bachmann, S. & Mutig, K., Feb 28 2013, In : Journal of the American Society of Nephrology. 24, 3, p. 407-418 12 p.

Research output: Contribution to journalArticle

63 Scopus citations