David Cohen

Professor

  • 3753 Citations
  • 34 h-Index
1990 …2019
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Research Output 1991 2019

  • 3753 Citations
  • 34 h-Index
  • 81 Article
  • 1 Chapter
  • 1 Letter
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Article
2019

Heritability and individuality of the plasma sodium concentration: a twin study in the United States veteran population

Timmons, A. K., Korpak, A. M., Tan, J., Moore, K. P., Liu, C. H., Forsberg, C. W., Goldberg, J., Smith, N. L. & Cohen, D., Jun 1 2019, In : American journal of physiology. Renal physiology. 316, 6, p. F1114-F1123

Research output: Contribution to journalArticle

Twin Studies
Veterans
Individuality
Sodium
Population
Nephrotic Syndrome
Adrenocorticotropic Hormone
Glucocorticoids
Kidney
Costs and Cost Analysis
2018
1 Citation (Scopus)

Elephant in the room

Hartung, D. M., Johnston, K., Cohen, D., Nguyen, T., Deodhar, A. A. & Bourdette, D., Jan 23 2018, (Accepted/In press) In : Annals of the Rheumatic Diseases.

Research output: Contribution to journalArticle

Polymyositis
Dermatomyositis
Adrenal Cortex Hormones
2017
4 Citations (Scopus)

NFAT5 and SLC4A10 loci associate with plasma osmolality

Böger, C. A., Gorski, M., McMahon, G. M., Xu, H., Chang, Y. P. C., Van Der Most, P. J., Navis, G., Nolte, I. M., De Borst, M. H., Zhang, W., Lehne, B., Loh, M., Tan, S. T., Boerwinkle, E., Grams, M. E., Sekula, P., Li, M., Wilmot, B., Moon, J. G., Scheet, P. & 86 others, Cucca, F., Xiao, X., Lyytikäinen, L. P., Delgado, G., Grammer, T. B., Kleber, M. E., Sedaghat, S., Rivadeneira, F., Corre, T., Kutalik, Z., Bergmann, S., Nielson, C., Srikanth, P., Teumer, A., Müller-Nurasyid, M., Brockhaus, A. C., Pfeufer, A., Rathmann, W., Peters, A., Matsumoto, M., De Andrade, M., Atkinson, E. J., Robinson-Cohen, C., De Boer, I. H., Hwang, S. J., Heid, I. M., Gögele, M., Concas, M. P., Tanaka, T., Bandinelli, S., Nalls, M. A., Singleton, A., Tajuddin, S. M., Adeyemo, A., Zhou, J., Doumatey, A., McWeeney, S., Murabito, J., Franceschini, N., Flessner, M., Shlipak, M., Wilson, J. G., Chen, G., Rotimi, C. N., Zonderman, A. B., Evans, M. K., Ferrucci, L., Devuyst, O., Pirastu, M., Shuldiner, A., Hicks, A. A., Pramstaller, P. P., Kestenbaum, B., Kardia, S. L. R., Turner, S. T., Study, L. C., Briske, T. E., Gieger, C., Strauch, K., Meisinger, C., Meitinger, T., Völker, U., Nauck, M., Völzke, H., Vollenweider, P., Bochud, M., Waeber, G., Kähönen, M., Lehtimäki, T., März, W., Dehghan, A., Franco, O. H., Uitterlinden, A. G., Hofman, A., Taylor, H. A., Chambers, J. C., Kooner, J. S., Fox, C. S., Hitzemann, R., Orwoll, E., Pattaro, C., Schlessinger, D., Köttgen, A., Snieder, H., Parsa, A. & Cohen, D., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2311-2321 11 p.

Research output: Contribution to journalArticle

Osmolar Concentration
Meta-Analysis
Water
Sodium
Hypernatremia
7 Citations (Scopus)

Trends and characteristics of US Medicare spending on repository corticotropin

Hartung, D. M., Johnston, K., Van Leuven, S., Deodhar, A. A., Cohen, D. & Bourdette, D., Nov 1 2017, In : JAMA Internal Medicine. 177, 11, p. 1680-1682 3 p.

Research output: Contribution to journalArticle

Medicare
Adrenocorticotropic Hormone
2016
1 Citation (Scopus)

Modeling the neurologic and cognitive effects of hyponatremia

Cohen, D., Mar 1 2016, In : Journal of the American Society of Nephrology. 27, 3, p. 659-661 3 p.

Research output: Contribution to journalArticle

Neurologic Gait Disorders
Inappropriate ADH Syndrome
Hyponatremia
Memory Disorders
Nervous System
15 Citations (Scopus)

The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis

Garinis, A. C., Cross, C. P., Srikanth, P., Carroll, K., Feeney, M. P., Keefe, D. H., Hunter, L. L., Putterman, D. B., Cohen, D., Gold, J. J. & Steyger, P., Jul 19 2016, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

Cystic Fibrosis
Hearing
Anti-Bacterial Agents
Aminoglycosides
Hearing Loss
2015
4 Citations (Scopus)

A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5′UTR causing primary hyperoxaluria type II

Fu, Y., Rope, R., Fargue, S., Cohen, H. T., Holmes, R. P. & Cohen, D., Nov 1 2015, In : Clinical Genetics. 88, 5, p. 494-498 5 p.

Research output: Contribution to journalArticle

Frameshift Mutation
Untranslated Regions
Mutation
Inborn Genetic Diseases
Luciferases
4 Citations (Scopus)

Evaluating hyponatremia

Cohen, D. & Ellison, D., Mar 24 2015, In : JAMA - Journal of the American Medical Association. 313, 12, p. 1260-1261 2 p.

Research output: Contribution to journalArticle

Inappropriate ADH Syndrome
Hyponatremia
Haloperidol
Sodium Chloride
Abdominal Pain
149 Citations (Scopus)

Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride

Terker, A. S., Zhang, C., McCormick, J. J., Lazelle, R. A., Zhang, C., Meermeier, N. P., Siler, D. A., Park, H. J., Fu, Y., Cohen, D., Weinstein, A. M., Wang, W. H., Yang, C-L. & Ellison, D., Jan 6 2015, In : Cell Metabolism. 21, 1, p. 39-50 12 p.

Research output: Contribution to journalArticle

Water-Electrolyte Balance
Chlorides
Potassium
Blood Pressure
Dietary Potassium
2014
7 Citations (Scopus)

Hourly oral sodium chloride for the rapid and predictable treatment of hyponatremia

Kerns, E., Patel, S. & Cohen, D., 2014, In : Clinical Nephrology. 82, 6, p. 397-401 5 p.

Research output: Contribution to journalArticle

Hyponatremia
Sodium Chloride
Sodium
Serum
Intensive Care Units
15 Citations (Scopus)

Individuality of the plasma sodium concentration

Zhang, Z., Duckart, J., Slatore, C. G., Fu, Y., Petrik, A. F., Thorp, M. L. & Cohen, D., Jun 15 2014, In : American Journal of Physiology - Renal Physiology. 306, 12

Research output: Contribution to journalArticle

Individuality
Sodium
Population
Normal Distribution
Creatinine
7 Citations (Scopus)

Transcriptome-based analysis of kidney gene expression changes associated with diabetes in OVE26 mice, in the presence and absence of losartan treatment

Komers, R., Xu, B., Fu, Y., McClelland, A., Kantharidis, P., Mittal, A., Cohen, H. T. & Cohen, D., May 14 2014, In : PLoS One. 9, 5, e96987.

Research output: Contribution to journalArticle

Losartan
Gene Expression Profiling
Medical problems
Gene expression
transcriptome
2013
Chronic Kidney Failure
Renal Artery Obstruction
Transplants
Kidney
Dialysis
10 Citations (Scopus)

Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma

Zeng, L., Bai, M., Mittal, A. K., El-Jouni, W., Zhou, J., Cohen, D., Zhou, M. I. & Cohen, H. T., Sep 1 2013, In : Cancer Research. 73, 17, p. 5371-5380 10 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Neoplasms
Phosphotransferases
Homeodomain Proteins
Plant Proteins
4 Citations (Scopus)
Arginine
Sodium
Serum
Gene Frequency
Population
2012
12 Citations (Scopus)

Heritability of serum sodium concentration: Evidence for sex- and ethnic-specific effects

Wilmot, B., Saroja Voruganti, V., Chang, Y. P. C., Fu, Y., Chen, Z., Taylor, H. A., Wilson, J. G., Gipson, T., Shah, V. O., Umans, J. G., Flessner, M. F., Hitzemann, R., Shuldiner, A. R., Comuzzie, A. G., McWeeney, S., Zager, P. G., Maccluer, J. W., Cole, S. A. & Cohen, D., Feb 2012, In : Physiological Genomics. 44, 3, p. 220-228 9 p.

Research output: Contribution to journalArticle

North American Indians
Sodium
Serum
Glomerular Filtration Rate
Glucose
2011
37 Citations (Scopus)

African American living-kidney donors should be screened for apol1 risk alleles

Cohen, D., Mittalhenkle, A., Scott, D., Young, C. J. & Norman, D., Oct 15 2011, In : Transplantation. 92, 7, p. 722-725 4 p.

Research output: Contribution to journalArticle

Living Donors
African Americans
Alleles
Kidney
Chronic Kidney Failure
2010
2 Citations (Scopus)

Absence of AVPR2 copy number variation in eunatremic and dysnatremic subjects in non-Hispanic Caucasian populations

Fu, Y., Chen, Z., Blakemore, A. I. F., Orwoll, E. & Cohen, D., Feb 2010, In : Physiological Genomics. 40, 3, p. 121-127 7 p.

Research output: Contribution to journalArticle

Vasopressin Receptors
Gene Dosage
Population
Genes
Sodium
62 Citations (Scopus)

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

Ceppa, E., Cattaruzza, F., Lyo, V., Amadesi, S., Pelayo, J. C., Poole, D. P., Vaksman, N., Liedtke, W., Cohen, D., Grady, E. F., Bunnett, N. W. & Kirkwood, K. S., Sep 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 3

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Ion Channels
Pancreatitis
Pain
Nociceptors
2009
67 Citations (Scopus)

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

Tian, W., Fu, Y., Garcia-Elias, A., Fernández-Fernández, J. M., Vicente, R., Kramer, P. L., Klein, R., Hitzemann, R., Orwoll, E., Wilmot, B., McWeeney, S., Valverde, M. A. & Cohen, D., Aug 18 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 33, p. 14034-14039 6 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Hyponatremia
Sodium
Alleles
Osmotic Pressure
55 Citations (Scopus)

Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion

Fu, Y., Tian, W., Pratt, E. B., Dirling, L. B., Shyng, S-L., Meshul, C. K. & Cohen, D., May 25 2009, In : PLoS One. 4, 5, e5679.

Research output: Contribution to journalArticle

insulin secretion
islets of Langerhans
Insulin-Secreting Cells
Rats
insulin
2008
101 Citations (Scopus)

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

Sipe, W. E. B., Brierley, S. M., Martin, C. M., Phillis, B. D., Cruz, F. B., Grady, E. F., Liedtke, W., Cohen, D., Vanner, S., Blackshaw, L. A. & Bunnett, N. W., May 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 5

Research output: Contribution to journalArticle

Visceral Afferents
PAR-2 Receptor
TRPV Cation Channels
Hyperalgesia
Afferent Neurons
48 Citations (Scopus)

TRPV4 enhances the cellular uptake of aminoglycoside antibiotics

Karasawa, T., Wang, Q., Fu, Y., Cohen, D. & Steyger, P., Sep 1 2008, In : Journal of Cell Science. 121, 17, p. 2871-2879 9 p.

Research output: Contribution to journalArticle

Aminoglycosides
Gentamicins
Anti-Bacterial Agents
Cell Line
Cochlea
4 Citations (Scopus)

White thrombus formation in blood tubing lines in a chronic hemodialysis unit

Watnick, S., Stooksbury, M., Winter, R., Riscoe, M. & Cohen, D., Mar 2008, In : Clinical Journal of the American Society of Nephrology. 3, 2, p. 382-386 5 p.

Research output: Contribution to journalArticle

Renal Dialysis
Thrombosis
Dialysis
Vascular Access Devices
United States Department of Veterans Affairs
2007
50 Citations (Scopus)

Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene

Xu, H., Tian, W., Fu, Y., Oyama, T. T., Anderson, S. & Cohen, D., Dec 2007, In : American Journal of Physiology - Renal Physiology. 293, 6

Research output: Contribution to journalArticle

Capsaicin
Genes
Neurogenic Inflammation
Transient Receptor Potential Channels
Nociception
34 Citations (Scopus)

Renal p38 MAP kinase activity in experimental diabetes

Komers, R., Lindsley, J. N., Oyama, T. T., Cohen, D. & Anderson, S., Jun 2007, In : Laboratory Investigation. 87, 6, p. 548-558 11 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Kidney
Dual Specificity Phosphatase 1
Diabetic Nephropathies
Mitogen-Activated Protein Kinase 6
18 Citations (Scopus)
TRPV Cation Channels
Transient Receptor Potential Channels
Osmoregulation
Cations
Kidney
2006
55 Citations (Scopus)
Transient Receptor Potential Channels
Glycosylation
Membranes
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Cell Membrane
36 Citations (Scopus)

Regulation of TRP channels by N-linked glycosylation

Cohen, D., Dec 2006, In : Seminars in Cell and Developmental Biology. 17, 6, p. 630-637 8 p.

Research output: Contribution to journalArticle

Glycosylation
Glucuronidase
Proteins
35 Citations (Scopus)

Regulation of TRPV1 by a novel renally expressed rat TRPV1 splice variant

Tian, W., Fu, Y., Wang, D. H. & Cohen, D., Jan 2006, In : American Journal of Physiology - Renal Physiology. 290, 1

Research output: Contribution to journalArticle

Kidney
RNA Splice Sites
Kidney Medulla
Sensory Ganglia
Transient Receptor Potential Channels
16 Citations (Scopus)

The role of MAPKs in B cell receptor-induced down-regulation of Egr-1 in immature B lymphoma cells

Ke, J., Gururajan, M., Kumar, A., Simmons, A., Turcios, L., Chelvarajan, R. L., Cohen, D., Wiest, D. L., Monroe, J. G. & Bondada, S., Dec 29 2006, In : Journal of Biological Chemistry. 281, 52, p. 39806-39818 13 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
Lymphoma
B-Lymphocytes
Down-Regulation
Cells
67 Citations (Scopus)

WNK kinases influence TRPV4 channel function and localization

Fu, Y., Subramanya, A., Rozansky, D. & Cohen, D., Jun 2006, In : American Journal of Physiology - Renal Physiology. 290, 6

Research output: Contribution to journalArticle

Phosphotransferases
Nephrons
Transient Receptor Potential Channels
HEK293 Cells
Hypercalcemia
2005
19 Citations (Scopus)

EphA2: Expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo

Xu, H., Tian, W., Lindsley, J. N., Oyama, T. T., Capasso, J. M., Rivard, C. J., Cohen, H. T., Bagnasco, S. M., Anderson, S. & Cohen, D., Apr 2005, In : American Journal of Physiology - Renal Physiology. 288, 4 57-4

Research output: Contribution to journalArticle

Urea
EphA2 Receptor
Kidney
Epidermal Growth Factor Receptor
Transcriptional Activation
39 Citations (Scopus)

Interleukin-10 suppresses tissue factor expression in lipopolysaccharide- stimulated macrophages via inhibition of Egr-1 and a serum response element/MEK-ERK1/2 pathway

Kamimura, M., Viedt, C., Dalpke, A., Rosenfeld, M. E., Mackman, N., Cohen, D., Blessing, E., Preusch, M., Weber, C. M., Kreuzer, J., Katus, H. A. & Bea, F., Aug 19 2005, In : Circulation Research. 97, 4, p. 305-313 9 p.

Research output: Contribution to journalArticle

Serum Response Element
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Thromboplastin
Interleukin-10
58 Citations (Scopus)

SRC family kinases in cell volume regulation

Cohen, D., Mar 2005, In : American Journal of Physiology - Cell Physiology. 288, 3 57-3

Research output: Contribution to journalArticle

Osmotic Pressure
Cell Size
Protein-Tyrosine Kinases
Phosphotransferases
Aptitude
45 Citations (Scopus)

TRPV4 and the mammalian kidney

Cohen, D., Oct 2005, In : Pflugers Archiv European Journal of Physiology. 451, 1, p. 168-175 8 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Kidney
Metabolites
Kidney Tubules
Osmoregulation
2004
102 Citations (Scopus)

Renal expression of osmotically responsive cation channel TRPV4 is restricted to water-impermeant nephron segments

Tian, W., Salanova, M., Xu, H., Lindsley, J. N., Oyama, T. T., Anderson, S., Bachmann, S. & Cohen, D., Jul 2004, In : American Journal of Physiology - Renal Physiology. 287, 1 56-1

Research output: Contribution to journalArticle

Nephrons
Cations
Extremities
Kidney
Water
2003
34 Citations (Scopus)
Cyclooxygenase 2
Transcriptional Activation
Epithelial Cells
Kidney
Epidermal Growth Factor Receptor
4 Citations (Scopus)

Of rafts and moving water.

Cohen, D., 2003, In : Science's STKE : signal transduction knowledge environment. 2003, 199

Research output: Contribution to journalArticle

Osmoregulation
Phospholipase C delta
Calcium
Calcium-Sensing Receptors
Water
147 Citations (Scopus)
Transient Receptor Potential Channels
Phosphorylation
src-Family Kinases
Osmotic Pressure
Tyrosine
13 Citations (Scopus)

Urea signalling to immediate-early gene transcription in renal medullary cells requires transactivation of the epidermal growth factor receptor

Zhao, H., Tian, W., Xu, H. & Cohen, D., Mar 1 2003, In : Biochemical Journal. 370, 2, p. 479-487 9 p.

Research output: Contribution to journalArticle

Genetic Transcription
Immediate-Early Genes
Transcription
Epidermal Growth Factor Receptor
Transcriptional Activation
2002
9 Citations (Scopus)

Effects of cyclooxygenase-2 (COX-2) inhibition on plasma and renal renin in diabetes

Komers, R., Tian, W., Lindsley, J. N., Oyama, T. T., Cohen, D. & Anderson, S., Nov 1 2002, In : Journal of Laboratory and Clinical Medicine. 140, 5, p. 351-357 7 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Medical problems
Renin
Rats
Angiotensin-Converting Enzyme Inhibitors
22 Citations (Scopus)
Protein Kinase C
Carrier Proteins
Osmotic Pressure
Protein Isoforms
rottlerin
21 Citations (Scopus)
Osmotic Pressure
Epidermal Growth Factor
Urea
Kidney
Cytoprotection
2001
36 Citations (Scopus)

Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells

Bernal-Mizrachi, E., Wen, W., Srinivasan, S., Klenk, A., Cohen, D. & Alan Permutt, M., 2001, In : American Journal of Physiology - Endocrinology and Metabolism. 281, 6 44-6

Research output: Contribution to journalArticle

ets-Domain Protein Elk-1
Proto-Oncogene Protein c-ets-1
Insulinoma
Islets of Langerhans
Epidermal Growth Factor
18 Citations (Scopus)
Kidney Medulla
Gene expression
Urea
Genes
Kidney
24 Citations (Scopus)

Urea and hypertonicity increase expression of heme oxygenase-1 in murine renal medullary cells

Tian, W., Bonkovsky, H. L., Shibahara, S. & Cohen, D., 2001, In : American Journal of Physiology - Renal Physiology. 281, 5 50-5

Research output: Contribution to journalArticle

Heme Oxygenase-1
Urea
Kidney
Response Elements
Messenger RNA
22 Citations (Scopus)

Urea inhibits hypertonicity-inducible TonEBP expression and action

Tian, W. & Cohen, D., May 2001, In : American Journal of Physiology - Renal Physiology. 280, 5 49-5

Research output: Contribution to journalArticle

NFATC Transcription Factors
Urea
Proteasome Endopeptidase Complex
Genes
Aldehyde Reductase
2 Citations (Scopus)

Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry

Yang, X. Y., Zhao, H., Zhang, Z., Rodland, K. D., Roullet, J-B. & Cohen, D., Jan 2001, In : American Journal of Physiology - Renal Physiology. 280, 1 49-1

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Urea
Phosphorylation
Calcium
Kidney