Charles Lopez

Associate Professor

  • 968 Citations
  • 17 h-Index
1990 …2020

Research output per year

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Research Output

  • 968 Citations
  • 17 h-Index
  • 29 Article
  • 5 Review article
  • 2 Comment/debate
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Article
2020

Effect of Time to Surgery of Colorectal Liver Metastases on Survival

Chen, E. Y., Mayo, S. C., Sutton, T., Kearney, M. R., Kardosh, A., Vaccaro, G. M., Billingsley, K. G. & Lopez, C. D., Jan 1 2020, (Accepted/In press) In : Journal of Gastrointestinal Cancer.

Research output: Contribution to journalArticle

Open Access
2019

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C. D., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G. & Sears, R. C., Jan 1 2019, In : Cancer Research. 79, 1, p. 209-219 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia

Schittenhelm, M. M., Walter, B., Tsintari, V., Federmann, B., Bajrami Saipi, M., Akmut, F., Illing, B., Mau-Holzmann, U., Fend, F., Lopez, C. & Kampa-Schittenhelm, K. M., Apr 1 2019, In : EBioMedicine. 42, p. 340-351 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A Phase II Study Alternating Erlotinib With Second-line mFOLFOX6 or FOLFIRI for Metastatic Colorectal Cancer

Kearney, M. R., Chen, E. Y., Vaccaro, G., Strother, J., Burt, A., Todd, K., Donovan, J., Kampa-Schittenhelm, K. M. & Lopez, C., Jan 1 2019, In : Anticancer Research. 39, 1, p. 245-252 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A Phase II Study of Celecoxib with Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Previously Untreated Advanced or Metastatic Colorectal Cancer

Chen, E. Y., Blanke, C., Haller, D. G., Benson, A. B., Dragovich, T., Lenz, H. J., Robles, C., Li, H., Mori, M. T., Mattek, N., Sanborn, R. E. & Lopez, C., Dec 1 2018, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 41, 12, p. 1193-1198 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S., Fischer, J. & 8 others, Jaboin, J., Billingsley, K., Lopez, C., Burchard, J., Gray, J., Coussens, L., Sheppard, B. & Wong, M., Sep 12 2018, In : Science advances. 4, 9, eaat7828.

Research output: Contribution to journalArticle

32 Scopus citations

Colorectal Cancer-Associated Spontaneous Tumor Lysis Syndrome: a Case Report and Review of the Current Literature

Kearney, M. R., Chen, E. Y., Stenzel, P., Corless, C., Deloughery, T., Zivney, M. & Lopez, C., Apr 25 2018, (Accepted/In press) In : Journal of Gastrointestinal Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Phase II open label pilot trial of aprepitant and palonosetron for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic FOLFOX chemotherapy for the treatment of colorectal cancer

Bubalo, J. S., Herrington, J. D., Takemoto, M., Willman, P., Edwards, M. S., Williams, C., Fisher, A., Palumbo, A., Chen, E., Blanke, C. & Lopez, C. D., Apr 1 2018, In : Supportive Care in Cancer. 26, 4, p. 1273-1279 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Chemoradiation for locally advanced unresectable pancreatic cancer - What now?

Vaccaro, G. & Lopez, C., Jun 1 2017, In : JAMA oncology. 3, 6, p. 850-851 2 p.

Research output: Contribution to journalArticle

ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival

Van Hook, K., Wang, Z., Chen, D., Nold, C., Zhu, Z., Anur, P., Lee, H. J., Yu, Z., Sheppard, B., Dai, M. S., Sears, R., Spellman, P. & Lopez, C. D., Jan 22 2017, In : Biochemical and Biophysical Research Communications. 482, 4, p. 1271-1277 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer

Farrell, A. S., Allen-Petersen, B., Daniel, C. J., Wang, X., Wang, Z., Rodriguez, S., Impey, S., Oddo, J., Vitek, M. P., Lopez, C., Christensen, D. J., Sheppard, B. & Sears, R. C., Jun 2014, In : Molecular Cancer Research. 12, 6, p. 924-939 16 p.

Research output: Contribution to journalArticle

54 Scopus citations
2013

Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure

Schittenhelm, M. M., Illing, B., Ahmut, F., Rasp, K. H., Blumenstock, G., Döhner, K., Lopez, C. D. & Kampa-Schittenhelm, K. M., Nov 27 2013, In : PloS one. 8, 11, e80193.

Research output: Contribution to journalArticle

11 Scopus citations

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

Wang, Z., Liu, Y., Takahashi, M., Van Hook, K., Kampa-Schittenhelm, K. M., Sheppard, B. C., Sears, R. C., Stork, P. J. S. & Lopez, C. D., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 312-317 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Putting the pieces together: Necrolytic migratory erythema and the glucagonoma syndrome

Halvorson, S. A. C., Gilbert, E., Hopkins, R. S., Liu, H., Lopez, C., Chu, M., Martin, M. & Sheppard, B., Nov 1 2013, In : Journal of general internal medicine. 28, 11, p. 1525-1529 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study

Safran, H., Miner, T., Bahary, N., Whiting, S., Lopez, C. D., Sun, W., Charpentier, K., Shipley, J., Anderson, E., McNulty, B., Schumacher, A., Clark, A., Vakharia, J., Kennedy, T. & Sio, T., Feb 1 2011, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 34, 1, p. 50-52 3 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

Kampa, K. M., Acoba, J. D., Chen, D., Gay, J., Lee, H., Beemer, K., Padiernos, E., Boonmark, N., Zhu, Z., Fan, A. C., Bailey, A. S., Fleming, W. H., Corless, C., Felsher, D. W., Naumovski, L. & Lopez, C. D., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4390-4395 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
33 Scopus citations
2008

E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair

Chen, D., Yu, Z., Zhu, Z. & Lopez, C. D., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 15381-15389 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells

Chen, D., Yu, Z., Zhu, Z. & Lopez, C. D., Apr 1 2006, In : Cancer Research. 66, 7, p. 3485-3494 10 p.

Research output: Contribution to journalArticle

66 Scopus citations
2005

Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene

Chen, D., Padiernos, E., Ding, F., Lossos, I. S. & Lopez, C. D., Apr 1 2005, In : Cell Death and Differentiation. 12, 4, p. 358-368 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

Control of ASPP2/53BP2L protein levels by proteasomal degradation modulates p53 apoptotic function

Zhu, Z., Ramos, J., Kampa, K., Adimoolam, S., Sirisawad, M., Yu, Z., Chen, D., Naumovski, L. & Lopez, C. D., Oct 14 2005, In : Journal of Biological Chemistry. 280, 41, p. 34473-34480 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2002

Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cel and follicular center lymphoma: Correlation with clinical outcome

Lossos, I. S., Natkunam, Y., Levy, R. & Lopez, C. D., Dec 1 2002, In : Leukemia and Lymphoma. 43, 12, p. 2309-2317 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites

Qian, H., Wang, T., Naumovski, L., Lopez, C. D. & Brachmann, R. K., Nov 7 2002, In : Oncogene. 21, 51, p. 7901-7911 11 p.

Research output: Contribution to journalArticle

109 Scopus citations

Inhibition of cell death by ribosomal protein L35a

Lopez, C. D., Martinovsky, G. & Naumovski, L., Jun 28 2002, In : Cancer Letters. 180, 2, p. 195-202 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2000

Deregulation of p53-interacting protein 53bp2 by chemotherapy drugs or proteasomal inhibition may modulate chemotherapy-induced cell death

Lee, K. & Lopez, C., Dec 1 2000, In : Blood. 96, 11 PART II, p. 174b

Research output: Contribution to journalArticle

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53

Lopez, C. D., Ao, Y., Rohde, L. H., Perez, T. D., O'Connor, D. J., Lu, X., Ford, J. M. & Naumovski, L., Jan 1 2000, In : Molecular and cellular biology. 20, 21, p. 8018-8025 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
1990

Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein

Yost, C. S., Lopez, C. D., Prusiner, S. B., Myers, R. M. & Lingappa, V. R., Jan 1 1990, In : Nature. 343, 6259, p. 669-672 4 p.

Research output: Contribution to journalArticle

104 Scopus citations

Unusual topogenic sequence directs prion protein biogenesis

Lopez, C. D., Yost, C. S., Prusiner, S. B., Myers, R. M. & Lingappa, V. R., Jan 1 1990, In : Science. 248, 4952, p. 226-229 4 p.

Research output: Contribution to journalArticle

109 Scopus citations