Charles Lopez

Associate Professor

  • 885 Citations
  • 16 h-Index
1990 …2019
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Research Output 1990 2019

  • 885 Citations
  • 16 h-Index
  • 32 Article
  • 3 Review article
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Article
2019
7 Citations (Scopus)

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

Allen-Petersen, B. L., Risom, T., Feng, Z., Wang, Z., Jenny, Z. P., Thoma, M. C., Pelz, K. R., Morton, J. P., Sansom, O. J., Lopez, C., Sheppard, B., Christensen, D. J., Ohlmeyer, M., Narla, G. & Sears, R., Jan 1 2019, In : Cancer Research. 79, 1, p. 209-219 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Adenocarcinoma
Phosphoric Monoester Hydrolases
Phosphotransferases
Growth

Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia

Schittenhelm, M. M., Walter, B., Tsintari, V., Federmann, B., Bajrami Saipi, M., Akmut, F., Illing, B., Mau-Holzmann, U., Fend, F., Lopez, C. & Kampa-Schittenhelm, K. M., Apr 1 2019, In : EBioMedicine. 42, p. 340-351 12 p.

Research output: Contribution to journalArticle

Open Access
Tumor Suppressor Protein p53
Alternative Splicing
Tumors
Protein Isoforms
Leukemia

A Phase II Study Alternating Erlotinib With Second-line mFOLFOX6 or FOLFIRI for Metastatic Colorectal Cancer

Kearney, M. R., Chen, E. Y., Vaccaro, G., Strother, J., Burt, A., Todd, K., Donovan, J., Kampa-Schittenhelm, K. M. & Lopez, C., Jan 1 2019, In : Anticancer Research. 39, 1, p. 245-252 8 p.

Research output: Contribution to journalArticle

irinotecan
Colorectal Neoplasms
oxaliplatin
Neutropenia
Combination Drug Therapy
2018
5 Citations (Scopus)

A Phase II Study of Celecoxib with Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Previously Untreated Advanced or Metastatic Colorectal Cancer

Chen, E. Y., Blanke, C., Haller, D. G., Benson, A. B., Dragovich, T., Lenz, H. J., Robles, C., Li, H., Mori, M. T., Mattek, N., Sanborn, R. E. & Lopez, C., Dec 1 2018, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 41, 12, p. 1193-1198 6 p.

Research output: Contribution to journalArticle

irinotecan
Celecoxib
Leucovorin
Fluorouracil
Colorectal Neoplasms
15 Citations (Scopus)

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival

Gast, C. E., Silk, A. D., Zarour, L., Riegler, L., Burkhart, J. G., Gustafson, K. T., Parappilly, M. S., Roh-Johnson, M., Goodman, J. R., Olson, B., Schmidt, M., Swain, J. R., Davies, P., Shasthri, V., Iizuka, S., Flynn, P., Watson, S., Korkola, J., Courtneidge, S., Fischer, J. & 8 others, Jaboin, J., Billingsley, K., Lopez, C., Burchard, J., Gray, J., Coussens, L., Sheppard, B. & Wong, M., Sep 12 2018, In : Science advances. 4, 9, eaat7828.

Research output: Contribution to journalArticle

Cell Fusion
Hybrid Cells
Survival
Neoplasms
Biomarkers

Colorectal Cancer-Associated Spontaneous Tumor Lysis Syndrome: a Case Report and Review of the Current Literature

Kearney, M. R., Chen, E. Y., Stenzel, P., Corless, C., Deloughery, T., Zivney, M. & Lopez, C., Apr 25 2018, (Accepted/In press) In : Journal of Gastrointestinal Cancer. p. 1-6 6 p.

Research output: Contribution to journalArticle

Tumor Lysis Syndrome
Colorectal Neoplasms
Oncology
Biopsy
Genes
Tumors
Testing
2017

Chemoradiation for locally advanced unresectable pancreatic cancer - What now?

Vaccaro, G. & Lopez, C., Jun 1 2017, In : JAMA oncology. 3, 6, p. 850-851 2 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Random Allocation
Chemoradiotherapy
Survival
1 Citation (Scopus)

Phase II open label pilot trial of aprepitant and palonosetron for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately emetogenic FOLFOX chemotherapy for the treatment of colorectal cancer

Bubalo, J., Herrington, J. D., Takemoto, M., Willman, P., Edwards, M. S., Williams, C., Fisher, A., Palumbo, A., Chen, E., Blanke, C. & Lopez, C., Oct 31 2017, (Accepted/In press) In : Supportive Care in Cancer. p. 1-7 7 p.

Research output: Contribution to journalArticle

aprepitant
Nausea
Vomiting
Colorectal Neoplasms
Drug Therapy
5 Citations (Scopus)

ΔN-ASPP2, a novel isoform of the ASPP2 tumor suppressor, promotes cellular survival

Van Hook, K., Wang, Z., Chen, D., Nold, C., Zhu, Z., Anur, P., Lee, H. J., Yu, Z., Sheppard, B., Dai, M., Sears, R., Spellman, P. & Lopez, C., Jan 22 2017, In : Biochemical and Biophysical Research Communications. 482, 4, p. 1271-1277 7 p.

Research output: Contribution to journalArticle

p53 Genes
DNA Damage
Tumors
Protein Isoforms
Apoptosis
2014
48 Citations (Scopus)

Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer

Farrell, A., Allen-Petersen, B., Daniel, C. J., Wang, X., Wang, Z., Rodriguez, S., Impey, S., Oddo, J., Vitek, M. P., Lopez, C., Christensen, D. J., Sheppard, B. & Sears, R., 2014, In : Molecular Cancer Research. 12, 6, p. 924-939 16 p.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
Protein Phosphatase 2
Pancreatic Neoplasms
Therapeutics
Cell Line
2013
11 Citations (Scopus)

Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure

Schittenhelm, M. M., Illing, B., Ahmut, F., Rasp, K. H., Blumenstock, G., Doḧner, K., Lopez, C. & Kampa-Schittenhelm, K. M., Nov 27 2013, In : PLoS One. 8, 11, e80193.

Research output: Contribution to journalArticle

leukemia
Leukemia
apoptosis
Apoptosis
therapeutics
34 Citations (Scopus)

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

Wang, Z., Liu, Y., Takahashi, M., Van Hook, K., Kampa-Schittenhelm, K. M., Sheppard, B., Sears, R., Stork, P. & Lopez, C., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 312-317 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Guanosine Triphosphate
Oncogenes
ras Proteins
Neoplasms
9 Citations (Scopus)

Putting the pieces together: Necrolytic migratory erythema and the glucagonoma syndrome

Halvorson, S., Gilbert, E., Hopkins, R., Liu, H., Lopez, C., Chu, M., Martin, M. & Sheppard, B., Nov 2013, In : Journal of General Internal Medicine. 28, 11, p. 1525-1529 5 p.

Research output: Contribution to journalArticle

Necrolytic Migratory Erythema
Glucagonoma
Neuroendocrine Tumors
Exanthema
Glucagon
9 Citations (Scopus)

Safety and Outcomes Following Resection of Colorectal Liver Metastases in the Era of Current Perioperative Chemotherapy

Gur, I., Diggs, B. S., Wagner, J. A., Vaccaro, G., Lopez, C., Sheppard, B., Orloff, S. & Billingsley, K., Dec 2013, In : Journal of Gastrointestinal Surgery. 17, 12, p. 2133-2142 10 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Safety
Drug Therapy
Liver
oxaliplatin
2011
30 Citations (Scopus)

Lapatinib and gemcitabine for metastatic pancreatic cancer: A phase II study

Safran, H., Miner, T., Bahary, N., Whiting, S., Lopez, C., Sun, W., Charpentier, K., Shipley, J., Anderson, E., McNulty, B., Schumacher, A., Clark, A., Vakharia, J., Kennedy, T. & Sio, T., Feb 2011, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 34, 1, p. 50-52 3 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Survival
Clinical Trials Data Monitoring Committees
Medical Futility
2009
37 Citations (Scopus)

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds

Kampa, K. M., Acoba, J. D., Chen, D., Gay, J., Lee, H., Beemer, K., Padiernos, E., Boonmark, N., Zhu, Z., Fan, A. C., Bailey, A. S., Fleming, W., Corless, C., Felsher, D. W., Naumovski, L. & Lopez, C., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4390-4395 6 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Proteins
Thymocytes
Gastrin-Secreting Cells
22 Citations (Scopus)

New insights into the expanding complexity of the tumor suppressor ASPP2

Kampa, K. M., Bonin, M. & Lopez, C., Sep 15 2009, In : Cell Cycle. 8, 18, p. 2871-2876 6 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Carrier Proteins
Growth
Proteins
31 Citations (Scopus)
docetaxel
Calcitriol
Pancreatic Neoplasms
gemcitabine
Hyperglycemia
2008
16 Citations (Scopus)

E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair

Chen, D., Yu, Z., Zhu, Z. & Lopez, C., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 15381-15389 9 p.

Research output: Contribution to journalArticle

DNA Repair
Repair
Genes
X-Rays
X rays

hADA2a and hADA3: New players in β-catenin signaling

Van Hook, K., Alumkal, J. & Lopez, C., Jan 2008, In : Cancer Biology and Therapy. 7, 1, p. 131-132 2 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
beta Catenin
Carcinogenesis
1 Citation (Scopus)

hADA2a and hADA3: new players in beta-catenin signaling.

Van Hook, K., Alumkal, J. & Lopez, C., Jan 2008, In : Cancer biology & therapy. 7, 1, p. 129-130 2 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Wnt Proteins
Histone Acetyltransferases
beta Catenin
Signal Transduction
2006
66 Citations (Scopus)

The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells

Chen, D., Yu, Z., Zhu, Z. & Lopez, C., Apr 1 2006, In : Cancer Research. 66, 7, p. 3485-3494 10 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Oligonucleotides
DNA Repair
Colorectal Neoplasms
Uracil
2005
50 Citations (Scopus)

Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene

Chen, D., Padiernos, E., Ding, F., Lossos, I. S. & Lopez, C., Apr 2005, In : Cell Death and Differentiation. 12, 4, p. 358-368 11 p.

Research output: Contribution to journalArticle

Apoptosis
Chromatin Immunoprecipitation
Luciferases
S Phase
Genes
29 Citations (Scopus)

Control of ASPP2/53BP2L protein levels by proteasomal degradation modulates p53 apoptotic function

Zhu, Z., Ramos, J., Kampa, K., Adimoolam, S., Sirisawad, M., Yu, Z., Chen, D., Naumovski, L. & Lopez, C., Oct 14 2005, In : Journal of Biological Chemistry. 280, 41, p. 34473-34480 8 p.

Research output: Contribution to journalArticle

Anthracyclines
Apoptosis
Degradation
Ubiquitinated Proteins
RNA
2002
45 Citations (Scopus)

Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cel and follicular center lymphoma: Correlation with clinical outcome

Lossos, I. S., Natkunam, Y., Levy, R. & Lopez, C., Dec 1 2002, In : Leukemia and Lymphoma. 43, 12, p. 2309-2317 9 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
L-Lactate Dehydrogenase
Apoptosis
Proteins
106 Citations (Scopus)

Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites

Qian, H., Wang, T., Naumovski, L., Lopez, C. & Brachmann, R. K., Nov 7 2002, In : Oncogene. 21, 51, p. 7901-7911 11 p.

Research output: Contribution to journalArticle

p53 Genes
Binding Sites
DNA
Apoptosis
Cell Cycle Checkpoints
26 Citations (Scopus)

Inhibition of cell death by ribosomal protein L35a

Lopez, C., Martinovsky, G. & Naumovski, L., Jun 28 2002, In : Cancer Letters. 180, 2, p. 195-202 8 p.

Research output: Contribution to journalArticle

Jurkat Cells
Ribosomal Proteins
Cell Death
Glioblastoma
Doxorubicin
2000
Chemotherapy
Deregulation
Cell death
Cell Death
Drug Therapy
35 Citations (Scopus)

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53

Lopez, C., Ao, Y., Rohde, L. H., Perez, T. D., O'Connor, D. J., Lu, X., Ford, J. M. & Naumovski, L., 2000, In : Molecular and Cellular Biology. 20, 21, p. 8018-8025 8 p.

Research output: Contribution to journalArticle

DNA Damage
Complementary DNA
Apoptosis
Tetracycline
Proteins
1990
104 Citations (Scopus)

Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein

Yost, C. S., Lopez, C., Prusiner, S. B., Myers, R. M. & Lingappa, V. R., Feb 15 1990, In : Nature. 343, 6259, p. 669-672 4 p.

Research output: Contribution to journalArticle

Codon
Protein Isoforms
Peptides
Proteins
Manuscripts
109 Citations (Scopus)

Unusual topogenic sequence directs prion protein biogenesis

Lopez, C., Yost, C. S., Prusiner, S. B., Myers, R. M. & Lingappa, V. R., Apr 13 1990, In : Science. 248, 4952, p. 226-229 4 p.

Research output: Contribution to journalArticle

Reticulocytes
Triticum
Rabbits
Protein Engineering
Cell-Free System