Carol Beadling

Research Assistant Professor

  • 2822 Citations
  • 26 h-Index
1987 …2017
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Research Output 1987 2017

  • 2822 Citations
  • 26 h-Index
  • 58 Article
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Article
2017
3 Citations (Scopus)

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

Succinate Dehydrogenase
Yeasts
Neoplasms
Early Detection of Cancer
Genes
18 Citations (Scopus)

Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions

Gay, N. D., Wang, Y., Beadling, C., Warrick, A., Neff, T., Corless, C. & Tolba, K., Feb 25 2017, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

16 Citations (Scopus)

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

Schaefer, I. M., Wang, Y., Liang, C. W., Bahri, N., Quattrone, A., Doyle, L., Marinõ-Enríquez, A., Lauria, A., Zhu, M., Debiec-Rychter, M., Grunewald, S., Hechtman, J. F., Dufresne, A., Antonescu, C. R., Beadling, C., Sicinska, E. T., Van De Rijn, M., Demetri, G. D., Ladanyi, M., Corless, C. & 4 others, Heinrich, M., Raut, C. P., Bauer, S. & Fletcher, J. A., Mar 8 2017, In : Nature Communications. 8, 14674.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Cell proliferation
deactivation
Tumors
tumors
2016
31 Citations (Scopus)

A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing

Beadling, C., Wald, A. I., Warrick, A., Neff, T. L., Zhong, S., Nikiforov, Y. E., Corless, C. & Nikiforova, M. N., Mar 1 2016, In : Journal of Molecular Diagnostics. 18, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

Gene Fusion
Neoplasms
Multiplex Polymerase Chain Reaction
Fluorescence In Situ Hybridization
Real-Time Polymerase Chain Reaction
2015
65 Citations (Scopus)

Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data

Grasso, C., Butler, T., Rhodes, K., Quist, M., Neff, T. L., Moore, S., Tomlins, S. A., Reinig, E., Beadling, C., Andersen, M. & Corless, C., Jan 1 2015, In : Journal of Molecular Diagnostics. 17, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

Libraries
Breast Neoplasms
Matched-Pair Analysis
Precision Medicine
Comparative Genomic Hybridization
22 Citations (Scopus)

KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation

Serrano, C., Wang, Y., Mariño-Enríquez, A., Lee, J. C., Ravegnini, G., Morgan, J. A., Bertagnolli, M. M., Beadling, C., Demetri, G. D., Corless, C., Heinrich, M. & Fletcher, J. A., Aug 1 2015, In : Journal of Clinical Oncology. 33, 22, p. e93-e96

Research output: Contribution to journalArticle

Neoplasm Drug Resistance
Proto-Oncogene Proteins
Piperazines
Benzamides
TOR Serine-Threonine Kinases
136 Citations (Scopus)

Molecular profiling and targeted therapy for advanced thoracic malignancies a biomarker-derived, multiarm, multihistology phase ii basket trial

Lopez-Chavez, A., Thomas, A., Rajan, A., Raffeld, M., Morrow, B., Kelly, R., Carter, C. A., Guha, U., Killian, K., Lau, C. C., Abdullaev, Z., Xi, L., Pack, S., Meltzer, P. S., Corless, C., Sandler, A., Beadling, C., Warrick, A., Liewehr, D. J., Steinberg, S. M. & 5 others, Berman, A., Doyle, A., Szabo, E., Wang, Y. & Giaccone, G., Mar 20 2015, In : Journal of Clinical Oncology. 33, 9, p. 1000-1007 8 p.

Research output: Contribution to journalArticle

Molecular Targeted Therapy
Thorax
Biomarkers
Mutation
Non-Small Cell Lung Carcinoma
1 Citation (Scopus)

Next generation sequencing in clinical diagnostics: Experiences of early adopters

Lyon, E., Cockerill, F. R., Bale, S. J., Beadling, C., Bry, L., Hagenkord, J., Kulkarni, S., Press, R. & Palomaki, G. E., Jan 1 2015, In : Clinical Chemistry. 61, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

Molecular Diagnostic Techniques
Genomics
DNA Sequence Analysis
Reproducibility of Results
Sensitivity and Specificity
19 Citations (Scopus)

Novel mutations in neuroendocrine carcinoma of the breast: Possible therapeutic targets

Ang, D., Ballard, M., Beadling, C., Warrick, A., Schilling, A., O'Gara, R., Pukay, M., Neff, T. L., West, R. B., Corless, C. & Troxell, M., Feb 28 2015, In : Applied Immunohistochemistry and Molecular Morphology. 23, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Breast
Mutation
Breast Neoplasms
Therapeutics
6 Citations (Scopus)

Utility of BRAF V600E mutation-specific immunohistochemistry in detecting BRAF V600E-Mutated gastrointestinal stromal tumors

Patil, D. T., Ma, S., Konishi, M., Carver, P. D., Pukay, M., Beadling, C., Corless, C. & Rubin, B. P., Nov 1 2015, In : American Journal of Clinical Pathology. 144, 5, p. 782-789 8 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Immunohistochemistry
Mutation
Stomach
Omentum
2014
4 Citations (Scopus)

Combination therapy for KIT-mutant mast cells: Targeting constitutive NFAT and KIT activity

Macleod, A. C., Klug, L. R., Patterson, J., Griffith, D. J., Beadling, C., Town, A. & Heinrich, M., Dec 1 2014, In : Molecular Cancer Therapeutics. 13, 12, p. 2840-2851 12 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Mast Cells
Calcineurin
Mastocytosis
Cell Line
23 Citations (Scopus)

Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions

C Ang, D., Warrick, A. L., Shilling, A., Beadling, C., Corless, C. & Troxell, M., 2014, In : Modern Pathology. 27, 5, p. 740-750 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Carcinoma, Intraductal, Noninfiltrating
Point Mutation
Breast
Hyperplasia
10 Citations (Scopus)

Genetic profiling to determine risk of relapse-free survival in high-risk localized prostate cancer

Barnett, C. M., Heinrich, M., Lim, J., Nelson, D., Beadling, C., Warrick, A., Neff, T., Higano, C. S., Garzotto, M., Qian, Z. D., Corless, C., Thomas, G. & Beer, T. T., 2014, In : Clinical Cancer Research. 20, 5, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Recurrence
Mutation
Survival
Point Mutation
16 Citations (Scopus)

Mutation profiling in gallbladder cancer in Indian population

Kumari, N., Corless, C., Warrick, A., Beadling, C., Nelson, D., Neff, T., Krishnani, N. & Kapoor, V. K., 2014, In : Indian Journal of Pathology and Microbiology. 57, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

Gallbladder Neoplasms
Mutation
Population
Neoplasms
Technology
17 Citations (Scopus)

Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract

Tseng, D., Kim, J., Warrick, A., Nelson, D., Pukay, M., Beadling, C., Heinrich, M., Selim, M. A., Corless, C. & Nelson, K., 2014, In : Journal of the American Academy of Dermatology. 71, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

Pigmented Nevus
Melanoma
Mutation
Mutation Rate
Genetic Heterogeneity
2013
80 Citations (Scopus)

BRAF mutant gastrointestinal stromal tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance

Falchook, G. S., Trent, J. C., Heinrich, M., Beadling, C., Patterson, J., Bastida, C. C., Blackman, S. C. & Kurzrock, R., 2013, In : Oncotarget. 4, 2, p. 310-315 6 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Proto-Oncogene Proteins B-raf
Exome
Mutation
Heterografts
97 Citations (Scopus)

Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping

Beadling, C., Neff, T. L., Heinrich, M., Rhodes, K., Thornton, M., Leamon, J., Andersen, M. & Corless, C., Mar 2013, In : Journal of Molecular Diagnostics. 15, 2, p. 171-176 6 p.

Research output: Contribution to journalArticle

Semiconductors
Paraffin
Formaldehyde
Point Mutation
Polymerase Chain Reaction
53 Citations (Scopus)

Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

Raué, H. P., Beadling, C., Haun, J. & Slifka, M., Jan 24 2013, In : Immunity. 38, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

Cytokines
Viruses
T-Lymphocytes
Interleukin-18
Interleukin-12
13 Citations (Scopus)

Frequent PIK3CA mutations in radial scars

Wolters, K. L., Ang, D., Warrick, A., Beadling, C., Corless, C. & Troxell, M., 2013, In : Diagnostic Molecular Pathology. 22, 4, p. 210-214 5 p.

Research output: Contribution to journalArticle

Cicatrix
Mutation
Breast Neoplasms
Mutation Rate
Point Mutation
273 Citations (Scopus)

Imatinib for melanomas harboring mutationally activated or amplified kit arising on mucosal, acral, and chronically sun-damaged skin

Hodi, F. S., Corless, C., Giobbie-Hurder, A., Fletcher, J. A., Zhu, M., Marino-Enriquez, A., Friedlander, P., Gonzalez, R., Weber, J. S., Gajewski, T. F., O'Day, S. J., Kim, K. B., Lawrence, D., Flaherty, K. T., Luke, J. J., Collichio, F. A., Ernstoff, M. S., Heinrich, M., Beadling, C., Zukotynski, K. A. & 4 others, Yap, J. T., Van Den Abbeele, A. D., Demetri, G. D. & Fisher, D. E., Sep 10 2013, In : Journal of Clinical Oncology. 31, 26, p. 3182-3190 9 p.

Research output: Contribution to journalArticle

Solar System
Melanoma
Extremities
Skin
Mutation
8 Citations (Scopus)

MDM2 amplification and PI3KCA mutation in a case of sclerosing rhabdomyosarcoma

Kikuchi, K., Wettach, G. R., Ryan, C., Hung, A., Hooper, J. E., Beadling, C., Warrick, A., Corless, C., Olson, S., Keller, C. & Mansoor, A., 2013, In : Sarcoma. 2013, 520858.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Mutation
Neoplasm Metastasis
Lung
Polyploidy
11 Citations (Scopus)

Novel method for PIK3CA mutation analysis: Locked nucleic acid-PCR sequencing

Ang, D., O'Gara, R., Schilling, A., Beadling, C., Warrick, A., Troxell, M. & Corless, C., May 2013, In : Journal of Molecular Diagnostics. 15, 3, p. 312-318 7 p.

Research output: Contribution to journalArticle

Polymerase Chain Reaction
Mutation
Exons
Codon
Pseudogenes
12 Citations (Scopus)

PIK3CA-AKT pathway mutations in micropapillary breast carcinoma

Flatley, E., Ang, D., Warrick, A., Beadling, C., Corless, C. & Troxell, M., Jul 2013, In : Human Pathology. 44, 7, p. 1320-1327 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
Carcinoma
Point Mutation
Ductal Carcinoma
2012
8 Citations (Scopus)

Biphasic papillary and lobular breast carcinoma with PIK3CA and IDH1 mutations

Ang, D., VanSandt, A., Beadling, C., Warrick, A., West, R. B., Corless, C. & Troxell, M., Dec 2012, In : Diagnostic Molecular Pathology. 21, 4, p. 221-224 4 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Point Mutation
Breast Neoplasms
Mutation
Papillary Carcinoma
17 Citations (Scopus)

BRAF and KRAS mutations in sporadic glomus tumors

Chakrapani, A., Warrick, A., Nelson, D., Beadling, C. & Corless, C., Jul 2012, In : American Journal of Dermatopathology. 34, 5, p. 533-535 3 p.

Research output: Contribution to journalArticle

Glomus Tumor
Mutation
Neoplasms
Fingers
Arm
25 Citations (Scopus)

Mucinous breast carcinomas lack PIK3CA and AKT1 mutations

Kehr, E. L., Jorns, J. M., Ang, D., Warrick, A., Neff, T., Degnin, M., Lewis, R., Beadling, C., Corless, C. & Troxell, M., Dec 2012, In : Human Pathology. 43, 12, p. 2207-2212 6 p.

Research output: Contribution to journalArticle

Mucinous Adenocarcinoma
Point Mutation
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Mutation
15 Citations (Scopus)

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W., Loriaux, M., Heinrich, M., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R., Press, R., Corless, C. & Fan, G., Dec 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Mutation
Cytogenetics
Genes
Leukemia
5 Citations (Scopus)

Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours

Kang, G., Lee, J., Jang, K. T., Beadling, C., Corless, C., Heinrich, M., Park, J. O., Kang, W. K., Park, C. K. & Kim, K. M., Aug 2012, In : Pathology. 44, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Mass Spectrometry
Mutation
Missense Mutation
Exons
43 Citations (Scopus)

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M., Loriaux, M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J., Dunlap, J., Corless, C. & Fan, G., Sep 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalArticle

Janus Kinase 3
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Mutation
29 Citations (Scopus)

Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions

Troxell, M., Brunner, A. L., Neff, T., Warrick, A., Beadling, C., Montgomery, K., Zhu, S., Corless, C. & West, R. B., Jul 2012, In : Modern Pathology. 25, 7, p. 930-937 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Breast
Mutation
Carcinoma
Point Mutation
1 Citation (Scopus)

RAS mutations in therapy-related acute myeloid leukemia after successful treatment of acute promyelocytic leukemia

Kelemen, K., Kovacsovics, T., Braziel, R., Corless, C., Beadling, C. & Fan, G., May 2012, In : Leukemia and Lymphoma. 53, 5, p. 999-1002 4 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
ras Genes
Second Primary Neoplasms
Acute Myeloid Leukemia
Antineoplastic Agents
2011
27 Citations (Scopus)

Immunohistochemical and molecular markers in breast phyllodes tumors

Korcheva, V., Levine, J., Beadling, C., Warrick, A., Countryman, G., Olson, N. R., Heinrich, M., Corless, C. & Troxell, M., Mar 2011, In : Applied Immunohistochemistry and Molecular Morphology. 19, 2, p. 119-125 7 p.

Research output: Contribution to journalArticle

Phyllodes Tumor
Breast Neoplasms
Mutation
Fibroadenoma
Ubiquitin-Protein Ligases
67 Citations (Scopus)

Multiplex Mutation screening by mass spectrometry: Evaluation of 820 cases from a personalized cancer medicine registry

Beadling, C., Heinrich, M., Warrick, A., Forbes, E. M., Nelson, D., Justusson, E., Levine, J., Neff, T. L., Patterson, J., Presnell, A., McKinley, A., Winter, L. J., Dewey, C., Harlow, A., Barney, O., Druker, B., Schuff, K. & Corless, C., Sep 2011, In : Journal of Molecular Diagnostics. 13, 5, p. 504-513 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Registries
Mass Spectrometry
Mutation
Neoplasms
2010
66 Citations (Scopus)

High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast

Troxell, M., Levine, J., Beadling, C., Warrick, A., Dunlap, J., Presnell, A., Patterson, J., Shukla, A., Olson, N. R., Heinrich, M. & Corless, C., Jan 2010, In : Modern Pathology. 23, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

Papilloma
Breast Neoplasms
Mutation
Carcinoma, Intraductal, Noninfiltrating
Papillary Carcinoma
54 Citations (Scopus)

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M. T., Heinrich, M., Deininger, M. W., Druker, B. & Loriaux, M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Leukemia, Myelomonocytic, Chronic
Proto-Oncogene Proteins c-met
Mutation
Poisons
2008
405 Citations (Scopus)

KIT gene mutations and copy number in melanoma subtypes

Beadling, C., Jacobson-Dunlop, E., Hodi, F. S., Le, C., Warrick, A., Patterson, J., Town, A., Harlow, A., Cruz, F., Azar, S., Rubin, B. P., Muller, S., West, R., Heinrich, M. & Corless, C., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 6821-6828 8 p.

Research output: Contribution to journalArticle

Gene Dosage
Melanoma
Mutation
Extremities
Exons
2006
27 Citations (Scopus)

Quantifying viable virus-specific T cells without a priori knowledge of fine epitope specificity

Beadling, C. & Slifka, M., Oct 2006, In : Nature Medicine. 12, 10, p. 1208-1212 5 p.

Research output: Contribution to journalArticle

T-cells
Viruses
Epitopes
Antigen-Presenting Cells
Major Histocompatibility Complex
66 Citations (Scopus)
Interleukin-27
Interleukin-23
Adaptive Immunity
Interleukin-12
Innate Immunity
2005
38 Citations (Scopus)

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

Beadling, C. & Slifka, M., Feb 1 2005, In : Blood. 105, 3, p. 1179-1186 8 p.

Research output: Contribution to journalArticle

T-cells
Viruses
Chemical activation
Cytokines
T-Lymphocytes
2004
93 Citations (Scopus)

How do viral infections predispose patients to bacterial infections?

Beadling, C. & Slifka, M., Jun 2004, In : Current Opinion in Infectious Diseases. 17, 3, p. 185-191 7 p.

Research output: Contribution to journalArticle

Virus Diseases
Bacterial Infections
Sepsis
Coinfection
Respiratory Tract Infections
2002
63 Citations (Scopus)

DNA array analysis of interleukin-2-regulated immediate/early genes

Beadling, C. & Smith, K. A., Nov 18 2002, In : Medical Immunology. 1, 2.

Research output: Contribution to journalArticle

Immediate-Early Genes
Oligonucleotide Array Sequence Analysis
Interleukin-2
Lymphocyte Activation
Genes
2001
6 Citations (Scopus)

Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival

Beadling, C., Cereseto, A., Fan, W., Naramura, M. & Smith, K. A., Mar 29 2001, In : Oncogene. 20, 14, p. 1771-1783 13 p.

Research output: Contribution to journalArticle

Phase Transition
G1 Phase
S Phase
Cell Cycle
Cytokines
1999
50 Citations (Scopus)

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest

Fan, W., Richter, G., Cereseto, A., Beadling, C. & Smith, K. A., Nov 11 1999, In : Oncogene. 18, 47, p. 6573-6582 10 p.

Research output: Contribution to journalArticle

Cytokines
Growth
Genes
Cyclin G2
Endoreduplication
86 Citations (Scopus)

Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes

Beadling, C., Druey, K. M., Richter, G., Kehrl, J. H. & Smith, K. A., Mar 1 1999, In : Journal of Immunology. 162, 5, p. 2677-2682 6 p.

Research output: Contribution to journalArticle

GTP-Binding Protein Regulators
GTP-Binding Proteins
Lymphocytes
T-Lymphocytes
Gene Expression
1997

Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene.

Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., Apr 1997, In : Molecular and Cellular Biology. 17, 4, p. 2351 1 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Interleukin-2 Receptor alpha Subunit
STAT5 Transcription Factor
Trans-Activators
Milk Proteins
3 Citations (Scopus)

Erratum: Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene (Molecular and Cellular Biology 16:12 (6831))

Lecine, P., Algarte, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., 1997, In : Molecular and Cellular Biology. 17, 4, p. 2351 1 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptor alpha Subunit
Cell Biology
Molecular Biology
Genes
1996
94 Citations (Scopus)

Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene

Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., 1996, In : Molecular and Cellular Biology. 16, 12, p. 6829-6840 12 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptors
Interleukin-2
Genes
T-Lymphocytes
Nucleotides
157 Citations (Scopus)

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway

Beadling, C., Ng, J., Babbage, J. W. & Cantrell, D. A., Apr 15 1996, In : EMBO Journal. 15, 8, p. 1902-1913 12 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Protein-Tyrosine Kinases
Interleukin-2
Phosphotransferases
Chemical activation
1995
97 Citations (Scopus)

Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Foxwell, B. M. J., Beadling, C., Guschin, D., Kerr, I. & Cantrell, D., Nov 1995, In : European Journal of Immunology. 25, 11, p. 3041-3046 6 p.

Research output: Contribution to journalArticle

STAT Transcription Factors
STAT5 Transcription Factor
Interleukin-7
T-Lymphocytes
Signal Transduction
1994
182 Citations (Scopus)

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes

Beadling, C., Guschin, D., Witthuhn, B. A., Ziemiecki, A., Ihle, J. N., Kerr, I. M. & Cantrell, D. A., Dec 1 1994, In : EMBO Journal. 13, 23, p. 5605-5615 11 p.

Research output: Contribution to journalArticle

STAT Transcription Factors
Janus Kinases
T-cells
T-Cell Antigen Receptor
Protein-Tyrosine Kinases