Carol Beadling

Research Assistant Professor

  • 2904 Citations
  • 27 h-Index
1987 …2017

Research output per year

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Research Output

  • 2904 Citations
  • 27 h-Index
  • 52 Article
  • 3 Review article
  • 2 Letter
  • 1 Comment/debate

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes

Beadling, C., Guschin, D., Witthuhn, B. A., Ziemiecki, A., Ihle, J. N., Kerr, I. M. & Cantrell, D. A., Dec 1 1994, In : EMBO Journal. 13, 23, p. 5605-5615 11 p.

Research output: Contribution to journalArticle

184 Scopus citations

A monoclonal mouse anti-human IL-2 receptor antibody (anti-Tac) will recognize molecules on the surface of Xenopus laevis immunocytes which specifically bind rIL-2 and are only slightly larger than the human Tac protein

Ruben, L. N., Langeberg, L., Malley, A., Clothier, R. H., Beadling, C., Lee, R. & Shiigi, S., May 1990, In : Immunology Letters. 24, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing

Beadling, C., Wald, A. I., Warrick, A., Neff, T. L., Zhong, S., Nikiforov, Y. E., Corless, C. & Nikiforova, M. N., Mar 1 2016, In : Journal of Molecular Diagnostics. 18, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data

Grasso, C., Butler, T., Rhodes, K., Quist, M., Neff, T. L., Moore, S., Tomlins, S. A., Reinig, E., Beadling, C., Andersen, M. & Corless, C. L., Jan 1 2015, In : Journal of Molecular Diagnostics. 17, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

72 Scopus citations

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Biphasic papillary and lobular breast carcinoma with PIK3CA and IDH1 mutations

Ang, D., Vansandt, A. M., Beadling, C., Warrick, A., West, R. B., Corless, C. L. & Troxell, M. L., Dec 1 2012, In : Diagnostic Molecular Pathology. 21, 4, p. 221-224 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

BRAF and KRAS mutations in sporadic glomus tumors

Chakrapani, A., Warrick, A., Nelson, D., Beadling, C. & Corless, C. L., Jul 1 2012, In : American Journal of Dermatopathology. 34, 5, p. 533-535 3 p.

Research output: Contribution to journalArticle

18 Scopus citations

BRAF mutant gastrointestinal stromal tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance

Falchook, G. S., Trent, J. C., Heinrich, M. C., Beadling, C., Patterson, J., Bastida, C. C., Blackman, S. C. & Kurzrock, R., 2013, In : Oncotarget. 4, 2, p. 310-315 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

Combination therapy for KIT-mutant mast cells: Targeting constitutive NFAT and KIT activity

Macleod, A. C., Klug, L. R., Patterson, J., Griffith, D. J., Beadling, C., Town, A. & Heinrich, M. C., Dec 1 2014, In : Molecular cancer therapeutics. 13, 12, p. 2840-2851 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping

Beadling, C., Neff, T. L., Heinrich, M. C., Rhodes, K., Thornton, M., Leamon, J., Andersen, M. & Corless, C. L., Mar 1 2013, In : Journal of Molecular Diagnostics. 15, 2, p. 171-176 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

Raué, H. P., Beadling, C., Haun, J. & Slifka, M. K., Jan 24 2013, In : Immunity. 38, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest

Fan, W., Richter, G., Cereseto, A., Beadling, C. & Smith, K. A., Nov 11 1999, In : Oncogene. 18, 47, p. 6573-6582 10 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival

Beadling, C., Cereseto, A., Fan, W., Naramura, M. & Smith, K. A., Mar 29 2001, In : Oncogene. 20, 14, p. 1771-1783 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
Open Access
10 Scopus citations

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

Beadling, C. & Slifka, M. K., Feb 1 2005, In : Blood. 105, 3, p. 1179-1186 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

DNA array analysis of interleukin-2-regulated immediate/early genes

Beadling, C. & Smith, K. A., Nov 18 2002, In : Medical Immunology. 1, 2.

Research output: Contribution to journalArticle

63 Scopus citations

Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions

Gay, N. D., Wang, Y., Beadling, C., Warrick, A., Neff, T., Corless, C. L. & Tolba, K., Aug 2017, In : Journal of Thoracic Oncology. 12, 8, p. e107-e110

Research output: Contribution to journalArticle

20 Scopus citations

Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene.

Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., Apr 1997, In : Molecular and Cellular Biology. 17, 4, p. 2351 1 p.

Research output: Contribution to journalArticle

Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene

Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., Nov 30 1996, In : Molecular and cellular biology. 16, 12, p. 6829-6840 12 p.

Research output: Contribution to journalArticle

95 Scopus citations

Erratum: Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene (Molecular and Cellular Biology 16:12 (6831))

Lecine, P., Algarte, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., Jan 1 1997, In : Molecular and cellular biology. 17, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions

C Ang, D., Warrick, A. L., Shilling, A., Beadling, C., Corless, C. L. & Troxell, M. L., May 2014, In : Modern Pathology. 27, 5, p. 740-750 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Frequent PIK3CA mutations in radial scars

Wolters, K. L., Ang, D., Warrick, A., Beadling, C., Corless, C. L. & Troxell, M. L., Dec 1 2013, In : Diagnostic Molecular Pathology. 22, 4, p. 210-214 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Genetic profiling to determine risk of relapse-free survival in high-risk localized prostate cancer

Barnett, C. M., Heinrich, M. C., Lim, J., Nelson, D., Beadling, C., Warrick, A., Neff, T., Higano, C. S., Garzotto, M., Qian, D., Corless, C. L., Thomas, G. V. & Beer, T. M., Jan 1 2014, In : Clinical Cancer Research. 20, 5, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast

Troxell, M. L., Levine, J., Beadling, C., Warrick, A., Dunlap, J., Presnell, A., Patterson, J., Shukla, A., Olson, N. R., Heinrich, M. C. & Corless, C. L., Jan 1 2010, In : Modern Pathology. 23, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

How do viral infections predispose patients to bacterial infections?

Beadling, C. & Slifka, M. K., Jun 1 2004, In : Current Opinion in Infectious Diseases. 17, 3, p. 185-191 7 p.

Research output: Contribution to journalReview article

96 Scopus citations

Imatinib for melanomas harboring mutationally activated or amplified kit arising on mucosal, acral, and chronically sun-damaged skin

Hodi, F. S., Corless, C. L., Giobbie-Hurder, A., Fletcher, J. A., Zhu, M., Marino-Enriquez, A., Friedlander, P., Gonzalez, R., Weber, J. S., Gajewski, T. F., O'Day, S. J., Kim, K. B., Lawrence, D., Flaherty, K. T., Luke, J. J., Collichio, F. A., Ernstoff, M. S., Heinrich, M. C., Beadling, C., Zukotynski, K. A. & 4 others, Yap, J. T., Van Den Abbeele, A. D., Demetri, G. D. & Fisher, D. E., Sep 10 2013, In : Journal of Clinical Oncology. 31, 26, p. 3182-3190 9 p.

Research output: Contribution to journalArticle

288 Scopus citations

Immunohistochemical and molecular markers in breast phyllodes tumors

Korcheva, V. B., Levine, J., Beadling, C., Warrick, A., Countryman, G., Olson, N. R., Heinrich, M. C., Corless, C. L. & Troxell, M. L., Mar 1 2011, In : Applied Immunohistochemistry and Molecular Morphology. 19, 2, p. 119-125 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

In search of cytokine-response genes

Beadling, C. & Smith, K. A., May 1994, In : Immunology Today. 15, 5, p. 197-199 3 p.

Research output: Contribution to journalArticle

In search of cytokine-response genes

Beadling, C. & Smith, K. A., May 1994, In : Trends in Immunology. 15, 5, p. 197-199 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway

Beadling, C., Ng, J., Babbage, J. W. & Cantrell, D. A., Apr 15 1996, In : EMBO Journal. 15, 8, p. 1902-1913 12 p.

Research output: Contribution to journalArticle

158 Scopus citations

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Foxwell, B. M. J., Beadling, C., Guschin, D., Kerr, I. & Cantrell, D., Nov 1995, In : European Journal of Immunology. 25, 11, p. 3041-3046 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Isolation of interleukin 2-induced immediate-early genes

Beadling, C., Johnson, K. W. & Smith, K. A., Apr 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 7, p. 2719-2723 5 p.

Research output: Contribution to journalArticle

Open Access
128 Scopus citations

KIT gene mutations and copy number in melanoma subtypes

Beadling, C., Jacobson-Dunlop, E., Hodi, F. S., Le, C., Warrick, A., Patterson, J., Town, A., Harlow, A., Cruz, F., Azar, S., Rubin, B. P., Muller, S., West, R., Heinrich, M. C. & Corless, C. L., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 6821-6828 8 p.

Research output: Contribution to journalArticle

414 Scopus citations

KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation

Serrano, C., Wang, Y., Mariño-Enríquez, A., Lee, J. C., Ravegnini, G., Morgan, J. A., Bertagnolli, M. M., Beadling, C., Demetri, G. D., Corless, C. L., Heinrich, M. C. & Fletcher, J. A., Aug 1 2015, In : Journal of Clinical Oncology. 33, 22, p. e93-e96

Research output: Contribution to journalArticle

25 Scopus citations

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

Schaefer, I. M., Wang, Y., Liang, C. W., Bahri, N., Quattrone, A., Doyle, L., Marinõ-Enríquez, A., Lauria, A., Zhu, M., Debiec-Rychter, M., Grunewald, S., Hechtman, J. F., Dufresne, A., Antonescu, C. R., Beadling, C., Sicinska, E. T., Van De Rijn, M., Demetri, G. D., Ladanyi, M., Corless, C. L. & 4 others, Heinrich, M. C., Raut, C. P., Bauer, S. & Fletcher, J. A., Mar 8 2017, In : Nature communications. 8, 14674.

Research output: Contribution to journalArticle

18 Scopus citations

MDM2 amplification and PI3KCA mutation in a case of sclerosing rhabdomyosarcoma

Kikuchi, K., Wettach, G. R., Ryan, C. W., Hung, A., Hooper, J. E., Beadling, C., Warrick, A., Corless, C. L., Olson, S. B., Keller, C. & Mansoor, A., Jun 11 2013, In : Sarcoma. 2013, 520858.

Research output: Contribution to journalArticle

8 Scopus citations

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J. W., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M., Heinrich, M. C., Deininger, M. W., Druker, B. J. & Loriaux, M. M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

54 Scopus citations

Molecular profiling and targeted therapy for advanced thoracic malignancies a biomarker-derived, multiarm, multihistology phase ii basket trial

Lopez-Chavez, A., Thomas, A., Rajan, A., Raffeld, M., Morrow, B., Kelly, R., Carter, C. A., Guha, U., Killian, K., Lau, C. C., Abdullaev, Z., Xi, L., Pack, S., Meltzer, P. S., Corless, C. L., Sandler, A., Beadling, C., Warrick, A., Liewehr, D. J., Steinberg, S. M. & 5 others, Berman, A., Doyle, A., Szabo, E., Wang, Y. & Giaccone, G., Mar 20 2015, In : Journal of Clinical Oncology. 33, 9, p. 1000-1007 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Mucinous breast carcinomas lack PIK3CA and AKT1 mutations

Kehr, E. L., Jorns, J. M., Ang, D., Warrick, A., Neff, T., Degnin, M., Lewis, R., Beadling, C., Corless, C. L. & Troxell, M. L., Dec 1 2012, In : Human Pathology. 43, 12, p. 2207-2212 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W. H., Loriaux, M., Heinrich, M. C., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R. M., Press, R., Corless, C. L. & Fan, G., Dec 1 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Multiplex Mutation screening by mass spectrometry: Evaluation of 820 cases from a personalized cancer medicine registry

Beadling, C., Heinrich, M. C., Warrick, A., Forbes, E. M., Nelson, D., Justusson, E., Levine, J., Neff, T. L., Patterson, J., Presnell, A., McKinley, A., Winter, L. J., Dewey, C., Harlow, A., Barney, O., Druker, B. J., Schuff, K. G. & Corless, C. L., Sep 2011, In : Journal of Molecular Diagnostics. 13, 5, p. 504-513 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours

Kang, G., Lee, J., Jang, K. T., Beadling, C., Corless, C. L., Heinrich, M. C., Park, J. O., Kang, W. K., Park, C. K. & Kim, K. M., Aug 2012, In : Pathology. 44, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mutation profiling in gallbladder cancer in Indian population

Kumari, N., Corless, C. L., Warrick, A., Beadling, C., Nelson, D., Neff, T., Krishnani, N. & Kapoor, V. K., Jan 1 2014, In : Indian Journal of Pathology and Microbiology. 57, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M. C., Loriaux, M. M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J. W., Dunlap, J., Corless, C. L. & Fan, G., Sep 1 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalLetter

43 Scopus citations

Next generation sequencing in clinical diagnostics: Experiences of early adopters

Lyon, E., Cockerill, F. R., Bale, S. J., Beadling, C., Bry, L., Hagenkord, J., Kulkarni, S., Press, R. & Palomaki, G. E., Jan 1 2015, In : Clinical chemistry. 61, 1, p. 41-49 9 p.

Research output: Contribution to journalReview article

1 Scopus citations

Novel method for PIK3CA mutation analysis: Locked nucleic acid-PCR sequencing

Ang, D., O'Gara, R., Schilling, A., Beadling, C., Warrick, A., Troxell, M. L. & Corless, C. L., May 1 2013, In : Journal of Molecular Diagnostics. 15, 3, p. 312-318 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Novel mutations in neuroendocrine carcinoma of the breast: Possible therapeutic targets

Ang, D., Ballard, M., Beadling, C., Warrick, A., Schilling, A., O'Gara, R., Pukay, M., Neff, T. L., West, R. B., Corless, C. L. & Troxell, M. L., Feb 28 2015, In : Applied Immunohistochemistry and Molecular Morphology. 23, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract

Tseng, D., Kim, J., Warrick, A., Nelson, D., Pukay, M., Beadling, C., Heinrich, M., Selim, M. A., Corless, C. L. & Nelson, K., Aug 2014, In : Journal of the American Academy of Dermatology. 71, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions

Troxell, M. L., Brunner, A. L., Neff, T., Warrick, A., Beadling, C., Montgomery, K., Zhu, S., Corless, C. L. & West, R. B., Jul 1 2012, In : Modern Pathology. 25, 7, p. 930-937 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

PIK3CA-AKT pathway mutations in micropapillary breast carcinoma

Flatley, E., Ang, D., Warrick, A., Beadling, C., Corless, C. L. & Troxell, M. L., Jul 1 2013, In : Human Pathology. 44, 7, p. 1320-1327 8 p.

Research output: Contribution to journalArticle

12 Scopus citations