Carol Beadling

Research Assistant Professor

  • 2837 Citations
  • 26 h-Index
1987 …2017

Research output per year

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Research Output

  • 2837 Citations
  • 26 h-Index
  • 58 Article
2017

Biochemical, molecular, and clinical characterization of succinate dehydrogenase subunit A variants of unknown significance

Bannon, A. E., Kent, J., Forquer, I., Town, A., Klug, L. R., McCann, K., Beadling, C., Harismendy, O., Sicklick, J. K., Corless, C., Shinde, U. & Heinrich, M., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6733-6743 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Durable Response to Afatinib in Lung Adenocarcinoma Harboring NRG1 Gene Fusions

Gay, N. D., Wang, Y., Beadling, C., Warrick, A., Neff, T., Corless, C. & Tolba, K., Feb 25 2017, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

18 Scopus citations

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

Schaefer, I. M., Wang, Y., Liang, C. W., Bahri, N., Quattrone, A., Doyle, L., Marinõ-Enríquez, A., Lauria, A., Zhu, M., Debiec-Rychter, M., Grunewald, S., Hechtman, J. F., Dufresne, A., Antonescu, C. R., Beadling, C., Sicinska, E. T., Van De Rijn, M., Demetri, G. D., Ladanyi, M., Corless, C. & 4 others, Heinrich, M., Raut, C. P., Bauer, S. & Fletcher, J. A., Mar 8 2017, In : Nature Communications. 8, 14674.

Research output: Contribution to journalArticle

16 Scopus citations
2016

A Multiplexed Amplicon Approach for Detecting Gene Fusions by Next-Generation Sequencing

Beadling, C., Wald, A. I., Warrick, A., Neff, T. L., Zhong, S., Nikiforov, Y. E., Corless, C. & Nikiforova, M. N., Mar 1 2016, In : Journal of Molecular Diagnostics. 18, 2, p. 165-175 11 p.

Research output: Contribution to journalArticle

31 Scopus citations
2015

Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data

Grasso, C., Butler, T., Rhodes, K., Quist, M., Neff, T. L., Moore, S., Tomlins, S. A., Reinig, E., Beadling, C., Andersen, M. & Corless, C., Jan 1 2015, In : Journal of Molecular Diagnostics. 17, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation

Serrano, C., Wang, Y., Mariño-Enríquez, A., Lee, J. C., Ravegnini, G., Morgan, J. A., Bertagnolli, M. M., Beadling, C., Demetri, G. D., Corless, C., Heinrich, M. & Fletcher, J. A., Aug 1 2015, In : Journal of Clinical Oncology. 33, 22, p. e93-e96

Research output: Contribution to journalArticle

23 Scopus citations

Molecular profiling and targeted therapy for advanced thoracic malignancies a biomarker-derived, multiarm, multihistology phase ii basket trial

Lopez-Chavez, A., Thomas, A., Rajan, A., Raffeld, M., Morrow, B., Kelly, R., Carter, C. A., Guha, U., Killian, K., Lau, C. C., Abdullaev, Z., Xi, L., Pack, S., Meltzer, P. S., Corless, C., Sandler, A., Beadling, C., Warrick, A., Liewehr, D. J., Steinberg, S. M. & 5 others, Berman, A., Doyle, A., Szabo, E., Wang, Y. & Giaccone, G., Mar 20 2015, In : Journal of Clinical Oncology. 33, 9, p. 1000-1007 8 p.

Research output: Contribution to journalArticle

136 Scopus citations

Next generation sequencing in clinical diagnostics: Experiences of early adopters

Lyon, E., Cockerill, F. R., Bale, S. J., Beadling, C., Bry, L., Hagenkord, J., Kulkarni, S., Press, R. & Palomaki, G. E., Jan 1 2015, In : Clinical Chemistry. 61, 1, p. 41-49 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Novel mutations in neuroendocrine carcinoma of the breast: Possible therapeutic targets

Ang, D., Ballard, M., Beadling, C., Warrick, A., Schilling, A., O'Gara, R., Pukay, M., Neff, T. L., West, R. B., Corless, C. & Troxell, M., Feb 28 2015, In : Applied Immunohistochemistry and Molecular Morphology. 23, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Utility of BRAF V600E mutation-specific immunohistochemistry in detecting BRAF V600E-Mutated gastrointestinal stromal tumors

Patil, D. T., Ma, S., Konishi, M., Carver, P. D., Pukay, M., Beadling, C., Corless, C. & Rubin, B. P., Nov 1 2015, In : American Journal of Clinical Pathology. 144, 5, p. 782-789 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Combination therapy for KIT-mutant mast cells: Targeting constitutive NFAT and KIT activity

Macleod, A. C., Klug, L. R., Patterson, J., Griffith, D. J., Beadling, C., Town, A. & Heinrich, M., Dec 1 2014, In : Molecular Cancer Therapeutics. 13, 12, p. 2840-2851 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Frequent phosphatidylinositol-3-kinase mutations in proliferative breast lesions

C Ang, D., Warrick, A. L., Shilling, A., Beadling, C., Corless, C. & Troxell, M., 2014, In : Modern Pathology. 27, 5, p. 740-750 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Genetic profiling to determine risk of relapse-free survival in high-risk localized prostate cancer

Barnett, C. M., Heinrich, M., Lim, J., Nelson, D., Beadling, C., Warrick, A., Neff, T., Higano, C. S., Garzotto, M., Qian, Z. D., Corless, C., Thomas, G. & Beer, T. T., 2014, In : Clinical Cancer Research. 20, 5, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mutation profiling in gallbladder cancer in Indian population

Kumari, N., Corless, C., Warrick, A., Beadling, C., Nelson, D., Neff, T., Krishnani, N. & Kapoor, V. K., 2014, In : Indian Journal of Pathology and Microbiology. 57, 1, p. 9-12 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Oncogenic mutations in melanomas and benign melanocytic nevi of the female genital tract

Tseng, D., Kim, J., Warrick, A., Nelson, D., Pukay, M., Beadling, C., Heinrich, M., Selim, M. A., Corless, C. & Nelson, K., 2014, In : Journal of the American Academy of Dermatology. 71, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2013

BRAF mutant gastrointestinal stromal tumor: First report of regression with BRAF inhibitor dabrafenib (GSK2118436) and whole exomic sequencing for analysis of acquired resistance

Falchook, G. S., Trent, J. C., Heinrich, M., Beadling, C., Patterson, J., Bastida, C. C., Blackman, S. C. & Kurzrock, R., 2013, In : Oncotarget. 4, 2, p. 310-315 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping

Beadling, C., Neff, T. L., Heinrich, M., Rhodes, K., Thornton, M., Leamon, J., Andersen, M. & Corless, C., Mar 2013, In : Journal of Molecular Diagnostics. 15, 2, p. 171-176 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Cytokine-Mediated Programmed Proliferation of Virus-Specific CD8+ Memory T Cells

Raué, H. P., Beadling, C., Haun, J. & Slifka, M., Jan 24 2013, In : Immunity. 38, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Frequent PIK3CA mutations in radial scars

Wolters, K. L., Ang, D., Warrick, A., Beadling, C., Corless, C. & Troxell, M., 2013, In : Diagnostic Molecular Pathology. 22, 4, p. 210-214 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Imatinib for melanomas harboring mutationally activated or amplified kit arising on mucosal, acral, and chronically sun-damaged skin

Hodi, F. S., Corless, C., Giobbie-Hurder, A., Fletcher, J. A., Zhu, M., Marino-Enriquez, A., Friedlander, P., Gonzalez, R., Weber, J. S., Gajewski, T. F., O'Day, S. J., Kim, K. B., Lawrence, D., Flaherty, K. T., Luke, J. J., Collichio, F. A., Ernstoff, M. S., Heinrich, M., Beadling, C., Zukotynski, K. A. & 4 others, Yap, J. T., Van Den Abbeele, A. D., Demetri, G. D. & Fisher, D. E., Sep 10 2013, In : Journal of Clinical Oncology. 31, 26, p. 3182-3190 9 p.

Research output: Contribution to journalArticle

277 Scopus citations

MDM2 amplification and PI3KCA mutation in a case of sclerosing rhabdomyosarcoma

Kikuchi, K., Wettach, G. R., Ryan, C., Hung, A., Hooper, J. E., Beadling, C., Warrick, A., Corless, C., Olson, S., Keller, C. & Mansoor, A., 2013, In : Sarcoma. 2013, 520858.

Research output: Contribution to journalArticle

8 Scopus citations

Novel method for PIK3CA mutation analysis: Locked nucleic acid-PCR sequencing

Ang, D., O'Gara, R., Schilling, A., Beadling, C., Warrick, A., Troxell, M. & Corless, C., May 2013, In : Journal of Molecular Diagnostics. 15, 3, p. 312-318 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

PIK3CA-AKT pathway mutations in micropapillary breast carcinoma

Flatley, E., Ang, D., Warrick, A., Beadling, C., Corless, C. & Troxell, M., Jul 2013, In : Human Pathology. 44, 7, p. 1320-1327 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

Biphasic papillary and lobular breast carcinoma with PIK3CA and IDH1 mutations

Ang, D., VanSandt, A., Beadling, C., Warrick, A., West, R. B., Corless, C. & Troxell, M., Dec 2012, In : Diagnostic Molecular Pathology. 21, 4, p. 221-224 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

BRAF and KRAS mutations in sporadic glomus tumors

Chakrapani, A., Warrick, A., Nelson, D., Beadling, C. & Corless, C., Jul 2012, In : American Journal of Dermatopathology. 34, 5, p. 533-535 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Mucinous breast carcinomas lack PIK3CA and AKT1 mutations

Kehr, E. L., Jorns, J. M., Ang, D., Warrick, A., Neff, T., Degnin, M., Lewis, R., Beadling, C., Corless, C. & Troxell, M., Dec 2012, In : Human Pathology. 43, 12, p. 2207-2212 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Multiplex high-throughput gene mutation analysis in acute myeloid leukemia

Dunlap, J., Beadling, C., Warrick, A., Neff, T., Fleming, W., Loriaux, M., Heinrich, M., Kovacsovics, T., Kelemen, K., Leeborg, N., Gatter, K., Braziel, R., Press, R., Corless, C. & Fan, G., Dec 2012, In : Human Pathology. 43, 12, p. 2167-2176 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Multiplex mutation screening by mass spectrometry in gastrointestinal stromal tumours

Kang, G., Lee, J., Jang, K. T., Beadling, C., Corless, C., Heinrich, M., Park, J. O., Kang, W. K., Park, C. K. & Kim, K. M., Aug 2012, In : Pathology. 44, 5, p. 460-464 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia

Bains, T., Heinrich, M., Loriaux, M., Beadling, C., Nelson, D., Warrick, A., Neff, T. L., Tyner, J., Dunlap, J., Corless, C. & Fan, G., Sep 2012, In : Leukemia. 26, 9, p. 2144-2146 3 p.

Research output: Contribution to journalArticle

43 Scopus citations

Phosphatidylinositol-3-kinase pathway mutations are common in breast columnar cell lesions

Troxell, M., Brunner, A. L., Neff, T., Warrick, A., Beadling, C., Montgomery, K., Zhu, S., Corless, C. & West, R. B., Jul 2012, In : Modern Pathology. 25, 7, p. 930-937 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

RAS mutations in therapy-related acute myeloid leukemia after successful treatment of acute promyelocytic leukemia

Kelemen, K., Kovacsovics, T., Braziel, R., Corless, C., Beadling, C. & Fan, G., May 2012, In : Leukemia and Lymphoma. 53, 5, p. 999-1002 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2011

Immunohistochemical and molecular markers in breast phyllodes tumors

Korcheva, V., Levine, J., Beadling, C., Warrick, A., Countryman, G., Olson, N. R., Heinrich, M., Corless, C. & Troxell, M., Mar 2011, In : Applied Immunohistochemistry and Molecular Morphology. 19, 2, p. 119-125 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Multiplex Mutation screening by mass spectrometry: Evaluation of 820 cases from a personalized cancer medicine registry

Beadling, C., Heinrich, M., Warrick, A., Forbes, E. M., Nelson, D., Justusson, E., Levine, J., Neff, T. L., Patterson, J., Presnell, A., McKinley, A., Winter, L. J., Dewey, C., Harlow, A., Barney, O., Druker, B., Schuff, K. & Corless, C., Sep 2011, In : Journal of Molecular Diagnostics. 13, 5, p. 504-513 10 p.

Research output: Contribution to journalArticle

67 Scopus citations
2010

High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast

Troxell, M., Levine, J., Beadling, C., Warrick, A., Dunlap, J., Presnell, A., Patterson, J., Shukla, A., Olson, N. R., Heinrich, M. & Corless, C., Jan 2010, In : Modern Pathology. 23, 1, p. 27-37 11 p.

Research output: Contribution to journalArticle

68 Scopus citations

MET receptor sequence variants R970C and T992I lack transforming capacity

Tyner, J., Fletcher, L. B., Wang, E. Q., Yang, W. F., Rutenberg-Schoenberg, M. L., Beadling, C., Mori, M. T., Heinrich, M., Deininger, M. W., Druker, B. & Loriaux, M., Aug 1 2010, In : Cancer Research. 70, 15, p. 6233-6237 5 p.

Research output: Contribution to journalArticle

54 Scopus citations
2008

KIT gene mutations and copy number in melanoma subtypes

Beadling, C., Jacobson-Dunlop, E., Hodi, F. S., Le, C., Warrick, A., Patterson, J., Town, A., Harlow, A., Cruz, F., Azar, S., Rubin, B. P., Muller, S., West, R., Heinrich, M. & Corless, C., Nov 1 2008, In : Clinical Cancer Research. 14, 21, p. 6821-6828 8 p.

Research output: Contribution to journalArticle

408 Scopus citations
2006

Quantifying viable virus-specific T cells without a priori knowledge of fine epitope specificity

Beadling, C. & Slifka, M., Oct 2006, In : Nature Medicine. 12, 10, p. 1208-1212 5 p.

Research output: Contribution to journalArticle

27 Scopus citations
66 Scopus citations
2005

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines

Beadling, C. & Slifka, M., Feb 1 2005, In : Blood. 105, 3, p. 1179-1186 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2004

How do viral infections predispose patients to bacterial infections?

Beadling, C. & Slifka, M., Jun 2004, In : Current Opinion in Infectious Diseases. 17, 3, p. 185-191 7 p.

Research output: Contribution to journalArticle

93 Scopus citations
2002

DNA array analysis of interleukin-2-regulated immediate/early genes

Beadling, C. & Smith, K. A., Nov 18 2002, In : Medical Immunology. 1, 2.

Research output: Contribution to journalArticle

63 Scopus citations
2001

Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival

Beadling, C., Cereseto, A., Fan, W., Naramura, M. & Smith, K. A., Mar 29 2001, In : Oncogene. 20, 14, p. 1771-1783 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
1999

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest

Fan, W., Richter, G., Cereseto, A., Beadling, C. & Smith, K. A., Nov 11 1999, In : Oncogene. 18, 47, p. 6573-6582 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes

Beadling, C., Druey, K. M., Richter, G., Kehrl, J. H. & Smith, K. A., Mar 1 1999, In : Journal of Immunology. 162, 5, p. 2677-2682 6 p.

Research output: Contribution to journalArticle

86 Scopus citations
1997

Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene.

Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., Apr 1997, In : Molecular and Cellular Biology. 17, 4, p. 2351 1 p.

Research output: Contribution to journalArticle

Erratum: Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene (Molecular and Cellular Biology 16:12 (6831))

Lecine, P., Algarte, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., 1997, In : Molecular and Cellular Biology. 17, 4, p. 2351 1 p.

Research output: Contribution to journalArticle

3 Scopus citations
1996

Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene

Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M. & Imbert, J., 1996, In : Molecular and Cellular Biology. 16, 12, p. 6829-6840 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway

Beadling, C., Ng, J., Babbage, J. W. & Cantrell, D. A., Apr 15 1996, In : EMBO Journal. 15, 8, p. 1902-1913 12 p.

Research output: Contribution to journalArticle

158 Scopus citations
1995

Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Foxwell, B. M. J., Beadling, C., Guschin, D., Kerr, I. & Cantrell, D., Nov 1995, In : European Journal of Immunology. 25, 11, p. 3041-3046 6 p.

Research output: Contribution to journalArticle

97 Scopus citations
1994

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon α, but not the T cell antigen receptor, in human T lymphocytes

Beadling, C., Guschin, D., Witthuhn, B. A., Ziemiecki, A., Ihle, J. N., Kerr, I. M. & Cantrell, D. A., Dec 1 1994, In : EMBO Journal. 13, 23, p. 5605-5615 11 p.

Research output: Contribution to journalArticle

182 Scopus citations