Brian Druker

Professor

  • 64549 Citations
  • 109 h-Index
1981 …2019
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Research Output 1981 2019

2019

Challenges and approaches to implementing master/basket trials in oncology

Burd, A., Schilsky, R. L., Byrd, J. C., Levine, R. L., Papadimitrakopoulou, V. A., Herbst, R. S., Redman, M. W., Druker, B. & Gandara, D. R., Jul 23 2019, In : Blood Advances. 3, 14, p. 2237-2243 7 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Research Personnel
Appetite
Epigenomics
Health Personnel
6 Citations (Scopus)

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Zhang, H., Savage, S., Schultz, A. R., Bottomly, D., White, L., Segerdell, E., Wilmot, B., McWeeney, S., Eide, C. A., Nechiporuk, T., Carlos, A., Henson, R., Lin, C., Searles, R., Ho, H., Lam, Y. L., Sweat, R., Follit, C., Jain, V., Lind, E. & 10 others, Borthakur, G., Garcia-Manero, G., Ravandi, F., Kantarjian, H. M., Cortes, J., Collins, R., Buelow, D. R., Baker, S. D., Druker, B. & Tyner, J., Dec 1 2019, In : Nature Communications. 10, 1, 244.

Research output: Contribution to journalArticle

leukemias
mutations
Acute Myeloid Leukemia
Mutation
inhibitors

Erratum: Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells (eLife (2019) 8 PII: e47174)

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribeiro, R., Viola, S. K., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Mar 29 2019, In : eLife. 8

Research output: Contribution to journalComment/debate

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Medicine
Bone

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Protein-Tyrosine Kinases
Bone

Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia

on behalf of the International CML Foundation Genomics Alliance, Jan 1 2019, In : Leukemia.

Research output: Contribution to journalReview article

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Neoplasm Genes
Treatment Failure
Mutation
1 Citation (Scopus)

Predicting response to BET inhibitors using computational modeling: A BEAT AML project study

Drusbosky, L. M., Vidva, R., Gera, S., Lakshminarayana, A. V., Shyamasundar, V. P., Agrawal, A. K., Talawdekar, A., Abbasi, T., Vali, S., Tognon, C. E., Kurtz, S. E., Tyner, J., McWeeney, S., Druker, B. & Cogle, C. R., Feb 1 2019, In : Leukemia Research. 77, p. 42-50 9 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Genomics
Computational Biology
MAP Kinase Signaling System
Chromosome Aberrations

Reply to n. Cerveira et al

Berman, E., Druker, B. & Burwick, R., Jan 1 2019, In : Journal of Clinical Oncology. 37, 1, 1 p.

Research output: Contribution to journalLetter

The combination of NPM1, DNMT3A, and IDH1/2 mutations leads to inferior overall survival in AML

Dunlap, J., Leonard, J., Rosenberg, M., Cook, R., Press, R., Fan, G., Raess, P., Druker, B. & Traer, E., Aug 1 2019, In : American Journal of Hematology. 94, 8, p. 913-920 8 p.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Mutation
Survival
Recurrence
Insertional Mutagenesis
1 Citation (Scopus)

The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

Nechiporuk, T., Kurtz, S. E., Nikolova, O., Liu, T., Jones, C. L., D’alessandro, A., Culp-Hill, R., D’almeida, A., Joshi, S. K., Rosenberg, M., Tognon, C. E., Danilov, A., Druker, B., Chang, B., McWeeney, S. & Tyner, J., Jul 1 2019, In : Cancer discovery. 9, 7, p. 910-925 16 p.

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Gene Silencing
Drug Combinations
Drug Resistance
2 Citations (Scopus)

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib

Latifi, Y., Moccetti, F., Wu, M., Xie, A., Packwood, W., Yue, Q., Ozawa, K., Shentu, W., Brown, E., Shirai, T., McCarty, O., Ruggeri, Z., Moslehi, J., Chen, J., Druker, B., López, J. A. & Lindner, J., Apr 4 2019, In : Blood. 133, 14, p. 1597-1606 10 p.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
von Willebrand Factor
Protein-Tyrosine Kinases
Platelets
Toxicity
2018
2 Citations (Scopus)

A novel AGGF1-PDGFRβ fusion in pediatric T-cell acute lymphoblastic leukemia

Zabriskie, M. S., Antelope, O., Verma, A. R., Draper, L. R., Eide, C. A., Pomicter, A. D., Tran, T. H., Druker, B., Tyner, J., Miles, R. R., Graham, J. M., Hwang, J. Y., Varley, K. E., Toydemir, R. M., Deininger, M. W., Raetz, E. A. & O’Hare, T., Jan 31 2018, In : Haematologica. 103, 2, p. e87-e91

Research output: Contribution to journalComment/debate

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics

Automated decision tree to evaluate genetic abnormalities when determining prognostic risk in acute myeloid leukemia

Watanabe-Smith, K., Druker, B., Tyner, J. & Edwards, D. K., Jul 31 2018, In : Haematologica. 103, 8, p. e351-e355

Research output: Contribution to journalLetter

Decision Trees
Acute Myeloid Leukemia
7 Citations (Scopus)

Chronic myelogenous leukemia: Pregnancy in the era of stopping tyrosine kinase inhibitor therapy

Berman, E., Druker, B. & Burwick, R., Apr 20 2018, In : Journal of Clinical Oncology. 36, 12, p. 1250-1256 7 p.

Research output: Contribution to journalReview article

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Pregnancy
Therapeutics

Dual inhibition of JAK1/2 kinases and BCL2: a promising therapeutic strategy for acute myeloid leukemia

Kurtz, S. E., Eide, C. A., Kaempf, A., Mori, M. T., Tognon, C. E., Borate, U., Druker, B. & Tyner, J., Sep 1 2018, In : Leukemia. 32, 9, p. 2025-2028 4 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Phosphotransferases
Therapeutics
31 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks
1 Citation (Scopus)

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M. T., Druker, B., Singer, J. W. & Agarwal, A., Mar 29 2018, (Accepted/In press) In : Leukemia. p. 1-14 14 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptor-Associated Kinases
Acute Myeloid Leukemia
Myeloid Cells
Therapeutics
Heterografts

Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms

MacHado-Neto, J. A., Fenerich, B. A., Scopim-Ribeiro, R., Eide, C. A., Coelho-Silva, J. L., Dechandt, C. R. P., Fernandes, J. C., Rodrigues Alves, A. P. N., Scheucher, P. S., Simões, B. P., Alberici, L. C., De Figueiredo Pontes, L. L., Tognon, C. E., Druker, B., Rego, E. M. & Traina, F., Mar 1 2018, In : Cell Death and Disease. 9, 3, 311.

Research output: Contribution to journalArticle

Metformin
Neoplasms
Polycythemia Vera
Cell Survival
Cell Proliferation
3 Citations (Scopus)

Rare but recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma

Davare, M., Henderson, J. J., Agarwal, A., Wagner, J. P., Iyer, S. R., Shah, N., Woltjer, R. R., Somwar, R., Gilheeney, S. W., DeCarvalo, A., Mikkelson, T., Van Meir, E. G., Ladanyi, M. & Druker, B., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

Oncogenes
Glioma
Glioblastoma
Chromosomes
Central Nervous System Neoplasms

Reply to D.M. Ross et al and V. Florou et al

Berman, E., Druker, B. & Burwick, R., Sep 1 2018, In : Journal of Clinical Oncology. 36, 25, p. 2660-2661 2 p.

Research output: Contribution to journalLetter

ethyl 3,4-dioxobutyrate-di-(4,4-dimethylthiosemicarbazone)
12 Citations (Scopus)

Targeting BCR-ABL-independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition

Mitchell, R., Hopcroft, L. E. M., Baquero, P., Allan, E. K., Hewit, K., James, D., Hamilton, G., Mukhopadhyay, A., O'Prey, J., Hair, A., Melo, J. V., Chan, E., Ryan, K. M., Maguer-Satta, V., Druker, B., Clark, R. E., Mitra, S., Herzyk, P., Nicolini, F. E., Salomoni, P. & 4 others, Shanks, E., Calabretta, B., Holyoake, T. L. & Helgason, G. V., Jan 1 2018, In : Journal of the National Cancer Institute. 110, 5, p. 467-478 12 p.

Research output: Contribution to journalArticle

Autophagy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Myeloid Cells
Pharmaceutical Preparations
4 Citations (Scopus)

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes
2017
4 Citations (Scopus)

Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: Findings and recommendations

Watanabe-Smith, K., Godil, J., Agarwal, A., Tognon, C. & Druker, B., 2017, In : Oncotarget. 8, 8, p. 12596-12606 11 p.

Research output: Contribution to journalArticle

Transgenes
Mutation
Intercellular Signaling Peptides and Proteins
Leukemia
Cytokine Receptors
1 Citation (Scopus)
Large Granular Lymphocytic Leukemia
Hematopoiesis
Mutation
12 Citations (Scopus)

CRISPR-Cas9–mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy

Ma, L., Boucher, J. I., Paulsen, J., Matuszewski, S., Eide, C. A., Ou, J., Eickelberg, G., Press, R., Zhu, L. J., Druker, B., Branford, S., Wolfe, S. A., Jensen, J. D., Schiffer, C. A., Green, M. R. & Bolon, D. N., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. 11751-11756 6 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Drug Resistance
Mutagenesis
Mutation
Oncogenes
1 Citation (Scopus)

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

Pietarinen, P. O., Eide, C. A., Ayuda-Durán, P., Potdar, S., Kuusanmäki, H., Andersson, E. I., Mpindi, J. P., Pemovska, T., Kontro, M., Heckman, C. A., Kallioniemi, O., Wennerberg, K., Hjorth-Hansen, H., Druker, B., Enserink, J. M., Tyner, J., Mustjoki, S. & Porkka, K., 2017, In : Oncotarget. 8, 14, p. 22606-22615 10 p.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Leukemia
Stem Cells
1 Citation (Scopus)

Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line

Henderson, J. J., Wagner, J. P., Hofmann, N. E., Eide, C. A., Cho, Y-J., Druker, B. & Davare, M., 2017, (Accepted/In press) In : Pediatric Blood and Cancer.

Research output: Contribution to journalArticle

Medulloblastoma
Tuberous Sclerosis
Cell Line
Mutation
Phosphotransferases
30 Citations (Scopus)

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J., Druker, B., Bagby, G. C., McWeeney, S. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

Interleukin-1
Acute Myeloid Leukemia
Disease Progression
Screening
Interleukin-1 Receptors
201 Citations (Scopus)

Long-term outcomes of imatinib treatment for chronic myeloid leukemia

Hochhaus, A., Larson, R. A., Guilhot, F., Radich, J. P., Branford, S., Hughes, T. P., Baccarani, M., Deininger, M. W., Cervantes, F., Fujihara, S., Ortmann, C. E., Menssen, H. D., Kantarjian, H., O'Brien, S. G. & Druker, B., Mar 9 2017, In : New England Journal of Medicine. 376, 10, p. 917-927 11 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytarabine
Interferon-alpha
Imatinib Mesylate
Leukemia, Myeloid, Chronic Phase
5 Citations (Scopus)

Maternal, fetal, and neonatal imatinib levels with treatment of chronic myeloid leukemia in pregnancy

Burwick, R., Kuo, K., Brewer, D. & Druker, B., 2017, In : Obstetrics and Gynecology. 129, 5, p. 831-834 4 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mothers
Pregnancy
Leukapheresis
Second Pregnancy Trimester
26 Citations (Scopus)

Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies

Kurtz, S. E., Eide, C. A., Kaempf, A., Khanna, V., Savage, S. L., Rofelty, A., English, I., Ho, H., Pandya, R., Bolosky, W. J., Poon, H., Deininger, M. W., Collins, R., Swords, R. T., Watts, J., Pollyea, D. A., Medeiros, B. C., Traer, E., Tognon, C. E., Mori, M. T. & 2 others, Druker, B. & Tyner, J., Sep 5 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 36, p. E7554-E7563

Research output: Contribution to journalArticle

Hematologic Neoplasms
Drug Combinations
Acute Myeloid Leukemia
B-Cell Chronic Lymphocytic Leukemia
Cytogenetics

Novel Method Enabling the Use of Cryopreserved Primary Acute Myeloid Leukemia Cells in Functional Drug Screens

Degnin, M., Agarwal, A., Tarlock, K., Meshinchi, S., Druker, B. & Tognon, C. E., 2017, In : Journal of Pediatric Hematology/Oncology. 39, 7, p. e359-e366

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Leukemia
Pharmaceutical Preparations
Cytokines

Peter C. Nowell (1928-2016)

Reed, J. C. & Druker, B., May 2 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 18, p. 4569-4570 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Recurrent cyclin D2 mutations in myeloid neoplasms

Khanna, V., Eide, C. A., Tognon, C. E., Maxson, J., Wilmot, B., Bottomly, D., McWeeney, S., Edwards, V. D. K., Druker, B. & Tyner, J., Sep 1 2017, In : Leukemia. 31, 9, p. 2005-2008 4 p.

Research output: Contribution to journalLetter

12 Citations (Scopus)

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia

Sasaki, T., Rivera-Mulia, J. C., Vera, D., Zimmerman, J., Das, S., Padget, M., Nakamichi, N., Chang, B., Tyner, J., Druker, B., Weng, A. P., Civin, C. I., Eaves, C. J. & Gilbert, D. M., Jul 1 2017, In : Experimental Hematology. 51, p. 71-82.e3

Research output: Contribution to journalArticle

DNA Replication Timing
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Heterografts
Lymphocytes
Serial Passage
2 Citations (Scopus)

Understanding cancer from the stem cells up

Eide, C. A. & Druker, B., Jun 6 2017, In : Nature Medicine. 23, 6, p. 656-657 2 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Stem cells
Therapeutics
Population
2016
57 Citations (Scopus)

A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer

Drilon, A., Somwar, R., Wagner, J. P., Vellore, N. A., Eide, C. A., Zabriskie, M. S., Arcila, M. E., Hechtman, J. F., Wang, L., Smith, R. S., Kris, M. G., Riely, G. J., Druker, B., O'Hare, T., Ladanyi, M. & Davare, M., May 15 2016, In : Clinical Cancer Research. 22, 10, p. 2351-2358 8 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Mutation
Therapeutics
Molecular Dynamics Simulation
crizotinib

Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women

Wiedmeier, J. E., Kato, C., Zhang, Z., Lee, H., Dunlap, J., Nutt, E., Rattray, R., McKay, S., Eide, C., Press, R., Mori, M. T., Druker, B. & Dao, K-H., Sep 1 2016, In : Experimental Hematology. 44, 9, p. 857-865.e5

Research output: Contribution to journalArticle

Hematopoiesis
Epigenomics
Regulator Genes
Mutation
Chromatin
3 Citations (Scopus)

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

Watanabe-Smith, K., Tognon, C., Tyner, J., Meijerink, J. P. P., Druker, B. & Agarwal, A., Sep 1 2016, In : Leukemia. 30, 9, p. 1950-1953 4 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia

Traer, E., Martinez, J., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Kovacsovics, T., Tyner, J., Wong, M. & Druker, B., Nov 15 2016, In : Cancer Research. 76, 22, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Acute Myeloid Leukemia
Bone Marrow
Ligands
Mutation
13 Citations (Scopus)

Identification and characterization of tyrosine kinase nonreceptor 2 mutations in leukemia through integration of kinase inhibitor screening and genomic analysis

Maxson, J., Abel, M. L., Wang, J., Deng, X., Reckel, S., Luty, S. B., Sun, H., Gorenstein, J., Hughes, S. B., Bottomly, D., Wilmot, B., McWeeney, S., Radich, J., Hantschel, O., Middleton, R. E., Gray, N. S., Druker, B. & Tyner, J., Jan 1 2016, In : Cancer Research. 76, 1, p. 127-138 12 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Leukemia
Phosphotransferases
Mutation
Leukemia, Myelomonocytic, Chronic
7 Citations (Scopus)

IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms

de Melo Campos, P., Machado-Neto, J. A., Eide, C. A., Savage, S. L., Scopim-Ribeiro, R., da Silva Souza Duarte, A., Favaro, P., Lorand-Metze, I., Costa, F. F., Tognon, C. E., Druker, B., Olalla Saad, S. T. & Traina, F., 2016, In : Oncotarget. 7, 6, p. 6948-6959 12 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Apoptosis
Neoplasms
Cell Survival
U937 Cells

JAK2V617I results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model

Brooks, S. A., Luty, S. B., Lai, H. Y., Morse, S. J., Nguyen, T. K., Royer, L. R., Agarwal, A., Druker, B. & Fleischman, A. G., Jan 1 2016, In : Experimental Hematology. 44, 1, p. 24-29.e1

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Hypersensitivity
Transplantation
Cytokines
Phenotype
15 Citations (Scopus)

Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Garbati, M. R., Welgan, C. A., Landefeld, S. H., Newell, L., Agarwal, A., Dunlap, J., Chourasia, T. K., Lee, H., Elferich, J., Traer, E., Rattray, R., Cascio, M., Press, R., Bagby, G. C., Tyner, J., Druker, B. & Dao, K-H., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

Calreticulin
Monocytes
Thrombocytosis
Primary Myelofibrosis
Genes
11 Citations (Scopus)

PBA2, a novel inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia

Gupta, P., Kathawala, R. J., Wei, L., Wang, F., Wang, X. K., Druker, B., Fu, L. W. & Chen, Z. S., Dec 28 2016, In : Cancer Letters. 383, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Mutation
Chromosome Breakage
Philadelphia Chromosome
G1 Phase
23 Citations (Scopus)

Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia

Leonard, J. T., Rowley, J. S. J., Eide, C. A., Traer, E., Hayes-Lattin, B., Loriaux, M., Spurgeon, S., Druker, B., Tyner, J. & Chang, B., Aug 31 2016, In : Science Translational Medicine. 8, 354, 354ra114.

Research output: Contribution to journalArticle

Philadelphia Chromosome
B-Cell Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Therapeutics
3 Citations (Scopus)

Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting

Jacob, T., Agarwal, A., Ramunno-Johnson, D., O'Hare, T., Gonen, M., Tyner, J., Druker, B. & Vu, T. T., Jun 20 2016, In : Scientific Reports. 6, 28163.

Research output: Contribution to journalArticle

Proteomics
Nanoparticles
Quantum Dots
Proteins
Pharmaceutical Preparations
2015
37 Citations (Scopus)

Age-related mutations and chronic myelomonocytic leukemia

Mason, C. C., Khorashad, J. S., Tantravahi, S. K., Kelley, T. W., Zabriskie, M. S., Yan, D., Pomicter, A. D., Reynolds, K. R., Eiring, A. M., Kronenberg, Z., Sherman, R. L., Tyner, J., Dalley, B. K., Dao, K-H., Yandell, M., Druker, B., Gotlib, J., O'Hare, T. & Deininger, M. W., Dec 9 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Mutation
Hematopoiesis
Genes
Exome
45 Citations (Scopus)

Cardio-oncology: How new targeted cancer therapies and precision medicine can inform cardiovascular discovery

Bellinger, A. M., Arteaga, C. L., Force, T., Humphreys, B. D., Demetri, G. D., Druker, B. & Moslehi, J. J., Dec 8 2015, In : Circulation. 132, 23, p. 2248-2258 11 p.

Research output: Contribution to journalArticle

Precision Medicine
Phosphotransferases
Neoplasms
Clinical Trials
Therapeutics
2 Citations (Scopus)

Chronic myelogenous leukemia

Druker, B. & Marin, D., Jan 7 2015, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology: Tenth Edition. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
36 Citations (Scopus)

Crosstalk between KIT and FGFR3 promotes gastrointestinal stromal tumor cell growth and drug resistance

Javidi-Sharifi, N., Traer, E., Martinez, J., Gupta, A., Taguchi, T., Dunlap, J., Heinrich, M., Corless, C., Rubin, B. P., Druker, B. & Tyner, J., Mar 1 2015, In : Cancer Research. 75, 5, p. 880-891 12 p.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Stromal Cells
Drug Resistance
Growth
Fibroblast Growth Factor 2