Bill Chang

Associate Professor

  • 2244 Citations
  • 24 h-Index
1993 …2020

Research output per year

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Research Output

  • 2244 Citations
  • 24 h-Index
  • 42 Article
  • 2 Letter
  • 1 Short survey
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Article
2020

Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia

Eide, C. A., Kurtz, S. E., Kaempf, A., Long, N., Agarwal, A., Tognon, C. E., Mori, M., Druker, B. J., Chang, B. H., Danilov, A. V. & Tyner, J. W., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

2019

Extracellular vesicles impose quiescence on residual hematopoietic stem cells in the leukemic niche

Abdelhamed, S., Butler, J. T., Doron, B., Halse, A., Nemecek, E., Wilmarth, P., Marks, D., Chang, B., Horton, T. & Kurre, P., Jul 1 2019, In : EMBO Reports. 20, 7, e47546.

Research output: Contribution to journalArticle

Replication timing alterations in leukemia affect clinically relevant chromosome domains

Rivera-Mulia, J. C., Sasaki, T., Trevilla-Garcia, C., Nakamichi, N., Knapp, D. J. H. F., Hammond, C. A., Chang, B. H., Tyner, J. W., Devidas, M., Zimmerman, J., Klein, K. N., Somasundaram, V., Druker, B. J., Gruber, T. A., Koren, A., Eaves, C. J. & Gilbert, D. M., Nov 12 2019, In : Blood Advances. 3, 21, p. 3201-3213 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells

Nechiporuk, T., Kurtz, S. E., Nikolova, O., Liu, T., Jones, C. L., D’alessandro, A., Culp-Hill, R., D’almeida, A., Joshi, S. K., Rosenberg, M., Tognon, C. E., Danilov, A. V., Druker, B. J., Chang, B. H., McWeeney, S. K. & Tyner, J. W., Jul 2019, In : Cancer discovery. 9, 7, p. 910-925 16 p.

Research output: Contribution to journalArticle

15 Scopus citations
2018

Dasatinib plus intensive chemotherapy in children, adolescents, and young adults with philadelphia chromosome–positive acute lymphoblastic leukemia: Results of children’s oncology group trial AALL0622

Slayton, W. B., Schultz, K. R., Kairalla, J. A., Devidas, M., Mi, X., Pulsipher, M. A., Chang, B., Mullighan, C., Iacobucci, I., Silverman, L. B., Borowitz, M. J., Carroll, A. J., Heerema, N. A., Gastier-Foster, J. M., Wood, B. L., Mizrahy, S. L., Merchant, T., Brown, V. I., Sieger, L., Siegel, M. J. & 5 others, Raetz, E. A., Winick, N. J., Loh, M. L., Carroll, W. L. & Hunger, S. P., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2306-2313 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL

Chow, M., Gao, L., MacManiman, J. D., Bicocca, V. T., Chang, B., Alumkal, J. & Tyner, J., May 30 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study

Sun, W., Malvar, J., Sposto, R., Verma, A., Wilkes, J. J., Dennis, R., Heym, K., Laetsch, T. W., Widener, M., Rheingold, S. R., Oesterheld, J., Hijiya, N., Sulis, M. L., Huynh, V., Place, A. E., Bittencourt, H., Hutchinson, R., Messinger, Y., Chang, B., Matloub, Y. & 10 others, Ziegler, D. S., Gardner, R., Cooper, T., Ceppi, F., Hermiston, M., Dalla-Pozza, L., Schultz, K. R., Gaynon, P., Wayne, A. S. & Whitlock, J. A., Nov 1 2018, In : Leukemia. 32, 11, p. 2316-2325 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Jenkins, C., Luty, S. B., Maxson, J., Eide, C. A., Abel, M. L., Togiai, C., Nemecek, E., Bottomly, D., McWeeney, S., Wilmot, B., Loriaux, M., Chang, B. & Tyner, J., Jul 17 2018, In : Science Signaling. 11, 539, eaao5617.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Clinical and immunological responses after CD30-specific chimeric antigen receptor-redirected lymphocytes

Ramos, C. A., Ballard, B., Zhang, H., Dakhova, O., Gee, A. P., Mei, Z., Bilgi, M., Wu, M. F., Liu, H., Grilley, B., Bollard, C. M., Chang, B., Rooney, C. M., Brenner, M. K., Heslop, H. E., Dotti, G. & Savoldo, B., Sep 1 2017, In : Journal of Clinical Investigation. 127, 9, p. 3462-3471 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Frismantas, V., Dobay, M. P., Rinaldi, A., Tchinda, J., Dunn, S. H., Kunz, J., Richter-Pechanska, P., Marovca, B., Pail, O., Jenni, S., Diaz-Flores, E., Chang, B. H., Brown, T. J., Collins, R. H., Uhrig, S., Balasubramanian, G. P., Bandapalli, O. R., Higi, S., Eugster, S., Voegeli, P. & 17 others, Delorenzi, M., Cario, G., Loh, M. L., Schrappe, M., Stanulla, M., Kulozik, A. E., Muckenthaler, M. U., Saha, V., Irving, J. A., Meisel, R., Radimerski, T., Von Stackelberg, A., Eckert, C., Tyner, J. W., Horvath, P., Bornhauser, B. C. & Bourquin, J. P., Mar 16 2017, In : Blood. 129, 11, p. e26-e37

Research output: Contribution to journalArticle

42 Scopus citations

Investigating the biology of relapsed acute leukemia: Proceedings of the Therapeutic Advances for Childhood Leukemia & Lymphoma (TACL) Consortium Biology Working Group

Bhojwani, D., Burke, M. J., Horton, T., Ziegler, D. S., Sulis, M. L., Schultz, K. R., Wayne, A., Izraeli, S. & Chang, B., Nov 29 2017, (Accepted/In press) In : Pediatric Hematology and Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Stability of patient-specific features of altered DNA replication timing in xenografts of primary human acute lymphoblastic leukemia

Sasaki, T., Rivera-Mulia, J. C., Vera, D., Zimmerman, J., Das, S., Padget, M., Nakamichi, N., Chang, B., Tyner, J., Druker, B., Weng, A. P., Civin, C. I., Eaves, C. J. & Gilbert, D. M., Jul 1 2017, In : Experimental Hematology. 51, p. 71-82.e3

Research output: Contribution to journalArticle

15 Scopus citations
2016

A phase i study of quizartinib combined with chemotherapy in relapsed childhood leukemia: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) study

Cooper, T. M., Cassar, J., Eckroth, E., Malvar, J., Sposto, R., Gaynon, P., Chang, B. H., Gore, L., August, K., Pollard, J. A., DuBois, S. G., Silverman, L. B., Oesterheld, J., Gammon, G., Magoon, D., Annesley, C. & Brown, P. A., Aug 15 2016, In : Clinical Cancer Research. 22, 16, p. 4014-4022 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia

Leonard, J. T., Rowley, J. S. J., Eide, C. A., Traer, E., Hayes-Lattin, B., Loriaux, M., Spurgeon, S., Druker, B., Tyner, J. & Chang, B., Aug 31 2016, In : Science Translational Medicine. 8, 354, 354ra114.

Research output: Contribution to journalArticle

30 Scopus citations
2015

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

Huan, J., Hornick, N. I., Goloviznina, N. A., Kamimae-Lanning, A. N., David, L., Wilmarth, P., Mori, M. T., Chevillet, J. R., Narla, A., Roberts, C., Loriaux, M., Chang, B. & Kurre, P., Jun 25 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

42 Scopus citations

Preventive antibiotics in pediatric patients with acute myeloid leukemia (AML)

Nolt, D., Lindemulder, S., Meyrowitz, J., Chang, B. H., Malempati, S., Thomas, G. & Stork, L., Jul 1 2015, In : Pediatric Blood and Cancer. 62, 7, p. 1149-1154 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

Geng, H., Hurtz, C., Lenz, K. B., Chen, Z., Baumjohann, D., Thompson, S., Goloviznina, N. A., Chen, W. Y., Huan, J., LaTocha, D., Ballabio, E., Xiao, G., Lee, J. W., Deucher, A., Qi, Z., Park, E., Huang, C., Nahar, R., Kweon, S. M., Shojaee, S. & 18 others, Chan, L. N., Yu, J., Kornblau, S. M., Bijl, J. J., Ye, B. H., Mark Ansel, K., Paietta, E., Melnick, A., Hunger, S. P., Kurre, P., Tyner, J. W., Loh, M. L., Roeder, R. G., Druker, B. J., Burger, J. A., Milne, T. A., Chang, B. H. & Müschen, M., Mar 9 2015, In : Cancer Cell. 27, 3, p. 409-425 17 p.

Research output: Contribution to journalArticle

57 Scopus citations

Serum Exosome MicroRNA as a minimally-invasive early biomarker of AML

Hornick, N. I., Huan, J., Doron, B., Goloviznina, N. A., Lapidus, J., Chang, B. H. & Kurre, P., Jun 12 2015, In : Scientific Reports. 5, 11295.

Research output: Contribution to journalArticle

83 Scopus citations

Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia

Tarlock, K., Chang, B., Cooper, T., Gross, T., Gupta, S., Neudorf, S., Adlard, K., Ho, P. A., Mcgoldrick, S., Watt, T., Templeman, T., Sisler, I., Garee, A., Thomson, B., Woolfrey, A., Estey, E., Meshinchi, S. & Pollard, J. A., Jun 1 2015, In : Pediatric Blood and Cancer. 62, 6, p. 1048-1054 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Therapeutically targetable ALK mutations in leukemia

Maxson, J. E., Davare, M. A., Luty, S. B., Eide, C. A., Chang, B. H., Loriaux, M. M., Tognon, C. E., Bottomly, D., Wilmot, B., McWeeney, S. K., Druker, B. J. & Tyner, J. W., Jun 1 2015, In : Cancer Research. 75, 11, p. 2146-2150 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway

Chang, B. H., Johnson, K., LaTocha, D., Rowley, J. S. J., Bryant, J., Burke, R., Smith, R. L., Loriaux, M., Müschen, M., Mullighan, C., Druker, B. J. & Tyner, J. W., Apr 22 2015, In : Journal of Hematology and Oncology. 8, 1, 39.

Research output: Contribution to journalArticle

18 Scopus citations
2013
4 Scopus citations

Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Tyner, J. W., Yang, W. F., Bankhead, A., Fan, G., Fletcher, L. B., Bryant, J., Glover, J. M., Chang, B. H., Spurgeon, S. E., Fleming, W. H., Kovacsovics, T., Gotlib, J. R., Oh, S. T., Deininger, M. W., Zwaan, C. M., Den Boer, M. L., Van Den Heuvel-Eibrink, M. M., O'Hare, T., Druker, B. J. & Loriaux, M. M., Jan 1 2013, In : Cancer Research. 73, 1, p. 285-296 12 p.

Research output: Contribution to journalArticle

91 Scopus citations

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J. E., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S. K., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B. H., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Jan 1 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

289 Scopus citations

TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

Sanda, T., Tyner, J. W., Gutierrez, A., Ngo, V. N., Glover, J., Chang, B. H., Yost, A., Ma, W., Fleischman, A. G., Zhou, W., Yang, Y., Kleppe, M., Ahn, Y., Tatarek, J., Kelliher, M. A., Neuberg, D. S., Levine, R. L., Moriggl, R., Müller, M., Gray, N. S. & 5 others, Jamieson, C. H. M., Weng, A. P., Staudt, L. M., Druker, B. J. & Thomas Look, A., May 1 2013, In : Cancer discovery. 3, 5, p. 564-577 14 p.

Research output: Contribution to journalArticle

75 Scopus citations
2012

Abnormal developmental control of replication-timing domains in pediatric acute lymphoblastic leukemia

Ryba, T., Battaglia, D., Chang, B. H., Shirley, J. W., Buckley, Q., Pope, B. D., Devidas, M., Druker, B. J. & Gilbert, D. M., Oct 1 2012, In : Genome Research. 22, 10, p. 1833-1844 12 p.

Research output: Contribution to journalArticle

62 Scopus citations

Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia

Bicocca, V. T., Chang, B. H., Masouleh, B. K., Muschen, M., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 13 2012, In : Cancer Cell. 22, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

96 Scopus citations
15 Scopus citations

Targeting survivin and p53 in pediatric acute lymphoblastic leukemia

Tyner, J. W., Jemal, A. M., Thayer, M., Druker, B. J. & Chang, B. H., Apr 2012, In : Leukemia. 26, 4, p. 623-632 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2009

RNAi screen for rapid therapeutic target identification in leukemia patients

Tyner, J. W., Deininger, M. W., Loriaux, M. M., Chang, B. H., Gotli, J. R., Willis, S. G., Erickson, H., Kovacsovics, T., O'Hare, T., Heinrich, M. C. & Druker, B. J., May 26 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 21, p. 8695-8700 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2008
9 Scopus citations
3 Scopus citations
2007

Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability

Chang, B. H., Smith, L., Huang, J. & Thayer, M., Mar 22 2007, In : Oncogene. 26, 13, p. 1852-1861 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint

Stauffer, D., Chang, B., Huang, J., Dunn, A. & Thayer, M., Mar 30 2007, In : Journal of Biological Chemistry. 282, 13, p. 9678-9687 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2006

Neuroblastoma Found in a 4-Year-Old After Rituximab Therapy for Opsoclonus-Myoclonus

Chang, B. H., Koch, T., Hopkins, K. & Malempati, S., Sep 1 2006, In : Pediatric Neurology. 35, 3, p. 213-215 3 p.

Research output: Contribution to journalArticle

5 Scopus citations
2001

Calcium/calmodulin-dependent protein kinase II inhibitor protein: Localization of isoforms in rat brain

Chang, B. H., Mukherji, S. & Soderling, T. R., Feb 14 2001, In : Neuroscience. 102, 4, p. 767-777 11 p.

Research output: Contribution to journalArticle

79 Scopus citations
1998

Ca2+/calmodulin-dependent kinase II mediates simultaneous enhancement of gap-junctional conductance and glutamatergic transmission

Pereda, A. E., Bell, T. D., Chang, B. H., Czernik, A. J., Nairn, A. C., Soderling, T. R. & Faber, D. S., Oct 27 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 22, p. 13272-13277 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Characterization of a calmodulin kinase II inhibitor protein in brain

Chang, B. H., Mukherji, S. & Soderling, T. R., Sep 1 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 18, p. 10890-10895 6 p.

Research output: Contribution to journalArticle

169 Scopus citations
1995

Identification in the calcineurin A subunit of the domain that binds the regulatory B subunit

Watanabe, Y., Perrino, B. A., Chang, B. H. & Soderling, T. R., Jan 1 1995, In : Journal of Biological Chemistry. 270, 1, p. 456-460 5 p.

Research output: Contribution to journalArticle

46 Scopus citations
1993

The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae

Geiser, J. R., Sundberg, H. A., Chang, B. H., Muller, E. G. D. & Davis, T. N., Dec 1993, In : Molecular and Cellular Biology. 13, 12, p. 7913-7924 12 p.

Research output: Contribution to journalArticle

Open Access
119 Scopus citations