Beverly Emerson

Staff Scientist

  • 4594 Citations
  • 31 h-Index
1984 …2017
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Research Output 1984 2017

  • 4594 Citations
  • 31 h-Index
  • 42 Article
  • 4 Review article
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Article
108 Citations (Scopus)

A methylation-mediator complex in hormone signaling

Xu, W., Cho, H., Kadam, S., Banayo, E. M., Anderson, S., Yates, J. R., Emerson, B. & Evans, R. M., Jan 15 2004, In : Genes and Development. 18, 2, p. 144-156 13 p.

Research output: Contribution to journalArticle

Open Access
Mediator Complex
Methylation
Hormones
Histones
Nucleosomes
54 Citations (Scopus)

Analysis of the tissue-specific enhancer at the 3' end of the chicken adult beta-globin gene.

Emerson, B., Nickol, J. M., Jackson, P. D. & Felsenfeld, G., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 14, p. 4786-4790 5 p.

Research output: Contribution to journalArticle

Open Access
beta-Globins
Base Pairing
Chickens
Erythrocytes
3' Flanking Region
36 Citations (Scopus)
Open Access
Superhelical DNA
T-Cell Antigen Receptor
T-Cell Receptor Genes
HMGA1a Protein
DNA
259 Citations (Scopus)

A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro

Armstrong, J. A., Bieker, J. J. & Emerson, B., Oct 2 1998, In : Cell. 95, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Open Access
Chromatin Assembly and Disassembly
Chromatin
Tissue
Globins
Genes
314 Citations (Scopus)

A transcriptional switch mediated by cofactor methylation

Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B., Montminy, M. & Evans, R. H., Dec 21 2001, In : Science. 294, 5551, p. 2507-2511 5 p.

Research output: Contribution to journalArticle

Methylation
CREB-Binding Protein
Hormones
Co-Repressor Proteins
Nucleosomes
128 Citations (Scopus)

BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells

Kaeser, M. D., Aslanian, A., Dong, M. Q., Yates, J. R. & Emerson, B., Nov 21 2008, In : Journal of Biological Chemistry. 283, 47, p. 32254-32263 10 p.

Research output: Contribution to journalArticle

Open Access
Embryonic Stem Cells
Stem cells
Transcriptional Activation
Genes
Chemical activation
3 Citations (Scopus)

Chromatin structure near transcriptionally active genes.

Felsenfeld, G., Emerson, B., Jackson, P. D., Lewis, C. D. & Nickol, J. M., Jan 1 1986, In : Progress in clinical and biological research. 218, p. 63-74 12 p.

Research output: Contribution to journalArticle

Genetic Transcription
Globins
Regulator Genes
Chromatin
Genes
22 Citations (Scopus)

Coordinate Transcriptional and Translational Repression of p53 by TGF-β1 Impairs the Stress Response

López-Díaz, F. J., Gascard, P., Balakrishnan, S. K., Zhao, J., delRincon, S. V., Spruck, C., Tlsty, T. D. & Emerson, B., May 23 2013, In : Molecular Cell. 50, 4, p. 552-564 13 p.

Research output: Contribution to journalArticle

Open Access
Switch Genes
Smad Proteins
Peptide Elongation Factors
Co-Repressor Proteins
Messenger RNA
23 Citations (Scopus)

Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro

Barton, M. C., Madani, N. & Emerson, B., Jul 8 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 14, p. 7257-7262 6 p.

Research output: Contribution to journalArticle

Open Access
DNA
Genes
Repressor Proteins
Superhelical DNA
Globins
26 Citations (Scopus)

DNA sequences and transcription factor interactions of active and inactive forms of mammalian 5 S RNA genes

Emerson, B. & Roeder, R. G., Jan 1 1984, In : Journal of Biological Chemistry. 259, 12, p. 7926-7935 10 p.

Research output: Contribution to journalArticle

DNA sequences
Transcription Factors
Genes
RNA
Amphibians
136 Citations (Scopus)

Epigenetic Silencing of the p16INK4a Tumor Suppressor Is Associated with Loss of CTCF Binding and a Chromatin Boundary

Witcher, M. & Emerson, B., May 15 2009, In : Molecular Cell. 34, 3, p. 271-284 14 p.

Research output: Contribution to journalArticle

Open Access
Epigenomics
Chromatin
Tumor Suppressor Genes
Adenosine Diphosphate
Carcinogenesis
45 Citations (Scopus)

Erythroid-specific activation and derepression of the chick β-globin promoter in vitro

Emerson, B., Nickol, J. M. & Fong, T. C., Jun 30 1989, In : Cell. 57, 7, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Globins
Chemical activation
Cells
Genes
Proteins
13 Citations (Scopus)

Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology

Balakrishnan, S. K., Witcher, M., Berggren, T. W. & Emerson, B., Aug 3 2012, In : PloS one. 7, 8, e42424.

Research output: Contribution to journalArticle

Open Access
Cytology
embryonic stem cells
Stem cells
cell biology
Cell Biology
175 Citations (Scopus)

Functional selectivity of recombinant mammalian SWI/SNF subunits

Kadam, S., McAlpine, G. S., Phelan, M. L., Kingston, R. E., Jones, K. A. & Emerson, B., Oct 1 2000, In : Genes and Development. 14, 19, p. 2441-2451 11 p.

Research output: Contribution to journalArticle

Open Access
Chromatin Assembly and Disassembly
Transcription Factors
Chromatin
Zinc Fingers
DNA
196 Citations (Scopus)

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program

Gomes, N. P., Bjerke, G., Llorente, B., Szostek, S. A., Emerson, B. & Espinosa, J. M., Mar 1 2006, In : Genes and Development. 20, 5, p. 601-612 12 p.

Research output: Contribution to journalArticle

Open Access
Peptide Elongation Factors
RNA Polymerase II
Transcription Factors
Phosphorylation
p53 Genes
659 Citations (Scopus)

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

Zhang, X., Odom, D. T., Koo, S. H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., Kadam, S., Ecker, J. R., Emerson, B., Hogenesch, J. B., Unterman, T., Young, R. A. & Montminy, M., Mar 22 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 12, p. 4459-4464 6 p.

Research output: Contribution to journalArticle

Open Access
Cyclic AMP Response Element-Binding Protein
Transcriptional Activation
Phosphorylation
Genome
Genes
27 Citations (Scopus)

Genome-wide targeting of the epigenetic regulatory protein ctcf to gene promoters by the transcription factor TFII-I

Peñ A-Hernández, R., Marques, M., Hilmi, K., Zhao, T., Saad, A., Alaoui-Jamali, M. A., Rincon, S. V. D., Ashworth, T., Roy, A. L., Emerson, B. & Witcher, M., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. E677-E686

Research output: Contribution to journalArticle

Open Access
Epigenomics
Transcription Factors
Cyclin-Dependent Kinase 8
Genome
Genes
36 Citations (Scopus)

HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology

Bagga, R., Michalowski, S., Sabnis, R., Griffith, J. D. & Emerson, B., Jul 1 2000, In : Nucleic acids research. 28, 13, p. 2541-2550 10 p.

Research output: Contribution to journalArticle

Open Access
Chromatin
DNA
Globins
HMGA1a Protein
Nucleosomes
4 Citations (Scopus)

Identification of kinase inhibitors that target transcription initiation by RNA polymerase II

Morachis, J. M., Huang, R. & Emerson, B., Jan 1 2011, In : Oncotarget. 2, 1-2, p. 18-28 11 p.

Research output: Contribution to journalArticle

Open Access
TATA-Box Binding Protein
RNA Polymerase II
Phosphotransferases
DNA-Directed RNA Polymerases
Clinical Trials
138 Citations (Scopus)

Identification of small-molecule antagonist that inhibit an activator:coactivator interaction

Best, J. L., Amezcua, C. A., Mayr, B., Flechner, L., Murawsky, C. M., Emerson, B., Zor, T., Gardner, K. H. & Montminy, M., Dec 21 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 51, p. 17622-17627 6 p.

Research output: Contribution to journalArticle

Open Access
Cyclic AMP Response Element-Binding Protein
Protein Binding
CREB-Binding Protein
Small Molecule Libraries
Histone Acetyltransferases
134 Citations (Scopus)

Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult β-globin gene: Nature of the binding domain

Emerson, B., Lewis, C. D. & Felsenfeld, G., Jan 1 1985, In : Cell. 41, 1, p. 21-30 10 p.

Research output: Contribution to journalArticle

Globins
Chickens
Genes
5' Flanking Region
Deoxyribonuclease I
21 Citations (Scopus)

Isolation and genomic arrangement of active and inactive forms of mammalian 5 S RNA genes

Emerson, B. & Roeder, R. G., Jan 1 1984, In : Journal of Biological Chemistry. 259, 12, p. 7916-7925 10 p.

Research output: Contribution to journalArticle

Genes
RNA
Clone Cells
Sequence Homology
Alu Elements
1 Citation (Scopus)
Matrix Attachment Regions
Locus Control Region
Physiological Phenomena
Genes
Cellular Structures
91 Citations (Scopus)

NF-E2 disrupts chromatin structure at human β-globin locus control region hypersensitive site 2 in vitro

Armstrong, J. A. & Emerson, B., Sep 30 1996, In : Molecular and Cellular Biology. 16, 10, p. 5634-5644 11 p.

Research output: Contribution to journalArticle

Locus Control Region
Globins
Nucleosomes
Chromatin
Deoxyribonuclease I
129 Citations (Scopus)

P50-associated COX-2 Extragenic RNA (pacer) activates human COX-2 gene expression by occluding repressive NF-κB p50 complexes

Krawczyk, M. & Emerson, B., Apr 29 2014, In : eLife. 2014, 3, e01776.

Research output: Contribution to journalArticle

Open Access
Long Noncoding RNA
Gene expression
RNA
Gene Expression
Chromatin
202 Citations (Scopus)

p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage

Espinosa, J. M., Verdun, R. E. & Emerson, B., Jan 1 2003, In : Molecular Cell. 12, 4, p. 1015-1027 13 p.

Research output: Contribution to journalArticle

Open Access
RNA Polymerase II
DNA Damage
Transcription Factor TFIIB
Tumor Suppressor Protein p53
p53 Genes
50 Citations (Scopus)

Regulated expression of the β-globin gene locus in synthetic nuclei

Barton, M. C. & Emerson, B., Oct 15 1994, In : Genes and Development. 8, 20, p. 2453-2465 13 p.

Research output: Contribution to journalArticle

Open Access
Globins
DNA Replication
Gene Expression
Chromatin
Chromatin Assembly and Disassembly
9 Citations (Scopus)

Regulated gene expression in reconstituted chromatin and synthetic nuclei

Barton, M. C. & Emerson, B., Jan 1 1996, In : Methods in Enzymology. 274, p. 299-312 14 p.

Research output: Contribution to journalArticle

Gene expression
Chromatin
64 Citations (Scopus)

Regulation of the p53 transcriptional response by structurally diverse core promoters

Morachis, J. M., Murawsky, C. M. & Emerson, B., Jan 15 2010, In : Genes and Development. 24, 2, p. 135-147 13 p.

Research output: Contribution to journalArticle

Open Access
RNA Polymerase II
Transcription Factors
cdc Genes
TATA Box
p53 Genes
6 Citations (Scopus)

Role of chromatin structure and distal enhancers in tissue-specific transcriptional regulation in vitro

Bagga, R., Armstrong, J. A. & Emerson, B., Jan 1 1998, In : Cold Spring Harbor symposia on quantitative biology. 63, p. 569-576 8 p.

Research output: Contribution to journalArticle

Chromatin
Tissue
70 Citations (Scopus)

Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing

Lee, M. C. W., Lopez-Diaz, F. J., Khan, S. Y., Tariq, M. A., Dayn, Y., Vaske, C. J., Radenbaugh, A. J., Kim, H. J., Emerson, B. & Pourm, N., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. E4726-E4735

Research output: Contribution to journalArticle

Open Access
Single-Cell Analysis
Drug Tolerance
RNA Sequence Analysis
Neoplasms
RNA
21 Citations (Scopus)

Site-directed, recombination-mediated mutagenesis of a complex gene locus

Barton, M. C., Hoekstra, M. F. & Emerson, B., Dec 1 1990, In : Nucleic acids research. 18, 24, p. 7349-7355 7 p.

Research output: Contribution to journalArticle

Globins
Mutagenesis
Genetic Recombination
Genes
Yeasts
145 Citations (Scopus)
Open Access
CREB-Binding Protein
Globins
Acetylation
Chromatin
Erythroid Cells
141 Citations (Scopus)
Open Access
Globins
Chickens
Hypersensitivity
Genes
5' Flanking Region

Specific protein-DNA interactions associated with active and inactive forms of the chicken adult β-globin gene

Emerson, B., Jackson, P. D. & Felsenfeld, G., Jan 1 1985, In : Federation Proceedings. 44, 5

Research output: Contribution to journalArticle

beta-Globins
Chickens
DNA
Genes
Proteins
37 Citations (Scopus)

The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled β-globin genes

Barton, M. C., Madani, N. & Emerson, B., Jan 1 1993, In : Genes and Development. 7, 9, p. 1796-1809 14 p.

Research output: Contribution to journalArticle

Open Access
Globins
Chromatin
TATA-Box Binding Protein
TATA Box
Genes
66 Citations (Scopus)

The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized β-globin TATA box

Fong, T. C. & Emerson, B., Jan 1 1992, In : Genes and Development. 6, 4, p. 521-532 12 p.

Research output: Contribution to journalArticle

Open Access
Transcription Factor TFIID
TATA Box
Globins
Proteins
Erythroid Cells
44 Citations (Scopus)

The HS2 enhancer of the β-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter

Ling, J., Baibakov, B., Pi, W., Emerson, B. & Tuan, D., Jul 29 2005, In : Journal of molecular biology. 350, 5, p. 883-896 14 p.

Research output: Contribution to journalArticle

Locus Control Region
Untranslated RNA
Globins
RNA
K562 Cells
3 Citations (Scopus)

The β-NAD+ salvage pathway and PKC-mediated signaling influence localized PARP-1 activity and CTCF Poly(ADP) ribosylation

Henderson, D. J. P., Miranda, J. J. L. & Emerson, B., Jan 1 2017, In : Oncotarget. 8, 39, p. 64698-64713 16 p.

Research output: Contribution to journalArticle

Open Access
NAD
Adenosine Diphosphate
Protein Kinase C
Insulator Elements
Chromatin
345 Citations (Scopus)

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment

Espinosa, J. M. & Emerson, B., Jan 1 2001, In : Molecular Cell. 8, 1, p. 57-69 13 p.

Research output: Contribution to journalArticle

Open Access
Chromatin
Binding Sites
Tumor Suppressor Protein p53
Histone Acetyltransferases
TATA Box
264 Citations (Scopus)

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

Kadam, S. & Emerson, B., Feb 1 2003, In : Molecular Cell. 11, 2, p. 377-389 13 p.

Research output: Contribution to journalArticle

Open Access
Chromatin Assembly and Disassembly
Adenosine Triphosphatases
Proteins
Ankyrin Repeat
Genomic Instability
76 Citations (Scopus)

Transcription of chromatin: These are complex times

Armstrong, J. A. & Emerson, B., Jan 1 1998, In : Current Opinion in Genetics and Development. 8, 2, p. 165-172 8 p.

Research output: Contribution to journalArticle

Chromatin
Chromatin Assembly and Disassembly
Acetylation
Histones
Genes