Arthur Vandenbark

Professor

  • 13331 Citations
  • 59 h-Index
1974 …2020

Research output per year

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Research Output

2020

A Novel Partial MHC Class II Construct, DRmQ, Inhibits Central and Peripheral Inflammatory Responses to Promote Neuroprotection in Experimental Stroke

Lee, J. Y., Castelli, V., Bonsack, B., Coats, A. B., Navarro-Torres, L., Garcia-Sanchez, J., Kingsbury, C., Nguyen, H., Vandenbark, A. A., Meza-Romero, R., Offner, H. & Borlongan, C. V., Aug 1 2020, In : Translational Stroke Research. 11, 4, p. 831-836 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Partial MHC/neuroantigen peptide constructs attenuate methamphetamine-seeking and brain chemokine (C–C motif) ligand 2 levels in rats

Loftis, J. M., Navis, T., Taylor, J., Hudson, R., Person, U., Lattal, K. M., Vandenbark, A. A., Shirley, R. & Huckans, M., Aug 5 2020, In : European Journal of Pharmacology. 880, 173175.

Research output: Contribution to journalArticle

Spleen participation in partial MHC class II construct neuroprotection in stroke

Brown, J., Kingsbury, C., Lee, J. Y., Vandenbark, A. A., Meza-Romero, R., Offner, H. & Borlongan, C. V., Jul 1 2020, In : CNS Neuroscience and Therapeutics. 26, 7, p. 663-669 7 p.

Research output: Contribution to journalReview article

Open Access

Surviving the storm: Dealing with COVID-19

Vandenbark, A. A., Meza-Romero, R. & Offner, H., Aug 2020, In : Cellular Immunology. 354, 104153.

Research output: Contribution to journalLetter

2019

A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury

Vandenbark, A. A., Meza-Romero, R., Benedek, G. & Offner, H., Jan 23 2019, In : Journal of Neuroinflammation. 16, 1, 14.

Research output: Contribution to journalReview article

4 Scopus citations

Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

Seifert, H. A., Gerstner, G., Kent, G., Vandenbark, A. A. & Offner, H., Oct 29 2019, In : Journal of Neuroinflammation. 16, 1, 195.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct

Meza-Romero, R., Benedek, G., Gerstner, G., Kent, G., Nguyen, H., Offner, H. & Vandenbark, A. A., Feb 1 2019, In : Metabolic brain disease. 34, 1, p. 153-164 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke

Seifert, H. A., Zhu, W., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Dec 1 2019, In : Metabolic brain disease. 34, 6, p. 1705-1712 8 p.

Research output: Contribution to journalArticle

2018

Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells

Seifert, H. A., Benedek, G., Nguyen, H., Gerstner, G., Zhang, Y., Kent, G., Vandenbark, A. A., Bernhagen, J. & Offner, H., Oct 1 2018, In : Metabolic brain disease. 33, 5, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Functional MRI and delay discounting in patients infected with hepatitis C

McCready, H., Kohno, M., Kolessar, M., Dennis, L., Kriz, D., Luber, H., Anderson, R., Chang, M., Sasaki, A., Flora, K., Vandenbark, A., Mitchell, S. H., Loftis, J. M., Hoffman, W. F. & Huckans, M., Dec 1 2018, In : Journal of neurovirology. 24, 6, p. 738-751 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

Regulatory B cells in experimental stroke

Seifert, H. A., Vandenbark, A. & Offner, H., Jan 1 2018, (Accepted/In press) In : Immunology.

Research output: Contribution to journalArticle

8 Scopus citations
2017

DRα1-MOG-35-55 Reduces Permanent Ischemic Brain Injury

Wang, J., Ye, Q., Xu, J., Benedek, G., Zhang, H., Yang, Y., Liu, H., Meza-Romero, R., Vandenbark, A. A., Offner, H. & Gao, Y., Jun 1 2017, In : Translational Stroke Research. 8, 3

Research output: Contribution to journalArticle

15 Scopus citations

DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury

Yang, L., Liu, Z., Ren, H., Zhang, L., Gao, S., Ren, L., Chai, Z., Meza-Romero, R., Benedek, G., Vandenbark, A. A., Offner, H. & Li, M., Oct 1 2017, In : Metabolic brain disease. 32, 5, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

Benedek, G., Zhang, J., Nguyen, H., Kent, G., Seifert, H. A., Davin, S., Stauffer, P., Vandenbark, A. A., Karstens, L., Asquith, M. & Offner, H., Sep 15 2017, In : Journal of Neuroimmunology. 310, p. 51-59 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen

Seifert, H. A., Benedek, G., Nguyen, H., Kent, G., Vandenbark, A. & Offner, H., Jul 8 2017, (Accepted/In press) In : Metabolic Brain Disease. p. 1-8 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

MIF and D-DT are potential disease severity modifiers in male MS subjects

Benedek, G., Meza-Romero, R., Jordan, K., Zhang, Y., Nguyen, H., Kent, G., Li, J., Siu, E., Frazer, J., Piecychna, M., Du, X., Sreih, A., Leng, L., Wiedrick, J., Caillier, S. J., Offner, H., Oksenberg, J. R., Yadav, V., Bourdette, D., Bucala, R. & 1 others, Vandenbark, A. A., Oct 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 40, p. E8421-E8429

Research output: Contribution to journalArticle

37 Scopus citations

Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice

Benedek, G., Zhang, J., Nguyen, H., Kent, G., Seifert, H., Vandenbark, A. A. & Offner, H., Apr 15 2017, In : Journal of Neuroimmunology. 305, p. 59-67 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sex-dependent treatment of chronic EAE with partial MHC class II constructs

Benedek, G., Chaudhary, P., Meza-Romero, R., Calkins, E., Kent, G., Offner, H., Bourdette, D. & Vandenbark, A. A., May 6 2017, In : Journal of Neuroinflammation. 14, 1, 100.

Research output: Contribution to journalArticle

7 Scopus citations

Sex differences in regulatory cells in experimental stroke

Seifert, H. A., Benedek, G., Liang, J., Nguyen, H., Kent, G., Vandenbark, A., Saugstad, J. & Offner, H., May 23 2017, (Accepted/In press) In : Cellular Immunology.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

Benedek, G., Zhang, J., Bodhankar, S., Nguyen, H., Kent, G., Jordan, K., Manning, D., Vandenbark, A. A. & Offner, H., Apr 15 2016, In : Journal of Neuroimmunology. 293, p. 45-53 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74

Meza-Romero, R., Benedek, G., Jordan, K., Leng, L., Pantouris, G., Lolis, E., Bucala, R. & Vandenbark, A., Dec 1 2016, In : Cytokine. 88, p. 62-70 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Partial MHC class II constructs as novel immunomodulatory therapy for stroke

Benedek, G., Vandenbark, A., Alkayed, N. & Offner, H., Sep 1 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

8 Scopus citations

Predicted structure of MIF/CD74 and RTL1000/CD74 complexes

Meza-Romero, R., Benedek, G., Leng, L., Bucala, R. & Vandenbark, A. A., Apr 1 2016, In : Metabolic brain disease. 31, 2, p. 249-255 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke

Yang, L., Kong, Y., Ren, H., Li, M., Wei, C. J., Shi, E., Jin, W. N., Hao, J., Vandenbark, A. & Offner, H., Sep 13 2016, (Accepted/In press) In : Neurochemistry International.

Research output: Contribution to journalArticle

6 Scopus citations
2015
15 Scopus citations

IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

Zhang, J., Benedek, G., Bodhankar, S., Lapato, A., Vandenbark, A. A. & Offner, H., Jan 1 2015, In : Journal of Neuroimmunology. 285, p. 129-136 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

PD-L1 monoclonal antibody treats ischemic stroke by controlling central nervous system inflammation

Bodhankar, S., Chen, Y., Lapato, A., Dotson, A. L., Wang, J., Vandenbark, A. A., Saugstad, J. A. & Offner, H., 2015, In : Stroke. 46, 10, p. 2926-2934 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Regulatory CD8+CD122+ T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells

Bodhankar, S., Chen, Y., Lapato, A., Vandenbark, A. A., Murphy, S. J., Saugstad, J. A. & Offner, H., Aug 1 2015, In : Metabolic brain disease. 30, 4, p. 911-924 14 p., A003.

Research output: Contribution to journalArticle

21 Scopus citations

Role for microglia in sex differences after ischemic stroke: importance of M2

Bodhankar, S., Lapato, A., Chen, Y., Vandenbark, A. A., Saugstad, J. A. & Offner, H., Dec 1 2015, In : Metabolic brain disease. 30, 6, p. 1515-1529 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

The use of flow cytometry to assess a novel drug efficacy in multiple sclerosis

Benedek, G., Meza-Romero, R., Bourdette, D. & Vandenbark, A. A., Aug 1 2015, In : Metabolic brain disease. 30, 4, p. 877-884 8 p., A002.

Research output: Contribution to journalReview article

1 Scopus citations

Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice

Zhang, J., Lapato, A., Bodhankar, S., Vandenbark, A. A. & Offner, H., Oct 10 2015, In : Metabolic brain disease. 30, 5, p. 1117-1127 11 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Mar 2014, In : Metabolic brain disease. 29, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Erratum to: A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke (Metabolic Brain Disease (2014) 29, (37-45) DOI: 10.1007/s11011-013-9440- 0)

Benedek, G., Zhu, W., Libal, N., Casper, A., Yu, X., Meza-Romero, R., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Jan 1 2014, In : Metabolic brain disease. 29, 3, 1 p.

Research output: Contribution to journalComment/debate

HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis

Meza-Romero, R., Benedek, G., Yu, X., Mooney, J. L., Dahan, R., Duvshani, N., Bucala, R., Offner, H., Reiter, Y., Burrows, G. G. & Vandenbark, A. A., May 1 2014, In : Journal of Immunology. 192, 9, p. 4164-4173 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Multi-analyte profile analysis of plasma immune proteins: Altered expression of peripheral immune factors is associated with neuropsychiatric symptom severity in adults with and without chronic hepatitis C virus infection

Huckans, M., Fuller, B. E., Olavarria, H., Sasaki, A. W., Chang, M., Flora, K. D., Kolessar, M., Kriz, D., Anderson, J. R., Vandenbark, A. A. & Loftis, J. M., Mar 2014, In : Brain and Behavior. 4, 2, p. 123-142 20 p.

Research output: Contribution to journalArticle

24 Scopus citations

Novel Humanized Recombinant T Cell Receptor Ligands Protect the Female Brain After Experimental Stroke

Pan, J., Palmateer, J., Schallert, T., Hart, M., Pandya, A., Vandenbark, A. A., Offner, H. & Hurn, P. D., Oct 2014, In : Translational Stroke Research. 5, 5, p. 577-585 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
42 Scopus citations
2013

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

Vandenbark, A. A., Meza-Romero, R., Benedek, G., Andrew, S., Huan, J., Chou, Y. K., Buenafe, A. C., Dahan, R., Reiter, Y., Mooney, J. L., Offner, H. & Burrows, G. G., Feb 1 2013, In : Journal of Autoimmunity. 40, 1, p. 96-110 15 p.

Research output: Contribution to journalArticle

28 Scopus citations

IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

Bodhankar, S., Chen, Y., Vandenbark, A. A., Murphy, S. J. & Offner, H., Sep 1 2013, In : Metabolic brain disease. 28, 3, p. 375-386 12 p.

Research output: Contribution to journalArticle

65 Scopus citations
10 Scopus citations

Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects

Benedek, G., Meza-Romero, R., Andrew, S., Leng, L., Burrows, G. G., Bourdette, D., Offner, H., Bucala, R. & Vandenbark, A. A., Apr 1 2013, In : European Journal of Immunology. 43, 5, p. 1309-1321 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1

Bodhankar, S., Chen, Y., Vandenbark, A. A., Murphy, S. J. & Offner, H., Sep 9 2013, In : Journal of Neuroinflammation. 10, 878.

Research output: Contribution to journalArticle

37 Scopus citations

Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice

Banerjee, A., Wang, J., Bodhankar, S., Vandenbark, A. A., Murphy, S. J. & Offner, H., Oct 7 2013, In : Translational Stroke Research. 4, 5, p. 554-563 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

The HLA-DRB1*15:01-restricted goodpasture's T cell epitope induces GN

Ooi, J. D., Chang, J., O'Sullivan, K. M., Pedchenko, V., Hudson, B. G., Vandenbark, A. A., Fugger, L., Holdsworth, S. R. & Kitching, A. R., Feb 28 2013, In : Journal of the American Society of Nephrology. 24, 3, p. 419-431 13 p.

Research output: Contribution to journalArticle

43 Scopus citations
2012

Contribution of GPR30 for 1,25 dihydroxyvitamin D 3 protection in EAE

Subramanian, S., Miller, L. M., Grafe, M. R., Vandenbark, A. A. & Offner, H., Mar 1 2012, In : Metabolic brain disease. 27, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

GILT required for RTL550-CYS-MOG to treat experimental autoimmune encephalomyelitis

Burrows, G. G., Meza-Romero, R., Huan, J., Sinha, S., Mooney, J. L., Vandenbark, A. A. & Offner, H., Jun 1 2012, In : Metabolic brain disease. 27, 2, p. 143-149 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice

Chen, Y., Bodhankar, S., Murphy, S. J., Vandenbark, A. A., Alkayed, N. J. & Offner, H., Dec 1 2012, In : Metabolic brain disease. 27, 4, p. 487-493 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity

Ren, X., Akiyoshi, K., Grafe, M. R., Vandenbark, A. A., Hurn, P. D., Herson, P. S. & Offner, H., Mar 1 2012, In : Metabolic brain disease. 27, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice

Adamus, G., Brown, L., Andrew, S., Meza-Romero, R., Burrows, G. G. & Vandenbark, A. A., Jan 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 1, p. 406-412 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
35 Scopus citations