Anupriya Agarwal

Assistant Professor

  • 1911 Citations
  • 20 h-Index
20082020

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Research Output

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2020

Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia

Eide, C. A., Kurtz, S. E., Kaempf, A., Long, N., Agarwal, A., Tognon, C. E., Mori, M., Druker, B. J., Chang, B. H., Danilov, A. V. & Tyner, J. W., Jan 1 2020, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

2019

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia

Agarwal, A., Bolosky, W. J., Wilson, D. B., Eide, C. A., Olson, S. B., Fan, G. & Druker, B. J., Dec 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24593-24599 7 p.

Research output: Contribution to journalArticle

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity

Sapre, A. A., Yong, G., Yeh, Y. S., Ruff, L. E., Plaut, J. S., Sayar, Z., Agarwal, A., Martinez, J., Nguyen, T. N., Liu, Y. T., Messmer, B. T., Esener, S. & Fischer, J., Mar 10 2019, In : Journal of Controlled Release. 297, p. 48-59 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M. A., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M., Druker, B. J., Singer, J. W. & Agarwal, A., Nov 1 2018, In : Leukemia. 32, 11, p. 2374-2387 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Rare but recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma

Davare, M., Henderson, J. J., Agarwal, A., Wagner, J. P., Iyer, S. R., Shah, N., Woltjer, R. R., Somwar, R., Gilheeney, S. W., DeCarvalo, A., Mikkelson, T., Van Meir, E. G., Ladanyi, M. & Druker, B., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A. V., Lee, P., Chantry, D., McWeeney, S. K., Druker, B. J., Tyner, J. W., Spurgeon, S. E. & Loriaux, M. M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: Findings and recommendations

Watanabe-Smith, K., Godil, J., Agarwal, A., Tognon, C. & Druker, B., Jan 1 2017, In : Oncotarget. 8, 8, p. 12596-12606 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J., Druker, B., Bagby, G. C., McWeeney, S. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

53 Scopus citations

Novel Method Enabling the Use of Cryopreserved Primary Acute Myeloid Leukemia Cells in Functional Drug Screens

Degnin, M., Agarwal, A., Tarlock, K., Meshinchi, S., Druker, B. & Tognon, C. E., 2017, In : Journal of Pediatric Hematology/Oncology. 39, 7, p. e359-e366

Research output: Contribution to journalArticle

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

Janghorban, M., Langer, E. M., Wang, X., Zachman, D., Daniel, C. J., Hooper, J., Fleming, W., Agarwal, A. & Sears, R., Nov 1 2017, In : PLoS One. 12, 11, e0188910.

Research output: Contribution to journalArticle

5 Scopus citations
2016
26 Scopus citations

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

Garbati, M. R., Hays, L. E., Keaney Rathbun, R., Jillette, N., Chin, K., Al-Dhalimy, M., Agarwal, A., Hanlon Newell, A. E., Olson, S. & Bagby, G. C., Mar 1 2016, In : Journal of Leukocyte Biology. 99, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia

Traer, E., Martinez, J., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Kovacsovics, T., Tyner, J., Wong, M. & Druker, B., Nov 15 2016, In : Cancer Research. 76, 22, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

JAK2V617I results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model

Brooks, S. A., Luty, S. B., Lai, H. Y., Morse, S. J., Nguyen, T. K., Royer, L. R., Agarwal, A., Druker, B. & Fleischman, A. G., Jan 1 2016, In : Experimental Hematology. 44, 1, p. 24-29.e1

Research output: Contribution to journalArticle

Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Garbati, M. R., Welgan, C. A., Landefeld, S. H., Newell, L., Agarwal, A., Dunlap, J., Chourasia, T. K., Lee, H., Elferich, J., Traer, E., Rattray, R., Cascio, M., Press, R., Bagby, G. C., Tyner, J., Druker, B. & Dao, K-H., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting

Jacob, T., Agarwal, A., Ramunno-Johnson, D., O'Hare, T., Gonen, M., Tyner, J., Druker, B. & Vu, T. T., Jun 20 2016, In : Scientific Reports. 6, 28163.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Acute promyelocytic leukemia with JAK2 V617F and severe differentiation syndrome

Braun, T. P., Maxson, J. E., Agarwal, A., Dunlap, J., Spurgeon, S. E. & Traer, E., Jan 1 2015, In : Leukemia Research Reports. 4, 1, p. 8-11 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia

Agarwal, A., Mackenzie, R. J., Eide, C. A., Davare, M. A., Watanabe-Smith, K., Tognon, C. E., Mongoue-Tchokote, S., Park, B., Braziel, R. M., Tyner, J. W. & Druker, B. J., Jun 4 2015, In : Oncogene. 34, 23, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia

Agarwal, A., MacKenzie, R. J., Pippa, R., Eide, C. A., Oddo, J., Tyner, J. W., Sears, R., Vitek, M. P., Odero, M. D., Christensen, D. J. & Druker, B. J., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2092-2103 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M. M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. J. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle

Braun, T. P., Szumowski, M., Levasseur, P. R., Grossberg, A. J., Zhu, X., Agarwal, A. & Marks, D. L., Sep 25 2014, In : PloS one. 9, 9, e106489.

Research output: Contribution to journalArticle

30 Scopus citations

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

Traer, E., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Martinez, J., Tyner, J. W., Wong, M. & Druker, B. J., Mar 6 2014, In : Blood. 123, 10, p. 1516-1524 9 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M. A., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J. W., Shinde, U. P., Lowe, S. W. & Druker, B. J., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J. E., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S. K., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B. H., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Jan 1 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

282 Scopus citations

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in Mice that is responsive to therapeutic JAK inhibition

Fleischman, A. G., Maxson, J. E., Luty, S. B., Agarwal, A., Royer, L. R., Abel, M. L., Macmaniman, J. D., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 21 2013, In : Blood. 122, 22, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

59 Scopus citations

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

O'Hare, T., Eide, C. A., Agarwal, A., Adrian, L. T., Zabriskie, M. S., MacKenzie, R. J., La Tocha, D. H., Johnson, K. J., You, H., Luo, J., Riddle, S. M., Marks, B. D., Vogel, K. W., Koop, D. R., Apgar, J., Tyner, J. W., Deininger, M. W. & Druker, B. J., Jun 1 2013, In : Cancer Research. 73, 11, p. 3356-3370 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B. J., Woltjer, R. L. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

Hurtz, C., Hatzi, K., Cerchietti, L., Braig, M., Park, E., Kim, Y. M., Herzog, S., Ramezani-Rad, P., Jumaa, H., Müller, M. C., Hofmann, W. K., Hochhaus, A., Ye, B. H., Agarwal, A., Druker, B. J., Shah, N. P., Melnick, A. M. & Müschen, M., Oct 24 2011, In : Journal of Experimental Medicine. 208, 11, p. 2163-2174 12 p.

Research output: Contribution to journalArticle

122 Scopus citations

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B. J., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

487 Scopus citations

The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia

O'Hare, T., Zabriskie, M. S., Eide, C. A., Agarwal, A., Adrian, L. T., You, H., Corbin, A. S., Yang, F., Press, R. D., Rivera, V. M., Toplin, J., Wong, S., Deininger, M. W. & Druker, B. J., Nov 10 2011, In : Blood. 118, 19, p. 5250-5254 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R. D., Loriaux, M. M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B. J., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

123 Scopus citations
2010

A specific need for CRKL in p210BCR-ABL - Induced transformation of mouse hematopoietic progenitors

Seo, J. H., Wood, L. J., Agarwal, A., O'Hare, T., Elsea, C. R., Griswold, I. J., Deininger, M. W. N., Imamoto, A. & Druker, B. J., Sep 15 2010, In : Cancer Research. 70, 18, p. 7325-7335 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells

Misra, S., Sharma, S., Agarwal, A., Khedkar, S. V., Tripathi, M. K., Mittal, M. K. & Chaudhuri, G., Mar 4 2010, In : Molecular Cancer. 9, 50.

Research output: Contribution to journalArticle

19 Scopus citations
2009

ERK2, but not ERK1, mediates acquired and "De novo" resistance to imatinib mesylate: Implication for CML therapy

Aceves-Luquero, C. I., Agarwal, A., Calllejas-Valera, J. L., Arias-González, L., Esparís-Ogando, A., Ovalke, L. D. P., Bellón-Echeverria, I., de la Cruz-Morcillo, M. A., Moya, E. M. G., Gimeno, I. M., Gómez, J. C., Deininger, M. W., Pandiella, A. & Prieto, R. S., Jul 1 2009, In : PloS one. 4, 7, e6124.

Research output: Contribution to journalArticle

32 Scopus citations
2008

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. J. & Deininger, M. W., Sep 1 2008, In : Blood. 112, 5, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

49 Scopus citations