Anupriya Agarwal

Assistant Professor

  • 1657 Citations
  • 19 h-Index
20082019
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Research Output 2008 2019

2019
3 Citations (Scopus)

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E., Kaempf, A., Mori, M. T., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. & Tyner, J., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Acute Myeloid Leukemia
Macrophage Colony-Stimulating Factor
Cytokines
Cells

Erratum: Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells (eLife (2019) 8 PII: e47174)

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribeiro, R., Viola, S. K., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Mar 29 2019, In : eLife. 8

Research output: Contribution to journalComment/debate

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Medicine
Bone

FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J., Druker, B. & Traer, E., Feb 5 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Exosomes
Fibroblast Growth Factor 2
Mesenchymal Stromal Cells
Protein-Tyrosine Kinases
Bone

Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity

Sapre, A. A., Yong, G., Yeh, Y. S., Ruff, L. E., Plaut, J. S., Sayar, Z., Agarwal, A., Martinez, J., Nguyen, T. N., Liu, Y. T., Messmer, B. T., Esener, S. & Fischer, J., Mar 10 2019, In : Journal of Controlled Release. 297, p. 48-59 12 p.

Research output: Contribution to journalArticle

Viral Genes
Adenoviridae
Silicon Dioxide
Heterografts
Glioma
2018
33 Citations (Scopus)

Functional genomic landscape of acute myeloid leukaemia

Tyner, J., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K-H., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M. T., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. & Druker, B., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
RNA Sequence Analysis
Pharmaceutical Preparations
Exome
Gene Regulatory Networks
4 Citations (Scopus)

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

Singer, J. W., Fleischman, A., Al-Fayoumi, S., Mascarenhas, J. O., Yu, Q. & Agarwal, A., Sep 1 2018, In : Oncotarget. 9, 70, p. 33416-33439 24 p.

Research output: Contribution to journalReview article

Interleukin-1 Receptor-Associated Kinases
Toll-Like Receptor 1
Protein-Serine-Threonine Kinases
Metabolic Diseases
Therapeutics
3 Citations (Scopus)

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M. T., Druker, B., Singer, J. W. & Agarwal, A., Mar 29 2018, (Accepted/In press) In : Leukemia. p. 1-14 14 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptor-Associated Kinases
Acute Myeloid Leukemia
Myeloid Cells
Therapeutics
Heterografts

Molecular biology of chronic leukemias

Eide, C. A., Blachly, J. S. & Agarwal, A., Nov 16 2018, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 1764-1772 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Biology
Leukemia
3 Citations (Scopus)

Rare but recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma

Davare, M., Henderson, J. J., Agarwal, A., Wagner, J. P., Iyer, S. R., Shah, N., Woltjer, R. R., Somwar, R., Gilheeney, S. W., DeCarvalo, A., Mikkelson, T., Van Meir, E. G., Ladanyi, M. & Druker, B., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

Oncogenes
Glioma
Glioblastoma
Chromosomes
Central Nervous System Neoplasms
4 Citations (Scopus)

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A., Lee, P., Chantry, D., McWeeney, S., Druker, B., Tyner, J., Spurgeon, S. & Loriaux, M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
B-Cell Chronic Lymphocytic Leukemia
Antineoplastic Agents
Monocytes
2017
4 Citations (Scopus)

Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: Findings and recommendations

Watanabe-Smith, K., Godil, J., Agarwal, A., Tognon, C. & Druker, B., 2017, In : Oncotarget. 8, 8, p. 12596-12606 11 p.

Research output: Contribution to journalArticle

Transgenes
Mutation
Intercellular Signaling Peptides and Proteins
Leukemia
Cytokine Receptors
32 Citations (Scopus)

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J., Druker, B., Bagby, G. C., McWeeney, S. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

Interleukin-1
Acute Myeloid Leukemia
Disease Progression
Screening
Interleukin-1 Receptors

Novel Method Enabling the Use of Cryopreserved Primary Acute Myeloid Leukemia Cells in Functional Drug Screens

Degnin, M., Agarwal, A., Tarlock, K., Meshinchi, S., Druker, B. & Tognon, C. E., 2017, In : Journal of Pediatric Hematology/Oncology. 39, 7, p. e359-e366

Research output: Contribution to journalArticle

Myeloid Cells
Acute Myeloid Leukemia
Leukemia
Pharmaceutical Preparations
Cytokines
4 Citations (Scopus)

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

Janghorban, M., Langer, E. M., Wang, X., Zachman, D., Daniel, C. J., Hooper, J., Fleming, W., Agarwal, A. & Sears, R., Nov 1 2017, In : PLoS One. 12, 11, e0188910.

Research output: Contribution to journalArticle

Tumor Suppressor Proteins
Protein Phosphatase 2
phosphoprotein phosphatase
Phosphatases
Stem cells
2016
22 Citations (Scopus)
Neoplasm Drug Resistance
Exosomes
Protein Kinase Inhibitors
MicroRNAs
Mesenchymal Stromal Cells
8 Citations (Scopus)

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B., Tyner, J., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Protein-Tyrosine Kinases
Protein Phosphatase 2
Cell Line
Phosphotransferases
6 Citations (Scopus)

Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

Garbati, M. R., Hays, L. E., Keaney Rathbun, R., Jillette, N., Chin, K., Al-Dhalimy, M., Agarwal, A., Hanlon Newell, A. E., Olson, S. & Bagby, G. C., Mar 1 2016, In : Journal of Leukocyte Biology. 99, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Hypersensitivity
Macrophages
Cytokines
Chromosome Breakage
4 Citations (Scopus)

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

Watanabe-Smith, K., Tognon, C., Tyner, J., Meijerink, J. P. P., Druker, B. & Agarwal, A., Sep 1 2016, In : Leukemia. 30, 9, p. 1950-1953 4 p.

Research output: Contribution to journalLetter

17 Citations (Scopus)

FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia

Traer, E., Martinez, J., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Kovacsovics, T., Tyner, J., Wong, M. & Druker, B., Nov 15 2016, In : Cancer Research. 76, 22, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Acute Myeloid Leukemia
Bone Marrow
Ligands
Mutation

JAK2V617I results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model

Brooks, S. A., Luty, S. B., Lai, H. Y., Morse, S. J., Nguyen, T. K., Royer, L. R., Agarwal, A., Druker, B. & Fleischman, A. G., Jan 1 2016, In : Experimental Hematology. 44, 1, p. 24-29.e1

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Hypersensitivity
Transplantation
Cytokines
Phenotype
16 Citations (Scopus)

Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Garbati, M. R., Welgan, C. A., Landefeld, S. H., Newell, L., Agarwal, A., Dunlap, J., Chourasia, T. K., Lee, H., Elferich, J., Traer, E., Rattray, R., Cascio, M., Press, R., Bagby, G. C., Tyner, J., Druker, B. & Dao, K-H., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

Calreticulin
Monocytes
Thrombocytosis
Primary Myelofibrosis
Genes
1 Citation (Scopus)

RNAi screening of leukemia cells using electroporation

Agarwal, A. & Tyner, J., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1470. p. 85-94 10 p. (Methods in Molecular Biology; vol. 1470).

Research output: Chapter in Book/Report/Conference proceedingChapter

Electroporation
RNA Interference
Transfection
Leukemia
Cell Line
3 Citations (Scopus)

Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting

Jacob, T., Agarwal, A., Ramunno-Johnson, D., O'Hare, T., Gonen, M., Tyner, J., Druker, B. & Vu, T. T., Jun 20 2016, In : Scientific Reports. 6, 28163.

Research output: Contribution to journalArticle

Proteomics
Nanoparticles
Quantum Dots
Proteins
Pharmaceutical Preparations
2015
1 Citation (Scopus)

Acute promyelocytic leukemia with JAK2 V617F and severe differentiation syndrome

Braun, T. P., Maxson, J., Agarwal, A., Dunlap, J., Spurgeon, S. & Traer, E., Jan 1 2015, In : Leukemia Research Reports. 4, 1, p. 8-11 4 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Cytokines
Essential Thrombocythemia
Primary Myelofibrosis
Dexamethasone
4 Citations (Scopus)

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia

Agarwal, A., Mackenzie, R. J., Eide, C. A., Davare, M., Watanabe-Smith, K., Tognon, C. E., Mongoue-Tchokote, S., Park, B., Braziel, R., Tyner, J. & Druker, B., Jun 4 2015, In : Oncogene. 34, 23, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Interleukin-2 Receptors
RNA Interference
Leukemia
Cytokines

Molecular biology of chronic leukemias

Blachly, J. S., Eide, C. A., Byrd, J. C. & Agarwal, A., Apr 15 2015, Cancer: Principles & Practice of Oncology: Primer of the Molecular Biology of Cancer: Second Edition. Wolters Kluwer Health

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Biology
Leukemia

Molecular biology of chronic leukemias

Blachly, J. S., Eide, C. A., Byrd, J. C. & Agarwal, A., Jan 7 2015, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology: Tenth Edition. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular Biology
Leukemia
2014
67 Citations (Scopus)

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia

Agarwal, A., MacKenzie, R. J., Pippa, R., Eide, C. A., Oddo, J., Tyner, J., Sears, R., Vitek, M. P., Odero, M. D., Christensen, D. J. & Druker, B., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2092-2103 12 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Drug Resistance
Protein-Tyrosine Kinases
15 Citations (Scopus)

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tumors
Leukemia
Cyclin-Dependent Kinases
28 Citations (Scopus)

Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle

Braun, T. P., Szumowski, M., Levasseur, P. R., Grossberg, A., Zhu, X., Agarwal, A. & Marks, D., Sep 25 2014, In : PLoS One. 9, 9, e106489.

Research output: Contribution to journalArticle

muscular atrophy
Chemotherapy
Muscular Atrophy
glucocorticoids
Glucocorticoids
32 Citations (Scopus)

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

Traer, E., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Martinez, J., Tyner, J., Wong, M. & Druker, B., Mar 6 2014, In : Blood. 123, 10, p. 1516-1524 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotransferases
Fibroblast Growth Factor Receptors
Mutation
2013
74 Citations (Scopus)

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J., Shinde, U., Lowe, S. W. & Druker, B., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

Proteins
Lung Neoplasms
Phosphotransferases
Cholangiocarcinoma
Glioblastoma
259 Citations (Scopus)

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B., Loriaux, M., Druker, B. & Tyner, J., 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Leukemia, Neutrophilic, Chronic
Mutation
Phosphotransferases
Neoplasms
53 Citations (Scopus)

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in Mice that is responsive to therapeutic JAK inhibition

Fleischman, A. G., Maxson, J., Luty, S. B., Agarwal, A., Royer, L. R., Abel, M. L., Macmaniman, J. D., Loriaux, M., Druker, B. & Tyner, J., Nov 21 2013, In : Blood. 122, 22, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Leukemia, Neutrophilic, Chronic
Mutation
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative
Spleen
17 Citations (Scopus)

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

O'Hare, T., Eide, C. A., Agarwal, A., Adrian, L. T., Zabriskie, M. S., MacKenzie, R. J., La Tocha, D. H., Johnson, K. J., You, H., Luo, J., Riddle, S. M., Marks, B. D., Vogel, K. W., Koop, D., Apgar, J., Tyner, J., Deininger, M. W. & Druker, B., Jun 1 2013, In : Cancer Research. 73, 11, p. 3356-3370 15 p.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Apoptosis
Phosphotransferases
2012
65 Citations (Scopus)

Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

Traer, E., MacKenzie, R., Snead, J., Agarwal, A., Eiring, A. M., O'Hare, T., Druker, B. & Deininger, M. W., May 2012, In : Leukemia. 26, 5, p. 1140-1143 4 p.

Research output: Contribution to journalArticle

Oncogene Proteins v-abl
Janus Kinase 2
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Antineoplastic Agents
3 Citations (Scopus)

CXCR4 antagonists for the treatment of CML

Agarwal, A., O'Hare, T. & Deininger, M., Jan 1 2012, Novel Developments in Stem Cell Mobilization: Focus on CXCR4. Springer US, p. 351-367 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

CXC Chemokines
Chemokine Receptors
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Stem Cells
Chemokine CXCL12
26 Citations (Scopus)

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B., Woltjer, R. R. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Phosphotransferases
Leukemia
Disease control
Stem cells
4 Citations (Scopus)

MDS: Roadblock to differentiation

Agarwal, A., Sep 6 2012, In : Blood. 120, 10, p. 1968-1969 2 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Ports and harbors
Stem cells
Blood
Epigenomics
2011
117 Citations (Scopus)

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

Hurtz, C., Hatzi, K., Cerchietti, L., Braig, M., Park, E., Kim, Y. M., Herzog, S., Ramezani-Rad, P., Jumaa, H., Müller, M. C., Hofmann, W. K., Hochhaus, A., Ye, B. H., Agarwal, A., Druker, B., Shah, N. P., Melnick, A. M. & Müschen, M., Oct 24 2011, In : Journal of Experimental Medicine. 208, 11, p. 2163-2174 12 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cell Survival
Leukemia
Stem Cells
Protein-Tyrosine Kinases
453 Citations (Scopus)

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia
Therapeutics
Survival
Myeloid Progenitor Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Imatinib Mesylate
22 Citations (Scopus)

The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia

O'Hare, T., Zabriskie, M. S., Eide, C. A., Agarwal, A., Adrian, L. T., You, H., Corbin, A. S., Yang, F., Press, R., Rivera, V. M., Toplin, J., Wong, S., Deininger, M. W. & Druker, B., Nov 10 2011, In : Blood. 118, 19, p. 5250-5254 5 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Phosphotransferases
Mutation
Structural integrity
108 Citations (Scopus)

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R., Loriaux, M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

Cells
Stem cells
Stem Cells
Assays
Neoplasms
2010
26 Citations (Scopus)

A specific need for CRKL in p210BCR-ABL - Induced transformation of mouse hematopoietic progenitors

Seo, J. H., Wood, L., Agarwal, A., O'Hare, T., Elsea, C. R., Griswold, I. J., Deininger, M. W. N., Imamoto, A. & Druker, B., Sep 15 2010, In : Cancer Research. 70, 18, p. 7325-7335 11 p.

Research output: Contribution to journalArticle

Myeloid Progenitor Cells
Genetic Translocation
src Homology Domains
Interleukin-3
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
17 Citations (Scopus)

Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells

Misra, S., Sharma, S., Agarwal, A., Khedkar, S. V., Tripathi, M. K., Mittal, M. K. & Chaudhuri, G., Mar 4 2010, In : Molecular Cancer. 9, 50.

Research output: Contribution to journalArticle

BRCA2 Gene
Cell Cycle
Breast Neoplasms
G1 Phase
Cell Cycle Resting Phase
2009
32 Citations (Scopus)

ERK2, but not ERK1, mediates acquired and "De novo" resistance to imatinib mesylate: Implication for CML therapy

Aceves-Luquero, C. I., Agarwal, A., Calllejas-Valera, J. L., Arias-González, L., Esparís-Ogando, A., Ovalke, L. D. P., Bellón-Echeverria, I., de la Cruz-Morcillo, M. A., Moya, E. M. G., Gimeno, I. M., Gómez, J. C., Deininger, M. W., Pandiella, A. & Prieto, R. S., Jul 1 2009, In : PLoS One. 4, 7, e6124.

Research output: Contribution to journalArticle

Emitter coupled logic circuits
mutation
therapeutics
Lama
recombinant fusion proteins
2008
45 Citations (Scopus)

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. & Deininger, M. W., Sep 1 2008, In : Blood. 112, 5, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Bone Marrow
Cells
F-Box Proteins
Transformed Cell Line
22 Citations (Scopus)

An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia

Agarwal, A., Eide, C. A., Harlow, A., Corbin, A. S., Mauro, M. J., Druker, B., Corless, C., Heinrich, M. & Deininger, M. W., 2008, In : Leukemia. 22, 12, p. 2269-2272 4 p.

Research output: Contribution to journalArticle

Neoplasm Drug Resistance
Proto-Oncogene Proteins
Piperazines
ras Proteins
Pyrimidines