Anupriya Agarwal

Assistant Professor

  • 2101 Citations
  • 21 h-Index
20082020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

Rana, S., Espinosa-Diez, C., Ruhl, R., Chatterjee, N., Hudson, C., Fraile-Bethencourt, E., Agarwal, A., Khou, S., Thomas, C. R. & Anand, S., Dec 1 2020, In : Scientific Reports. 10, 1, 5581.

Research output: Contribution to journalArticle

Open Access

Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia

Eide, C. A., Kurtz, S. E., Kaempf, A., Long, N., Agarwal, A., Tognon, C. E., Mori, M., Druker, B. J., Chang, B. H., Danilov, A. V. & Tyner, J. W., Sep 1 2020, In : Leukemia. 34, 9, p. 2342-2353 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells

Edwards, D. K., Watanabe-Smith, K., Rofelty, A., Damnernsawad, A., Laderas, T., Lamble, A., Lind, E. F., Kaempf, A., Mori, M., Rosenberg, M., d’Almeida, A., Long, N., Agarwal, A., Sweeney, D. T., Loriaux, M., McWeeney, S. K. & Tyner, J. W., Feb 7 2019, In : Blood. 133, 6, p. 588-599 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia

Agarwal, A., Bolosky, W. J., Wilson, D. B., Eide, C. A., Olson, S. B., Fan, G. & Druker, B. J., Dec 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24593-24599 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Erratum: Correction: FGF2-FGFR1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells (eLife (2019) 8 PII: e47174)

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribeiro, R., Viola, S. K., Edwards, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J. W., Druker, B. J. & Traer, E., Mar 29 2019, In : eLife. 8, e47174.

Research output: Contribution to journalComment/debate

Open Access

Fgf2-fgfr1 signaling regulates release of leukemia-protective exosomes from bone marrow stromal cells

Javidi-Sharifi, N., Martinez, J., English, I., Joshi, S. K., Scopim-Ribiero, R., Edwards V, D. K., Agarwal, A., Lopez, C., Jorgens, D., Tyner, J. W., Druker, B. J. & Traer, E., Feb 2019, In : eLife. 8, e40033.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Silica cloaking of adenovirus enhances gene delivery while reducing immunogenicity

Sapre, A. A., Yong, G., Yeh, Y. S., Ruff, L. E., Plaut, J. S., Sayar, Z., Agarwal, A., Martinez, J., Nguyen, T. N., Liu, Y. T., Messmer, B. T., Esener, S. & Fischer, J., Mar 10 2019, In : Journal of Controlled Release. 297, p. 48-59 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Functional genomic landscape of acute myeloid leukaemia

Tyner, J. W., Tognon, C. E., Bottomly, D., Wilmot, B., Kurtz, S. E., Savage, S. L., Long, N., Schultz, A. R., Traer, E., Abel, M., Agarwal, A., Blucher, A., Borate, U., Bryant, J., Burke, R., Carlos, A., Carpenter, R., Carroll, J., Chang, B. H., Coblentz, C. & 68 others, d’Almeida, A., Cook, R., Danilov, A., Dao, K. H. T., Degnin, M., Devine, D., Dibb, J., Edwards, D. K., Eide, C. A., English, I., Glover, J., Henson, R., Ho, H., Jemal, A., Johnson, K., Johnson, R., Junio, B., Kaempf, A., Leonard, J., Lin, C., Liu, S. Q., Lo, P., Loriaux, M. M., Luty, S., Macey, T., MacManiman, J., Martinez, J., Mori, M., Nelson, D., Nichols, C., Peters, J., Ramsdill, J., Rofelty, A., Schuff, R., Searles, R., Segerdell, E., Smith, R. L., Spurgeon, S. E., Sweeney, T., Thapa, A., Visser, C., Wagner, J., Watanabe-Smith, K., Werth, K., Wolf, J., White, L., Yates, A., Zhang, H., Cogle, C. R., Collins, R. H., Connolly, D. C., Deininger, M. W., Drusbosky, L., Hourigan, C. S., Jordan, C. T., Kropf, P., Lin, T. L., Martinez, M. E., Medeiros, B. C., Pallapati, R. R., Pollyea, D. A., Swords, R. T., Watts, J. M., Weir, S. J., Wiest, D. L., Winters, R. M., McWeeney, S. K. & Druker, B. J., Oct 25 2018, In : Nature. 562, 7728, p. 526-531 6 p.

Research output: Contribution to journalArticle

140 Scopus citations

Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy

Singer, J. W., Fleischman, A., Al-Fayoumi, S., Mascarenhas, J. O., Yu, Q. & Agarwal, A., Sep 1 2018, In : Oncotarget. 9, 70, p. 33416-33439 24 p.

Research output: Contribution to journalReview article

21 Scopus citations

Inhibition of interleukin-1 receptor-associated kinase-1 is a therapeutic strategy for acute myeloid leukemia subtypes

Hosseini, M. M., Kurtz, S. E., Abdelhamed, S., Mahmood, S., Davare, M. A., Kaempf, A., Elferich, J., McDermott, J. E., Liu, T., Payne, S. H., Shinde, U., Rodland, K. D., Mori, M., Druker, B. J., Singer, J. W. & Agarwal, A., Nov 1 2018, In : Leukemia. 32, 11, p. 2374-2387 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular biology of chronic leukemias

Eide, C. A., Blachly, J. S. & Agarwal, A., Nov 16 2018, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 1764-1772 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rare but recurrent ROS1 fusions resulting from chromosome 6q22 microdeletions are targetable oncogenes in glioma

Davare, M. A., Henderson, J. J., Agarwal, A., Wagner, J. P., Iyer, S. R., Shah, N., Woltjer, R., Somwar, R., Gilheeney, S. W., DeCarvalo, A., Mikkelson, T., Van Meir, E. G., Ladanyi, M. & Druker, B. J., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Targeting of colony-stimulating factor 1 receptor (CSF1R) in the CLL microenvironment yields antineoplastic activity in primary patient samples

Edwards V, D. K., Sweeney, D. T., Ho, H., Eide, C. A., Rofelty, A., Agarwal, A., Liu, S. Q., Danilov, A. V., Lee, P., Chantry, D., McWeeney, S. K., Druker, B. J., Tyner, J. W., Spurgeon, S. E. & Loriaux, M. M., May 15 2018, In : Oncotarget. 9, 37, p. 24576-24589 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Analysis of acquired mutations in transgenes arising in Ba/F3 transformation assays: Findings and recommendations

Watanabe-Smith, K., Godil, J., Agarwal, A., Tognon, C. & Druker, B., 2017, In : Oncotarget. 8, 8, p. 12596-12606 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Identification of Interleukin-1 by Functional Screening as a Key Mediator of Cellular Expansion and Disease Progression in Acute Myeloid Leukemia

Carey, A., Edwards, D. K., Eide, C. A., Newell, L., Traer, E., Medeiros, B. C., Pollyea, D. A., Deininger, M. W., Collins, R. H., Tyner, J. W., Druker, B. J., Bagby, G., McWeeney, S. K. & Agarwal, A., Mar 28 2017, In : Cell Reports. 18, 13, p. 3204-3218 15 p.

Research output: Contribution to journalArticle

57 Scopus citations

Novel Method Enabling the Use of Cryopreserved Primary Acute Myeloid Leukemia Cells in Functional Drug Screens

Degnin, M., Agarwal, A., Tarlock, K., Meshinchi, S., Druker, B. J. & Tognon, C. E., 2017, In : Journal of Pediatric Hematology/Oncology. 39, 7, p. e359-e366

Research output: Contribution to journalArticle

The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

Janghorban, M., Langer, E. M., Wang, X., Zachman, D., Daniel, C. J., Hooper, J., Fleming, W. H., Agarwal, A. & Sears, R. C., Nov 2017, In : PloS one. 12, 11, e0188910.

Research output: Contribution to journalArticle

7 Scopus citations
2016
29 Scopus citations

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Richard, N. P., Pippa, R., Cleary, M. M., Puri, A., Tibbitts, D., Mahmood, S., Christensen, D. J., Jeng, S., McWeeney, S., Look, A. T., Chang, B. H., Tyner, J. W., Vitek, M. P., Odero, M. D., Sears, R. & Agarwal, A., 2016, In : Oncotarget. 7, 51, p. 84214-84227 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

Garbati, M. R., Hays, L. E., Keaney Rathbun, R., Jillette, N., Chin, K., Al-Dhalimy, M., Agarwal, A., Hanlon Newell, A. E., Olson, S. B. & Bagby, G. C., Mar 2016, In : Journal of Leukocyte Biology. 99, 3, p. 455-465 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Discovery and functional characterization of a germline, CSF2RB-activating mutation in leukemia

Watanabe-Smith, K., Tognon, C., Tyner, J. W., Meijerink, J. P. P., Druker, B. J. & Agarwal, A., Sep 1 2016, In : Leukemia. 30, 9, p. 1950-1953 4 p.

Research output: Contribution to journalLetter

7 Scopus citations

FGF2 from marrow microenvironment promotes resistance to FLT3 inhibitors in acute myeloid leukemia

Traer, E., Martinez, J., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Kovacsovics, T., Tyner, J. W., Wong, M. & Druker, B. J., Nov 15 2016, In : Cancer Research. 76, 22, p. 6471-6482 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

JAK2V617I results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model

Brooks, S. A., Luty, S. B., Lai, H. Y., Morse, S. J., Nguyen, T. K., Royer, L. R., Agarwal, A., Druker, B. J. & Fleischman, A. G., Jan 1 2016, In : Experimental hematology. 44, 1, p. 24-29.e1

Research output: Contribution to journalArticle

1 Scopus citations

Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Garbati, M. R., Welgan, C. A., Landefeld, S. H., Newell, L. F., Agarwal, A., Dunlap, J. B., Chourasia, T. K., Lee, H., Elferich, J., Traer, E., Rattray, R., Cascio, M. J., Press, R. D., Bagby, G. C., Tyner, J. W., Druker, B. J. & Dao, K. H. T., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

RNAi screening of leukemia cells using electroporation

Agarwal, A. & Tyner, J. W., 2016, Methods in Molecular Biology. Humana Press Inc., p. 85-94 10 p. (Methods in Molecular Biology; vol. 1470).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Ultrasensitive proteomic quantitation of cellular signaling by digitized nanoparticle-protein counting

Jacob, T., Agarwal, A., Ramunno-Johnson, D., O'Hare, T., Gönen, M., Tyner, J. W., Druker, B. J. & Vu, T. Q., Jun 20 2016, In : Scientific Reports. 6, 28163.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Acute promyelocytic leukemia with JAK2 V617F and severe differentiation syndrome

Braun, T. P., Maxson, J. E., Agarwal, A., Dunlap, J., Spurgeon, S. E. & Traer, E., Jan 1 2015, In : Leukemia Research Reports. 4, 1, p. 8-11 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia

Agarwal, A., Mackenzie, R. J., Eide, C. A., Davare, M. A., Watanabe-Smith, K., Tognon, C. E., Mongoue-Tchokote, S., Park, B., Braziel, R. M., Tyner, J. W. & Druker, B. J., Jun 4 2015, In : Oncogene. 34, 23, p. 2991-2999 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Molecular biology of chronic leukemias

Blachly, J. S., Eide, C. A., Byrd, J. C. & Agarwal, A., Jan 7 2015, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology: Tenth Edition. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Molecular biology of chronic leukemias

Blachly, J. S., Eide, C. A., Byrd, J. C. & Agarwal, A., Apr 15 2015, Cancer: Principles & Practice of Oncology: Primer of the Molecular Biology of Cancer: Second Edition. Wolters Kluwer Health

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia

Agarwal, A., MacKenzie, R. J., Pippa, R., Eide, C. A., Oddo, J., Tyner, J. W., Sears, R., Vitek, M. P., Odero, M. D., Christensen, D. J. & Druker, B. J., Apr 15 2014, In : Clinical Cancer Research. 20, 8, p. 2092-2103 12 p.

Research output: Contribution to journalArticle

80 Scopus citations

BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein

Agarwal, A., Mackenzie, R. J., Besson, A., Jeng, S., Carey, A., LaTocha, D. H., Fleischman, A. G., Duquesnes, N., Eide, C. A., Vasudevan, K. B., Loriaux, M. M., Firpo, E., Cortes, J. E., McWeeney, S., O'Hare, T., Roberts, J. M., Druker, B. J. & Deininger, M. W., Nov 20 2014, In : Blood. 124, 22, p. 3260-3273 14 p.

Research output: Contribution to journalArticle

16 Scopus citations

Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle

Braun, T. P., Szumowski, M., Levasseur, P. R., Grossberg, A. J., Zhu, X., Agarwal, A. & Marks, D. L., Sep 25 2014, In : PloS one. 9, 9, e106489.

Research output: Contribution to journalArticle

33 Scopus citations

Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

Traer, E., Javidi-Sharifi, N., Agarwal, A., Dunlap, J., English, I., Martinez, J., Tyner, J. W., Wong, M. & Druker, B. J., Mar 6 2014, In : Blood. 123, 10, p. 1516-1524 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

Davare, M. A., Saborowski, A., Eide, C. A., Tognon, C., Smith, R. L., Elferich, J., Agarwal, A., Tyner, J. W., Shinde, U. P., Lowe, S. W. & Druker, B. J., Nov 26 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 48, p. 19519-19524 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML

Maxson, J. E., Gotlib, J., Pollyea, D. A., Fleischman, A. G., Agarwal, A., Eide, C. A., Bottomly, D., Wilmot, B., McWeeney, S. K., Tognon, C. E., Pond, J. B., Collins, R. H., Goueli, B., Stephen, T. O., Michael, W. D., Chang, B. H., Loriaux, M. M., Druker, B. J. & Tyner, J. W., 2013, In : New England Journal of Medicine. 368, 19, p. 1781-1790 10 p.

Research output: Contribution to journalArticle

299 Scopus citations

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in Mice that is responsive to therapeutic JAK inhibition

Fleischman, A. G., Maxson, J. E., Luty, S. B., Agarwal, A., Royer, L. R., Abel, M. L., Macmaniman, J. D., Loriaux, M. M., Druker, B. J. & Tyner, J. W., Nov 21 2013, In : Blood. 122, 22, p. 3628-3631 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis

O'Hare, T., Eide, C. A., Agarwal, A., Adrian, L. T., Zabriskie, M. S., MacKenzie, R. J., La Tocha, D. H., Johnson, K. J., You, H., Luo, J., Riddle, S. M., Marks, B. D., Vogel, K. W., Koop, D. R., Apgar, J., Tyner, J. W., Deininger, M. W. & Druker, B. J., Jun 1 2013, In : Cancer Research. 73, 11, p. 3356-3370 15 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

Traer, E., MacKenzie, R., Snead, J., Agarwal, A., Eiring, A. M., O'Hare, T., Druker, B. J. & Deininger, M. W., May 2012, In : Leukemia. 26, 5, p. 1140-1143 4 p.

Research output: Contribution to journalLetter

71 Scopus citations

CXCR4 antagonists for the treatment of CML

Agarwal, A., O'Hare, T. & Deininger, M., Jan 1 2012, Novel Developments in Stem Cell Mobilization: Focus on CXCR4. Springer US, p. 351-367 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML

Agarwal, A., Fleischman, A. G., Petersen, C. L., MacKenzie, R., Luty, S., Loriaux, M., Druker, B. J., Woltjer, R. L. & Deininger, M. W., Sep 27 2012, In : Blood. 120, 13, p. 2658-2668 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

MDS: Roadblock to differentiation

Agarwal, A., Sep 6 2012, In : Blood. 120, 10, p. 1968-1969 2 p.

Research output: Contribution to journalComment/debate

4 Scopus citations
2011

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

Hurtz, C., Hatzi, K., Cerchietti, L., Braig, M., Park, E., Kim, Y. M., Herzog, S., Ramezani-Rad, P., Jumaa, H., Müller, M. C., Hofmann, W. K., Hochhaus, A., Ye, B. H., Agarwal, A., Druker, B. J., Shah, N. P., Melnick, A. M. & Müschen, M., Oct 24 2011, In : Journal of Experimental Medicine. 208, 11, p. 2163-2174 12 p.

Research output: Contribution to journalArticle

125 Scopus citations

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Corbin, A. S., Agarwal, A., Loriaux, M., Cortes, J., Deininger, M. W. & Druker, B. J., Jan 4 2011, In : Journal of Clinical Investigation. 121, 1, p. 396-409 14 p.

Research output: Contribution to journalArticle

508 Scopus citations

The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia

O'Hare, T., Zabriskie, M. S., Eide, C. A., Agarwal, A., Adrian, L. T., You, H., Corbin, A. S., Yang, F., Press, R. D., Rivera, V. M., Toplin, J., Wong, S., Deininger, M. W. & Druker, B. J., Nov 10 2011, In : Blood. 118, 19, p. 5250-5254 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms

Fleischman, A. G., Aichberger, K. J., Luty, S. B., Bumm, T. G., Petersen, C. L., Doratotaj, S., Vasudevan, K. B., LaTocha, D. H., Yang, F., Press, R. D., Loriaux, M. M., Pahl, H. L., Silver, R. T., Agarwal, A., O'Hare, T., Druker, B. J., Bagby, G. C. & Deininger, M. W., Dec 8 2011, In : Blood. 118, 24, p. 6392-6398 7 p.

Research output: Contribution to journalArticle

135 Scopus citations
2010

A specific need for CRKL in p210BCR-ABL - Induced transformation of mouse hematopoietic progenitors

Seo, J. H., Wood, L. J., Agarwal, A., O'Hare, T., Elsea, C. R., Griswold, I. J., Deininger, M. W. N., Imamoto, A. & Druker, B. J., Sep 15 2010, In : Cancer Research. 70, 18, p. 7325-7335 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells

Misra, S., Sharma, S., Agarwal, A., Khedkar, S. V., Tripathi, M. K., Mittal, M. K. & Chaudhuri, G., Mar 4 2010, In : Molecular Cancer. 9, 50.

Research output: Contribution to journalArticle

20 Scopus citations
2009

ERK2, but not ERK1, mediates acquired and "De novo" resistance to imatinib mesylate: Implication for CML therapy

Aceves-Luquero, C. I., Agarwal, A., Calllejas-Valera, J. L., Arias-González, L., Esparís-Ogando, A., Ovalke, L. D. P., Bellón-Echeverria, I., de la Cruz-Morcillo, M. A., Moya, E. M. G., Gimeno, I. M., Gómez, J. C., Deininger, M. W., Pandiella, A. & Prieto, R. S., Jul 1 2009, In : PloS one. 4, 7, e6124.

Research output: Contribution to journalArticle

33 Scopus citations