Ann Hessell

Research Assistant Professor

  • 4916 Citations
  • 25 h-Index
20002019

Research output per year

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Research Output

2019

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge

Pegu, A., Borate, B., Huang, Y., Pauthner, M. G., Hessell, A. J., Julg, B., Doria-Rose, N. A., Schmidt, S. D., Carpp, L. N., Cully, M. D., Chen, X., Shaw, G. M., Barouch, D. H., Haigwood, N. L., Corey, L., Burton, D. R., Roederer, M., Gilbert, P. B., Mascola, J. R. & Huang, Y., Sep 11 2019, In : Cell Host and Microbe. 26, 3, p. 336-346.e3

Research output: Contribution to journalArticle

4 Scopus citations

Antibodies Tip the Balance Towards an HIV Cure

Haigwood, N. & Hessell, A., May 1 2019, In : Trends in Immunology. 40, 5, p. 375-377 3 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Divergent HIV-1-directed immune responses generated by systemic and mucosal immunization with replicating single-cycle adenoviruses in rhesus macaques

Matchett, W. E., Anguiano-Zarate, S. S., Nehete, P. N., Shelton, K., Nehete, B. P., Yang, G., Dorta-Estremera, S., Barnette, P., Xiao, P., Byrareddy, S. N., Villinger, F., Hessell, A., Haigwood, N., Sastry, K. J. & Barry, M. A., May 1 2019, In : Journal of virology. 93, 10, e02016-18.

Research output: Contribution to journalArticle

2 Scopus citations

IL-33 enhances the kinetics and quality of the antibody response to a DNA and protein-based HIV-1 Env vaccine

Sarkar, S., Piepenbrink, M. S., Basu, M., Thakar, J., Keefer, M. C., Hessell, A. J., Haigwood, N. L. & Kobie, J. J., Apr 17 2019, In : Vaccine. 37, 17, p. 2322-2330 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses

Hessell, A., Powell, R., Jiang, X., Luo, C., Weiss, S., Dussupt, V., Itri, V., Fox, A., Shapiro, M. B., Pandey, S., Cheever, T., Fuller, D. H., Park, B., Krebs, S. J., Totrov, M., Haigwood, N., Kong, X. P. & Zolla-Pazner, S., Jul 23 2019, In : Cell Reports. 28, 4, p. 877-895.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Passive and active antibody studies in primates to inform HIV vaccines

Hessell, A., Malherbe, D. & Haigwood, N., Feb 1 2018, In : Expert Review of Vaccines. 17, 2, p. 127-144 18 p.

Research output: Contribution to journalReview article

10 Scopus citations

Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated simian/human immunodeficiency virus challenges

Hessell, A. J., Shapiro, M. B., Powell, R., Malherbe, D. C., McBurney, S. P., Pandey, S., Cheever, T., Sutton, W. F., Kahl, C., Park, B., Zolla-Pazner, S. & Haigwood, N. L., Jun 1 2018, In : Journal of virology. 92, 11, e02198-17.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Envspecific antibody response in SHIV-infected rhesus macaques

Jaworski, J. P., Bryk, P., Brower, Z., Zheng, B., Hessell, A., Rosenberg, A. F., Wu, T. T., Sanz, I., Keefer, M. C., Haigwood, N. & Kobie, J. J., Feb 1 2017, In : PLoS One. 12, 2, e0172524.

Research output: Contribution to journalArticle

2 Scopus citations

Use of broadly neutralizing antibodies for HIV-1 prevention

Pegu, A., Hessell, A., Mascola, J. R. & Haigwood, N., Jan 1 2017, In : Immunological Reviews. 275, 1, p. 296-312 17 p.

Research output: Contribution to journalReview article

66 Scopus citations
2016

Achieving potent autologous neutralizing antibody responses against tier 2 HIV-1 viruses by strategic selection of envelope immunogens

Hessell, A. J., Malherbe, D. C., Pissani, F., McBurney, S., Krebs, S. J., Gomes, M., Pandey, S., Sutton, W. F., Burwitz, B. J., Gray, M., Robins, H., Park, B. S., Sacha, J. B., La Branche, C. C., Fuller, D. H., Montefiori, D. C., Stamatatos, L., Sather, D. N. & Haigwood, N. L., Apr 1 2016, In : Journal of Immunology. 196, 7, p. 3064-3078 15 p.

Research output: Contribution to journalArticle

31 Scopus citations

Differential induction of anti-V3 crown antibodies with cradle- and ladle-binding modes in response to HIV-1 envelope vaccination

Balasubramanian, P., Kumar, R., Williams, C., Itri, V., Wang, S., Lu, S., Hessell, A., Haigwood, N., Sinangil, F., Higgins, K. W., Liu, L., Li, L., Nyambi, P., Gorny, M. K., Totrov, M., Nadas, A., Kong, X. P., Zolla-Pazner, S. & Hioe, C. E., Aug 18 2016, (Accepted/In press) In : Vaccine.

Research output: Contribution to journalArticle

6 Scopus citations

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques

Hessell, A., Jaworski, J. P., Epson, E., Matsuda, K., Pandey, S., Kahl, C., Reed, J., Sutton, W. F., Hammond, K. B., Cheever, T. A., Barnette, P. T., Legasse, A. W., Planer, S., Stanton, J., Pegu, A., Chen, X., Wang, K., Siess, D., Burke, D., Park, B. & 7 others, Axthelm, M., Lewis, A., Hirsch, V. M., Graham, B. S., Mascola, J. R., Sacha, J. & Haigwood, N., Apr 1 2016, In : Nature Medicine. 22, 4, p. 362-368 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides

Hessell, A., McBurney, S., Pandey, S., Sutton, W., Liu, L., Li, L., Totrov, M., Zolla-Pazner, S., Haigwood, N. & Gorny, M. K., May 23 2016, In : Vaccine. 34, 24, p. 2713-2721 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

Animal models in HIV-1 protection and therapy

Hessell, A. J. & Haigwood, N. L., May 27 2015, In : Current Opinion in HIV and AIDS. 10, 3, p. 170-176 7 p.

Research output: Contribution to journalReview article

32 Scopus citations

Functional and Molecular Characteristics of Novel and Conserved Cross-Clade HIV Envelope Specific Human Monoclonal Antibodies

Kobie, J. J., Zheng, B., Piepenbrink, M. S., Hessell, A. J., Haigwood, N. L., Keefer, M. C. & Sanz, I., Apr 1 2015, In : Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 34, 2, p. 65-72 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1

Sather, D. N., Carbonetti, S., Malherbe, D. C., Pissani, F., Stuart, A. B., Hessell, A. J., Gray, M. D., Mikell, I., Kalams, S. A., Haigwood, N. L. & Stamatatos, L., Jan 1 2014, In : Journal of virology. 88, 22, p. 12968-12981 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Envelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits

Malherbe, D. C., Pissani, F., Noah Sather, D., Guo, B., Pandey, S., Sutton, W. F., Stuart, A. B., Robins, H., Park, B., Krebs, S. J., Schuman, J. T., Kalams, S., Hessell, A. J. & Haigwood, N. L., Jan 1 2014, In : Journal of virology. 88, 22, p. 12949-12967 19 p.

Research output: Contribution to journalArticle

22 Scopus citations

Simplifying the synthesis of SIgA: Combination of dIgA and rhSC using affinity chromatography

Moldt, B., Saye-Francisco, K., Schultz, N., Burton, D. R. & Hessell, A. J., Jan 1 2014, In : Methods. 65, 1, p. 127-132 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The MHC class II cofactor HLA-DM interacts with Ig in B cells

Macmillan, H., Strohman, M. J., Ayyangar, S., Jiang, W., Rajasekaran, N., Spura, A., Hessell, A. J., Madec, A. M. & Mellins, E. D., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 2641-2650 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

FcγRs Across Species

Moldt, B. & Hessell, A. J., Sep 1 2013, Antibody Fc: Linking Adaptive and Innate Immunity. Elsevier Inc., p. 145-157 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques

Jaworski, J. P., Kobie, J., Brower, Z., Malherbe, D. C., Landucci, G., Sutton, W. F., Guo, B., Reed, J. S., Leon, E. J., Engelmann, F., Zheng, B., Legasse, A., Park, B., Dickerson, M., Lewis, A. D., Colgin, L. M. A., Axthelm, M., Messaoudi, I., Sacha, J. B., Burton, D. R. & 3 others, Forthal, D. N., Hessell, A. J. & Haigwood, N. L., Oct 28 2013, In : Journal of virology. 87, 19, p. 10447-10459 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced Fcγriiia-Mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

Moldt, B., Shibata-Koyama, M., Rakasz, E. G., Schultz, N., Kand, Y., Dunlop, D. C., Finstad, S. L., Jin, C., Landucci, G., Alpert, M. D., Dugast, A. S., Parren, P. W. H. I., Nimmerjahn, F., Evans, D. T., Alter, G., Forthal, D. N., Schmitz, J. E., Iida, S., Poignard, P., Watkins, D. I. & 2 others, Hessell, A. J. & Burton, D. R., Jun 1 2012, In : Journal of virology. 86, 11, p. 6189-6196 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Neutralizing antibodies and control of HIV: Moves and countermoves

Hessell, A. J. & Haigwood, N. L., Mar 1 2012, In : Current HIV/AIDS Reports. 9, 1, p. 64-72 9 p.

Research output: Contribution to journalReview article

18 Scopus citations

Neutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 Are influenced by the transmembrane domain and the plasma membrane

Montero, M., Gulzar, N., Klaric, K. A., Donald, J. E., Lepik, C., Wu, S., Tsai, S., Julien, J. P., Hessell, A. J., Wang, S., Lu, S., Burton, D. R., Pai, E. F., DeGrado, W. F. & Scott, J. K., Mar 1 2012, In : Journal of virology. 86, 6, p. 2930-2941 12 p.

Research output: Contribution to journalArticle

46 Scopus citations
2011

A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for Fcγ receptors to define the role of effector functions in protection against HIV

Moldt, B., Schultz, N., Dunlop, D. C., Alpert, M. D., Harvey, J. D., Evans, D. T., Poignard, P., Hessell, A. J. & Burton, D. R., Oct 1 2011, In : Journal of virology. 85, 20, p. 10572-10581 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Design, synthesis, and biological evaluation of a biyouyanagin compound library

Nicolaou, K. C., Sanchini, S., Sarlah, D., Lu, G., Wu, T. R., Nomura, D. K., Cravatt, B. F., Cubitt, B., De La Torre, J. C., Hessell, A. J. & Burton, D. R., Apr 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 17, p. 6715-6720 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

Burton, D. R., Hessell, A. J., Keele, B. F., Klasse, P. J., Ketas, T. A., Moldt, B., Dunlop, D. C., Poignard, P., Doyle, L. A., Cavacini, L., Veazey, R. S. & Moore, J. P., Jul 5 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 27, p. 11181-11186 6 p.

Research output: Contribution to journalArticle

197 Scopus citations

Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus

Weinfurter, J. T., May, G. E., Soma, T., Hessell, A. J., León, E. J., MacNair, C. E., Piaskowski, S. M., Weisgrau, K., Furlott, J., Maness, N. J., Reed, J., Wilson, N. A., Rakasz, E. G., Burton, D. R. & Friedrich, T. C., Jan 1 2011, In : Journal of virology. 85, 1, p. 530-541 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synthesis and biological evaluation of 2′,4′- and 3′,4′-bridged nucleoside analogues

Nicolaou, K. C., Ellery, S. P., Rivas, F., Saye, K., Rogers, E., Workinger, T. J., Schallenberger, M., Tawatao, R., Montero, A., Hessell, A., Romesberg, F., Carson, D. & Burton, D., Sep 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 18, p. 5648-5669 22 p.

Research output: Contribution to journalArticle

12 Scopus citations
2010

Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L

Hessell, A. J., Rakasz, E. G., Tehrani, D. M., Huber, M., Weisgrau, K. L., Landucci, G., Forthal, D. N., Koff, W. C., Poignard, P., Watkins, D. I. & Burton, D. R., Feb 1 2010, In : Journal of virology. 84, 3, p. 1302-1313 12 p.

Research output: Contribution to journalArticle

249 Scopus citations

Emergence of monoclonal antibody b12-resistant human immunodeficiency virus type 1 variants during natural infection in the absence of humoral or cellular immune pressure

Bunnik, E. M., Van Gils, M. J., Lobbrecht, M. S. D., Pisas, L., Nanlohy, N. M., Van Baarle, D., Van Nuenen, A. C., Hessell, A. J. & Schuitemaker, H., May 1 2010, In : Journal of General Virology. 91, 5, p. 1354-1364 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Macaques vaccinated with Simian Immunodeficiency Virus SIVmac239Δnef delay acquisition and control replication after repeated low-dose heterologous SIV challenge

Reynolds, M. R., Weiler, A. M., Piaskowski, S. M., Kolar, H. L., Hessell, A. J., Weiker, M., Weisgrau, K. L., León, E. J., Rogers, W. E., Makowsky, R., McDermott, A. B., Boyle, R., Wilson, N. A., Allison, D. B., Burton, D. R., Koff, W. C. & Watkins, D. I., Sep 1 2010, In : Journal of virology. 84, 18, p. 9190-9199 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Potent inhibition of HIV-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis

Gavrilyuk, J., Uehara, H., Otsubo, N., Hessell, A., Burton, D. R. & Barbas, C. F., Oct 18 2010, In : ChemBioChem. 11, 15, p. 2113-2118 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2009

Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers

Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I. & Burton, D. R., May 1 2009, In : PLoS pathogens. 5, 5, e1000433.

Research output: Contribution to journalArticle

380 Scopus citations

Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques

Hessell, A. J., Poignard, P., Hunter, M., Hangartner, L., Tehrani, D. M., Bleeker, W. K., Parren, P. W. H. I., Marx, P. A. & Burton, D. R., Aug 1 2009, In : Nature medicine. 15, 8, p. 951-954 4 p.

Research output: Contribution to journalArticle

408 Scopus citations

P04-38. Crystal structure of gp120 in complex with the CD4-binding-site antibody b13 suggests precise targeting is needed for neutralization

Zhou, T., Yang, Z., Xu, L., Hessell, A. J., Burton, D. R., Nabel, G. J. & Kwong, P. D., Oct 22 2009, In : Retrovirology. 6, SUPPL. 3, p. P66 1742.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120

Chen, L., Do Kwon, Y., Zhou, T., Wu, X., O'Dell, S., Cavacini, L., Hessell, A. J., Pancera, M., Tang, M., Xu, L., Yang, Z. Y., Zhang, M. Y., Arthos, J., Burton, D. R., Dimitrov, D. S., Nabel, G. J., Posner, M. R., Sodroski, J., Wyatt, R., Mascola, J. R. & 1 others, Kwong, P. D., Nov 20 2009, In : Science. 326, 5956, p. 1123-1127 5 p.

Research output: Contribution to journalArticle

231 Scopus citations

Techniques and tactics used in determining the structure of the trimeric ebolavirus glycoprotein

Lee, J. E., Fusco, M. L., Abelson, D. M., Hessell, A. J., Burton, D. R. & Saphire, E. O., Dec 1 2009, In : Acta Crystallographica Section D: Biological Crystallography. 65, 11, p. 1162-1180 19 p.

Research output: Contribution to journalArticle

22 Scopus citations
2008

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

Lee, J. E., Fusco, M. L., Hessell, A. J., Oswald, W. B., Burton, D. R. & Saphire, E. O., Jul 10 2008, In : Nature. 454, 7201, p. 177-182 6 p.

Research output: Contribution to journalArticle

450 Scopus citations
2007

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10

Nelson, J. D., Brunel, F. M., Jensen, R., Crooks, E. T., Cardoso, R. M. F., Wang, M., Hessell, A., Wilson, I. A., Binley, J. M., Dawson, P. E., Burton, D. R. & Zwick, M. B., Apr 1 2007, In : Journal of virology. 81, 8, p. 4033-4043 11 p.

Research output: Contribution to journalArticle

138 Scopus citations

A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo

Williams, J. V., Chen, Z., Cseke, G., Wright, D. W., Keefer, C. J., Tollefson, S. J., Hessell, A., Podsiad, A., Shepherd, B. E., Sanna, P. P., Burton, D. R., Crowe, J. E. & Williamson, R. A., Aug 1 2007, In : Journal of virology. 81, 15, p. 8315-8324 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

Fc receptor but not complement binding is important in antibody protection against HIV

Hessell, A. J., Hangartner, L., Hunter, M., Havenith, C. E. G., Beurskens, F. J., Bakker, J. M., Lanigan, C. M. S., Landucci, G., Forthal, D. N., Parren, P. W. H. I., Marx, P. A. & Burton, D. R., Sep 6 2007, In : Nature. 449, 7158, p. 101-104 4 p.

Research output: Contribution to journalArticle

609 Scopus citations

Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region

Mantis, N. J., Palaia, J., Hessell, A. J., Mehta, S., Zhu, Z., Corthésy, B., Neutra, M. R., Burton, D. R. & Janoff, E. N., Sep 1 2007, In : Journal of Immunology. 179, 5, p. 3144-3152 9 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Zhou, T., Xu, L., Dey, B., Hessell, A. J., Van Ryk, D., Xiang, S. H., Yang, X., Zhang, M. Y., Zwick, M. B., Arthos, J., Burton, D. R., Dimitrov, D. S., Sodroski, J., Wyatt, R., Nabel, G. J. & Kwong, P. D., Feb 15 2007, In : Nature. 445, 7129, p. 732-737 6 p.

Research output: Contribution to journalArticle

622 Scopus citations
2002

Detection of antibodies against the four subtypes of ebola virus in Sera from any species using a novel antibody-phage indicator assay

Meissner, F., Maruyama, T., Frentsch, M., Hessell, A. J., Rodriguez, L. L., Geisbert, T. W., Jahrling, P. B., Burton, D. R. & Parren, P. W. H. I., Jan 1 2002, In : Virology. 300, 2, p. 236-243 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2001

Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro

Parren, P. W. H. I., Marx, P. A., Hessell, A. J., Luckay, A., Harouse, J., Cheng-Mayer, C., Moore, J. P. & Burton, D. R., Aug 23 2001, In : Journal of virology. 75, 17, p. 8340-8347 8 p.

Research output: Contribution to journalArticle

568 Scopus citations

Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1

Hezareh, M., Hessell, A. J., Jensen, R. C., Van De Winkel, J. G. J. & Parren, P. W. H. I., Dec 17 2001, In : Journal of virology. 75, 24, p. 12161-12168 8 p.

Research output: Contribution to journalArticle

151 Scopus citations
2000

Absence of specific mucosal antibody responses in HIV-exposed uninfected sex workers from the Gambia

Dorrell, L., Hessell, A. J., Wang, M., Whittle, H., Sabally, S., Rowland-Jones, S., Burton, D. R. & Parren, P. W. H. I., Jul 12 2000, In : AIDS. 14, 9, p. 1117-1122 6 p.

Research output: Contribution to journalArticle

91 Scopus citations