Andras Gruber

Professor

  • 4031 Citations
  • 33 h-Index
1978 …2019
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Research Output 1984 2019

  • 4031 Citations
  • 33 h-Index
  • 105 Article
  • 2 Chapter
  • 2 Conference contribution
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Article
2019
8 Citations (Scopus)

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivanov, I., Matafonov, A., Sun, M. F., Mohammed, B. M., Cheng, Q., Dickeson, S. K., Kundu, S., Verhamme, I. M., Gruber, A., McCrae, K. & Gailani, D., Mar 7 2019, In : Blood. 133, 10, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

Hereditary Angioedemas
Factor XII
Prekallikrein
Kallikreins
Chemical activation
1 Citation (Scopus)

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

Mohammed, B. M., Cheng, Q., Matafonov, A., Verhamme, I. M., Emsley, J., McCrae, K. R., McCarty, O., Gruber, A. & Gailani, D., Jan 1 2019, In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Factor XI
Glycosaminoglycans
Blood Vessels
Prekallikrein
Heparin
6 Citations (Scopus)

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Lorentz, C. U., Verbout, N. G., Wallisch, M., Hagen, M. W., Shatzel, J. J., Olson, S. R., Puy, C., Hinds, M., McCarty, O., Gailani, D., Gruber, A. & Tucker, E., Apr 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

Open Access
Factor XI
Antibodies
Thrombosis
Hemostasis
Primates
2 Citations (Scopus)

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

Puy, C., Ngo, A. T. P., Pang, J., Keshari, R. S., Hagen, M. W., Hinds, M., Gailani, D., Gruber, A., Lupu, F. & McCarty, O., Jul 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 7, p. 1390-1401 12 p.

Research output: Contribution to journalArticle

Open Access
Factor XIa
Plasminogen Inactivators
Plasminogen Activator Inhibitor 1
Endothelial Cells
Kallikreins

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Shirai, T., Revenko, A. S., Tibbitts, J., Ngo, A. T. P., Mitrugno, A., Healy, L. D., Johnson, J., Tucker, E. I., Hinds, M. T., Coussens, L. M., McCarty, O. J. T., Monia, B. P. & Gruber, A., Oct 22 2019, In : Blood Advances. 3, 20, p. 3080-3091 12 p.

Research output: Contribution to journalArticle

Open Access
Thrombopoietin
Gene Silencing
Platelet Count
Breast Neoplasms
Liver
3 Citations (Scopus)

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death

Silasi, R., Keshari, R. S., Lupu, C., Van Rensburg, W. J., Chaaban, H., Regmi, G., Shamanaev, A., Shatzel, J. J., Puy, C., Lorentz, C. U., Tucker, E., Gailani, D., Gruber, A., McCarty, O. & Lupu, F., Feb 26 2019, In : Blood advances. 3, 4, p. 658-669 12 p.

Research output: Contribution to journalArticle

Open Access
Factor XI
Contact Inhibition
Papio
Sepsis
Disseminated Intravascular Coagulation
7 Citations (Scopus)

The role of coagulation and platelets in colon cancer-associated thrombosis

Mitrugno, A., Tassi Yunga, S., Sylman, J. L., Zilberman-Rudenko, J., Shirai, T., Hebert, J. F., Kayton, R., Zhang, Y., Nan, X., Shatzel, J. J., Esener, S., Duvernay, M. T., Hamm, H. E., Gruber, A., Williams, C. D., Takata, Y., Armstrong, R., Morgan, T. & McCarty, O., Feb 1 2019, In : American journal of physiology. Cell physiology. 316, 2, p. C264-C273

Research output: Contribution to journalArticle

Colonic Neoplasms
Thrombosis
Blood Platelets
Neoplasms
Cell Communication
2018
2 Citations (Scopus)

Factor XI contributes to myocardial ischemia-reperfusion injury in mice

Lorentz, C. U., Verbout, N. G., Cao, Z., Liu, L., Hinds, M., McCarty, O., Ivanov, I., Tucker, E., Gailani, D. & Gruber, A., Jan 23 2018, In : Blood advances. 2, 2, p. 85-88 4 p.

Research output: Contribution to journalArticle

Factor XIIa
Factor XI
Protein Interaction Domains and Motifs
Myocardial Reperfusion Injury
Reperfusion Injury
3 Citations (Scopus)

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo

Zilberman-Rudenko, J., Reitsma, S. E., Puy, C., Rigg, R. A., Smith, S. A., Tucker, E., Silasi, R., Merkulova, A., McCrae, K. R., Maas, C., Urbanus, R. T., Gailani, D., Morrissey, J. H., Gruber, A., Lupu, F., Schmaier, A. H. & McCarty, O., Aug 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 8, p. 1748-1760 13 p.

Research output: Contribution to journalArticle

Factor XII
Polyphosphates
Platelet Activation
Blood Platelets
Sepsis
5 Citations (Scopus)

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Popescu, N. I., Silasi, R., Keshari, R. S., Girton, A., Burgett, T., Zeerleder, S. S., Gailani, D., Gruber, A., Lupu, F. & Mark Coggeshall, K., Aug 23 2018, In : Blood. 132, 8, p. 849-860 12 p.

Research output: Contribution to journalArticle

Peptidoglycan
Papio
Disseminated Intravascular Coagulation
Coagulation
Chemical activation
6 Citations (Scopus)

Plasma contact factors as therapeutic targets

Tillman, B. F., Gruber, A., McCarty, O. & Gailani, D., Jan 1 2018, (Accepted/In press) In : Blood Reviews.

Research output: Contribution to journalArticle

Hemostasis
Hemorrhage
Anticoagulants
Thrombosis
Factor XI

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Rigg, R. A., Healy, L. D., Chu, T. T., Ngo, A. T. P., Mitrugno, A., Zilberman-Rudenko, J., Aslan, J., Hinds, M., Vecchiarelli, L. D., Morgan, T., Gruber, A., Temple, K. J., Lindsley, C. W., Duvernay, M. T., Hamm, H. E. & McCarty, O., Jan 1 2018, (Accepted/In press) In : Platelets.

Research output: Contribution to journalArticle

Leukocytes
Blood Platelets
Cathepsin G
Fibrinolysin
Platelet Activation
3 Citations (Scopus)

α 2 -Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC: α 2 M Levels Are Associated with Venous Thromboembolism

Martos, L., Ramón, L. A., Oto, J., Fernández-Pardo, Á., Bonanad, S., Cid, A. R., Gruber, A., Griffin, J. H., España, F., Navarro, S. & Medina, P., Feb 15 2018, (Accepted/In press) In : Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Macroglobulins
Protein C Inhibitor
Venous Thromboembolism
Protein C
Enzyme-Linked Immunosorbent Assay
2017
26 Citations (Scopus)

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Healy, L. D., Puy, C., Fernández, J. A., Mitrugno, A., Keshari, R. S., Taku, N. A., Chu, T. T., Xu, X., Gruber, A., Lupu, F., Griffin, J. H. & McCarty, O., May 26 2017, In : Journal of Biological Chemistry. 292, 21, p. 8616-8629 14 p.

Research output: Contribution to journalArticle

Protein C
Chemical activation
Neutrophils
Macrophage-1 Antigen
Platelets
13 Citations (Scopus)

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen

Ivanov, I., Shakhawat, R., Sun, M. F., Dickeson, S. K., Puy, C., McCarty, O., Gruber, A., Matafonov, A. & Gailani, D., 2017, In : Thrombosis and Haemostasis. 117, 4, p. 671-681 11 p.

Research output: Contribution to journalArticle

High Molecular Weight Kininogens
Factor XI
Prekallikrein
Nucleic Acids
Factor XIIa
33 Citations (Scopus)

Platelet-localized FXI promotes a vascular coagulationinflammatory circuit in arterial hypertension

Kossmann, S., Lagrange, J., Jäckel, S., Jurk, K., Ehlken, M., Schönfelder, T., Weihert, Y., Knorr, M., Brandt, M., Xia, N., Li, H., Daiber, A., Oelze, M., Reinhardt, C., Lackner, K., Gruber, A., Monia, B., Karbach, S. H., Walter, U., Ruggeri, Z. M. & 4 others, Renné, T., Ruf, W., Münzel, T. & Wenzel, P., Feb 1 2017, In : Science Translational Medicine. 9, 375, eaah4923.

Research output: Contribution to journalArticle

Factor XI
Blood Vessels
Blood Platelets
Hypertension
Thrombin
1 Citation (Scopus)

Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions

Garland, K. S., Reitsma, S. E., Shirai, T., Zilberman-Rudenko, J., Tucker, E., Gailani, D., Gruber, A., McCarty, O. & Puy, C., Jan 1 2017, In : Frontiers in Medicine. 4, DEC, 232.

Research output: Contribution to journalArticle

Open Access
Factor XIa
Factor XI
von Willebrand Factor
Blood Platelets
Endothelial Cells
20 Citations (Scopus)

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Kamikubo, Y., Mendolicchio, G. L., Zampolli, A., Marchese, P., Rothmeier, A. S., Orje, J. N., Gale, A. J., Krishnaswamy, S., Gruber, A., Østergaard, H., Petersen, L. C., Ruf, W. & Ruggeri, Z. M., Oct 5 2017, In : Blood. 130, 14, p. 1661-1670 10 p.

Research output: Contribution to journalArticle

Factor VIII
Thromboplastin
Chemical activation
Tissue
Thrombin
2016
5 Citations (Scopus)

Biorheology of Platelet Activation in the Bloodstream Distal to Thrombus Formation

Zilberman-Rudenko, J., Itakura, A., Maddala, J., Baker-Groberg, S. M., Vetter, R., Tucker, E., Gruber, A., Gerdes, C. & McCarty, O., May 25 2016, (Accepted/In press) In : Cellular and Molecular Bioengineering. p. 1-13 13 p.

Research output: Contribution to journalArticle

Platelets
Platelet Activation
Activation
Thrombosis
Chemical activation
17 Citations (Scopus)

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow

Zilberman-Rudenko, J., Itakura, A., Wiesenekker, C. P., Vetter, R., Maas, C., Gailani, D., Tucker, E., Gruber, A., Gerdes, C. & McCarty, O., Jan 14 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

Factor XI
Platelet Activation
Thrombosis
Blood Platelets
Thrombin
2 Citations (Scopus)

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin

Sylman, J. L., Daalkhaijav, U., Zhang, Y., Gray, E. M., Farhang, P. A., Chu, T. T., Zilberman-Rudenko, J., Puy, C., Tucker, E., Smith, S. A., Morrissey, J. H., Walker, T. W., Nan, X., Gruber, A. & McCarty, O., Dec 8 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-13 13 p.

Research output: Contribution to journalArticle

Coagulation
Chemical activation
Ellagic acid
Gelation
Tissue
27 Citations (Scopus)

Factor XI as a Therapeutic Target

Gailani, D. & Gruber, A., May 12 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

Factor XIa
Factor XI
Thrombin
Factor XI Deficiency
Therapeutics
23 Citations (Scopus)

Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice

Bane, C. E., Ivanov, I., Matafonov, A., Boyd, K. L., Cheng, Q., Sherwood, E. R., Tucker, E., Smiley, S. T., McCarty, O., Gruber, A. & Gailani, D., Apr 1 2016, In : PLoS One. 11, 4, e0152968.

Research output: Contribution to journalArticle

Factor XI Deficiency
Factor XI
sepsis (infection)
Sepsis
Peptide Hydrolases
29 Citations (Scopus)

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

Rigg, R. A., Aslan, J., Healy, L. D., Wallisch, M., Thierheimer, M. L. D., Loren, C. P., Pang, J., Hinds, M., Gruber, A. & McCarty, O., Mar 1 2016, In : American Journal of Physiology - Cell Physiology. 310, 5, p. C373-C380

Research output: Contribution to journalArticle

Oral Administration
Platelet Activation
Platelet Aggregation
Hemorrhage
Immunoreceptor Tyrosine-Based Activation Motif
9 Citations (Scopus)

Platelet-derived short-chain polyphosphates enhance the inactivation of tissue factor pathway inhibitor by activated coagulation factor XI

Puy, C., Tucker, E., Ivanov, I. S., Gailani, D., Smith, S. A., Morrissey, J. H., Gruber, A. & McCarty, O., Oct 1 2016, In : PLoS One. 11, 10, e0165172.

Research output: Contribution to journalArticle

Factor XIa
Factor XI
Polyphosphates
polyphosphates
Platelets
7 Citations (Scopus)

The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI

Schwarzmaier, S. M., De Chaumont, C., Balbi, M., Terpolilli, N. A., Kleinschnitz, C., Gruber, A. & Plesnila, N., Sep 1 2016, In : Journal of Neurotrauma. 33, 17, p. 1634-1644 11 p.

Research output: Contribution to journalArticle

Factor XI
Microvessels
Brain
Factor XI Deficiency
Hemorrhage
2015
27 Citations (Scopus)

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Puy, C., Tucker, E., Matafonov, A., Cheng, Q., Zientek, K. D., Gailani, D., Gruber, A. & McCarty, O., Feb 26 2015, In : Blood. 125, 9, p. 1488-1496 9 p.

Research output: Contribution to journalArticle

Factor XIa
Factor XI
Chemical activation
Hemostatics
Thrombin
28 Citations (Scopus)

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Sparkenbaugh, E. M., Chantrathammachart, P., Wang, S., Jonas, W., Kirchhofer, D., Gailani, D., Gruber, A., Kasthuri, R., Key, N. S., Mackman, N. & Pawlinski, R., 2015, In : Haematologica. 100, 3, p. 308-313 6 p.

Research output: Contribution to journalArticle

Thromboplastin
Heme
Factor XI
Leukocytes
Endothelial Cells
57 Citations (Scopus)

Factor XI and contact activation as targets for antithrombotic therapy

Gailani, D., Bane, C. E. & Gruber, A., Aug 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 8, p. 1383-1395 13 p.

Research output: Contribution to journalArticle

Factor XI
Thrombin
Enzyme Precursors
Anticoagulants
Thrombosis
29 Citations (Scopus)

The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

Loren, C. P., Aslan, J., Rigg, R. A., Nowak, M. S., Healy, L. D., Gruber, A., Druker, B. & McCarty, O., Jan 1 2015, In : Thrombosis Research. 135, 1, p. 155-160 6 p.

Research output: Contribution to journalArticle

Immunoreceptor Tyrosine-Based Activation Motif
Platelet Activation
Blood Platelets
Protein-Tyrosine Kinases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
4 Citations (Scopus)

WEDGE: An anticoagulant thrombin mutant produced by autoactivation

Wood, D. C., Pelc, L. A., Pozzi, N., Wallisch, M., Verbout, N. G., Tucker, E., Gruber, A. & Di Cera, E., Jan 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 1, p. 111-114 4 p.

Research output: Contribution to journalArticle

Thrombin
Anticoagulants
Peptide Hydrolases
Enzyme Precursors
Trypsin
2014
17 Citations (Scopus)

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

Yokota, N., Zarpellon, A., Chakrabarty, S., Bogdanov, V. Y., Gruber, A., Castellino, F. J., Mackman, N., Ellies, L. G., Weiler, H., Ruggeri, Z. M. & Ruf, W., Jan 2014, In : Journal of Thrombosis and Haemostasis. 12, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

Thromboplastin
Thrombin
Neoplasm Metastasis
Blood Platelets
Neoplasms
114 Citations (Scopus)

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Matafonov, A., Leung, P. Y., Gailani, A. E., Grach, S. L., Puy, C., Cheng, Q., Sun, M. F., McCarty, O., Tucker, E., Kataoka, H., Renné, T., Morrissey, J. H., Gruber, A. & Gailani, D., Mar 13 2014, In : Blood. 123, 11, p. 1739-1746 8 p.

Research output: Contribution to journalArticle

Factor XII
Primates
Thrombosis
Factor XI
Fibrin
12 Citations (Scopus)

The role of the contact pathway in thrombus propagation

Gruber, A., 2014, In : Thrombosis Research. 133, SUPPL. 1

Research output: Contribution to journalArticle

Factor XII
Factor XIIa
Thrombin
Thrombosis
Hemostasis
8 Citations (Scopus)

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis

Verbout, N. G., Yu, X., Healy, L. D., Phillips, K. G., Tucker, E., Gruber, A., McCarty, O. & Offner, H., 2014, In : Metabolic Brain Disease. 30, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Neurology
Protein C
Thrombin
Multiple Sclerosis
2013
68 Citations (Scopus)

Antithrombotic effect of antisense factor xi oligonucleotide treatment in primates

Crosby, J. R., Marzec, U., Revenko, A. S., Zhao, C., Gao, D., Matafonov, A., Gailani, D., MacLeod, A. R., Tucker, E., Gruber, A., Hanson, S. R. & Monia, B. P., Jul 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 7, p. 1670-1678 9 p.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Oligonucleotides
Primates
Hemostasis
Thrombosis
28 Citations (Scopus)

Evidence for factor IX-independent roles for factor XIa in blood coagulation

Matafonov, A., Cheng, Q., Geng, Y., Verhamme, I. M., Umunakwe, O., Tucker, E., Sun, M. F., Serebrov, V., Gruber, A. & Gailani, D., Dec 2013, In : Journal of Thrombosis and Haemostasis. 11, 12, p. 2118-2127 10 p.

Research output: Contribution to journalArticle

Factor XIa
Factor IX
Blood Coagulation
Thrombin
Anti-Idiotypic Antibodies
40 Citations (Scopus)

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates

Puy, C., Tucker, E., Wong, Z. C., Gailani, D., Smith, S. A., Choi, S. H., Morrissey, J. H., Gruber, A. & McCarty, O., Jul 2013, In : Journal of Thrombosis and Haemostasis. 11, 7, p. 1341-1352 12 p.

Research output: Contribution to journalArticle

Factor XI
Factor XII
Polyphosphates
Prekallikrein
Thrombosis
19 Citations (Scopus)

Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis

Luo, D., Lin, J. S., Parent, M. A., Mullarky-Kanevsky, I., Szaba, F. M., Kummer, L. W., Duso, D. K., Tighe, M., Hill, J., Gruber, A., Mackman, N., Gailani, D. & Smiley, S. T., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4149-4161 13 p.

Research output: Contribution to journalArticle

Yersinia pestis
Fibrin
Plague
T-Lymphocytes
Neutrophils
5 Citations (Scopus)

Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells

Tormoen, G. W., Recht, O., Gruber, A., Levine, R. L. & McCarty, O., Oct 2013, In : Physical Biology. 10, 5, 056010.

Research output: Contribution to journalArticle

Phosphatidylserines
Thromboplastin
Acute Myeloid Leukemia
cancer procoagulant
Phenotype
4 Citations (Scopus)
Factor X
Factor IX
Thromboplastin
Thrombosis
Factor VII
107 Citations (Scopus)

Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates

Perzborn, E., Gruber, A., Tinel, H., Marzec, U. M., Buetehorn, U., Buchmuelle, A., Heitmeier, S. & Laux, V., 2013, In : Thrombosis and Haemostasis. 110, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

Hemostatics
Anticoagulants
Primates
Bleeding Time
Papio
5 Citations (Scopus)

Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear

Baker-Groberg, S. M., Itakura, A., Gruber, A. & McCarty, O., Nov 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 9

Research output: Contribution to journalArticle

Colon
Adenocarcinoma
Thrombosis
Fibrillar Collagens
Fibrinogen
2012
6 Citations (Scopus)

Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model

Heeb, M. J., Marzec, U., Gruber, A. & Hanson, S. R., Apr 2012, In : Thrombosis and Haemostasis. 107, 4, p. 690-698 9 p.

Research output: Contribution to journalArticle

Papio
Protein S
Protein C
Thrombosis
Blood Platelets
19 Citations (Scopus)

Factor xi-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis

Luo, D., Szaba, F. M., Kummer, L. W., Johnson, L. L., Tucker, E., Gruber, A., Gailani, D. & Smiley, S. T., Jan 2012, In : Infection and Immunity. 80, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

Listeriosis
Factor XI
Fibrin
Listeria monocytogenes
Inflammation
48 Citations (Scopus)

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Tucker, E., Verbout, N. G., Leung, P. Y., Hurst, S., McCarty, O., Gailani, D. & Gruber, A., May 17 2012, In : Blood. 119, 20, p. 4762-4768 7 p.

Research output: Contribution to journalArticle

Factor XI
Sepsis
Chemical activation
Inflammation
Coagulation
29 Citations (Scopus)

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

Leung, P. Y., Hurst, S., Berny-Lang, M. A., Verbout, N. G., Gailani, D., Tucker, E., Wang, R. K., McCarty, O. & Gruber, A., Sep 2012, In : Translational Stroke Research. 3, 3, p. 381-389 9 p.

Research output: Contribution to journalArticle

Factor XI
Factor XII
Stroke
Hemostasis
Antibodies
9 Citations (Scopus)

Plasma kallikrein: Novel functions for an old protease

Renné, T. & Gruber, A., Jun 2012, In : Thrombosis and Haemostasis. 107, 6, p. 1012-1013 2 p.

Research output: Contribution to journalArticle

Prekallikrein
Plasma Kallikrein
Hemostasis
Thrombosis
Peptide Hydrolases
44 Citations (Scopus)

Suppression of arterial thrombosis without affecting hemostatic parameters with a cell-penetrating PAR1 pepducin

Zhang, P., Gruber, A., Kasuda, S., Kimmelstiel, C., O'Callaghan, K., Cox, D. H., Bohm, A., Baleja, J. D., Covic, L. & Kuliopulos, A., Jul 3 2012, In : Circulation. 126, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Hemostatics
Percutaneous Coronary Intervention
Thrombosis
Acute Coronary Syndrome
Blood Platelets
2011
25 Citations (Scopus)

Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes

Itakura, A., Verbout, N. G., Phillips, K. G., Insall, R. H., Gailani, D., Tucker, E., Gruber, A. & McCarty, O., Nov 2011, In : Journal of Leukocyte Biology. 90, 5, p. 923-927 5 p.

Research output: Contribution to journalArticle

Factor XIa
Chemotaxis
Neutrophils
Leukocytes
Innate Immunity