Andras Gruber

Professor

  • 4090 Citations
  • 33 h-Index
1978 …2020

Research output per year

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Research Output

  • 4090 Citations
  • 33 h-Index
  • 106 Article
  • 2 Chapter
  • 2 Conference contribution
2020

The protein C activator AB002 rapidly interrupts thrombus development in baboons

Tucker, E. I., Verbout, N. G., Markway, B. D., Wallisch, M., Lorentz, C. U., Hinds, M. T., Shatzel, J. J., Pelc, L. A., Wood, D. C., McCarty, O. J. T., Di Cera, E. & Gruber, A., Feb 27 2020, In : Blood. 135, 9, p. 689-699 11 p.

Research output: Contribution to journalArticle

Open Access
2019

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivanov, I., Matafonov, A., Sun, M. F., Mohammed, B. M., Cheng, Q., Dickeson, S. K., Kundu, S., Verhamme, I. M., Gruber, A., McCrae, K. & Gailani, D., Mar 7 2019, In : Blood. 133, 10, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

Mohammed, B. M., Cheng, Q., Matafonov, A., Verhamme, I. M., Emsley, J., McCrae, K. R., McCarty, O., Gruber, A. & Gailani, D., Jan 1 2019, In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

3 Scopus citations

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Lorentz, C. U., Verbout, N. G., Wallisch, M., Hagen, M. W., Shatzel, J. J., Olson, S. R., Puy, C., Hinds, M., McCarty, O., Gailani, D., Gruber, A. & Tucker, E., Apr 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

Puy, C., Ngo, A. T. P., Pang, J., Keshari, R. S., Hagen, M. W., Hinds, M., Gailani, D., Gruber, A., Lupu, F. & McCarty, O., Jul 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 7, p. 1390-1401 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Shirai, T., Revenko, A. S., Tibbitts, J., Ngo, A. T. P., Mitrugno, A., Healy, L. D., Johnson, J., Tucker, E. I., Hinds, M. T., Coussens, L. M., McCarty, O. J. T., Monia, B. P. & Gruber, A., Oct 22 2019, In : Blood Advances. 3, 20, p. 3080-3091 12 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death

Silasi, R., Keshari, R. S., Lupu, C., Van Rensburg, W. J., Chaaban, H., Regmi, G., Shamanaev, A., Shatzel, J. J., Puy, C., Lorentz, C. U., Tucker, E., Gailani, D., Gruber, A., McCarty, O. & Lupu, F., Feb 26 2019, In : Blood advances. 3, 4, p. 658-669 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Prevention of acute venous stent-induced thrombosis using inhibition of fxii

Nguyen, K. P., Wallisch, M., Johnson, J., Gruber, A. & Hinds, M., Jan 1 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

The role of coagulation and platelets in colon cancer-associated thrombosis

Mitrugno, A., Tassi Yunga, S., Sylman, J. L., Zilberman-Rudenko, J., Shirai, T., Hebert, J. F., Kayton, R., Zhang, Y., Nan, X., Shatzel, J. J., Esener, S., Duvernay, M. T., Hamm, H. E., Gruber, A., Williams, C. D., Takata, Y., Armstrong, R., Morgan, T. & McCarty, O., Feb 1 2019, In : American journal of physiology. Cell physiology. 316, 2, p. C264-C273

Research output: Contribution to journalArticle

7 Scopus citations
2018

Factor XI contributes to myocardial ischemia-reperfusion injury in mice

Lorentz, C. U., Verbout, N. G., Cao, Z., Liu, L., Hinds, M., McCarty, O., Ivanov, I., Tucker, E., Gailani, D. & Gruber, A., Jan 23 2018, In : Blood advances. 2, 2, p. 85-88 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo

Zilberman-Rudenko, J., Reitsma, S. E., Puy, C., Rigg, R. A., Smith, S. A., Tucker, E., Silasi, R., Merkulova, A., McCrae, K. R., Maas, C., Urbanus, R. T., Gailani, D., Morrissey, J. H., Gruber, A., Lupu, F., Schmaier, A. H. & McCarty, O., Aug 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 8, p. 1748-1760 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways

Popescu, N. I., Silasi, R., Keshari, R. S., Girton, A., Burgett, T., Zeerleder, S. S., Gailani, D., Gruber, A., Lupu, F. & Mark Coggeshall, K., Aug 23 2018, In : Blood. 132, 8, p. 849-860 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Plasma contact factors as therapeutic targets

Tillman, B. F., Gruber, A., McCarty, O. & Gailani, D., Jan 1 2018, (Accepted/In press) In : Blood Reviews.

Research output: Contribution to journalArticle

7 Scopus citations

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Rigg, R. A., Healy, L. D., Chu, T. T., Ngo, A. T. P., Mitrugno, A., Zilberman-Rudenko, J., Aslan, J., Hinds, M., Vecchiarelli, L. D., Morgan, T., Gruber, A., Temple, K. J., Lindsley, C. W., Duvernay, M. T., Hamm, H. E. & McCarty, O., Jan 1 2018, (Accepted/In press) In : Platelets.

Research output: Contribution to journalArticle

1 Scopus citations

α 2 -Macroglobulin Is a Significant In Vivo Inhibitor of Activated Protein C and Low APC: α 2 M Levels Are Associated with Venous Thromboembolism

Martos, L., Ramón, L. A., Oto, J., Fernández-Pardo, Á., Bonanad, S., Cid, A. R., Gruber, A., Griffin, J. H., España, F., Navarro, S. & Medina, P., Feb 15 2018, (Accepted/In press) In : Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo

Healy, L. D., Puy, C., Fernández, J. A., Mitrugno, A., Keshari, R. S., Taku, N. A., Chu, T. T., Xu, X., Gruber, A., Lupu, F., Griffin, J. H. & McCarty, O., May 26 2017, In : Journal of Biological Chemistry. 292, 21, p. 8616-8629 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen

Ivanov, I., Shakhawat, R., Sun, M. F., Dickeson, S. K., Puy, C., McCarty, O., Gruber, A., Matafonov, A. & Gailani, D., 2017, In : Thrombosis and Haemostasis. 117, 4, p. 671-681 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Platelet-localized FXI promotes a vascular coagulationinflammatory circuit in arterial hypertension

Kossmann, S., Lagrange, J., Jäckel, S., Jurk, K., Ehlken, M., Schönfelder, T., Weihert, Y., Knorr, M., Brandt, M., Xia, N., Li, H., Daiber, A., Oelze, M., Reinhardt, C., Lackner, K., Gruber, A., Monia, B., Karbach, S. H., Walter, U., Ruggeri, Z. M. & 4 others, Renné, T., Ruf, W., Münzel, T. & Wenzel, P., Feb 1 2017, In : Science Translational Medicine. 9, 375, eaah4923.

Research output: Contribution to journalArticle

35 Scopus citations

Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions

Garland, K. S., Reitsma, S. E., Shirai, T., Zilberman-Rudenko, J., Tucker, E., Gailani, D., Gruber, A., McCarty, O. & Puy, C., Jan 1 2017, In : Frontiers in Medicine. 4, DEC, 232.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Selective factor VIII activation by the tissue factor–factor VIIa–factor Xa complex

Kamikubo, Y., Mendolicchio, G. L., Zampolli, A., Marchese, P., Rothmeier, A. S., Orje, J. N., Gale, A. J., Krishnaswamy, S., Gruber, A., Østergaard, H., Petersen, L. C., Ruf, W. & Ruggeri, Z. M., Oct 5 2017, In : Blood. 130, 14, p. 1661-1670 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2016

Biorheology of Platelet Activation in the Bloodstream Distal to Thrombus Formation

Zilberman-Rudenko, J., Itakura, A., Maddala, J., Baker-Groberg, S. M., Vetter, R., Tucker, E., Gruber, A., Gerdes, C. & McCarty, O., May 25 2016, (Accepted/In press) In : Cellular and Molecular Bioengineering. p. 1-13 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow

Zilberman-Rudenko, J., Itakura, A., Wiesenekker, C. P., Vetter, R., Maas, C., Gailani, D., Tucker, E., Gruber, A., Gerdes, C. & McCarty, O., Jan 14 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

17 Scopus citations

Contact-activation pathways as targets for new anticoagulants

Gailani, D., Renné, T. & Gruber, A., Apr 19 2016, New Therapeutic Agents in Thrombosis and Thrombolysis: Third Edition. CRC Press, p. 377-397 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Differential Roles for the Coagulation Factors XI and XII in Regulating the Physical Biology of Fibrin

Sylman, J. L., Daalkhaijav, U., Zhang, Y., Gray, E. M., Farhang, P. A., Chu, T. T., Zilberman-Rudenko, J., Puy, C., Tucker, E., Smith, S. A., Morrissey, J. H., Walker, T. W., Nan, X., Gruber, A. & McCarty, O., Dec 8 2016, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-13 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Factor XI as a Therapeutic Target

Gailani, D. & Gruber, A., May 12 2016, (Accepted/In press) In : Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journalArticle

28 Scopus citations

Factor XI deficiency alters the cytokine response and activation of contact proteases during polymicrobial sepsis in mice

Bane, C. E., Ivanov, I., Matafonov, A., Boyd, K. L., Cheng, Q., Sherwood, E. R., Tucker, E., Smiley, S. T., McCarty, O., Gruber, A. & Gailani, D., Apr 1 2016, In : PLoS One. 11, 4, e0152968.

Research output: Contribution to journalArticle

24 Scopus citations

Oral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function

Rigg, R. A., Aslan, J., Healy, L. D., Wallisch, M., Thierheimer, M. L. D., Loren, C. P., Pang, J., Hinds, M., Gruber, A. & McCarty, O., Mar 1 2016, In : American Journal of Physiology - Cell Physiology. 310, 5, p. C373-C380

Research output: Contribution to journalArticle

31 Scopus citations

Platelet-derived short-chain polyphosphates enhance the inactivation of tissue factor pathway inhibitor by activated coagulation factor XI

Puy, C., Tucker, E., Ivanov, I. S., Gailani, D., Smith, S. A., Morrissey, J. H., Gruber, A. & McCarty, O., Oct 1 2016, In : PLoS One. 11, 10, e0165172.

Research output: Contribution to journalArticle

9 Scopus citations

The Formation of Microthrombi in Parenchymal Microvessels after Traumatic Brain Injury Is Independent of Coagulation Factor XI

Schwarzmaier, S. M., De Chaumont, C., Balbi, M., Terpolilli, N. A., Kleinschnitz, C., Gruber, A. & Plesnila, N., Sep 1 2016, In : Journal of Neurotrauma. 33, 17, p. 1634-1644 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor

Puy, C., Tucker, E., Matafonov, A., Cheng, Q., Zientek, K. D., Gailani, D., Gruber, A. & McCarty, O., Feb 26 2015, In : Blood. 125, 9, p. 1488-1496 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Excess of heme induces tissue factor-dependent activation of coagulation in mice

Sparkenbaugh, E. M., Chantrathammachart, P., Wang, S., Jonas, W., Kirchhofer, D., Gailani, D., Gruber, A., Kasthuri, R., Key, N. S., Mackman, N. & Pawlinski, R., 2015, In : Haematologica. 100, 3, p. 308-313 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Factor XI and contact activation as targets for antithrombotic therapy

Gailani, D., Bane, C. E. & Gruber, A., Aug 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 8, p. 1383-1395 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

The BCR-ABL inhibitor ponatinib inhibits platelet immunoreceptor tyrosine-based activation motif (ITAM) signaling, platelet activation and aggregate formation under shear

Loren, C. P., Aslan, J., Rigg, R. A., Nowak, M. S., Healy, L. D., Gruber, A., Druker, B. & McCarty, O., Jan 1 2015, In : Thrombosis Research. 135, 1, p. 155-160 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

WEDGE: An anticoagulant thrombin mutant produced by autoactivation

Wood, D. C., Pelc, L. A., Pozzi, N., Wallisch, M., Verbout, N. G., Tucker, E., Gruber, A. & Di Cera, E., Jan 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 1, p. 111-114 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

Yokota, N., Zarpellon, A., Chakrabarty, S., Bogdanov, V. Y., Gruber, A., Castellino, F. J., Mackman, N., Ellies, L. G., Weiler, H., Ruggeri, Z. M. & Ruf, W., Jan 2014, In : Journal of Thrombosis and Haemostasis. 12, 1, p. 71-81 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Matafonov, A., Leung, P. Y., Gailani, A. E., Grach, S. L., Puy, C., Cheng, Q., Sun, M. F., McCarty, O., Tucker, E., Kataoka, H., Renné, T., Morrissey, J. H., Gruber, A. & Gailani, D., Mar 13 2014, In : Blood. 123, 11, p. 1739-1746 8 p.

Research output: Contribution to journalArticle

117 Scopus citations

The role of the contact pathway in thrombus propagation

Gruber, A., 2014, In : Thrombosis Research. 133, SUPPL. 1

Research output: Contribution to journalArticle

12 Scopus citations

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis

Verbout, N. G., Yu, X., Healy, L. D., Phillips, K. G., Tucker, E., Gruber, A., McCarty, O. & Offner, H., 2014, In : Metabolic Brain Disease. 30, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Antithrombotic effect of antisense factor xi oligonucleotide treatment in primates

Crosby, J. R., Marzec, U., Revenko, A. S., Zhao, C., Gao, D., Matafonov, A., Gailani, D., MacLeod, A. R., Tucker, E., Gruber, A., Hanson, S. R. & Monia, B. P., Jul 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 7, p. 1670-1678 9 p.

Research output: Contribution to journalArticle

70 Scopus citations

Evidence for factor IX-independent roles for factor XIa in blood coagulation

Matafonov, A., Cheng, Q., Geng, Y., Verhamme, I. M., Umunakwe, O., Tucker, E., Sun, M. F., Serebrov, V., Gruber, A. & Gailani, D., Dec 2013, In : Journal of Thrombosis and Haemostasis. 11, 12, p. 2118-2127 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates

Puy, C., Tucker, E., Wong, Z. C., Gailani, D., Smith, S. A., Choi, S. H., Morrissey, J. H., Gruber, A. & McCarty, O., Jul 2013, In : Journal of Thrombosis and Haemostasis. 11, 7, p. 1341-1352 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis

Luo, D., Lin, J. S., Parent, M. A., Mullarky-Kanevsky, I., Szaba, F. M., Kummer, L. W., Duso, D. K., Tighe, M., Hill, J., Gruber, A., Mackman, N., Gailani, D. & Smiley, S. T., Apr 15 2013, In : Journal of Immunology. 190, 8, p. 4149-4161 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Phosphatidylserine index as a marker of the procoagulant phenotype of acute myelogenous leukemia cells

Tormoen, G. W., Recht, O., Gruber, A., Levine, R. L. & McCarty, O., Oct 2013, In : Physical Biology. 10, 5, 056010.

Research output: Contribution to journalArticle

5 Scopus citations
4 Scopus citations

Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates

Perzborn, E., Gruber, A., Tinel, H., Marzec, U. M., Buetehorn, U., Buchmuelle, A., Heitmeier, S. & Laux, V., 2013, In : Thrombosis and Haemostasis. 110, 1, p. 162-172 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear

Baker-Groberg, S. M., Itakura, A., Gruber, A. & McCarty, O., Nov 1 2013, In : American Journal of Physiology - Cell Physiology. 305, 9

Research output: Contribution to journalArticle

6 Scopus citations
2012

Antithrombotic activity of protein S infused without activated protein C in a baboon thrombosis model

Heeb, M. J., Marzec, U., Gruber, A. & Hanson, S. R., Apr 2012, In : Thrombosis and Haemostasis. 107, 4, p. 690-698 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Factor xi-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis

Luo, D., Szaba, F. M., Kummer, L. W., Johnson, L. L., Tucker, E., Gruber, A., Gailani, D. & Smiley, S. T., Jan 2012, In : Infection and Immunity. 80, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

Tucker, E., Verbout, N. G., Leung, P. Y., Hurst, S., McCarty, O., Gailani, D. & Gruber, A., May 17 2012, In : Blood. 119, 20, p. 4762-4768 7 p.

Research output: Contribution to journalArticle

49 Scopus citations

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

Leung, P. Y., Hurst, S., Berny-Lang, M. A., Verbout, N. G., Gailani, D., Tucker, E., Wang, R. K., McCarty, O. & Gruber, A., Sep 2012, In : Translational Stroke Research. 3, 3, p. 381-389 9 p.

Research output: Contribution to journalArticle

30 Scopus citations