Andras Gruber

Professor

  • 3997 Citations
  • 32 h-Index
1978 …2019
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  • 7 Similar Profiles
Factor XI Medicine & Life Sciences
Protein C Medicine & Life Sciences
Thrombosis Medicine & Life Sciences
Thrombin Medicine & Life Sciences
Blood Platelets Medicine & Life Sciences
Factor XII Medicine & Life Sciences
Primates Medicine & Life Sciences
Factor XIa Medicine & Life Sciences

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Projects 1978 2017

Factor XI
Sepsis
Disseminated Intravascular Coagulation
Hemorrhage
Therapeutics
Factor XI
Sepsis
Monoclonal Antibodies
Factor XIIa
Therapeutics

Therapeutic thrombin analogs

Tucker, E., Tucker, E. & Gruber, A.

National Institutes of Health

12/1/086/30/17

Project: Research project

Thrombin
Fibrinolytic Agents
Enzyme Activators
Protein C
Stroke

REPRODUCTIVE STEROIDS AND EXPERIMENTAL STROKE

Ronnekleiv, O., Hess, D., Casey, D., Duell, P., Machida, C., Dissen, G., Moses, A., Nelson, J., Kohama, S., Wong, S., Urbanski, H., Spindel, E., Stouffer, R., Smith, M. (., Axthelm, M., Neuringer, M., Ojeda, S., Bethea, C., Grove, K., Zelinski, M., Patton, P., Grove, K., Hess, D., Zelinski, M., Orloff, S., Mitalipov, S., Ronnekleiv, O., Lee, D., Coleman, K., Jensen, J., Grove, K., Slayden, O., Picker, L., Sherman, L. (., Zelinski, M., Hennebold, J., Slifka, M., Banine, F., Gruber, A., Wright, J., Ferguson, B., Cornea, A., Grant, K. (., Dissen, G., Lomniczi, A., De Filippis, V., Xu, F., Mitalipov, S., Edelman, A., Haigwood, N., Grigsby, P., Roberts, C., Streblow, D., Kroenke, C. (., Rasanen, J., Lee, D., Lewis, A., Frueh, K., Morrison, S., Reddy, P. (., Helms, C., Cornea, A., Coleman, K., Carbone, L., Lindner, J., McBride, J., Brambrink, A., Sullivan, E., Mallley, A., Beatty, C., Phoenix, C., Funan, H., Fahrenbach, W., Alexander, N., Portman, O., Howard, C., Palotay, J., Egerer, C., Gliessman, P., Critchlow, B. V., Webb, M., Burnham, J., Hill, J., Janina, E., Toyooka, A., McDonald, I., Resko, J., Melner, M., Hermsmeyer, K., Olson, L., McNulty, W., Malinow, R., Kelley, S., Maslar, I. L. A., Joel, I., Hoskins, D., Saneto, R., Ellinwood, W., Towne, D., Critchlow, V., Coffin, R., Koler, R., Laster, L., Malley, A., Kohler, P., Sorensen, T., Lentz, S., Schatten, G., Spence, J. C., Rxnnekleiv, O., Reimann, K., Beer, B., Rajkovic, A., Duffy, D., Sadowsky, D., Shiigi, S., Stouffer Richard, L., Matrisian, L., Toole, J., Meng, L. I., Kohler, P. O., Robertson, J., R Nnekleiv, O., Ridker, P., Shimakawa, T., Karlsson, G., Gravett, M., Hirsch, V., Garg, R., Folsom, A., Gerhard, G., Verhage, H., Murphy, S., Hermsmeyer, R. K., Haluska, G., Hirsch, V., Garg, R., Novy, M. J., Folsom, A., Gerhard, G., Karlsson, G., Gravett, M., Verhage, H., Lewinsohn, D., Lewinsohn, D. M., Letvin, N., Yoshihara, P. H., Rodland, K. D., Sodroski, J., Smith, E., Vitetta, E., Clark, A., K-Y Francis, P., Gravett, M., Cowley, M., Novy, M. J., Frueh, K., Nikolich-Zugich, J., Cowley, D., Adamus, G., [No Value], V. Z., Hanson, S., Lewinsohn, D., Xuemei, W., Adams Waldorf, K., Mayerhofer, A., Sadowsky, D., Dubay, C., Jeffrey, B., Messaoudi, I., Song, P., Matagne, V., Madden, C., Stenzel-Poore, M., Doane, C., Frueh, K., Hoffman, G., Jung, H., McCarron, D., Herzlich, B., Watanabe, M., Nagalla, S., Kronzon, I., Drake, T., Sakata, H., Jennes, L., Gerald, L., Aach, J., Vijayaraghavan, S., Smith, G., Eaton, G., Schwartz, S., Hermsmeyer, R. K., Haluska, G., Novy, M., Spies, H., Kodama, T., Kittner, S., Brenner, R., Simerly, R., Mayerhofer, A., Malinow, M., Wolf, D., Conn, P. M., Cameron, J., Lewinsohn, D., Lewinsohn, D. & Madden, C. (.

National Institutes of Health

5/1/784/30/14

Project: Research project

Middle Cerebral Artery Infarction
Hormones
Primates
Estrogens
Steroids

Research Output 1984 2019

  • 3997 Citations
  • 32 h-Index
  • 105 Article
  • 2 Chapter
  • 2 Conference contribution
7 Citations (Scopus)

A mechanism for hereditary angioedema with normal C1 inhibitor: an inhibitory regulatory role for the factor XII heavy chain

Ivanov, I., Matafonov, A., Sun, M. F., Mohammed, B. M., Cheng, Q., Dickeson, S. K., Kundu, S., Verhamme, I. M., Gruber, A., McCrae, K. & Gailani, D., Mar 7 2019, In : Blood. 133, 10, p. 1152-1163 12 p.

Research output: Contribution to journalArticle

Hereditary Angioedemas
Factor XII
Prekallikrein
Kallikreins
Chemical activation
1 Citation (Scopus)

A non-circulating pool of factor XI associated with glycosaminoglycans in mice

Mohammed, B. M., Cheng, Q., Matafonov, A., Verhamme, I. M., Emsley, J., McCrae, K. R., McCarty, O., Gruber, A. & Gailani, D., Jan 1 2019, In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Factor XI
Glycosaminoglycans
Blood Vessels
Prekallikrein
Heparin
3 Citations (Scopus)

Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Lorentz, C. U., Verbout, N. G., Wallisch, M., Hagen, M. W., Shatzel, J. J., Olson, S. R., Puy, C., Hinds, M., McCarty, O., Gailani, D., Gruber, A. & Tucker, E., Apr 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 4, p. 799-809 11 p.

Research output: Contribution to journalArticle

Open Access
Factor XI
Antibodies
Thrombosis
Hemostasis
Primates
1 Citation (Scopus)

Endothelial PAI-1 (Plasminogen Activator Inhibitor-1) Blocks the Intrinsic Pathway of Coagulation, Inducing the Clearance and Degradation of FXIa (Activated Factor XI)

Puy, C., Ngo, A. T. P., Pang, J., Keshari, R. S., Hagen, M. W., Hinds, M., Gailani, D., Gruber, A., Lupu, F. & McCarty, O., Jul 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 7, p. 1390-1401 12 p.

Research output: Contribution to journalArticle

Open Access
Factor XIa
Plasminogen Inactivators
Plasminogen Activator Inhibitor 1
Endothelial Cells
Kallikreins

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

Shirai, T., Revenko, A. S., Tibbitts, J., Ngo, A. T. P., Mitrugno, A., Healy, L. D., Johnson, J., Tucker, E. I., Hinds, M. T., Coussens, L. M., McCarty, O. J. T., Monia, B. P. & Gruber, A., Oct 22 2019, In : Blood Advances. 3, 20, p. 3080-3091 12 p.

Research output: Contribution to journalArticle

Open Access
Thrombopoietin
Gene Silencing
Platelet Count
Breast Neoplasms
Liver