An-Sheng Zhang

Research Associate Professor

  • 1996 Citations
  • 26 h-Index
20012020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independent of iron overload

Wortham, A. M., Goldman, D. C., Chen, J., Fleming, W. H., Zhang, A. S., Enns, C. A. & Peter Guengerich, F., Mar 20 2020, In : Journal of Biological Chemistry. 295, 12, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

2019
1 Scopus citations
2017

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

Wahedi, M., Wortham, A. M., Kleven, M. D., Zhao, N., Jue, S., Enns, C. A. & Zhang, A. S., Nov 3 2017, In : Journal of Biological Chemistry. 292, 44, p. 18354-18371 18 p.

Research output: Contribution to journalArticle

27 Scopus citations

The tumor suppressor, P53, decreases the metal transporter, ZIP14

Zhao, N., Zhang, A. S., Wortham, A. M., Jue, S., Knutson, M. D. & Enns, C. A., Dec 8 2017, In : Nutrients. 9, 12, 1335.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

Kleven, M. D., Enns, C. & Zhang, A-S., Mar 1 2016, In : Gastroenterology. 150, 3, p. 556-559 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver

Zhao, N., Maxson, J., Zhang, R. H., Wahedi, M., Enns, C. & Zhang, A-S., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12322-12335 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Low intracellular iron increases the stability of Matriptase-2

Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., Eisenstein, R. S., Enns, C. A. & Zhang, A. S., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 4432-4446 15 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014
31 Scopus citations
2013

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C. A., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A. S., Apr 2 2013, In : PloS one. 8, 4, e60534.

Research output: Contribution to journalArticle

38 Scopus citations

Iron regulation by hepcidin

Zhao, N., Zhang, A. S. & Enns, C. A., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2337-2343 7 p.

Research output: Contribution to journalArticle

114 Scopus citations
2012

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

Enns, C. A., Ahmed, R. & Zhang, A. S., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35104-35117 14 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A. S., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H. & Enns, C. A., Feb 3 2011, In : Blood. 117, 5, p. 1687-1899 213 p.

Research output: Contribution to journalArticle

70 Scopus citations
2010
48 Scopus citations

Stoichiometries of transferrin receptors 1 and 2 in human liver

Chloupková, M., Zhang, A. S. & Enns, C. A., Jan 1 2010, In : Blood Cells, Molecules, and Diseases. 44, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

Zhang, A. S., Gao, J., Koeberl, D. D. & Enns, C. A., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16416-16423 8 p.

Research output: Contribution to journalArticle

58 Scopus citations
2009

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A. S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C. A., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A. S. & Enns, C. A., Mar 4 2009, In : Cell Metabolism. 9, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

210 Scopus citations

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

Maxson, J. E., Enns, C. A. & Zhang, A. S., Feb 19 2009, In : Blood. 113, 8, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2008

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

Xiong, S., She, H., Zhang, A. S., Wang, J., Mkrtchyan, H., Dynnyk, A., Gordeuk, V. R., French, S. W., Enns, C. A. & Tsukamoto, H., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G512-G521

Research output: Contribution to journalArticle

32 Scopus citations

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane

Zhang, A. S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J. & Enns, C. A., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17494-17502 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms

Zhang, A. S., Canonne-Hergaux, F., Gruenheid, S., Gros, P. & Ponka, P., Oct 1 2008, In : Experimental hematology. 36, 10, p. 1227-1235 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Direct interorganellar transfer of iron from endosome to mitochondrion

Sheftel, A. D., Zhang, A. S., Brown, C., Shirihai, O. S. & Ponka, P., Jul 1 2007, In : Blood. 110, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

173 Scopus citations

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

Zhang, A. S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S. & Enns, C. A., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12547-12556 10 p.

Research output: Contribution to journalArticle

92 Scopus citations
2006

The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling

Zhang, A. S., Sheftel, A. D. & Ponka, P., May 1 2006, In : Experimental hematology. 34, 5, p. 593-598 6 p.

Research output: Contribution to journalArticle

30 Scopus citations
2005
4 Scopus citations

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

Zhang, A. S., West, A. P., Wyman, A. E., Bjorkman, P. J. & Enns, C. A., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 33885-33894 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

Intracellular kinetics of iron in reticulocytes: Evidence for endosome involvement in iron targeting to mitochondria

Zhang, A. S., Sheftel, A. D. & Ponka, P., Jan 1 2005, In : Blood. 105, 1, p. 368-375 8 p.

Research output: Contribution to journalArticle

96 Scopus citations

The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Carlson, H., Zhang, A. S., Fleming, W. H. & Enns, C. A., Mar 15 2005, In : Blood. 105, 6, p. 2564-2570 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
2004

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Zhang, A. S., Xiong, S., Tsukamoto, H. & Enns, C. A., Feb 15 2004, In : Blood. 103, 4, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

143 Scopus citations
2003

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

Davies, P. S., Zhang, A. S., Anderson, E. L., Roy, C. N., Lampson, M. A., McGraw, T. E. & Enns, C. A., Jul 1 2003, In : Biochemical Journal. 373, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation

Zhang, A. S., Davies, P. S., Carlson, H. L. & Enns, C. A., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9500-9505 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
2002

Iron targeting to mitochondria in erythroid cells

Ponka, P., Sheftel, A. D. & Zhang, A. S., Aug 1 2002, In : Biochemical Society transactions. 30, 4, p. 735-738 4 p.

Research output: Contribution to journalArticle

23 Scopus citations
2001

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice

Canonne-Hergaux, F., Zhang, A. S., Ponka, P. & Gros, P., Dec 15 2001, In : Blood. 98, 13, p. 3823-3830 8 p.

Research output: Contribution to journalArticle

117 Scopus citations