An-Sheng Zhang

Research Associate Professor

  • 1944 Citations
  • 24 h-Index
20012019
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Research Output 2001 2019

  • 1944 Citations
  • 24 h-Index
  • 37 Article
  • 1 Review article
2019
1 Citation (Scopus)
Hepcidins
Iron
Hormones
matriptase 2
Liver
2018
1 Citation (Scopus)

A long sought after "receptor" for ERFE?

Zhang, A-S. & Enns, C., Oct 4 2018, In : Blood. 132, 14, p. 1463-1464 2 p.

Research output: Contribution to journalReview article

Erythropoietin
Hepcidins
Bone Morphogenetic Proteins
Blood
2017
24 Citations (Scopus)

Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway

Wahedi, M., Wortham, A. M., Kleven, M. D., Zhao, N., Jue, S., Enns, C. & Zhang, A-S., 2017, In : Journal of Biological Chemistry. 292, 44, p. 18354-18371 18 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Bone Morphogenetic Protein Receptors
Transferrin Receptors
Liver
5 Citations (Scopus)

The tumor suppressor, P53, decreases the metal transporter, ZIP14

Zhao, N., Zhang, A-S., Wortham, A. M., Jue, S., Knutson, M. D. & Enns, C., Dec 8 2017, In : Nutrients. 9, 12, 1335.

Research output: Contribution to journalArticle

transporters
Iron
Metals
metals
iron
2016
4 Citations (Scopus)

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

Kleven, M. D., Enns, C. & Zhang, A-S., Mar 1 2016, In : Gastroenterology. 150, 3, p. 556-559 4 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 6
Hepcidins
Iron Overload
Hemochromatosis
Missense Mutation
20 Citations (Scopus)

Neogenin facilitates the induction of hepcidin expression by hemojuvelin in the liver

Zhao, N., Maxson, J., Zhang, R. H., Wahedi, M., Enns, C. & Zhang, A-S., Jun 3 2016, In : Journal of Biological Chemistry. 291, 23, p. 12322-12335 14 p.

Research output: Contribution to journalArticle

Hepcidins
Liver
Bone Morphogenetic Proteins
Furin
Type I Bone Morphogenetic Protein Receptors
2015
26 Citations (Scopus)

Low intracellular iron increases the stability of Matriptase-2

Zhao, N., Nizzi, C. P., Anderson, S. A., Wang, J., Ueno, A., Tsukamoto, H., Eisenstein, R. S., Enns, C. & Zhang, A-S., Feb 13 2015, In : Journal of Biological Chemistry. 290, 7, p. 4432-4446 15 p.

Research output: Contribution to journalArticle

Iron
Hepcidins
Hepatocytes
Homeostasis
Stabilization
2014
27 Citations (Scopus)
Membrane Transport Proteins
Glycosylation
Iron
Metals
Cell Membrane
2013
37 Citations (Scopus)

Increased Iron Loading Induces Bmp6 Expression in the Non-Parenchymal Cells of the Liver Independent of the BMP-Signaling Pathway

Enns, C., Ahmed, R., Wang, J., Ueno, A., Worthen, C., Tsukamoto, H. & Zhang, A-S., Apr 2 2013, In : PLoS One. 8, 4, e60534.

Research output: Contribution to journalArticle

Liver
hepatocytes
Hepatocytes
Iron
iron
105 Citations (Scopus)

Iron regulation by hepcidin

Zhao, N., Zhang, A-S. & Enns, C., Jun 3 2013, In : Journal of Clinical Investigation. 123, 6, p. 2337-2343 7 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Erythropoiesis
Bone Morphogenetic Protein 6
Bone Morphogenetic Protein Receptors
2012
47 Citations (Scopus)

Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage

Enns, C., Ahmed, R. & Zhang, A-S., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35104-35117 14 p.

Research output: Contribution to journalArticle

Oligosaccharides
Cell membranes
matriptase 2
neogenin
Hepatocytes
2011
67 Citations (Scopus)

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

Zhang, A-S., Anderson, S. A., Wang, J., Yang, F., DeMaster, K., Ahmed, R., Nizzi, C. P., Eisenstein, R. S., Tsukamoto, H. & Enns, C., Feb 3 2011, In : Blood. 117, 5, p. 1687-1899 213 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Liver
Rats
Transferrin
2010
24 Citations (Scopus)

Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis

Zhang, A-S., Nov 2010, In : Advances in Nutrition. 1, 1, p. 38-45 8 p.

Research output: Contribution to journalArticle

Hepcidins
homeostasis
Homeostasis
Iron
iron
47 Citations (Scopus)
Proprotein Convertases
Hepcidins
Bone
Down-Regulation
Bone and Bones
12 Citations (Scopus)

Stoichiometries of transferrin receptors 1 and 2 in human liver

Chloupková, M., Zhang, A-S. & Enns, C., Jan 2010, In : Blood Cells, Molecules, and Diseases. 44, 1, p. 28-33 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Liver
Proteins
Iron
Hepcidins
57 Citations (Scopus)

The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo

Zhang, A-S., Gao, J., Koeberl, D. D. & Enns, C., May 28 2010, In : Journal of Biological Chemistry. 285, 22, p. 16416-16423 8 p.

Research output: Contribution to journalArticle

Hepcidins
Hepatocytes
Bone
Bone and Bones
Liver
2009
59 Citations (Scopus)

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

Zhang, A-S., Yang, F., Wang, J., Tsukamoto, H. & Enns, C., Aug 21 2009, In : Journal of Biological Chemistry. 284, 34, p. 22580-22589 10 p.

Research output: Contribution to journalArticle

Hepcidins
Bone
Bone and Bones
Proteins
Liver
208 Citations (Scopus)

Interaction of the Hereditary Hemochromatosis Protein HFE with Transferrin Receptor 2 Is Required for Transferrin-Induced Hepcidin Expression

Gao, J., Chen, J., Kramer, M., Tsukamoto, H., Zhang, A-S. & Enns, C., Mar 4 2009, In : Cell Metabolism. 9, 3, p. 217-227 11 p.

Research output: Contribution to journalArticle

Hepcidins
Transferrin Receptors
Transferrin
Iron
Hep G2 Cells
105 Citations (Scopus)

Iron homeostasis: Recently identified proteins provide insight into novel control mechanisms

Zhang, A-S. & Enns, C., Jan 9 2009, In : Journal of Biological Chemistry. 284, 2, p. 711-715 5 p.

Research output: Contribution to journalArticle

Homeostasis
Iron
Proteins
Superoxides
Biochemical Phenomena
88 Citations (Scopus)
Homeostasis
Iron
Hepcidins
Iron-Regulatory Proteins
Dietary Iron
29 Citations (Scopus)

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

Maxson, J., Enns, C. & Zhang, A-S., Feb 19 2009, In : Blood. 113, 8, p. 1786-1793 8 p.

Research output: Contribution to journalArticle

Hep G2 Cells
Cell membranes
Hepcidins
Bone Morphogenetic Proteins
Cell Membrane

Reply

Gao, J., Chen, J., Zhang, A-S. & Enns, C., Sep 2009, In : Gastroenterology. 137, 3, p. 1175 1 p.

Research output: Contribution to journalArticle

2008
32 Citations (Scopus)

Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

Xiong, S., She, H., Zhang, A-S., Wang, J., Mkrtchyan, H., Dynnyk, A., Gordeuk, V. R., French, S. W., Enns, C. & Tsukamoto, H., Sep 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3

Research output: Contribution to journalArticle

Alcoholic Fatty Liver
Iron
Macrophages
Liver
Kupffer Cells
33 Citations (Scopus)

Neogenin-mediated hemojuvelin shedding occurs after hemojuvelin traffics to the plasma membrane

Zhang, A-S., Yang, F., Meyer, K., Hernandez, C., Chapman-Arvedson, T., Bjorkman, P. J. & Enns, C., Jun 20 2008, In : Journal of Biological Chemistry. 283, 25, p. 17494-17502 9 p.

Research output: Contribution to journalArticle

Cell membranes
Cell Membrane
Hepcidins
Endocytosis
Hepatocytes
17 Citations (Scopus)

Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms

Zhang, A-S., Canonne-Hergaux, F., Gruenheid, S., Gros, P. & Ponka, P., Oct 2008, In : Experimental Hematology. 36, 10, p. 1227-1235 9 p.

Research output: Contribution to journalArticle

Reticulocytes
Cricetulus
Ovary
Iron
Transferrin
2007
170 Citations (Scopus)

Direct interorganellar transfer of iron from endosome to mitochondrion

Sheftel, A. D., Zhang, A-S., Brown, C., Shirihai, O. S. & Ponka, P., Jul 1 2007, In : Blood. 110, 1, p. 125-132 8 p.

Research output: Contribution to journalArticle

Mitochondria
Endosomes
Iron
Oxygen
Metals
91 Citations (Scopus)

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

Zhang, A-S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S. & Enns, C., Apr 27 2007, In : Journal of Biological Chemistry. 282, 17, p. 12547-12556 10 p.

Research output: Contribution to journalArticle

Hepcidins
Iron
Muscle
Skeletal Muscle
Cells
2006

Iron in mammals: Pathophysiological mechanisms of overload and deficiency in relation to disease

Johnson, M. B., Enns, C. & Zhang, A-S., 2006, In : Topics in Current Genetics. 14, p. 155-191 37 p.

Research output: Contribution to journalArticle

Mammals
Iron
Hemochromatosis
Protein Transport
Anemia
30 Citations (Scopus)

The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling

Zhang, A-S., Sheftel, A. D. & Ponka, P., May 2006, In : Experimental Hematology. 34, 5, p. 593-598 6 p.

Research output: Contribution to journalArticle

Transferrin
Anemia
Hemoglobins
Iron
Reticulocytes
2005
3 Citations (Scopus)
Plasminogen Activator Inhibitor 1
Hep G2 Cells
Salvia miltiorrhiza
Culture Media
Control Groups
113 Citations (Scopus)

Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells

Zhang, A-S., West, A. P., Wyman, A. E., Bjorkman, P. J. & Enns, C., Oct 7 2005, In : Journal of Biological Chemistry. 280, 40, p. 33885-33894 10 p.

Research output: Contribution to journalArticle

Iron
Kidney
GPI-Linked Proteins
Mutation
Hepcidins
95 Citations (Scopus)

Intracellular kinetics of iron in reticulocytes: Evidence for endosome involvement in iron targeting to mitochondria

Zhang, A-S., Sheftel, A. D. & Ponka, P., Jan 1 2005, In : Blood. 105, 1, p. 368-375 8 p.

Research output: Contribution to journalArticle

Mitochondria
Endosomes
Reticulocytes
Transferrin
Iron
23 Citations (Scopus)

The hereditary hemochromatosis protein, HFE, lowers intracellular iron levels independently of transferrin receptor 1 in TRVb cells

Carlson, H., Zhang, A-S., Fleming, W. & Enns, C., Mar 15 2005, In : Blood. 105, 6, p. 2564-2570 7 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Iron
Transferrin
Proteins
Hemochromatosis
2004
141 Citations (Scopus)

Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

Zhang, A-S., Xiong, S., Tsukamoto, H. & Enns, C., Feb 15 2004, In : Blood. 103, 4, p. 1509-1514 6 p.

Research output: Contribution to journalArticle

Metabolism
Liver
Rats
Hepatocytes
Iron
2003
29 Citations (Scopus)

Evidence for the interaction of the hereditary haemochromatosis protein, HFE, with the transferrin receptor in endocytic compartments

Davies, P., Zhang, A-S., Anderson, E. L., Roy, C. N., Lampson, M. A., McGraw, T. E. & Enns, C., Jul 1 2003, In : Biochemical Journal. 373, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Proteins
Endosomes
Transferrin
Iron
36 Citations (Scopus)

Mechanisms of HFE-induced regulation of iron homeostasis: Insights from the W81A HFE mutation

Zhang, A-S., Davies, P., Carlson, H. L. & Enns, C., Aug 5 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9500-9505 6 p.

Research output: Contribution to journalArticle

Transferrin Receptors
Transferrin
Homeostasis
Iron
Mutation
2002
22 Citations (Scopus)

Iron targeting to mitochondria in erythroid cells

Ponka, P., Sheftel, A. D. & Zhang, A-S., Aug 2002, In : Biochemical Society Transactions. 30, 4, p. 735-738 4 p.

Research output: Contribution to journalArticle

Erythroid Cells
Mitochondria
Endosomes
Heme
Iron
2001
116 Citations (Scopus)

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice

Canonne-Hergaux, F., Zhang, A-S., Ponka, P. & Gros, P., Dec 15 2001, In : Blood. 98, 13, p. 3823-3830 8 p.

Research output: Contribution to journalArticle

Blood
Iron
Erythrocytes
Cells
Reticulocytes