Amy Farrell

Research Assistant Professor

Research Assistant Professor, Molecular & Medical Genetics

Emailfarrelam@ohsu.edu

461 Citations
9 h-Index

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11 Similar Profiles

Tumor Suppressor Proteins Medicine & Life Sciences

Protein Phosphatase 2 Medicine & Life Sciences

Breast Neoplasms Medicine & Life Sciences

Tumors Chemical Compounds

Proto-Oncogene Proteins c-myc Medicine & Life Sciences

Neoplasms Medicine & Life Sciences

Cells Chemical Compounds

Phosphorylation Medicine & Life Sciences

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Research Output 2009 2017

461 Citations
9 h-Index
9 Article

12 Citations (Scopus)

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Farrell, A., Joly, M. M., Allen-Petersen, B. L., Worth, P. J., Lanciault, C., Sauer, D., Link, J., Pelz, C., Heiser, L., Morton, J. P., Muthalagu, N., Hoffman, M. T., Manning, S. L., Pratt, E. D., Kendsersky, N. D., Egbukichi, N., Amery, T. S., Thoma, M. C., Jenny, Z. P., Rhim, A. D. & 5 others, Murphy, D. J., Sansom, O. J., Crawford, H. C., Sheppard, B. & Sears, R., Dec 1 2017, In : Nature Communications. 8, 1, 1728.

Research output: Contribution to journal › Article

Synaptophysin

plastic properties

markers

Plasticity

Tumors

111 Citations (Scopus)

MYC degradation

Farrell, A. S. & Sears, R. C., 2014, In : Cold Spring Harbor perspectives in medicine. 4, 3, a014365.

Research output: Contribution to journal › Article

Proteasome Endopeptidase Complex

Ubiquitin

Degradation

Proteins

Oncogene Proteins

83 Citations (Scopus)

Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer

Janghorban, M., Farrell, A., Allen-Petersen, B. L., Pelz, C., Daniel, C. J., Oddo, J., Langer, E. M., Christensen, D. J. & Sears, R., Jun 24 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 25, p. 9157-9162 6 p.

Research output: Contribution to journal › Article

Protein Phosphatase 2

Breast Neoplasms

Serine

Phosphorylation

Tumor Suppressor Proteins

49 Citations (Scopus)

Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer

Farrell, A., Allen-Petersen, B., Daniel, C. J., Wang, X., Wang, Z., Rodriguez, S., Impey, S., Oddo, J., Vitek, M. P., Lopez, C., Christensen, D. J., Sheppard, B. & Sears, R., 2014, In : Molecular Cancer Research. 12, 6, p. 924-939 16 p.

Research output: Contribution to journal › Article

Tumor Suppressor Proteins

Protein Phosphatase 2

Pancreatic Neoplasms

Therapeutics

Cell Line

53 Citations (Scopus)

Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

Farrell, A., Pelz, C., Wang, X., Daniel, C. J., Wang, Z., Su, Y., Janghorban, M., Zhang, X., Morgan, C., Impey, S. & Sears, R., Aug 2013, In : Molecular and Cellular Biology. 33, 15, p. 2930-2949 20 p.

Research output: Contribution to journal › Article

Carcinogenesis

DNA

Peptidylprolyl Isomerase

Genes

myc Genes