Amanda McCullough

Associate Professor

  • 1450 Citations
  • 19 h-Index
1994 …2020
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Research Output 1994 2020

  • 1450 Citations
  • 19 h-Index
  • 42 Article
  • 1 Review article
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Article
2020

Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Coskun, E., Coskun, S. H., Jaruga, P., Yeo, J., David, S. S., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Jan 2020, In : DNA Repair. 85, 102741.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Adducts
Oligodeoxyribonucleotides
DNA
Substrate Specificity
2019
3 Citations (Scopus)

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Schaser, A. J., Osterberg, V. R., Dent, S. E., Stackhouse, T. L., Wakeham, C. M., Boutros, S. W., Weston, L. J., Owen, N., Weissman, T. A., Luna, E., Raber, J., Luk, K. C., McCullough, A., Woltjer, R. R. & Unni, V., Dec 1 2019, In : Scientific Reports. 9, 1, 10919.

Research output: Contribution to journalArticle

Open Access
Lewy Bodies
alpha-Synuclein
DNA-Binding Proteins
DNA Repair
DNA Damage
1 Citation (Scopus)

Characterization of rare NEIL1 variants found in East Asian populations

Minko, I., Vartanian, V. L., Tozaki, N. N., Linde, O. K., Jaruga, P., Coskun, S. H., Coskun, E., Qu, C., He, H., Xu, C., Chen, T., Song, Q., Jiao, Y., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. & Lloyd, R. S., Jul 1 2019, In : DNA Repair. 79, p. 32-39 8 p.

Research output: Contribution to journalArticle

Aflatoxin B1
Hepatocellular Carcinoma
Hepatitis B
DNA Repair
Repair
2018
1 Citation (Scopus)

An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity

Juarez, E., Chambwe, N., Tang, W., Mitchell, A. D., Owen, N., Kumari, A., Monnat, R. J. & McCullough, A., Jan 1 2018, (Accepted/In press) In : DNA Repair.

Research output: Contribution to journalArticle

RNA Interference
DNA Repair
Formaldehyde
DNA Damage
Repair
3 Citations (Scopus)

Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways

Sha, Y., Vartanian, V., Owen, N., Mengden Koon, S. J., Calkins, M. J., Thompson, C. S., Mirafzali, Z., Mir, S., Goldsmith, L. E., He, H., Luo, C., Brown, S. M., Doetsch, P. W., Kaempf, A., Lim, J. Y., McCullough, A. & Lloyd, R. S., Dec 1 2018, In : Scientific Reports. 8, 1, 705.

Research output: Contribution to journalArticle

Nuclear Localization Signals
DNA Repair
Carcinogenesis
Liposomes
Cell-Penetrating Peptides
3 Citations (Scopus)

Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3

Minko, I., Christov, P. P., Li, L., Stone, M. P., McCullough, A. & Lloyd, R. S., Jan 1 2018, (Accepted/In press) In : DNA Repair.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Adducts
Aflatoxin B1
Mechlorethamine
Processing
2017
14 Citations (Scopus)

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice

Vartanian, V., Minko, I., Chawanthayatham, S., Egner, P. A., Lin, Y. C., Earley, L. F., Makar, R., Eng, J. R., Camp, M. T., Li, L., Stone, M. P., Lasarev, M. R., Groopman, J. D., Croy, R. G., Essigmann, J. M., McCullough, A. & Lloyd, R. S., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4207-4212 6 p.

Research output: Contribution to journalArticle

Aflatoxins
Hepatocellular Carcinoma
DNA Glycosylases
DNA Repair
Xeroderma Pigmentosum
2016
6 Citations (Scopus)

Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Minko, I., Jacobs, A. C., De Leon, A. R., Gruppi, F., Donley, N., Harris, T. M., Rizzo, C. J., McCullough, A. & Lloyd, R. S., Jul 1 2016, In : Scientific Reports. 6, 28894.

Research output: Contribution to journalArticle

DNA Glycosylases
Deoxyribose
DNA Cleavage
Single-Stranded DNA Breaks
Purines
5 Citations (Scopus)

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure

Lin, Y. C., Owen, N., Minko, I., Lange, S. S., Li, L., Stone, M. P., Wood, R. D., McCullough, A. & Lloyd, R. S., Nov 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. 13774-13779 6 p.

Research output: Contribution to journalArticle

Aflatoxin B1
Aflatoxins
DNA-Directed DNA Polymerase
Cell Survival
Chromatids
2 Citations (Scopus)

Enhanced sensitivity of Neil1−/− mice to chronic UVB exposure

Calkins, M. J., Vartanian, V., Owen, N., Kirkali, G., Jaruga, P., Dizdaroglu, M., McCullough, A. & Lloyd, R. S., Dec 1 2016, In : DNA Repair. 48, p. 43-50 8 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Deoxyribonuclease (Pyrimidine Dimer)
Repair
DNA
DNA Damage
2015
5 Citations (Scopus)

BLM protein mitigates formaldehyde-induced genomic instability

Kumari, A., Owen, N., Juarez, E. & McCullough, A., Apr 1 2015, In : DNA Repair. 28, p. 73-82 10 p.

Research output: Contribution to journalArticle

Genomic Instability
Formaldehyde
Proteins
Cells
Repair
20 Citations (Scopus)

Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)

Donley, N., Jaruga, P., Coskun, E., Dizdaroglu, M., McCullough, A. & Lloyd, R. S., Oct 16 2015, In : ACS Chemical Biology. 10, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Molecules
Repair
DNA Repair
DNA
2013
18 Citations (Scopus)

Inhibition of DNA glycosylases via small molecule purine analogs

Jacobs, A. C., Calkins, M. J., Jadhav, A., Dorjsuren, D., Maloney, D., Simeonov, A., Jaruga, P., Dizdaroglu, M., McCullough, A. & Lloyd, R. S., Dec 9 2013, In : PLoS One. 8, 12, e81667.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
purines
Molecules
DNA
2012
28 Citations (Scopus)

Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway

Kumari, A., Lim, Y. X., Newell, A. H., Olson, S. & McCullough, A., Mar 1 2012, In : DNA Repair. 11, 3, p. 236-246 11 p.

Research output: Contribution to journalArticle

Genomic Instability
Formaldehyde
Genes
Repair
Cells
26 Citations (Scopus)

Regulation of DNA glycosylases and their role in limiting disease

Sampath, H., McCullough, A. & Lloyd, R. S., Apr 2012, In : Free Radical Research. 46, 4, p. 460-478 19 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
DNA Damage
Repair
DNA
2011
4 Citations (Scopus)

Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase

Ryabinina, O. P., Minko, I., Lasarev, M. R., McCullough, A. & Lloyd, R. S., Oct 10 2011, In : DNA Repair. 10, 10, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
Lyases
Modulation
Enzymes
Mutagenesis
13 Citations (Scopus)

TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage

Johnson, J. L., Lowell, B. C., Ryabinina, O. P., Lloyd, R. S. & McCullough, A., Mar 2011, In : Journal of Investigative Dermatology. 131, 3, p. 753-761 9 p.

Research output: Contribution to journalArticle

DNA Repair Enzymes
Trans-Activators
DNA Repair
DNA Damage
Skin
25 Citations (Scopus)

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.

Sampath, H., Batra, A. K., Vartanian, V., Carmical, J. R., Prusak, D., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D., McCullough, A. & Lloyd, R. S., Apr 2011, In : American journal of physiology. Endocrinology and metabolism. 300, 4

Research output: Contribution to journalArticle

Penetrance
Adiposity
High Fat Diet
Phenotype
Oxidative Stress
5 Citations (Scopus)

γ-Hydroxy-1, N 2-propano-2′-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage

Huang, H., Wang, H., Voehler, M. W., Kozekova, A., Rizzo, C. J., McCullough, A., Lloyd, R. S. & Stone, M. P., Jul 18 2011, In : Chemical Research in Toxicology. 24, 7, p. 1123-1133 11 p.

Research output: Contribution to journalArticle

Deoxyguanosine
DNA Adducts
Amines
Peptides
DNA
2010
11 Citations (Scopus)

Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1, N 2-γ- hydroxypropanodeoxyguanosine lesion with a trimethylene linkage

Huang, H., Kozekov, I. D., Kozekova, A., Rizzo, C. J., McCullough, A., Lloyd, R. S. & Stone, M. P., Jul 27 2010, In : Biochemistry. 49, 29, p. 6155-6164 10 p.

Research output: Contribution to journalArticle

Acrolein
Amines
Peptides
DNA
Lysine
20 Citations (Scopus)

Modulation of UvrD helicase activity by covalent DNA-protein cross-links

Kumari, A., Minko, I., Smith, R. L., Lloyd, R. S. & McCullough, A., Jul 9 2010, In : Journal of Biological Chemistry. 285, 28, p. 21313-21322 10 p.

Research output: Contribution to journalArticle

Modulation
DNA
Proteins
DNA Replication
link protein
2009
56 Citations (Scopus)

Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks

de Graaf, B., Clore, A. & McCullough, A., Oct 2 2009, In : DNA Repair. 8, 10, p. 1207-1214 8 p.

Research output: Contribution to journalArticle

Damage tolerance
Gene Deletion
DNA Repair
Formaldehyde
DNA Damage
2007
51 Citations (Scopus)

Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, L. M., Jaruga, P., Wood, T. G., McCullough, A., Dizdaroglu, M. & Lloyd, R. S., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15790-15798 9 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Oligonucleotides
Gas Chromatography-Mass Spectrometry
Gas chromatography
Mass spectrometry
18 Citations (Scopus)
Mitochondrial DNA
Base Pairing
Deoxyribonuclease IV (Phage T4-Induced)
Cockayne Syndrome
Superhelical DNA
2006
19 Citations (Scopus)

Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA

Golan, G., Zharkov, D. O., Grollman, A. P., Dodson, M. L., McCullough, A., Lloyd, R. S. & Shoham, G., Sep 15 2006, In : Journal of Molecular Biology. 362, 2, p. 241-258 18 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
Imines
DNA
Nucleotides
DNA Glycosylases
161 Citations (Scopus)

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, V., Lowell, B., Minko, I., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C., McCullough, A. & Lloyd, R. S., Feb 15 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 6, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

DNA Glycosylases
DNA Repair
Fatty Liver
Mitochondrial DNA
Liver Diseases
8 Citations (Scopus)

Uncoupling of nucleotide flipping and DNA bending by the T4 pyrimidine dimer DNA glycosylase

Walker, R. K., McCullough, A. & Lloyd, R. S., Nov 28 2006, In : Biochemistry. 45, 47, p. 14192-14200 9 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
Nucleotides
DNA
2-Aminopurine
Thymine
2004
33 Citations (Scopus)

Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancer

Wooden, S. H., Bassett, H. M., Wood, T. G. & McCullough, A., Mar 8 2004, In : Cancer Letters. 205, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

Adenine
Colorectal Neoplasms
DNA Glycosylases
Viverridae
Mutation
45 Citations (Scopus)

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase

Manuel, R. C., Hitomi, K., Arvai, A. S., House, P. G., Kurtz, A. J., Dodson, M. L., McCullough, A., Tainer, J. A. & Lloyd, R. S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46930-46939 10 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Reaction intermediates
Adenine
Escherichia coli
Lyases
2002
19 Citations (Scopus)
Chlorella
Pyrimidine Dimers
hydroxyl radicals
pyrimidines
viruses
2001
124 Citations (Scopus)
Adenine
Cell Cycle
Proliferating Cell Nuclear Antigen
DNA Replication
DNA Glycosylases
42 Citations (Scopus)

The reaction mechanism of DNA glycosylase/AP lyases at abasic sites

McCullough, A., Sanchez, A., Dodson, M. L., Marapaka, P., Taylor, J. S. & Lloyd, R. S., Jan 16 2001, In : Biochemistry. 40, 2, p. 561-568 8 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Glycosylases
Pyrimidine Dimers
Sugars
Deoxyribose
2000
76 Citations (Scopus)

AP lyases and dRPases: Commonality of mechanism

Piersen, C. E., McCullough, A. & Lloyd, R. S., Feb 16 2000, In : Mutation Research - DNA Repair. 459, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

Lyases
DNA
DNA Glycosylases
Deoxyribose
Escherichia coli
15 Citations (Scopus)

Intron conservation in a UV-specific DNA repair gene encoded by chlorella viruses

Sun, L., Li, Y., McCullough, A., Wood, T. G., Lloyd, R. S., Adams, B., Gurnon, J. R. & Van Etten, J. L., 2000, In : Journal of Molecular Evolution. 50, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

Chlorella
DNA repair
Viruses
DNA Repair
Introns
1999
302 Citations (Scopus)

Initiation of base excision repair: Glycosylase mechanisms and structures

McCullough, A., Dodson, M. L. & Lloyd, R. S., 1999, In : Annual Review of Biochemistry. 68, p. 255-285 31 p.

Research output: Contribution to journalArticle

DNA Repair
Lyases
Repair
Catalysis
DNA
1998
41 Citations (Scopus)

Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1

McCullough, A., Romberg, M. T., Nyaga, S., Wei, Y., Wood, T. G., Taylor, J. S., Van Etten, J. L., Dodson, M. L. & Lloyd, R. S., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 13136-13142 7 p.

Research output: Contribution to journalArticle

Phycodnaviridae
DNA-(Apurinic or Apyrimidinic Site) Lyase
Paramecium
Pyrimidine Dimers
Chlorella
1997
50 Citations (Scopus)

Chlorella virus PBCV-1 encodes a homolog of the bacteriophage T4 UV damage repair gene denV

Furuta, M., Schrader, J. O., Schrader, H. S., Kokjohn, T. A., Nyaga, S., McCullough, A., Lloyd, R. S., Burbank, D. E., Landstein, D., Lane, L. & Van Etten, J. L., Apr 1997, In : Applied and Environmental Microbiology. 63, 4, p. 1551-1556 6 p.

Research output: Contribution to journalArticle

Paramecium bursaria Chlorella virus 1
Chlorella
Bacteriophage T4
bacteriophage
bacteriophages
56 Citations (Scopus)

The role of base flipping in damage recognition and catalysis by T4 endonuclease V

McCullough, A., Dodson, M. L., Schärer, O. D. & Lloyd, R. S., 1997, In : Journal of Biological Chemistry. 272, 43, p. 27210-27217 8 p.

Research output: Contribution to journalArticle

Pyrimidine Dimers
Catalysis
Thymine
DNA
Deoxyribonuclease (Pyrimidine Dimer)
1996
Deoxyribonuclease (Pyrimidine Dimer)
glycosylases
Endonucleases
DNA Glycosylases
pyrrolidines
27 Citations (Scopus)

Structural determinants for specific recognition by T4 endonuclease V

McCullough, A., Schärer, O., Verdine, G. L. & Lloyd, R. S., 1996, In : Journal of Biological Chemistry. 271, 50, p. 32147-32152 6 p.

Research output: Contribution to journalArticle

Deoxyribonuclease (Pyrimidine Dimer)
Assays
Sugar Phosphates
DNA Glycosylases
Pyrimidine Dimers
1994
17 Citations (Scopus)

Nucleotide excision repair in E. coli

Van Houten, B. & McCullough, A., 1994, In : Annals of the New York Academy of Sciences. 726, p. 236-251 16 p.

Research output: Contribution to journalArticle

Escherichia coli
Repair
Nucleotides
74 Citations (Scopus)

Removal of 3′-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

Winters, T. A., Henner, W. D., Russell, P. S., McCullough, A. & Jorgensen, T. J., May 25 1994, In : Nucleic Acids Research. 22, 10, p. 1866-1873 8 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Breaks
Oligonucleotides
Endonucleases
DNA