Amanda McCullough

Associate Professor

  • 1542 Citations
  • 20 h-Index
1994 …2020

Research output per year

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Research Output

  • 1542 Citations
  • 20 h-Index
  • 40 Article
  • 3 Review article
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Article
2020

Recognition of DNA adducts by edited and unedited forms of DNA glycosylase NEIL1

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Coskun, E., Coskun, S. H., Jaruga, P., Yeo, J., David, S. S., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Jan 2020, In : DNA Repair. 85, 102741.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Schaser, A. J., Osterberg, V. R., Dent, S. E., Stackhouse, T. L., Wakeham, C. M., Boutros, S. W., Weston, L. J., Owen, N., Weissman, T. A., Luna, E., Raber, J., Luk, K. C., McCullough, A., Woltjer, R. R. & Unni, V., Dec 1 2019, In : Scientific Reports. 9, 1, 10919.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Characterization of rare NEIL1 variants found in East Asian populations

Minko, I. G., Vartanian, V. L., Tozaki, N. N., Linde, O. K., Jaruga, P., Coskun, S. H., Coskun, E., Qu, C., He, H., Xu, C., Chen, T., Song, Q., Jiao, Y., Stone, M. P., Egli, M., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Jul 2019, In : DNA Repair. 79, p. 32-39 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3

Minko, I. G., Christov, P. P., Li, L., Stone, M. P., McCullough, A. K. & Lloyd, R. S., Jan 2019, In : DNA Repair. 73, p. 49-54 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity

Juarez, E., Chambwe, N., Tang, W., Mitchell, A. D., Owen, N., Kumari, A., Monnat, R. J. & McCullough, A., Jan 1 2018, (Accepted/In press) In : DNA Repair.

Research output: Contribution to journalArticle

3 Scopus citations

Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways

Sha, Y., Vartanian, V., Owen, N., Mengden Koon, S. J., Calkins, M. J., Thompson, C. S., Mirafzali, Z., Mir, S., Goldsmith, L. E., He, H., Luo, C., Brown, S. M., Doetsch, P. W., Kaempf, A., Lim, J. Y., McCullough, A. & Lloyd, R. S., Dec 1 2018, In : Scientific Reports. 8, 1, 705.

Research output: Contribution to journalArticle

4 Scopus citations
2017

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice

Vartanian, V., Minko, I. G., Chawanthayatham, S., Egner, P. A., Lin, Y. C., Earley, L. F., Makar, R., Eng, J. R., Camp, M. T., Li, L., Stone, M. P., Lasarev, M. R., Groopman, J. D., Croy, R. G., Essigmann, J. M., McCullough, A. K. & Lloyd, R. S., Apr 18 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. 4207-4212 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Catalysts of DNA Strand Cleavage at Apurinic/Apyrimidinic Sites

Minko, I., Jacobs, A. C., De Leon, A. R., Gruppi, F., Donley, N., Harris, T. M., Rizzo, C. J., McCullough, A. & Lloyd, R. S., Jul 1 2016, In : Scientific Reports. 6, 28894.

Research output: Contribution to journalArticle

6 Scopus citations

DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure

Lin, Y. C., Owen, N., Minko, I. G., Lange, S. S., Li, L., Stone, M. P., Wood, R. D., McCullough, A. K. & Lloyd, R. S., Nov 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 48, p. 13774-13779 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Enhanced sensitivity of Neil1−/− mice to chronic UVB exposure

Calkins, M. J., Vartanian, V., Owen, N., Kirkali, G., Jaruga, P., Dizdaroglu, M., McCullough, A. & Lloyd, R. S., Dec 1 2016, In : DNA Repair. 48, p. 43-50 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

BLM protein mitigates formaldehyde-induced genomic instability

Kumari, A., Owen, N., Juarez, E. & McCullough, A. K., Apr 1 2015, In : DNA Repair. 28, p. 73-82 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1)

Donley, N., Jaruga, P., Coskun, E., Dizdaroglu, M., McCullough, A. K. & Lloyd, R. S., Oct 16 2015, In : ACS chemical biology. 10, 10, p. 2334-2343 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Inhibition of DNA glycosylases via small molecule purine analogs

Jacobs, A. C., Calkins, M. J., Jadhav, A., Dorjsuren, D., Maloney, D., Simeonov, A., Jaruga, P., Dizdaroglu, M., McCullough, A. K. & Stephen Lloyd, R., Dec 9 2013, In : PloS one. 8, 12, e81667.

Research output: Contribution to journalArticle

25 Scopus citations
2012

Formaldehyde-induced genome instability is suppressed by an XPF-dependent pathway

Kumari, A., Lim, Y. X., Newell, A. H., Olson, S. B. & McCullough, A. K., Mar 1 2012, In : DNA Repair. 11, 3, p. 236-246 11 p.

Research output: Contribution to journalArticle

28 Scopus citations
2011

Modulation of the processive abasic site lyase activity of a pyrimidine dimer glycosylase

Ryabinina, O. P., Minko, I. G., Lasarev, M. R., McCullough, A. K. & Lloyd, R. S., Oct 10 2011, In : DNA Repair. 10, 10, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage

Johnson, J. L., Lowell, B. C., Ryabinina, O. P., Lloyd, R. S. & McCullough, A. K., Mar 2011, In : Journal of Investigative Dermatology. 131, 3, p. 753-761 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.

Sampath, H., Batra, A. K., Vartanian, V., Carmical, J. R., Prusak, D., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D. L., McCullough, A. K. & R Stephen, L., Apr 1 2011, In : American journal of physiology. Endocrinology and metabolism. 300, 4, p. E724-734

Research output: Contribution to journalArticle

27 Scopus citations

γ-Hydroxy-1, N 2-propano-2′-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage

Huang, H., Wang, H., Voehler, M. W., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P., Jul 18 2011, In : Chemical Research in Toxicology. 24, 7, p. 1123-1133 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010

Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1, N 2-γ- hydroxypropanodeoxyguanosine lesion with a trimethylene linkage

Huang, H., Kozekov, I. D., Kozekova, A., Rizzo, C. J., McCullough, A. K., Lloyd, R. S. & Stone, M. P., Jul 27 2010, In : Biochemistry. 49, 29, p. 6155-6164 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Modulation of UvrD helicase activity by covalent DNA-protein cross-links

Kumari, A., Minko, I. G., Smith, R. L., Lloyd, R. S. & McCullough, A. K., Jul 9 2010, In : Journal of Biological Chemistry. 285, 28, p. 21313-21322 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA-protein crosslinks

de Graaf, B., Clore, A. & McCullough, A. K., Oct 2 2009, In : DNA Repair. 8, 10, p. 1207-1214 8 p.

Research output: Contribution to journalArticle

65 Scopus citations
2007

Human polymorphic variants of the NEIL1 DNA glycosylase

Roy, L. M., Jaruga, P., Wood, T. G., McCullough, A. K., Dizdaroglu, M. & Lloyd, R. S., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15790-15798 9 p.

Research output: Contribution to journalArticle

53 Scopus citations
19 Scopus citations
2006

Structure of T4 Pyrimidine Dimer Glycosylase in a Reduced Imine Covalent Complex with Abasic Site-containing DNA

Golan, G., Zharkov, D. O., Grollman, A. P., Dodson, M. L., McCullough, A. K., Lloyd, R. S. & Shoham, G., Sep 15 2006, In : Journal of molecular biology. 362, 2, p. 241-258 18 p.

Research output: Contribution to journalArticle

20 Scopus citations

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, V., Lowell, B., Minko, I. G., Wood, T. G., Ceci, J. D., George, S., Ballinger, S. W., Corless, C. L., McCullough, A. K. & Lloyd, R. S., Feb 15 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 6, p. 1864-1869 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Uncoupling of nucleotide flipping and DNA bending by the T4 pyrimidine dimer DNA glycosylase

Walker, R. K., McCullough, A. K. & Lloyd, R. S., Nov 28 2006, In : Biochemistry. 45, 47, p. 14192-14200 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2004

Identification of critical residues required for the mutation avoidance function of human MutY (hMYH) and implications in colorectal cancer

Wooden, S. H., Bassett, H. M., Wood, T. G. & McCullough, A. K., Mar 8 2004, In : Cancer Letters. 205, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase

Manuel, R. C., Hitomi, K., Arvai, A. S., House, P. G., Kurtz, A. J., Dodson, M. L., McCullough, A. K., Tainer, J. A. & Lloyd, R. S., Nov 5 2004, In : Journal of Biological Chemistry. 279, 45, p. 46930-46939 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
2002
20 Scopus citations
2001
125 Scopus citations

The reaction mechanism of DNA glycosylase/AP lyases at abasic sites

McCullough, A. K., Sanchez, A., Dodson, M. L., Marapaka, P., Taylor, J. S. & Stephen Lloyd, R., Jan 16 2001, In : Biochemistry. 40, 2, p. 561-568 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
2000

AP lyases and dRPases: Commonality of mechanism

Piersen, C. E., McCullough, A. K. & Lloyd, R. S., Feb 16 2000, In : Mutation Research - DNA Repair. 459, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Intron conservation in a UV-specific DNA repair gene encoded by chlorella viruses

Sun, L., Li, Y., McCullough, A. K., Wood, T. G., Lloyd, R. S., Adams, B., Gurnon, J. R. & Van Etten, J. L., Jan 1 2000, In : Journal of Molecular Evolution. 50, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
1998

Characterization of a novel cis-syn and trans-syn-II pyrimidine dimer glycosylase/AP lyase from a eukaryotic algal virus, Paramecium bursaria chlorella virus-1

McCullough, A. K., Romberg, M. T., Nyaga, S., Wei, Y., Wood, T. G., Taylor, J. S., Van Etten, J. L., Dodson, M. L. & Lloyd, R. S., May 22 1998, In : Journal of Biological Chemistry. 273, 21, p. 13136-13142 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
1997

Chlorella virus PBCV-1 encodes a homolog of the bacteriophage T4 UV damage repair gene denV

Furuta, M., Schrader, J. O., Schrader, H. S., Kokjohn, T. A., Nyaga, S., McCullough, A. K., Lloyd, R. S., Burbank, D. E., Landstein, D., Lane, L. & Van Etten, J. L., Apr 1 1997, In : Applied and Environmental Microbiology. 63, 4, p. 1551-1556 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

The role of base flipping in damage recognition and catalysis by T4 endonuclease V

McCullough, A. K., Dodson, M. L., Schärer, O. D. & Lloyd, R. S., Nov 1 1997, In : Journal of Biological Chemistry. 272, 43, p. 27210-27217 8 p.

Research output: Contribution to journalArticle

56 Scopus citations
1996

Specific interactions of t4 endonuclease v with a proposed transition state analogue for dna glycosylases

McCullough, A. K., Verdine, G. L. & Stephen Lloyd, R., Dec 1 1996, In : FASEB Journal. 10, 6, p. A966

Research output: Contribution to journalArticle

Structural determinants for specific recognition by T4 endonuclease V

McCullough, A. K., Schärer, O., Verdine, G. L. & Stephen Lloyd, R., Dec 30 1996, In : Journal of Biological Chemistry. 271, 50, p. 32147-32152 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
1994

Nucleotide Excision Repair in E. Coli

HOUXEN, BEN. VAN. & McCULLOUGH, AMANDA., Jul 1994, In : Annals of the New York Academy of Sciences. 726, 1, p. 236-251 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Removal of 3′-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

Winters, T. A., Henner, W. D., Russell, P. S., Mccullough, A. & Jorgensen, T. J., May 25 1994, In : Nucleic acids research. 22, 10, p. 1866-1873 8 p.

Research output: Contribution to journalArticle

77 Scopus citations