Alejandro Lomniczi

Research Assistant Professor

  • 2100 Citations
  • 28 h-Index
1978 …2020
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Research Output 1998 2019

  • 2100 Citations
  • 28 h-Index
  • 60 Article
  • 3 Chapter
  • 2 Review article
2019
4 Citations (Scopus)

EAP1 regulation of GnRH promoter activity is important for human pubertal timing

Mancini, A., Howard, S. R., Cabrera, C. P., Barnes, M. R., David, A., Wehkalampi, K., Heger, S., Lomniczi, A., Guasti, L., Ojeda, S. & Dunkel, L., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1357-1368 12 p.

Research output: Contribution to journalArticle

Open Access
Puberty
Gonadotropin-Releasing Hormone
Delayed Puberty
Mutation
Hypothalamus
10 Citations (Scopus)

Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

Aylwin, C. F., Toro, C. A., Shirtcliff, E. & Lomniczi, A., Mar 1 2019, In : Journal of Research on Adolescence. 29, 1, p. 54-79 26 p.

Research output: Contribution to journalReview article

Open Access
Epigenomics
Gonadotropin-Releasing Hormone
adolescence
Sexual Maturation
puberty
1 Citation (Scopus)
G-Protein-Coupled Receptors
Primates
Ethanol
Alcohols
Nucleus Accumbens
1 Citation (Scopus)

The Emerging Role of Chromatin Remodeling Factors in Female Pubertal Development

Aylwin, C. F., Vigh-Conrad, K. & Lomniczi, A., Sep 1 2019, In : Neuroendocrinology. 109, 3, p. 208-217 10 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Gonadotropin-Releasing Hormone
Puberty
Epigenomics
Neuroglia
2018
4 Citations (Scopus)

Elucidating the genetic architecture of reproductive ageing in the Japanese population

Horikoshi, M., Day, F. R., Akiyama, M., Hirata, M., Kamatani, Y., Matsuda, K., Ishigaki, K., Kanai, M., Wright, H., Toro, C. A., Ojeda, S., Lomniczi, A., Kubo, M., Ong, K. K. & Perry, J. R. B., Dec 1 2018, In : Nature Communications. 9, 1, 1977.

Research output: Contribution to journalArticle

Menopause
Receptor-Like Protein Tyrosine Phosphatases
Genes
Aging of materials
time measurement
6 Citations (Scopus)

Hypothalamic epigenetics driving female puberty

Toro, C. A., Aylwin, C. F. & Lomniczi, A., Jul 1 2018, In : Journal of Neuroendocrinology. 30, 7, e12589.

Research output: Contribution to journalReview article

Puberty
Epigenomics
Gonadotropin-Releasing Hormone
Fertility
Genes
2 Citations (Scopus)

Methylome profiling of healthy and central precocious puberty girls

Bessa, D. S., Maschietto, M., Aylwin, C. F., Canton, A. P. M., Brito, V. N., Macedo, D. B., Cunha-Silva, M., Palhares, H. M. C., de Resende, E. A. M. R., Borges, M. D. F., Mendonca, B. B., Netchine, I., Krepischi, A. C. V., Lomniczi, A., Ojeda, S. & Latronico, A. C., Nov 22 2018, In : Clinical Epigenetics. 10, 1, 1 p.

Research output: Contribution to journalArticle

Puberty
Zinc Fingers
DNA Methylation
Genes
Methylation
9 Citations (Scopus)

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., Heras, V., Velasco, I., Dieguez, C., Pinilla, L., Gaytan, F., Nogueiras, R., Bosch, M. A., Ronnekleiv, O., Lomniczi, A., Ojeda, S. & Tena-Sempere, M., Dec 1 2018, In : Nature Communications. 9, 1, 4194.

Research output: Contribution to journalArticle

Sirtuin 1
obesity
cues
nutrients
Nutrients
12 Citations (Scopus)

Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

Toro, C. A., Wright, H., Aylwin, C. F., Ojeda, S. & Lomniczi, A., Dec 1 2018, In : Nature Communications. 9, 1, 02512.

Research output: Contribution to journalArticle

chromatin
Puberty
Genetic Promoter Regions
Chromatin
leukemias
2017
3 Citations (Scopus)

Changes in the expression of genes involved in the ovarian function of rats caused by daily exposure to 3-methylcholanthrene and their prevention by α-naphthoflavone

Rhon-Calderón, E. A., Toro, C. A., Lomniczi, A., Galarza, R. A. & Faletti, A. G., Nov 1 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Methylcholanthrene
Rats
Genes
Gene Expression
Aryl Hydrocarbon Receptors
2016
3 Citations (Scopus)

Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update

Dissen, G., Adachi, K., Lomniczi, A., Chatkupt, T., Davidson, B., Nakai, H. & Ojeda, S., 2016, (Accepted/In press) In : Reproduction in Domestic Animals.

Research output: Contribution to journalArticle

Dependovirus
Gene Silencing
gene silencing
hypothalamus
RNA Interference
28 Citations (Scopus)

The emerging role of epigenetics in the regulation of female puberty

Lomniczi, A. & Ojeda, S., 2016, In : Endocrine Development. 29, p. 1-16 16 p.

Research output: Contribution to journalArticle

Puberty
Epigenomics
Kisspeptins
Arcuate Nucleus of Hypothalamus
Gene Silencing
4 Citations (Scopus)

The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of α-naphthoflavone

Rhon-Calderón, E. A., Galarza, R. A., Lomniczi, A. & Faletti, A. G., Apr 15 2016, In : Toxicology. 353-354, p. 58-69 12 p.

Research output: Contribution to journalArticle

Methylcholanthrene
Toxicity
Ovulation
Estrous Cycle
Oocytes
2015
42 Citations (Scopus)

Epigenetic regulation of female puberty

Lomniczi, A., Wright, H. & Ojeda, S., Jan 1 2015, In : Frontiers in Neuroendocrinology. 36, p. 90-107 18 p.

Research output: Contribution to journalArticle

Puberty
Epigenomics
Gonadotropin-Releasing Hormone
Epigenetic Repression
Gene Targeting
33 Citations (Scopus)

Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression

Lomniczi, A., Wright, H., Castellano, J. M., Matagne, V., Toro, C. A., Ramaswamy, S., Plant, T. M. & Ojeda, S., Dec 16 2015, In : Nature Communications. 6, 10195.

Research output: Contribution to journalArticle

hypothalamus
primates
monkeys
secretions
Zinc Fingers
1 Citation (Scopus)

Gene networks, epigenetics and the control of female puberty

Lomniczi, A., Castellano, J. M., Wright, H., Selcuk, B., Sonmez, M. K. & Ojeda, S., 2015, In : Research and Perspectives in Endocrine Interactions. 13, p. 97-119 23 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Puberty
Epigenomics
Genes
Histone Code
2014
5 Citations (Scopus)

An alternative transcription start site yields estrogen-unresponsive kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats

Castellano, J. M., Wright, H., Ojeda, S. & Lomniczi, A., 2014, In : Neuroendocrinology. 99, 2, p. 94-107 14 p.

Research output: Contribution to journalArticle

Transcription Initiation Site
Hypothalamus
Exons
Estrogens
Messenger RNA
42 Citations (Scopus)

Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome

Topaloglu, A. K., Lomniczi, A., Kretzschmar, D., Dissen, G., Kotan, L. D., McArdle, C. A., Koc, A. F., Hamel, B. C., Guclu, M., Papatya, E. D., Eren, E., Mengen, E., Gurbuz, F., Cook, M., Castellano, J. M., Kekil, M. B., Mungan, N. O., Yuksel, B. & Ojeda, S., Oct 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 10, p. E2067-E2075

Research output: Contribution to journalArticle

Hypogonadism
Gonadotropin-Releasing Hormone
Mutation
Phospholipids
Bearings (structural)
39 Citations (Scopus)

Loss of NTRK2/KISS1R signaling in oocytes causes premature Ovarian failure

Dorfman, M. D., Garcia-Rudaz, C., Alderman, Z., Kerr, B., Lomniczi, A., Dissen, G., Castellano, J. M., Garcia-Galiano, D., Gaytan, F., Xu, B., Tena-Sempere, M. & Ojeda, S., 2014, In : Endocrinology. 155, 8, p. 3098-3111 14 p.

Research output: Contribution to journalArticle

Primary Ovarian Insufficiency
Oocytes
Gonadotropins
Kisspeptins
Brain-Derived Neurotrophic Factor
35 Citations (Scopus)

Puberty in 2013: Unravelling the mystery of puberty

Ojeda, S. & Lomniczi, A., Feb 2014, In : Nature Reviews Endocrinology. 10, 2, p. 67-69 3 p.

Research output: Contribution to journalArticle

Genetic Transcription
Neurosecretory Systems
Puberty
Epigenomics
Malnutrition
2013
27 Citations (Scopus)

A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates

Lomniczi, A., Wright, H., Castellano, J. M., Sonmez, M. K. & Ojeda, S., Jul 2013, In : Hormones and Behavior. 64, 2, p. 175-186 12 p.

Research output: Contribution to journalArticle

Systems Biology
Puberty
Gonadotropin-Releasing Hormone
Primates
Neuroglia
136 Citations (Scopus)

Epigenetic control of female puberty

Lomniczi, A., Loche, A., Castellano, J. M., Ronnekleiv, O., Bosch, M., Kaidar, G., Knoll, J. G., Wright, H., Pfeifer, G. P. & Ojeda, S., Mar 2013, In : Nature Neuroscience. 16, 3, p. 281-289 9 p.

Research output: Contribution to journalArticle

Puberty
Epigenomics
Histone Code
Polycomb-Group Proteins
Delayed Puberty
2012
6 Citations (Scopus)

Applying Gene Silencing Technology to Contraception

Dissen, G., Lomniczi, A., Boudreau, R. L., Chen, Y. H., Davidson, B. L. & Ojeda, S., Dec 2012, In : Reproduction in Domestic Animals. 47, SUPPL. 6, p. 381-386 6 p.

Research output: Contribution to journalArticle

contraception
Gene Silencing
gene silencing
Contraception
Technology
20 Citations (Scopus)

A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates

Lomniczi, A., Garcia-Rudaz, C., Ramakrishnan, R., Wilmot, B., Khouangsathiene, S., Ferguson, B., Dissen, G. & Ojeda, S., Jan 2012, In : Endocrinology. 153, 1, p. 339-349 11 p.

Research output: Contribution to journalArticle

Oligomenorrhea
Amenorrhea
Primates
Single Nucleotide Polymorphism
Periodicity
27 Citations (Scopus)

Hypothalamic EAP1 (Enhanced at Puberty 1) is required for menstrual cyclicity in nonhuman primates

Dissen, G., Lomniczi, A., Heger, S., Neff, T. L. & Ojeda, S., Jan 2012, In : Endocrinology. 153, 1, p. 350-361 12 p.

Research output: Contribution to journalArticle

Periodicity
Puberty
Primates
Gonadotropin-Releasing Hormone
Middle Hypothalamus
5 Citations (Scopus)

Targeted gene silencing to induce permanent sterility

Dissen, G., Lomniczi, A., Boudreau, R. L., Chen, Y. H., Davidson, B. L. & Ojeda, S., Aug 2012, In : Reproduction in Domestic Animals. 47, SUPPL.4, p. 228-232 5 p.

Research output: Contribution to journalArticle

Gene Silencing
gene silencing
Infertility
brain
gene therapy
19 Citations (Scopus)

Transcription of the human EAP1 gene is regulated by upstream components of a puberty-controlling Tumor Suppressor Gene network

Mueller, J. K., Koch, I., Lomniczi, A., Loche, A., Rulfs, T., Castellano, J. M., Kiess, W., Ojeda, S. & Heger, S., Apr 4 2012, In : Molecular and Cellular Endocrinology. 351, 2, p. 184-198 15 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Transcription
Puberty
Tumor Suppressor Genes
Tumors
2011
29 Citations (Scopus)

A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2

Yeung, K. T., Das, S., Zhang, J., Lomniczi, A., Ojeda, S., Xu, C. F., Neubert, T. A. & Samuels, H. H., Jun 2011, In : Molecular and Cellular Biology. 31, 11, p. 2287-2298 12 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Apoptosis
Breast Neoplasms
Puberty
Interferon Regulatory Factor-2
46 Citations (Scopus)

Transcriptional regulation of the human KiSS1 gene

Mueller, J. K., Dietzel, A., Lomniczi, A., Loche, A., Tefs, K., Kiess, W., Danne, T., Ojeda, S. & Heger, S., Aug 6 2011, In : Molecular and Cellular Endocrinology. 342, 1-2, p. 8-19 12 p.

Research output: Contribution to journalArticle

Puberty
Kisspeptins
Genes
Trans-Activators
Initiator Codon
2010
34 Citations (Scopus)

Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty

Ojeda, S., Lomniczi, A. & Sandau, U., Dec 2010, In : European Journal of Neuroscience. 32, 12, p. 2003-2010 8 p.

Research output: Contribution to journalArticle

Puberty
Neuroglia
Gonadotropin-Releasing Hormone
Neurons
Adhesiveness
108 Citations (Scopus)

Gene networks and the neuroendocrine regulation of puberty

Ojeda, S., Dubay, C., Lomniczi, A., Kaidar, G., Matagne, V., Sandau, U. S. & Dissen, G., Aug 2010, In : Molecular and Cellular Endocrinology. 324, 1-2, p. 3-11 9 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Puberty
Gonadotropin-Releasing Hormone
Neuroglia
Genes

Neuroendocrinology of puberty

Lomniczi, A., Matagne, V. & Ojeda, S., 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 367-375 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuroendocrinology
Puberty
Gonadotropin-Releasing Hormone
Portal System
Neurons
29 Citations (Scopus)

The transcriptional control of female puberty

Ojeda, S., Lomniczi, A., Loche, A., Matagne, V., Kaidar, G., Sandau, U. S. & Dissen, G., Dec 10 2010, In : Brain Research. 1364, p. 164-174 11 p.

Research output: Contribution to journalArticle

Puberty
Gonadotropin-Releasing Hormone
Neuroglia
Kisspeptins
Genes
2009
15 Citations (Scopus)

A role for glial cells of the neuroendocrine brain in the central control of female sexual development

Lomniczi, A. & Ojeda, S., 2009, Astrocytes in (Patho)Physiology of the Nervous System. Springer US, p. 487-511 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sexual Development
Neuroglia
Neurons
Gonadotropin-Releasing Hormone
Brain
35 Citations (Scopus)

In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles

Dissen, G., Lomniczi, A., Neff, T. L., Hobbs, T., Kohama, S., Kroenke, C. C., Galimi, F. & Ojeda, S., Sep 2009, In : Methods. 49, 1, p. 70-77 8 p.

Research output: Contribution to journalArticle

Gene expression
Primates
Gene Expression
Lentivirus
Genes
52 Citations (Scopus)

New concepts on the control of the onset of puberty

Ojeda, S., Lomniczi, A., Sandau, U. & Matagne, V., Nov 24 2009, Pediatric Neuroendocrinology. S. Karger AG, Vol. 17. p. 44-51 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Puberty
DNA Methylation
Epigenomics
Systems Biology
Gene Regulatory Networks

New concepts on the control of the onset of puberty

Ojeda, S., Lomniczi, A., Sandau, U. & Matagne, V., Nov 2009, In : Endocrine Development. 17, p. 44-51 8 p.

Research output: Contribution to journalArticle

Puberty
DNA Methylation
Epigenomics
Systems Biology
Gene Regulatory Networks
2008
93 Citations (Scopus)

Glial-gonadotrophin hormone (GnRH) neurone interactions in the median eminence and the control of gnrh secretion

Ojeda, S., Lomniczi, A. & Sandau, U. S., Jun 2008, In : Journal of Neuroendocrinology. 20, 6, p. 732-742 11 p.

Research output: Contribution to journalArticle

Median Eminence
Gonadotropins
Neuroglia
Hormones
Neurons
32 Citations (Scopus)

Oxytocin facilitates female sexual maturation through a glia-to-neuron signaling pathway

Parent, A. S., Rasier, G., Matagne, V., Lomniczi, A., Lebrethon, M. C., Gérard, A., Ojeda, S. & Bourguignon, J. P., Mar 2008, In : Endocrinology. 149, 3, p. 1358-1365 8 p.

Research output: Contribution to journalArticle

Sexual Maturation
Oxytocin
Neuroglia
Gonadotropin-Releasing Hormone
Neurons
2007
32 Citations (Scopus)

A contactin-receptor-like protein tyrosine phosphatase β complex mediates adhesive communication between astroglial cells and gonadotrophin-releasing hormone neurones

Parent, A. S., Mungenast, A. E., Lomniczi, A., Sandau, U. S., Peles, E., Bosch, M. A., Ronnekleiv, O. & Ojeda, S., Nov 2007, In : Journal of Neuroendocrinology. 19, 11, p. 847-858 12 p.

Research output: Contribution to journalArticle

Receptor-Like Protein Tyrosine Phosphatases
Contactins
Gonadotropin-Releasing Hormone
Adhesives
Communication
69 Citations (Scopus)

Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis

Heger, S., Mastronardi, C., Dissen, G., Lomniczi, A., Cabrera, R., Roth, C. L., Jung, H., Galimi, F., Sippell, W. & Ojeda, S., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2145-2154 10 p.

Research output: Contribution to journalArticle

Puberty
Gonadotropin-Releasing Hormone
Neurons
Hypothalamus
Rodentia
62 Citations (Scopus)

Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty

Roth, C. L., Mastronardi, C., Lomniczi, A., Wright, H., Cabrera, R., Mungenast, A. E., Heger, S., Jung, H., Dubay, C. & Ojeda, S., Nov 2007, In : Endocrinology. 148, 11, p. 5147-5161 15 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Puberty
Hypothalamus
Genes
Neoplasms
2006
19 Citations (Scopus)

Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins

De La Cal, C., Lomniczi, A., Mohn, C. E., De Laurentiis, A., Casal, M., Chiarenza, A., Paz, D., McCann, S. M., Rettori, V. & Elverdín, J. C., Aug 2006, In : NeuroImmunoModulation. 13, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

Prostaglandins
Nitric Oxide
Radiation
Prostaglandins E
Submandibular Gland
30 Citations (Scopus)
Excitatory Amino Acids
Transforming Growth Factors
Median Eminence
Neuroglia
Tumor Necrosis Factor-alpha
210 Citations (Scopus)

Minireview: The neuroendocrine regulation of puberty: Is the time ripe for a systems biology approach?

Ojeda, S., Lomniczi, A., Mastronardi, C., Heger, S., Roth, C., Parent, A. S., Matagne, V. & Mungenast, A. E., Mar 2006, In : Endocrinology. 147, 3, p. 1166-1174 9 p.

Research output: Contribution to journalArticle

Systems Biology
Puberty
Neuroglia
Gonadotropin-Releasing Hormone
Genes
35 Citations (Scopus)

Neuroendocrine mechanisms controlling female puberty: New approaches, new concepts

Ojeda, S., Roth, C., Mungenast, A., Heger, S., Mastronardi, C., Parent, A. S., Lomniczi, A., Jung, H. & Høgberg, J., Feb 2006, In : International Journal of Andrology. 29, 1, p. 256-263 8 p.

Research output: Contribution to journalArticle

Puberty
Gonadotropin-Releasing Hormone
Neurons
Neuroglia
Communication
29 Citations (Scopus)

Quantitative proteomics identifies a change in glial glutamate metabolism at the time of female puberty

Roth, C. L., McCormack, A. L., Lomniczi, A., Mungenast, A. E. & Ojeda, S., Jul 25 2006, In : Molecular and Cellular Endocrinology. 254-255, p. 51-59 9 p.

Research output: Contribution to journalArticle

Puberty
Metabolism
Neuroglia
Proteomics
Glutamic Acid
2005
57 Citations (Scopus)

erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function

Prevot, V., Lomniczi, A., Corfas, G. & Ojeda, S., Mar 2005, In : Endocrinology. 146, 3, p. 1465-1472 8 p.

Research output: Contribution to journalArticle

Sexual Development
Gonadotropin-Releasing Hormone
Astrocytes
Neuroglia
Puberty
2003
75 Citations (Scopus)

Glia-to-neuron signaling and the neuroendocrine control of female puberty

Ojeda, S., Prevot, V., Heger, S., Lomniczi, A., Dziedzic, B. & Mungenast, A., 2003, In : Annals of Medicine. 35, 4, p. 244-255 12 p.

Research output: Contribution to journalArticle

Puberty
Neuroglia
Neurons
Gonadotropin-Releasing Hormone
Excitatory Amino Acids
16 Citations (Scopus)

Interaction among beta-endorphin, nitric oxide and prostaglandins during ovulation in rats

Faletti, A. G., Mohn, C., Farina, M., Lomniczi, A. & Rettori, V., Apr 1 2003, In : Reproduction. 125, 4, p. 469-477 9 p.

Research output: Contribution to journalArticle

Endorphins
beta-Endorphin
Ovulation
Prostaglandins
Nitric Oxide