Alejandro Aballay

Professor

  • 2127 Citations
  • 24 h-Index
19952019
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Research Output 1995 2019

2019
2 Citations (Scopus)

Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling

Singh, J. & Aballay, A., Apr 8 2019, In : Developmental Cell. 49, 1, p. 89-99.e4

Research output: Contribution to journalArticle

Genes
Caenorhabditis elegans
Intestines
Pathogens
Aptitude
1 Citation (Scopus)

Role of neurons in the control of immune defense

Hoffman, C. & Aballay, A., Oct 1 2019, In : Current opinion in immunology. 60, p. 30-36 7 p.

Research output: Contribution to journalReview article

Caenorhabditis elegans
Vertebrates
Neurons
Vagus Nerve
Dissection
1 Citation (Scopus)

Similar neural pathways control foraging in mosquitoes and worms

Singh, J. & Aballay, A., Mar 1 2019, In : mBio. 10, 2, e00656-19.

Research output: Contribution to journalArticle

Open Access
Neural Pathways
Neuropeptide Y Receptors
Culicidae
Disease Vectors
Caenorhabditis elegans
2018

Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection

Olaitan, A. O. & Aballay, A., Sep 1 2018, In : PLoS Genetics. 14, 9, e1007693.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Proteasome Endopeptidase Complex
transcription (genetics)
Infection
infection
2017
29 Citations (Scopus)

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease

Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S. S., Ross, C. A., Eroglu, C. & Thiele, D. J., Feb 13 2017, In : Nature Communications. 8, 14405.

Research output: Contribution to journalArticle

Transcription factors
Huntington Disease
Transcription Factors
shock
degradation
5 Citations (Scopus)

Distinct Roles of Sensory Neurons in Mediating Pathogen Avoidance and Neuropeptide-Dependent Immune Regulation

Cao, X., Kajino-Sakamoto, R., Doss, A. & Aballay, A., Nov 7 2017, In : Cell Reports. 21, 6, p. 1442-1451 10 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Pathogens
Sensory Receptor Cells
Neuropeptides
Neurons
12 Citations (Scopus)

Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans

Wyatt, L. H., Luz, A. L., Cao, X., Maurer, L. L., Blawas, A. M., Aballay, A., Pan, W. K. Y. & Meyer, J. N., Apr 1 2017, In : DNA Repair. 52, p. 31-48 18 p.

Research output: Contribution to journalArticle

Mitochondrial Genome
Caenorhabditis elegans
Mercury
DNA Damage
Homeostasis
3 Citations (Scopus)
Endoplasmic Reticulum Stress
Lipoproteins
Immunity
Unfolded Protein Response
Caenorhabditis elegans
6 Citations (Scopus)

Natural genetic variation in the Caenorhabditis elegans response to Pseudomonas aeruginosa

Martin, N., Singh, J. & Aballay, A., Apr 1 2017, In : G3: Genes, Genomes, Genetics. 7, 4, p. 1137-1147 11 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Pseudomonas aeruginosa
Pseudomonas Infections
Avoidance Learning
Alleles
2 Citations (Scopus)

Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans

Head, B. P., Olaitan, A. O. & Aballay, A., Apr 3 2017, In : Virulence. 8, 3, p. 261-274 14 p.

Research output: Contribution to journalArticle

GATA2 Transcription Factor
Pseudomonas Infections
p38 Mitogen-Activated Protein Kinases
Pseudomonas aeruginosa
Communicable Diseases
2016
2 Citations (Scopus)
Neural Inhibition
RNA Interference
Immunity
immunity
Biological Sciences
12 Citations (Scopus)

Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner

Cao, X. & Aballay, A., Sep 12 2016, In : Current Biology. 26, 17, p. 2329-2334 6 p.

Research output: Contribution to journalArticle

Neural Inhibition
Neurology
nervous system
Nervous System
Immunity
2015
3 Citations (Scopus)

Alternative NF-κB isoforms in the drosophila neuromuscular junction and brain

Zhou, B., Lindsay, S. A., Wasserman, S. A. & Aballay, A., Jul 13 2015, In : PLoS One. 10, 7

Research output: Contribution to journalArticle

Neuromuscular Junction
Drosophila
Brain
Protein Isoforms
Cactaceae
2 Citations (Scopus)

Cellular Responses to Infections in Caenorhabditis elegans

Sun, J., Aballay, A. & Singh, V., Jan 1 2015, Organizational Cell Biology. Elsevier Inc., Vol. 2. p. 845-852 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Caenorhabditis elegans
Infection
Soil
Pattern Recognition Receptors
Adaptive Immunity
11 Citations (Scopus)

Genetic screen reveals link between the maternal effect sterile gene mes-1 and pseudomonas aeruginosa-induced neurodegeneration in caenorhabditis elegans

Wu, Q., Cao, X., Yan, D., Wang, D. & Aballay, A., Dec 4 2015, In : Journal of Biological Chemistry. 290, 49, p. 29231-29239 9 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Germ Cells
Pseudomonas aeruginosa
Animals
Pseudomonas Infections
2014
6 Citations (Scopus)

Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2

Head, B. & Aballay, A., Jan 1 2014, In : PLoS Genetics. 10, 10

Research output: Contribution to journalArticle

GATA2 Transcription Factor
Infection
infection
GATA Transcription Factors
gene
17 Citations (Scopus)

Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways

Cai, Y., Cao, X. & Aballay, A., Aug 12 2014, In : mBio. 5, 4

Research output: Contribution to journalArticle

Colistin
Immunologic Factors
Anti-Bacterial Agents
Infection
Bacterial Infections
2013
18 Citations (Scopus)
Caenorhabditis elegans
Bacterial Infections
Innate Immunity
Nervous System
Bacteria

Virulence profile: Alejandro Aballay

Aballay, A., Jan 1 2013, In : Virulence. 4, 7, p. 638-640 3 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Host-Pathogen Interactions
Animal Disease Models
Salmonella enterica
2012
13 Citations (Scopus)

Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1

Singh, V. & Aballay, A., Sep 28 2012, In : Journal of Biological Chemistry. 287, 40, p. 33191-33197 7 p.

Research output: Contribution to journalArticle

Arrestin
Endoplasmic Reticulum Stress
G-Protein-Coupled Receptors
Homeostasis
Neurons
37 Citations (Scopus)

Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation

Sun, J., Liu, Y. & Aballay, A., Sep 1 2012, In : EMBO Reports. 13, 9, p. 855-860 6 p.

Research output: Contribution to journalReview article

Unfolded Protein Response
Chemical activation
Endoplasmic Reticulum
Proteins
Catecholamine Receptors
2011
3 Citations (Scopus)

Models to study ancient host-pathogen interactions: Lessons from Crete

Means, T. K. & Aballay, A., Jan 1 2011, In : EMBO Reports. 12, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

Human Experimentation
Host-Pathogen Interactions
Animal Disease Models
Mycoses
Greece
109 Citations (Scopus)

Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes

Sun, J., Singh, V., Kajino-Sakamoto, R. & Aballay, A., May 6 2011, In : Science. 332, 6030, p. 729-732 4 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
G-Protein-Coupled Receptors
Innate Immunity
Nervous System
Catecholamine Receptors
2010
58 Citations (Scopus)

A conserved PMK-1/p38 MAPK is required in Caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection

Bolz, D. D., Tenor, J. L. & Aballay, A., Apr 2 2010, In : Journal of Biological Chemistry. 285, 14, p. 10832-10840 9 p.

Research output: Contribution to journalArticle

Yersinia Infections
Yersinia pestis
Caenorhabditis elegans
p38 Mitogen-Activated Protein Kinases
Genes
26 Citations (Scopus)

C. elegans germline-deficient mutants respond to pathogen infection using shared and distinct mechanisms

Tekippe, M. & Aballay, A., Aug 20 2010, In : PLoS One. 5, 7, e11777.

Research output: Contribution to journalArticle

Pathogens
Gram-Negative Bacteria
germ cells
mutants
Cryptococcus neoformans
2009
16 Citations (Scopus)

Neural regulation of immunity: Role of NPR-1 in pathogen avoidance and regulation of innate immunity

Aballay, A., Apr 1 2009, In : Cell Cycle. 8, 7, p. 966-969 4 p.

Research output: Contribution to journalArticle

Innate Immunity
Nervous System
Immunity
Caenorhabditis elegans
Immune System
36 Citations (Scopus)

Nucleolar proteins suppress Caenorhabditis elegans innate immunity by inhibiting p53/CEP-1

Fuhrman, L. E., Goel, A. K., Smith, J., Shianna, K. V. & Aballay, A., Sep 1 2009, In : PLoS Genetics. 5, 9, e1000657.

Research output: Contribution to journalArticle

Caenorhabditis elegans
Nuclear Proteins
immunity
Innate Immunity
mutation
37 Citations (Scopus)

Regulation of DAF-16-mediated innate immunity in Caenorhabditis elegans

Singh, V. & Aballay, A., Dec 18 2009, In : Journal of Biological Chemistry. 284, 51, p. 35580-35587 8 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Caenorhabditis elegans
Innate Immunity
Aquaporins
Immune system
2008
106 Citations (Scopus)

A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity

Tenor, J. L. & Aballay, A., Jan 1 2008, In : EMBO Reports. 9, 1, p. 103-109 7 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Caenorhabditis elegans
Innate Immunity
Immunity
Pathogens
7 Citations (Scopus)

High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection

Fuhrman, L. E., Shianna, K. V. & Aballay, A., Aug 6 2008, In : PLoS One. 3, 8, e2882.

Research output: Contribution to journalArticle

Pathogens
Sorting
Single Nucleotide Polymorphism
Nucleotide Mapping
Throughput
111 Citations (Scopus)

Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR

Styer, K. L., Singh, V., Macosko, E., Steele, S. E., Bargmann, C. I. & Aballay, A., Oct 17 2008, In : Science. 322, 5900, p. 460-464 5 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
G-Protein-Coupled Receptors
Innate Immunity
Neurons
Neuropeptide Y Receptors
95 Citations (Scopus)

Resistance of Yersinia pestis to complement-dependent killing is mediated by the ail outer membrane protein

Bartra, S. S., Styer, K. L., O'Bryant, D. M., Nilles, M. L., Hinnebusch, B. J., Aballay, A. & Plano, G. V., Feb 1 2008, In : Infection and Immunity. 76, 2, p. 612-622 11 p.

Research output: Contribution to journalArticle

Yersinia pestis
Membrane Proteins
Siphonaptera
Proteins
Plague
46 Citations (Scopus)

Unfolded Protein Response Genes Regulated by CED-1 Are Required for Caenorhabditis elegans Innate Immunity

Haskins, K. A., Russell, J. F., Gaddis, N., Dressman, H. K. & Aballay, A., Jul 8 2008, In : Developmental Cell. 15, 1, p. 87-97 11 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Caenorhabditis elegans
Innate Immunity
Genes
Pathogens
2007
4 Citations (Scopus)

Study of the role of CCR5 in a mouse model of intranasal challenge with Yersinia pestis

Styer, K. L., Click, E. M., Hopkins, G. W., Frothingham, R. & Aballay, A., Jul 1 2007, In : Microbes and Infection. 9, 9, p. 1135-1138 4 p.

Research output: Contribution to journalArticle

Yersinia Infections
Yersinia pestis
Chemokine CCL5
Smallpox
Plague
2006
60 Citations (Scopus)

GATA transcription factor required for immunity to bacterial and fungal pathogens

Kerry, S., TeKippe, M., Gaddis, N. C. & Aballay, A., Dec 20 2006, In : PLoS One. 1, 1, e77.

Research output: Contribution to journalArticle

GATA Transcription Factors
Pathogens
Immunity
Transcription Factors
Salmonella enterica
32 Citations (Scopus)

Heat shock and genetic activation of HSF-1 enhance immunity to bacteria

Singh, V. & Aballay, A., Nov 1 2006, In : Cell Cycle. 5, 21, p. 2443-2446 4 p.

Research output: Contribution to journalReview article

Immunity
Shock
Hot Temperature
Bacteria
Caenorhabditis elegans
119 Citations (Scopus)
Caenorhabditis elegans
Immunity
Yersinia pestis
Pattern Recognition Receptors
Architectural Accessibility
21 Citations (Scopus)

The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis

Burton, E. A., Pendergast, A. M. & Aballay, A., Jul 1 2006, In : Applied and Environmental Microbiology. 72, 7, p. 5043-5051 9 p.

Research output: Contribution to journalArticle

Shigella flexneri
Caenorhabditis elegans
virulence
Protein-Tyrosine Kinases
tyrosine
2005
96 Citations (Scopus)

Worms and flies as genetically tractable animal models to study host-pathogen interactions

Mylonakis, E. & Aballay, A., Jul 1 2005, In : Infection and Immunity. 73, 7, p. 3833-3841 9 p.

Research output: Contribution to journalShort survey

Host-Pathogen Interactions
Genetically Modified Animals
Caenorhabditis elegans
Gene Expression Profiling
Virulence Factors
31 Citations (Scopus)

Yersinia pestis kills Caenorhabditis elegans by a biofilm-independent process that involves novel virulence factors

Styer, K. L., Hopkins, G. W., Bartra, S. S., Plano, G. V., Frothingham, R. & Aballay, A., Oct 1 2005, In : EMBO Reports. 6, 10, p. 992-997 6 p.

Research output: Contribution to journalArticle

Yersinia pestis
Caenorhabditis elegans
Biofilms
Virulence Factors
Genes
2004
103 Citations (Scopus)

Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions

Tenor, J. L., McCormick, B. A., Ausubel, F. M. & Aballay, A., Jun 8 2004, In : Current Biology. 14, 11, p. 1018-1024 7 p.

Research output: Contribution to journalArticle

Host-Pathogen Interactions
Salmonella
Salmonella enterica
host-pathogen relationships
Caenorhabditis elegans
2003
119 Citations (Scopus)

Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway

Aballay, A., Drenkard, E., Hilbun, L. R. & Ausubel, F. M., Jan 8 2003, In : Current Biology. 13, 1, p. 47-52 6 p.

Research output: Contribution to journalArticle

Salmonella
Salmonella enterica
Caenorhabditis elegans
Cell death
Mitogen-Activated Protein Kinases
2002
112 Citations (Scopus)

Caenorhabditis elegans as a host for the study of host-pathogen interactions

Aballay, A. & Ausubel, F. M., Jan 1 2002, In : Current Opinion in Microbiology. 5, 1, p. 97-101 5 p.

Research output: Contribution to journalReview article

Host-Pathogen Interactions
Caenorhabditis elegans
Virulence
Clone Cells
2001
147 Citations (Scopus)
Caenorhabditis elegans
Salmonella typhimurium
Cell Death
Gonads
Germ Cells
2000
30 Citations (Scopus)

A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion

Hoffenberg, S., Liu, X., Nikolova, L., Hall, H. S., Dai, W., Baughn, R. E., Dickey, B. F., Barbieri, M. A., Aballay, A., Stahl, P. D. & Knoll, B. J., Aug 11 2000, In : Journal of Biological Chemistry. 275, 32, p. 24661-24669 9 p.

Research output: Contribution to journalArticle

rab5 GTP-Binding Proteins
Endosomes
Fusion reactions
Membranes
Proteins
121 Citations (Scopus)

Intracellular trafficking of Brucella abortus in J774 macrophages

Arenas, G. N., Staskevich, A. S., Aballay, A. & Mayorga, L. S., Jul 1 2000, In : Infection and Immunity. 68, 7, p. 4255-4263 9 p.

Research output: Contribution to journalArticle

Brucella abortus
Phagosomes
Macrophages
Bacteria
Lysosomes
233 Citations (Scopus)

Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegans

Aballay, A., Yorgey, P. & Ausubel, F. M., Nov 30 2000, In : Current Biology. 10, 23, p. 1539-1542 4 p.

Research output: Contribution to journalArticle

Salmonella
Caenorhabditis elegans
Salmonella typhimurium
Salmonella Typhimurium
Escherichia coli
1999
21 Citations (Scopus)

Phorbol ester promotes endocytosis by activating a factor involved in endosome fusion

Aballay, A., Stahl, P. D. & Mayorga, L. S., Sep 2 1999, In : Journal of Cell Science. 112, 15, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

Endosomes
Phorbol Esters
Endocytosis
Zinc
Transport Vesicles
1998
3 Citations (Scopus)

A phorbol ester-binding protein is required downstream of Rab5 in endosome fusion

Aballay, A., Barbieri, M. A., Colombo, M. I., Arenas, G. N., Stahl, P. D. & Mayorga, L. S., Dec 28 1998, In : FEBS Letters. 441, 3, p. 373-378 6 p.

Research output: Contribution to journalArticle

Endosomes
Fusion reactions
Phorbol Esters
rab5 GTP-Binding Proteins
Zinc
1997
6 Citations (Scopus)

A factor with a zinc- and phorbol ester-binding domain is necessary for endosome fusion

Aballay, A., Arenas, N. G., Quest, A. F. G. & Mayorga, L. S., Aug 25 1997, In : Experimental Cell Research. 235, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Endosomes
Phorbol Esters
Protein Kinase C
Zinc
Cysteine