Afam Okoye

Research Assistant Professor

  • 887 Citations
  • 11 h-Index
20032019

Research output per year

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Research Output

  • 887 Citations
  • 11 h-Index
  • 16 Article
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Article
2019

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Bender, A. M., Simonetti, F. R., Kumar, M. R., Fray, E. J., Bruner, K. M., Timmons, A. E., Tai, K. Y., Jenike, K. M., Antar, A. A. R., Liu, P. T., Ho, Y. C., Raugi, D. N., Seydi, M., Gottlieb, G. S., Okoye, A., Del Prete, G. Q., Picker, L., Mankowski, J. L., Lifson, J. D., Siliciano, J. D. & 4 others, Laird, G. M., Barouch, D. H., Clements, J. E. & Siliciano, R. F., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 73-85.e4

Research output: Contribution to journalArticle

5 Scopus citations
2018

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A., Hansen, S., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M., Picker, L. & Lifson, J. D., Sep 1 2018, In : Nature Medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Thompson, H. L., Smithey, M. J., Uhrlaub, J. L., Jeftić, I., Jergović, M., White, S. E., Currier, N., Lang, A. M., Okoye, A., Park, B., Picker, L., Surh, C. D. & Nikolich-Žugich, J., Jan 1 2018, (Accepted/In press) In : Aging Cell. e12865.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome

Rasmussen, T. A., McMahon, J., Chang, J. J., Symons, J., Roche, M., Dantanarayana, A., Okoye, A., Hiener, B., Palmer, S., Lee, W. S., Kent, S. J., Van Der Weyden, C., Prince, H. M., Cameron, P. U. & Lewin, S. R., Aug 24 2017, In : AIDS. 31, 13, p. 1839-1845 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Wake me up before you go: A strategy to reduce the latent HIV reservoir

Chomont, N., Okoye, A., Favre, D. & Trautmann, L., Nov 10 2017, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques

Degottardi, M. Q., Okoye, A., Vaidya, M., Talla, A., Konfe, A. L., Reyes, M. D., Clock, J. A., Duell, D. M., Legasse, A. W., Sabnis, A., Park, B., Axthelm, M., Estes, J., Reiman, K. A., Sekaly, R. P. & Picker, L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1183-1198 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. & 2 others, Lifson, J. D. & Picker, L., 2015, In : Nature Medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

257 Scopus citations

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A., Sammader, P., Legasse, A. W., Park, B., Axthelm, M., Nikolich-Žugich, J. & Picker, L., Nov 1 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

CD4+ T-Cell Depletion In Hiv Infection: Mechanisms Of Immunological Failure

Okoye, A. & Picker, L., Jul 2013, In : Immunological Reviews. 254, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

145 Scopus citations
2012

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B., Piatak, M., Lifson, J. D., Axthelm, M. & Picker, L., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2009

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M., Schmitz, J. E. & Picker, L., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

Erratum: Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection (Journal of Experimental Medicine (September 3, 2007) 204, 9, (2171-2185))

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M., Grossman, Z. & Picker, L., Oct 1 2007, In : Journal of Experimental Medicine. 204, 10, p. 2493 1 p.

Research output: Contribution to journalArticle

Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M., Grossman, Z. & Picker, L., Sep 3 2007, In : Journal of Experimental Medicine. 204, 9, p. 2171-2185 15 p.

Research output: Contribution to journalArticle

202 Scopus citations
2005

Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2

Okoye, A., Cordano, P., Taylor, E. R., Morgan, I. M., Everett, R. & Campo, M. S., Mar 2005, In : Virus Research. 108, 1-2, p. 1-14 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2003

A Novel RGD-independent Cell Adhesion Pathway Mediated by Fibronectin-bound Tissue Transglutaminase Rescues Cells from Anoikis

Verderio, E. A. M., Telci, D., Okoye, A., Melino, G. & Griffin, M., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 42604-42614 11 p.

Research output: Contribution to journalArticle

104 Scopus citations