Afam Okoye

Research Assistant Professor

  • 863 Citations
  • 11 h-Index
20032019
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Research Output 2003 2019

  • 863 Citations
  • 11 h-Index
  • 16 Article
2019
3 Citations (Scopus)

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Bender, A. M., Simonetti, F. R., Kumar, M. R., Fray, E. J., Bruner, K. M., Timmons, A. E., Tai, K. Y., Jenike, K. M., Antar, A. A. R., Liu, P. T., Ho, Y. C., Raugi, D. N., Seydi, M., Gottlieb, G. S., Okoye, A., Del Prete, G. Q., Picker, L., Mankowski, J. L., Lifson, J. D., Siliciano, J. D. & 4 others, Laird, G. M., Barouch, D. H., Clements, J. E. & Siliciano, R. F., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 73-85.e4

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
HIV-2
Viral Genome
HIV Infections
Genome
2018
14 Citations (Scopus)

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound

Okoye, A., Hansen, S., Vaidya, M., Fukazawa, Y., Park, H., Duell, D. M., Lum, R., Hughes, C. M., Ventura, A. B., Ainslie, E., Ford, J. C., Morrow, D., Gilbride, R. M., Legasse, A. W., Hesselgesser, J., Geleziunas, R., Li, Y., Oswald, K., Shoemaker, R., Fast, R. & 6 others, Bosche, W. J., Borate, B. R., Edlefsen, P. T., Axthelm, M., Picker, L. & Lifson, J. D., Sep 1 2018, In : Nature Medicine. 24, 9, p. 1430-1440 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Secondary Prevention
Viruses
Cytomegalovirus
Macaca mulatta
5 Citations (Scopus)

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Thompson, H. L., Smithey, M. J., Uhrlaub, J. L., Jeftić, I., Jergović, M., White, S. E., Currier, N., Lang, A. M., Okoye, A., Park, B., Picker, L., Surh, C. D. & Nikolich-Žugich, J., Jan 1 2018, (Accepted/In press) In : Aging Cell. e12865.

Research output: Contribution to journalArticle

Rejuvenation
Primates
Lymph Nodes
T-Lymphocytes
Fibroblast Growth Factor 7
2017
5 Citations (Scopus)

Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome

Rasmussen, T. A., McMahon, J., Chang, J. J., Symons, J., Roche, M., Dantanarayana, A., Okoye, A., Hiener, B., Palmer, S., Lee, W. S., Kent, S. J., Van Der Weyden, C., Prince, H. M., Cameron, P. U. & Lewin, S. R., Aug 24 2017, In : AIDS. 31, 13, p. 1839-1845 7 p.

Research output: Contribution to journalArticle

Sezary Syndrome
HIV
T-Lymphocytes
Therapeutics
DNA
1 Citation (Scopus)

Wake me up before you go: A strategy to reduce the latent HIV reservoir

Chomont, N., Okoye, A., Favre, D. & Trautmann, L., Nov 10 2017, (Accepted/In press) In : AIDS.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
Computer Simulation
Primates
Shock
2016
15 Citations (Scopus)

Effect of anti-IL-15 administration on T Cell and NK cell homeostasis in rhesus macaques

Degottardi, M. Q., Okoye, A., Vaidya, M., Talla, A., Konfe, A. L., Reyes, M. D., Clock, J. A., Duell, D. M., Legasse, A. W., Sabnis, A., Park, B., Axthelm, M., Estes, J., Reiman, K. A., Sekaly, R. P. & Picker, L., Aug 15 2016, In : Journal of Immunology. 197, 4, p. 1183-1198 16 p.

Research output: Contribution to journalArticle

Interleukin-15
Macaca mulatta
Natural Killer Cells
Homeostasis
T-Lymphocytes
2015
248 Citations (Scopus)

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Fukazawa, Y., Lum, R., Okoye, A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., Morcock, D., Swanson, T., Legasse, A. W., Axthelm, M., Hesselgesser, J., Geleziunas, R., Hirsch, V. M., Edlefsen, P. T., Piatak, M., Estes, J. & 2 others, Lifson, J. D. & Picker, L., 2015, In : Nature Medicine. 21, 2, p. 132-139 8 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Viruses
B-Lymphocytes
T-cells
13 Citations (Scopus)

Effect of IL-7 therapy on naive and memory T cell homeostasis in aged rhesus macaques

Okoye, A., Rohankhedkar, M., Konfe, A. L., Abana, C. O., Reyes, M. D., Clock, J. A., Duell, D. M., Sylwester, A., Sammader, P., Legasse, A. W., Park, B., Axthelm, M., Nikolich-Žugich, J. & Picker, L., Nov 1 2015, In : Journal of Immunology. 195, 9, p. 4292-4305 14 p.

Research output: Contribution to journalArticle

Interleukin-7
Macaca mulatta
Homeostasis
T-Lymphocytes
Therapeutics
2013
141 Citations (Scopus)

CD4+ T-Cell Depletion In Hiv Infection: Mechanisms Of Immunological Failure

Okoye, A. & Picker, L., Jul 2013, In : Immunological Reviews. 254, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Infection
Opportunistic Infections
Regeneration
Population
2012
18 Citations (Scopus)

Naive T cells are dispensable for memory CD4 + T cell homeostasis in progressive simian immunodeficiency virus infection

Okoye, A., Rohankhedkar, M., Abana, C., Pattenn, A., Reyes, M., Pexton, C., Lum, R., Sylwester, A., Planer, S. L., Legasse, A., Park, B., Piatak, M., Lifson, J. D., Axthelm, M. & Picker, L., Apr 9 2012, In : Journal of Experimental Medicine. 209, 4, p. 641-651 11 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Homeostasis
T-Lymphocytes
Disease Progression
2010
27 Citations (Scopus)

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

Leone, A., Rohankhedkar, M., Okoye, A., Legasse, A., Axthelm, M., Villinger, F., Piatak, M., Lifson, J. D., Assouline, B., Morre, M., Picker, L. & Sodora, D. L., Aug 1 2010, In : Journal of Immunology. 185, 3, p. 1650-1659 10 p.

Research output: Contribution to journalArticle

Interleukin-7
Simian Immunodeficiency Virus
Macaca
T-Lymphocytes
Therapeutics
2009
56 Citations (Scopus)

Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis

Okoye, A., Park, H., Rohankhedkar, M., Coyne-Johnson, L., Lum, R., Walker, J. M., Planer, S. L., Legasse, A. W., Sylwester, A., Piatak, M., Lifson, J. D., Sodora, D. L., Villinger, F., Axthelm, M., Schmitz, J. E. & Picker, L., Jul 6 2009, In : Journal of Experimental Medicine. 206, 7, p. 1575-1588 14 p.

Research output: Contribution to journalArticle

Lymphocyte Depletion
Simian Immunodeficiency Virus
T-Lymphocytes
Virus Diseases
Macaca mulatta
2007

Erratum: Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection (Journal of Experimental Medicine (September 3, 2007) 204, 9, (2171-2185))

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M., Grossman, Z. & Picker, L., Oct 1 2007, In : Journal of Experimental Medicine. 204, 10, p. 2493 1 p.

Research output: Contribution to journalArticle

Biomedical Research
Chronic Disease
T-Lymphocytes
Infection
201 Citations (Scopus)

Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection

Okoye, A., Meier-Schellersheim, M., Brenchley, J. M., Hagen, S. I., Walker, J. M., Rohankhedkar, M., Lum, R., Edgar, J. B., Planer, S. L., Legasse, A., Sylwester, A., Piatak, M., Lifson, J. D., Maino, V. C., Sodora, D. L., Douek, D. C., Axthelm, M., Grossman, Z. & Picker, L., Sep 3 2007, In : Journal of Experimental Medicine. 204, 9, p. 2171-2185 15 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
Chronic Disease
T-Lymphocytes
Acquired Immunodeficiency Syndrome
2005
12 Citations (Scopus)

Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2

Okoye, A., Cordano, P., Taylor, E. R., Morgan, I. M., Everett, R. & Campo, M. S., Mar 2005, In : Virus Research. 108, 1-2, p. 1-14 14 p.

Research output: Contribution to journalArticle

Human papillomavirus 16
DNA Replication
Transcriptional Activation
Life Cycle Stages
Mutagenesis
2003
104 Citations (Scopus)

A Novel RGD-independent Cell Adhesion Pathway Mediated by Fibronectin-bound Tissue Transglutaminase Rescues Cells from Anoikis

Verderio, E. A. M., Telci, D., Okoye, A., Melino, G. & Griffin, M., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 42604-42614 11 p.

Research output: Contribution to journalArticle

Anoikis
Cell adhesion
Fibronectins
Cell Adhesion
Cells