Aaron Janowsky

Professor

  • 4673 Citations
  • 39 h-Index
1977 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 4673 Citations
  • 39 h-Index
  • 106 Article
  • 4 Review article
  • 1 Chapter
Filter
Article
2019

Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2

Shi, X., Swanson, T. L., Miner, N. B., Eshleman, A. J. & Janowsky, A., Oct 1 2019, In : Molecular pharmacology. 96, 4, p. 493-504 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters

Eshleman, A. J., Nagarajan, S., Wolfrum, K. M., Reed, J. F., Swanson, T. L., Nilsen, A. & Janowsky, A., Mar 1 2019, In : Psychopharmacology. 236, 3, p. 939-952 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

Stafford, A. M., Reed, C., Baba, H., Walter, N. A., Mootz, J. R., Williams, R. W., Neve, K., Fedorov, L., Janowsky, A. & Phillips, T., Jul 9 2019, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
3 Scopus citations

Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence

Loftis, J. M., Lasarev, M., Shi, X., Lapidus, J., Janowsky, A., Hoffman, W. F. & Huckans, M., Jan 1 2019, In : PloS one. 14, 10, e0220270.

Research output: Contribution to journalArticle

Open Access
2018

Characterization of the neurochemical and behavioral effects of solriamfetol (JZP-110), a selective dopamine and norepinephrine reuptake inhibitor

Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R. B., Hyman, D. L., Carter, L. P. & Janowsky, A., Aug 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 366, 2, p. 367-376 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: High potency agonists at 5-HT2A receptors

Eshleman, A. J., Wolfrum, K. M., Reed, J. F., Kim, S. O., Johnson, R. A. & Janowsky, A., Dec 1 2018, In : Biochemical Pharmacology. 158, p. 27-34 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Repurposing of a nucleoside scaffold from adenosine receptor agonists to opioid receptor antagonists

Tosh, D. K., Ciancetta, A., Mannes, P., Warnick, E., Janowsky, A., Eshleman, A. J., Gizewski, E., Brust, T. F., Bohn, L. M., Auchampach, J. A., Gao, Z. G. & Jacobson, K. A., Jan 1 2018, In : ACS Omega. 3, 10, p. 12658-12678 21 p.

Research output: Contribution to journalArticle

2 Scopus citations

Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter

Provencher, B. A., Eshleman, A. J., Johnson, R. A., Shi, X., Kryatova, O., Nelson, J., Tian, J., Gonzalez, M., Meltzer, P. C. & Janowsky, A., Oct 25 2018, In : Journal of Medicinal Chemistry. 61, 20, p. 9121-9131 11 p.

Research output: Contribution to journalArticle

2017

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters

Tosh, D. K., Janowsky, A., Eshleman, A. J., Warnick, E., Gao, Z. G., Chen, Z., Gizewski, E., Auchampach, J. A., Salvemini, D. & Jacobson, K. A., Apr 13 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 3109-3123 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

Structure-activity relationships of substituted cathinones, with transporter binding, uptake, and release

Eshleman, A. J., Wolfrum, K. M., Reed, J. F., Kim, S. O., Swanson, T., Johnson, R. A. & Janowsky, A., Jan 1 2017, In : Journal of Pharmacology and Experimental Therapeutics. 360, 1, p. 33-47 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

Trace amine-associated receptor 1 regulation of methamphetamine-induced neurotoxicity

Miner, N. B., Elmore, J. S., Baumann, M. H., Phillips, T. & Janowsky, A., Dec 1 2017, In : NeuroToxicology. 63, p. 57-69 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Verification of a genetic locus for methamphetamine intake and the impact of morphine

Eastwood, E. C., Eshleman, A. J., Janowsky, A. & Phillips, T., Nov 10 2017, (Accepted/In press) In : Mammalian Genome. p. 1-13 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Genetic polymorphisms affect mouse and human trace amine-associated receptor 1 function

Shi, X., Walter, N. A. R., Harkness, J. H., Neve, K., Williams, R. W., Lu, L., Belknap, J., Eshleman, A. J., Phillips, T. & Janowsky, A., Mar 1 2016, In : PLoS One. 11, 3, e0152581.

Research output: Contribution to journalArticle

23 Scopus citations

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

Zou, M. F., Keck, T. M., Kumar, V., Donthamsetti, P., Michino, M., Burzynski, C., Schweppe, C., Bonifazi, A., Free, R. B., Sibley, D. R., Janowsky, A., Shi, L., Javitch, J. A. & Newman, A. H., Apr 28 2016, In : Journal of Medicinal Chemistry. 59, 7, p. 2973-2988 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Rigid adenine nucleoside derivatives as novel modulators of the human sodium symporters for dopamine and norepinephrine

Janowsky, A., Tosh, D. K., Eshleman, A. J. & Jacobson, K. A., Apr 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity

Miner, N. B., O'Callaghan, J. P., Phillips, T. & Janowsky, A., Nov 10 2016, (Accepted/In press) In : Neurotoxicology and Teratology.

Research output: Contribution to journalArticle

13 Scopus citations
2015

Trace Amine-Associated Receptor 1 Regulation of Methamphetamine Intake and Related Traits

Harkness, J. H., Shi, X., Janowsky, A. & Phillips, T. J., Aug 16 2015, In : Neuropsychopharmacology. 40, 9, p. 2175-2184 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2014

Behavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: Mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function

Eshleman, A. J., Forster, M. J., Wolfrum, K. M., Johnson, R. A., Janowsky, A. & Gatch, M. B., Mar 1 2014, In : Psychopharmacology. 231, 5, p. 875-888 14 p.

Research output: Contribution to journalArticle

31 Scopus citations

Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro

Janowsky, A., Eshleman, A. J., Johnson, R. A., Wolfrum, K. M., Hinrichs, D. J., Yang, J., Zabriskie, T. M., Smilkstein, M. J. & Riscoe, M. K., Jul 2014, In : Psychopharmacology. 231, 14, p. 2771-2783 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1

Liu, X., Grandy, D. K. & Janowsky, A., Jul 2014, In : Journal of Pharmacology and Experimental Therapeutics. 350, 1, p. 124-129 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Effect of Iboga Alkaloids on μ-Opioid Receptor-Coupled G Protein Activation

Antonio, T., Childers, S. R., Rothman, R. B., Dersch, C. M., King, C., Kuehne, M., Bornmann, W. G., Eshleman, A. J., Janowsky, A., Simon, E. R., Reith, M. E. A. & Alper, K., Oct 16 2013, In : PloS one. 8, 10, e77262.

Research output: Contribution to journalArticle

20 Scopus citations

Substituted methcathinones differ in transporter and receptor interactions

Eshleman, A. J., Wolfrum, K. M., Hatfield, M. G., Johnson, R. A., Murphy, K. V. & Janowsky, A., May 2 2013, In : Biochemical Pharmacology. 85, 12, p. 1803-1815 13 p.

Research output: Contribution to journalArticle

123 Scopus citations
2012

Formylated polyamines as peptidomimetics

Javor, S., Janowsky, A., Johnson, R., Wolfrum, K., Tadayoni-Rebek, M. & Rebek, J., Nov 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 21, p. 6580-6582 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Melittin initiates dopamine transporter internalization and recycling in transfected HEK-293 cells

Keith, D. J., Wolfrum, K., Eshleman, A. J. & Janowsky, A., Sep 5 2012, In : European Journal of Pharmacology. 690, 1-3, p. 13-21 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Substituted heteroaromatic compounds: Effect on nicotine self-administration in rats

Cashman, J. R., Okolotowicz, K., Cerny, M., Johnson, R., Janowsky, A. & Azar, M. R., Jun 1 2012, In : Psychopharmacology. 221, 4, p. 637-648 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2011

Abuse liability profile of three substituted tryptamines

Gatch, M. B., Forster, M. J., Janowsky, A. & Eshleman, A. J., Jul 1 2011, In : Journal of Pharmacology and Experimental Therapeutics. 338, 1, p. 280-289 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
7 Scopus citations

The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes

Purushotham, M., Sheri, A., Pham-Huu, D. P., Madras, B. K., Janowsky, A. & Meltzer, P. C., Jan 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 1, p. 48-51 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

2,5-Disubstituted tetrahydrofurans as selective serotonin re-uptake inhibitors

Voelker, T., Xia, H., Fandrick, K., Johnson, R., Janowsky, A. & Cashman, J. R., Mar 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 5, p. 2047-2068 22 p.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of dual function acridones as a new antimalarial chemotype

Kelly, J. X., Smilkstein, M. J., Brun, R., Wittlin, S., Cooper, R. A., Lane, K. D., Janowsky, A., Johnson, R. A., Dodean, R. A., Winter, R., Hinrichs, D. J. & Riscoe, M. K., May 14 2009, In : Nature. 459, 7244, p. 270-273 4 p.

Research output: Contribution to journalArticle

138 Scopus citations

Genetically correlated effects of selective breeding for high and low methamphetamine consumption

Wheeler, J. M., Reed, C., Burkhart-Kasch, S., Li, N., Cunningham, C. L., Janowsky, A., Franken, F. H., Wiren, K. M., Hashimoto, J. G., Scibelli, A. C. & Phillips, T. J., Nov 1 2009, In : Genes, Brain and Behavior. 8, 8, p. 758-771 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression

Cashman, J. R., Voelker, T., Johnson, R. & Janowsky, A., Jan 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 1, p. 337-343 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2008

Lobeline effects on tonic and methamphetamine-induced dopamine release

Wilhelm, C. J., Johnson, R. A., Eshleman, A. J. & Janowsky, A., Mar 15 2008, In : Biochemical Pharmacology. 75, 6, p. 1411-1415 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

The synthesis of bivalent 2β-carbomethoxy-3β-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters

Meltzer, P. C., Kryatova, O., Pham-Huu, D. P., Donovan, P. & Janowsky, A., Feb 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 4, p. 1832-1841 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain

Basile, A. S., Janowsky, A., Golembiowska, K., Kowalska, M., Tam, E., Benveniste, M., Popik, P., Nikiforuk, A., Krawczyk, M., Nowak, G., Krieter, P. A., Lippa, A. S., Skolnick, P. & Koustova, E., Jun 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 321, 3, p. 1208-1225 18 p.

Research output: Contribution to journalArticle

48 Scopus citations

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum

Kelly, J. X., Smilkstein, M. J., Cooper, R. A., Lane, K. D., Johnson, R. A., Janowsky, A., Dodean, R. A., Hinrichs, D. J., Winter, R. & Riscoe, M., Nov 1 2007, In : Antimicrobial agents and chemotherapy. 51, 11, p. 4133-4140 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter

Froimowitz, M., Gu, Y., Dakin, L. A., Nagafuji, P. M., Kelley, C. J., Parrish, D., Deschamps, J. R. & Janowsky, A., Jan 25 2007, In : Journal of Medicinal Chemistry. 50, 2, p. 219-232 14 p.

Research output: Contribution to journalArticle

29 Scopus citations
2006

Hydrogen ion concentration differentiates effects of methamphetamine and dopamine on transporter-mediated efflux

Wilhelm, C. J., Johnson, R. A., Eshleman, A. J. & Janowsky, A., Feb 1 2006, In : Journal of Neurochemistry. 96, 4, p. 1149-1159 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677

Popik, P., Krawczyk, M., Golembiowska, K., Nowak, G., Janowsky, A., Skolnick, P., Lippa, A. & Basile, A. S., Jul 1 2006, In : Cellular and Molecular Neurobiology. 26, 4-6, p. 857-873 17 p.

Research output: Contribution to journalArticle

35 Scopus citations
2004

Effects of methamphetamine and lobeline on vesicular monoamine and dopamine transporter-mediated dopamine release in a cotransfected model system

Wilhelm, C. J., Johnson, R. A., Lysko, P. G., Eshleman, A. J. & Janowsky, A., Sep 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 310, 3, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2003

Antidepressant-like actions of DOV 21,947: A "triple" reuptake inhibitor

Skolnick, P., Popik, P., Janowsky, A., Beer, B. & Lippa, A. S., Feb 14 2003, In : European Journal of Pharmacology. 461, 2-3, p. 99-104 6 p.

Research output: Contribution to journalArticle

129 Scopus citations

Bivalent biogenic amine reuptake inhibitors

Fandrick, K., Feng, X., Janowsky, A., Johnson, R. & Cashman, J. R., Jul 7 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 13, p. 2151-2154 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques

Lu, N. Z., Eshleman, A. J., Janowsky, A. & Bethea, C. L., Jun 25 2003, In : Molecular Psychiatry. 8, 3, p. 353-360 8 p.

Research output: Contribution to journalArticle

94 Scopus citations

Syntheses of 3-carbomethoxy-4-(aryl)piperidines and in vitro and in vivo pharmacological evaluation: Identification of inhibitors of the human dopamine transporter

Feng, X., Fandrick, K., Johnson, R., Janowsky, A. & Cashman, J. R., Mar 1 2003, In : Bioorganic and Medicinal Chemistry. 11, 5, p. 775-780 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

The niacin skin flush abnormality in schizophrenia: A quantitative dose-response study

Messamore, E., Hoffman, W. F. & Janowsky, A., Aug 1 2003, In : Schizophrenia Research. 62, 3, p. 251-258 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2- propylaminopentane

Shimazu, S., Tsunekawa, H., Yoneda, F., Katsuki, H., Akaike, A. & Janowsky, A., Dec 15 2003, In : European Journal of Pharmacology. 482, 1-3, p. 9-16 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2002
28 Scopus citations

Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter

Houlihan, W. J., Kelly, L., Pankuch, J., Koletar, J., Brand, L., Janowsky, A. & Kopajtic, T. A., Sep 12 2002, In : Journal of Medicinal Chemistry. 45, 19, p. 4097-4109 13 p.

Research output: Contribution to journalArticle

27 Scopus citations