Research Output 1987 2019

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2009
52 Citations (Scopus)

Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of μ-opioid receptors in CNS neurons

Yu, Y. J., Arttamangkul, S., Evans, C. J., Williams, J. & Von Zastrow, M., Jan 7 2009, In : Journal of Neuroscience. 29, 1, p. 222-233 12 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Opioid Receptors
Endocytosis
Morphine
Neurons
73 Citations (Scopus)

New sites of action for GIRK and SK channels

Luján, R., Maylie, J. & Adelman, J., Jul 2009, In : Nature Reviews Neuroscience. 10, 7, p. 475-480 6 p.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
GTP-Binding Proteins
Post-Synaptic Density
Dendritic Spines
Proteins
295 Citations (Scopus)

Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

Ballas, N., Lioy, D. T., Grunseich, C. & Mandel, G., Mar 2009, In : Nature Neuroscience. 12, 3, p. 311-317 7 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
Neuroglia
Neurons
Astrocytes
292 Citations (Scopus)

Pore architecture and ion sites in acid-sensing ion channels and P2X receptors

Gonzales, E. B., Kawate, T. & Gouaux, E., Jul 30 2009, In : Nature. 460, 7255, p. 599-604 6 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Ion Channels
Ions
FMRFamide
Epithelial Sodium Channels
40 Citations (Scopus)

Presynaptically expressed long-term potentiation increases multivesicular release at parallel fiber synapses

Bender, V. A., Pugh, J. R. & Jahr, C., Sep 2 2009, In : Journal of Neuroscience. 29, 35, p. 10974-10978 5 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Synapses
Interneurons
Presynaptic Receptors
Purinergic P1 Receptors
18 Citations (Scopus)

Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J., Mikkelsen, J. D. & Mirza, N. R., Sep 29 2009, In : Neuroscience. 163, 1, p. 73-81 9 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Brain-Derived Neurotrophic Factor
Messenger RNA
Doxycycline
Parahippocampal Gyrus
36 Citations (Scopus)

Selective expression of ligand-gated ion channels in L5 pyramidal cell axons

Christie, J. M. & Jahr, C., Sep 16 2009, In : Journal of Neuroscience. 29, 37, p. 11441-11450 10 p.

Research output: Contribution to journalArticle

Ligand-Gated Ion Channels
Pyramidal Cells
N-Methyl-D-Aspartate Receptors
Axons
Visual Cortex
27 Citations (Scopus)

SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells

Murthy, V., Maison, S. F., Taranda, J., Haque, N., Bond, C. T., Elgoyhen, A. B., Adelman, J., Liberman, M. C. & Vetter, D. E., Jan 5 2009, In : Molecular and Cellular Neuroscience. 40, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Synapses
Auditory Hair Cells
Down-Regulation
Genes
212 Citations (Scopus)

Structure and mechanism of a Na+-independent amino acid transporter

Shaffer, P. L., Goehring, A., Shankaranarayanan, A. & Gouaux, E., 2009, In : Science. 325, 5943, p. 1010-1014 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Protons
Lysine
Amines
Sodium
21 Citations (Scopus)
Synaptic Vesicles
Exocytosis
Rats
Egtazic Acid
Buffers
37 Citations (Scopus)
Neurotransmitter Transport Proteins
neurotransmitters
Synapses
Neurotransmitter Agents
transporters
42 Citations (Scopus)

The time course of dopamine transmission in the ventral tegmental area

Ford, C. P., Phillips, P. E. M. & Williams, J., Oct 21 2009, In : Journal of Neuroscience. 29, 42, p. 13344-13352 9 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Dopamine
G-Protein-Coupled Receptors
Mesencephalon
Potassium Channels
104 Citations (Scopus)

The unitary event underlying multiquantal EPSCs at a hair cell's ribbon synapse

Li, G. L., Keen, E., Andor-Ardó, D., Hudspeth, A. J. & Von Gersdorff, H., Jun 10 2009, In : Journal of Neuroscience. 29, 23, p. 7558-7568 11 p.

Research output: Contribution to journalArticle

Synapses
AMPA Receptors
Membranes
Synaptic Vesicles
Exocytosis
4 Citations (Scopus)

Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Kim, J. H. & Von Gersdorff, H., Jul 30 2009, In : Neuron. 63, 2, p. 143-145 3 p.

Research output: Contribution to journalArticle

Endocytosis
Synaptic Vesicles
Exocytosis
Catalytic Domain
Neurons
241 Citations (Scopus)

Unlocking the molecular secrets of sodium-coupled transporters

Krishnamurthy, H., Piscitelli, C. L. & Gouaux, E., May 21 2009, In : Nature. 459, 7245, p. 347-355 9 p.

Research output: Contribution to journalArticle

Sodium
Physiological Phenomena
Ions
Membranes
679 Citations (Scopus)

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

Sobolevsky, A. I., Rosconi, M. P. & Gouaux, E., Dec 10 2009, In : Nature. 462, 7274, p. 745-756 12 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Glutamate Receptors
Ion Channels
X-Rays
Ionotropic Glutamate Receptors
2008
298 Citations (Scopus)

A competitive inhibitor traps LeuT in an open-to-out conformation

Singh, S. K., Piscitelli, C. L., Yamashita, A. & Gouaux, E., Dec 12 2008, In : Science. 322, 5908, p. 1655-1661 7 p.

Research output: Contribution to journalArticle

tryptophan-leucine
Leucine
Plasma Membrane Neurotransmitter Transport Proteins
Ions
Aspartic Acid
82 Citations (Scopus)

A genome-wide screen for β-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression

Yochum, G. S., Cleland, R. & Goodman, R., Dec 2008, In : Molecular and Cellular Biology. 28, 24, p. 7368-7379 12 p.

Research output: Contribution to journalArticle

Catenins
myc Genes
Binding Sites
Genome
Gene Expression
39 Citations (Scopus)

Agonist-specific regulation of μ-opioid receptor desensitization and recovery from desensitization

Virk, M. S. & Williams, J., Apr 2008, In : Molecular Pharmacology. 73, 4, p. 1301-1308 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Opioid Analgesics
Oxycodone
Enkephalins
Oxymorphone
410 Citations (Scopus)

An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP

Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H. Y. M., Marks, D., Obrietan, K., Soderling, T., Goodman, R. & Impey, S., Jul 1 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 26, p. 9093-9098 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Dendrites
Cyclic AMP Response Element-Binding Protein
Gene Regulatory Networks
Growth
15 Citations (Scopus)

Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit

Stackman, R. W., Bond, C. T. & Adelman, J., Apr 2008, In : Learning and Memory. 15, 4, p. 208-213 6 p.

Research output: Contribution to journalArticle

Memory Disorders
Neuronal Plasticity
Apamin
Calcium-Activated Potassium Channels
Transgenic Mice
223 Citations (Scopus)

Control of KCa Channels by Calcium Nano/Microdomains

Fakler, B. & Adelman, J., Sep 25 2008, In : Neuron. 59, 6, p. 873-881 9 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Cell Physiological Phenomena
Calcium Channels
Ions
Neurons
54 Citations (Scopus)

Co-transmission of dopamine and GABA in periglomerular cells

Maher, B. J. & Westbrook, G., Mar 2008, In : Journal of Neurophysiology. 99, 3, p. 1559-1564 6 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Dopamine
Olfactory Receptor Neurons
Tyrosine
Excitatory Postsynaptic Potentials
62 Citations (Scopus)

CRF Facilitates Calcium Release from Intracellular Stores in Midbrain Dopamine Neurons

Riegel, A. C. & Williams, J., Feb 28 2008, In : Neuron. 57, 4, p. 559-570 12 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Corticotropin-Releasing Hormone
Mesencephalon
Calcium
Neuronal Plasticity
64 Citations (Scopus)

Dendritic NMDA Receptors Activate Axonal Calcium Channels

Christie, J. M. & Jahr, C., Oct 23 2008, In : Neuron. 60, 2, p. 298-307 10 p.

Research output: Contribution to journalArticle

Calcium Channels
N-Methyl-D-Aspartate Receptors
Axons
Monovalent Cations
Interneurons
78 Citations (Scopus)

Differential activation and trafficking of μ-opioid receptors in brain slices

Arttamangkul, S., Quillinan, N., Low, M. J., Von Zastrow, M., Pintar, J. & Williams, J., Oct 2008, In : Molecular Pharmacology. 74, 4, p. 972-979 8 p.

Research output: Contribution to journalArticle

Opioid Receptors
Enkephalins
Brain
Neurons
Epitopes
37 Citations (Scopus)

Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D

Luvisetto, S., Basso, E., Petronilli, V., Bernardi, P. & Forte, M., Aug 26 2008, In : Neuroscience. 155, 3, p. 585-596 12 p.

Research output: Contribution to journalArticle

Avoidance Learning
Anxiety
Obesity
White Adipose Tissue
cyclophilin D
28 Citations (Scopus)

Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells

Kong, J. H., Adelman, J. & Fuchs, P. A., Nov 15 2008, In : Journal of Physiology. 586, 22, p. 5471-5485 15 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Calcium-Activated Potassium Channels
Cholinergic Receptors
Outer Auditory Hair Cells
Inner Auditory Hair Cells
68 Citations (Scopus)

Functional roles of a Ca2+ -activated K+ channel in atrioventricular nodes

Zhang, Q., Timofeyev, V., Lu, L., Li, N., Singapuri, A., Long, M. K., Bond, C. T., Adelman, J. & Chiamvimonvat, N., Feb 2008, In : Circulation Research. 102, 4, p. 465-471 7 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Atrioventricular Node
Ion Channels
Action Potentials
Cardiac Arrhythmias
16 Citations (Scopus)

Function of neuromuscular synapses in the zebrafish choline- acetyltransferase mutant bajan

Wang, M., Wen, H. & Brehm, P., Oct 2008, In : Journal of Neurophysiology. 100, 4, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Choline O-Acetyltransferase
Zebrafish
Synapses
Fatigue
Acetylcholine
15 Citations (Scopus)

Heterogeneous Ca2+ influx along the adult calyx of held: A structural and computational study

Spirou, G. A., Chirila, F. V., Von Gersdorff, H. & Manis, P. B., Jun 12 2008, In : Neuroscience. 154, 1, p. 171-185 15 p.

Research output: Contribution to journalArticle

Action Potentials
Ion Channels
Evoked Potentials
Synapses
Axons
178 Citations (Scopus)

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

Chiara, F., Castellaro, D., Marin, O., Petronilli, V., Brusilow, W. S., Juhaszova, M., Sollott, S. J., Forte, M., Bernardi, P. & Rasola, A., Mar 19 2008, In : PLoS One. 3, 3, e1852.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Mitochondria
Hexokinase
hexokinase
anions
4 Citations (Scopus)

Mesoprefrontal Dopamine Neurons Distinguish Themselves

Ford, C. P. & Williams, J., Mar 13 2008, In : Neuron. 57, 5, p. 631-632 2 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Ventral Tegmental Area
Dopamine
Neurons
30 Citations (Scopus)

Morphine produces circuit-specific neuroplasticity in the bed nucleus of the stria terminalis

Dumont, É. C., Rycroft, B. K., Maiz, J. & Williams, J., Apr 22 2008, In : Neuroscience. 153, 1, p. 232-239 8 p.

Research output: Contribution to journalArticle

Septal Nuclei
Neuronal Plasticity
Morphine
Neurons
Ventral Tegmental Area
50 Citations (Scopus)

Neurotransmitter Modulation of Small-Conductance Ca2+-Activated K+ Channels by Regulation of Ca2+ Gating

Maingret, F., Coste, B., Hao, J., Giamarchi, A., Allen, D., Crest, M., Litchfield, D. W., Adelman, J. & Delmas, P., Aug 14 2008, In : Neuron. 59, 3, p. 439-449 11 p.

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Calmodulin
Neurotransmitter Agents
Casein Kinase II
Protein Phosphatase 2
73 Citations (Scopus)

Neurotrophin-dependent dendritic filopodial motility: A convergence on PI3K signaling

Luikart, B. W., Zhang, W., Wayman, G. A., Kwon, C. H., Westbrook, G. & Parada, L. F., Jul 2 2008, In : Journal of Neuroscience. 28, 27, p. 7006-7012 7 p.

Research output: Contribution to journalArticle

Pseudopodia
1-Phosphatidylinositol 4-Kinase
Nerve Growth Factors
Receptor Protein-Tyrosine Kinases
Brain-Derived Neurotrophic Factor
123 Citations (Scopus)

Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation

Basso, E., Petronilli, V., Forte, M. & Bernardi, P., Sep 26 2008, In : Journal of Biological Chemistry. 283, 39, p. 26307-26311 5 p.

Research output: Contribution to journalArticle

Ablation
Cyclosporine
Vanadates
Permeability
Phosphates
18 Citations (Scopus)

Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: A study of GIRK-knockout mice

Torrecilla, M., Quillinan, N., Williams, J. & Wickman, K., Aug 2008, In : European Journal of Neuroscience. 28, 3, p. 618-624 7 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Knockout Mice
Morphine
Neurons
Opioid Analgesics
15 Citations (Scopus)

Protein kinase C modulates synaptic vesicle acidification in a ribbon type nerve terminal in the retina

Abreu, B. J., Guimarães, M., Uliana, L. C., Vigh, J., Von Gersdorff, H., Prado, M. A. & Guatimosim, C., Nov 2008, In : Neurochemistry International. 53, 5, p. 155-164 10 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Protein Kinase C
Retina
Fluorescence
Retinal Bipolar Cells
41 Citations (Scopus)

Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2

Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T. J., Shinde, U. & Stork, P., Dec 2008, In : Molecular and Cellular Biology. 28, 23, p. 7109-7125 17 p.

Research output: Contribution to journalArticle

Cyclic AMP
Guanine Nucleotide Exchange Factors
Monomeric GTP-Binding Proteins
PC12 Cells
Exocytosis
35 Citations (Scopus)

Release of the styryl dyes from single synaptic vesicles in hippocampal neurons

Chen, X., Barg, S. & Almers, W., Feb 20 2008, In : Journal of Neuroscience. 28, 8, p. 1894-1903 10 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Coloring Agents
Exocytosis
Neurons
Signal-To-Noise Ratio
140 Citations (Scopus)

SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses

Lin, M. T., Luján, R., Watanabe, M., Adelman, J. & Maylie, J., Feb 2008, In : Nature Neuroscience. 11, 2, p. 170-177 8 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Synapses
Hippocampus
AMPA Receptors
Excitatory Postsynaptic Potentials
26 Citations (Scopus)

SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors

Jacobsen, J. P. R., Weikop, P., Hansen, H. H., Mikkelsen, J. D., Redrobe, J. P., Holst, D., Bond, C. T., Adelman, J., Christophersen, P. & Mirza, N. R., Nov 2008, In : Genes, Brain and Behavior. 7, 8, p. 836-848 13 p.

Research output: Contribution to journalArticle

Dopamine
Serotonin
Synaptic Transmission
Hindlimb Suspension
Corpus Striatum
34 Citations (Scopus)

Small-conductance, Ca2+-activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder

Thorneloe, K. S., Knorn, A. M., Doetsch, P. E., Lashinger, E. S. R., Liu, A. X., Bond, C. T., Adelman, J. & Nelson, M. T., May 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 5

Research output: Contribution to journalArticle

Calcium-Activated Potassium Channels
Urinary Bladder
Apamin
Smooth Muscle
Galactosidases
22 Citations (Scopus)

Synaptic homeostasis in a zebrafish glial glycine transporter mutant

Mongeon, R., Gleason, M. R., Masino, M. A., Fetcho, J. R., Mandel, G., Brehm, P. & Dallman, J. E., Oct 2008, In : Journal of Neurophysiology. 100, 4, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

Glycine Plasma Membrane Transport Proteins
Zebrafish
Neuroglia
Glycine
Homeostasis
99 Citations (Scopus)

Synaptic vesicle endocytosis: fast and slow modes of membrane retrieval

Smith, S., Renden, R. & Von Gersdorff, H., Nov 2008, In : Trends in Neurosciences. 31, 11, p. 559-568 10 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Endocytosis
Exocytosis
Membranes
Flicker Fusion
43 Citations (Scopus)

The pool of fast releasing vesicles is augmented by myosin light chain kinase inhibition at the calyx of held synapse

Srinivasan, G., Jun, H. K. & Von Gersdorff, H., Apr 2008, In : Journal of Neurophysiology. 99, 4, p. 1810-1824 15 p.

Research output: Contribution to journalArticle

Myosin-Light-Chain Kinase
Synapses
Excitatory Postsynaptic Potentials
Transport Vesicles
Cytoskeletal Proteins
128 Citations (Scopus)

T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites

Cueni, L., Canepari, M., Luján, R., Emmenegger, Y., Watanabe, M., Bond, C. T., Franken, P., Adelman, J. & Lüthi, A., Jun 2008, In : Nature Neuroscience. 11, 6, p. 683-692 10 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum Calcium-Transporting ATPases
Dendrites
Sleep
Thalamus
Eye Movements
3 Citations (Scopus)

Ultraweak Signals Can Cause Synaptic Depression and Adaptation

Demb, J. B. & Von Gersdorff, H., Mar 27 2008, In : Neuron. 57, 6, p. 802-804 3 p.

Research output: Contribution to journalArticle

Synapses
Photons
Retina
Neurons
Light
2007
289 Citations (Scopus)

A biochemical approach to identifying microRNA targets

Karginov, F. V., Conaco, C., Xuan, Z., Schmidt, B. H., Parker, J. S., Mandel, G. & Hannon, G. J., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19291-19296 6 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
MicroRNAs
Messenger RNA
Microarray Analysis
Seeds