Research Output 1987 2019

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2011
89 Citations (Scopus)

Sharp Ca 2+ Nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses

Graydon, C. W., Cho, S., Li, G. L., Kachar, B. & Von Gersdorff, H., Nov 16 2011, In : Journal of Neuroscience. 31, 46, p. 16637-16650 14 p.

Research output: Contribution to journalArticle

Synapses
Buffers
Synaptic Vesicles
Rana catesbeiana
Egtazic Acid
46 Citations (Scopus)

SK2 channels are neuroprotective for ischemia-induced neuronal cell death

Allen, D., Nakayama, S., Kuroiwa, M., Nakano, T., Palmateer, J., Kosaka, Y., Ballesteros, C., Watanabe, M., Bond, C. T., Luján, R., Maylie, J., Adelman, J. & Herson, P. S., Dec 2011, In : Journal of Cerebral Blood Flow and Metabolism. 31, 12, p. 2302-2312 11 p.

Research output: Contribution to journalArticle

Cardiopulmonary Resuscitation
Cell Death
Ischemia
Heart Arrest
N-Methyl-D-Aspartate Receptors
101 Citations (Scopus)

The Ca v3.3 calcium channel is the major sleep spindle pacemaker in thalamus

Astori, S., Wimmer, R. D., Prosser, H. M., Corti, C., Corsi, M., Liaudet, N., Volterra, A., Franken, P., Adelman, J. & Lüthi, A., Aug 16 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 33, p. 13823-13828 6 p.

Research output: Contribution to journalArticle

Calcium Channels
Thalamus
Sleep
Electroencephalography
Eye Movements
36 Citations (Scopus)

The SK2-long isoform directs synaptic localization and function of SK2-containing channels

Allen, D., Bond, C. T., Lujàn, R., Ballesteros-Merino, C., Lin, M. T., Wang, K., Klett, N., Watanabe, M., Shigemoto, R., Stackman Jr, R. W., Maylie, J. & Adelman, J., Jun 2011, In : Nature Neuroscience. 14, 6, p. 744-749 6 p.

Research output: Contribution to journalArticle

Protein Isoforms
Post-Synaptic Density
Neuronal Plasticity
Pyramidal Cells
Learning
2010
17 Citations (Scopus)
Locus Coeruleus
Potassium Channels
Methadone
Opioid Receptors
N-Methylaspartate
43 Citations (Scopus)

Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2

Vo, N., Dalton, R. P., Liu, N., Olson, E. N. & Goodman, R., Nov 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19231-19236 6 p.

Research output: Contribution to journalArticle

MicroRNAs
Transcription Factors
Messenger RNA
3' Untranslated Regions
Computational Biology
200 Citations (Scopus)

An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling

Impey, S., Davare, M., Lasiek, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T., Goodman, R. & Wayman, G. A., Jan 2010, In : Molecular and Cellular Neuroscience. 43, 1, p. 146-156 11 p.

Research output: Contribution to journalArticle

Dendritic Spines
MicroRNAs
Spine
Neuronal Plasticity
Gene Regulatory Networks
51 Citations (Scopus)

A β-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers

Yochum, G. S., Sherrick, C. M., MacPartlin, M. & Goodman, R., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 145-150 6 p.

Research output: Contribution to journalArticle

Catenins
Chromatin
Mitogens
Gene Expression
Wnt Signaling Pathway
9 Citations (Scopus)

Cholinergic Signaling through Synaptic SK Channels: It's a Protein Kinase but Which One?

Maylie, J. & Adelman, J., Dec 9 2010, In : Neuron. 68, 5, p. 809-811 3 p.

Research output: Contribution to journalArticle

Protein Kinases
Cholinergic Agents
Neurons
Cognition
77 Citations (Scopus)

Control of extracellular dopamine at dendrite and axon terminals

Ford, C. P., Gantz, S. C., Phillips, P. E. M. & Williams, J., May 19 2010, In : Journal of Neuroscience. 30, 20, p. 6975-6983 9 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Dendrites
Dopamine
Ventral Tegmental Area
Dextrans
22 Citations (Scopus)

Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors

Lin, M. T., Luján, R., Watanabe, M., Frerking, M., Maylie, J. & Adelman, J., Sep 1 2010, In : Journal of Neuroscience. 30, 35, p. 11726-11734 9 p.

Research output: Contribution to journalArticle

AMPA Receptors
Long-Term Potentiation
Endocytosis
Exocytosis
Spine
107 Citations (Scopus)

Cyclophilin D in mitochondrial pathophysiology

Giorgio, V., Soriano, M. E., Basso, E., Bisetto, E., Lippe, G., Forte, M. & Bernardi, P., Jun 2010, In : Biochimica et Biophysica Acta - Bioenergetics. 1797, 6-7, p. 1113-1118 6 p.

Research output: Contribution to journalArticle

Cyclophilins
Mitochondrial Proton-Translocating ATPases
Peptidylprolyl Isomerase
Mitochondria
Cell death
58 Citations (Scopus)

Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+

Yamashita, T., Eguchi, K., Saitoh, N., Von Gersdorff, H. & Takahashi, T., Jul 2010, In : Nature Neuroscience. 13, 7, p. 838-844 7 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Endocytosis
Synapses
Exocytosis
Calcineurin
64 Citations (Scopus)

Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction

Wen, H., Linhoff, M. W., McGinley, M. J., Li, G. L., Corson, G. M., Mandel, G. & Brehm, P., Aug 3 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 31, p. 13906-13911 6 p.

Research output: Contribution to journalArticle

Synaptotagmins
Neuromuscular Junction
Zebrafish
Protein Isoforms
Synaptotagmin II
201 Citations (Scopus)

Dynamic superresolution imaging of endogenous proteins on living cells at ultra-high density

Giannone, G., Hosy, E., Levet, F., Constals, A., Schulze, K., Sobolevsky, A. I., Rosconi, M. P., Gouaux, E., Tampe, R., Choquet, D. & Cognet, L., Aug 9 2010, In : Biophysical Journal. 99, 4, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

Proteins
Membrane Proteins
Membranes
Biological Science Disciplines
Synapses
60 Citations (Scopus)

Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model

Larsson, H. P., Wang, X., Lev, B., Baconguis, I., Caplan, D. A., Vyleta, N. P., Koch, H. P., Diez-Sampedro, A. & Noskov, S. Y., Aug 3 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 31, p. 13912-13917 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Sodium
Binding Sites
Glutamic Acid
Ions
3 Citations (Scopus)

Extending the realm of membrane capacitance measurements to nerve terminals with complex morphologies

Kim, M. H. & Von Gersdorff, H., Jun 2010, In : Journal of Physiology. 588, 12, p. 2011-2012 2 p.

Research output: Contribution to journalArticle

Electric Capacitance
Ion Channel Gating
Neurological Models
Miniature Postsynaptic Potentials
Retinal Rod Photoreceptor Cells
57 Citations (Scopus)

Inputs to the dorsal striatum of the mouse reflect the parallel circuit architecture of the forebrain

Pan, W. X., Mao, T. & Dudman, J. T., Dec 27 2010, In : Frontiers in Neuroanatomy. DEC

Research output: Contribution to journalArticle

Prosencephalon
Basal Ganglia
Corpus Striatum
Raphe Nuclei
Amygdala
275 Citations (Scopus)

MicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

Magill, S. T., Cambronne, X., Luikart, B. W., Lioy, D. T., Leighton, B. H., Westbrook, G., Mandel, G. & Goodman, R., Nov 23 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 47, p. 20382-20387 6 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Cyclic AMP Response Element-Binding Protein
MicroRNAs
Hippocampus
Neurons
59 Citations (Scopus)

MicroRNA pathways in neural development and plasticity

Vo, N., Cambronne, X. & Goodman, R., Aug 2010, In : Current Opinion in Neurobiology. 20, 4, p. 457-465 9 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
MicroRNAs
Neurons
Aptitude
RNA Stability
72 Citations (Scopus)

Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

Banerjee, A., Mikhailova, E., Cheley, S., Gu, L. Q., Montoya, M., Nagaoka, Y., Gouaux, E. & Bayley, H., May 4 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 18, p. 8165-8170 6 p.

Research output: Contribution to journalArticle

Nanopores
Protein Engineering
Porins
Crystallography
Hemolysin Proteins
96 Citations (Scopus)

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site

Piscitelli, C. L., Krishnamurthy, H. & Gouaux, E., Dec 23 2010, In : Nature. 468, 7327, p. 1129-1133 5 p.

Research output: Contribution to journalArticle

Plasma Membrane Neurotransmitter Transport Proteins
Binding Sites
Sodium
Neurotransmitter Agents
Calorimetry
11 Citations (Scopus)

Opioid receptor internalization contributes to dermorphin-mediated antinociception

Macey, T. A., Ingram, S., Bobeck, E. N., Hegarty, D. M., Aicher, S., Arttamangkul, S. & Morgan, M. M., Jun 2010, In : Neuroscience. 168, 2, p. 543-550 8 p.

Research output: Contribution to journalArticle

Periaqueductal Gray
Microinjections
Opioid Receptors
Dynamins
mu Opioid Receptor
10 Citations (Scopus)
Clamping devices
Motor Neurons
Zebrafish
Neurons
Muscle
4 Citations (Scopus)

Post-tetanic potentiation involves the presynaptic binding of calcium to calmodulin

Balakrishnan, V., Srinivasan, G. & Von Gersdorff, H., Sep 2010, In : Journal of General Physiology. 136, 3, p. 243-245 3 p.

Research output: Contribution to journalArticle

Myosin Type II
Myosin-Light-Chain Kinase
Neuronal Plasticity
Synaptic Vesicles
Excitatory Postsynaptic Potentials
47 Citations (Scopus)

Presynaptic resurgent Na+ currents sculpt the action potential waveform and increase firing reliability at a CNS nerve terminal

Kim, J. H., Kushmerick, C. & Von Gersdorff, H., Nov 17 2010, In : Journal of Neuroscience. 30, 46, p. 15479-15490 12 p.

Research output: Contribution to journalArticle

Action Potentials
Dialysis
Peptide Fragments
Presynaptic Terminals
Lidocaine
94 Citations (Scopus)

Sensing muscle ischemia: Coincident detection of acid and ATP via interplay of two ion channels

Birdsong, W. T., Fierro, L., Williams, F. G., Spelta, V., Naves, L. A., Knowles, M., Marsh-Haffner, J., Adelman, J., Almers, W., Elde, R. P. & McCleskey, E. W., Nov 18 2010, In : Neuron. 68, 4, p. 739-749 11 p.

Research output: Contribution to journalArticle

Adenine Nucleotides
Ion Channels
Ischemia
Sensory Receptor Cells
Pain
65 Citations (Scopus)

Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Knowles, M. K., Barg, S., Wan, L., Midorikawa, M., Chen, X. & Almers, W., Nov 30 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 48, p. 20810-20815 6 p.

Research output: Contribution to journalArticle

Synaptosomal-Associated Protein 25
Syntaxin 1
Secretory Vesicles
Fluorescence
Exocytosis
70 Citations (Scopus)

Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Barg, S., Knowles, M. K., Chen, X., Midorikawa, M. & Almers, W., Nov 30 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 48, p. 20804-20809 6 p.

Research output: Contribution to journalArticle

Qa-SNARE Proteins
Secretory Vesicles
Exocytosis
Cell Membrane
SNARE Proteins
33 Citations (Scopus)

The interaction of Epac1 and ran promotes Rap1 activation at the nuclear envelope

Liu, C., Takahashi, M., Li, Y., Dillon, T. J., Kaech-Petrie, S. & Stork, P., Aug 2010, In : Molecular and Cellular Biology. 30, 16, p. 3956-3969 14 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Cyclic AMP
Nuclear Pore
Monomeric GTP-Binding Proteins
ras Proteins
89 Citations (Scopus)

The mitochondrial permeability transition from yeast to mammals

Azzolin, L., von Stockum, S., Basso, E., Petronilli, V., Forte, M. & Bernardi, P., Jun 2010, In : FEBS Letters. 584, 12, p. 2504-2509 6 p.

Research output: Contribution to journalArticle

Mammals
Yeast
Permeability
Mitochondria
Yeasts
34 Citations (Scopus)

The New York Consortium on Membrane Protein Structure (NYCOMPS): A high-throughput platform for structural genomics of integral membrane proteins

Love, J., Mancia, F., Shapiro, L., Punta, M., Rost, B., Girvin, M., Wang, D. N., Zhou, M., Hunt, J. F., Szyperski, T., Gouaux, E., MacKinnon, R., McDermott, A., Honig, B., Inouye, M., Montelione, G. & Hendrickson, W. A., Sep 2010, In : Journal of Structural and Functional Genomics. 11, 3, p. 191-199 9 p.

Research output: Contribution to journalArticle

Genomics
Membrane Proteins
Throughput
Pipelines
Crystallography
2009
123 Citations (Scopus)

Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation

Li, N., Timofeyev, V., Tuteja, D., Xu, D., Lu, L., Zhang, Q., Zhang, Z., Singapuri, A., Albert, T. R., Rajagopal, A. V., Bond, C. T., Periasamy, M., Adelman, J. & Chiamvimonvat, N., 2009, In : Journal of Physiology. 587, 5, p. 1087-1100 14 p.

Research output: Contribution to journalArticle

Atrial Fibrillation
Muscle Cells
Action Potentials
Cardiac Arrhythmias
Wild Animals
98 Citations (Scopus)

Axonal degeneration in multiple sclerosis: The mitochondrial hypothesis

Su, K. G., Banker, G., Bourdette, D. & Forte, M., 2009, In : Current Neurology and Neuroscience Reports. 9, 5, p. 411-417 7 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Axonal Transport
Demyelinating Diseases
Free Radicals
Permeability
30 Citations (Scopus)

Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization

Virk, M. S., Arttamangkul, S., Birdsong, W. T. & Williams, J., Jun 3 2009, In : Journal of Neuroscience. 29, 22, p. 7341-7348 8 p.

Research output: Contribution to journalArticle

Buprenorphine
Opioid Receptors
Oxymorphone
Etorphine
Locus Coeruleus
51 Citations (Scopus)

Ca2+ signaling by T-type Ca2+ channels in neurons

Cueni, L., Canepari, M., Adelman, J. & Lüthi, A., Mar 2009, In : Pflugers Archiv European Journal of Physiology. 457, 5, p. 1161-1172 12 p.

Research output: Contribution to journalArticle

Neurons
Electric potential
Chemical activation
41 Citations (Scopus)

CRF enhancement of GIRK channel-mediated transmission in dopamine neurons

Beckstead, M. J., Gantz, S. C., Ford, C. P., Stenzel-Poore, M., Phillips, P. E. M., Mark, G. & Williams, J., Jul 2009, In : Neuropsychopharmacology. 34, 8, p. 1926-1935 10 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Corticotropin-Releasing Hormone
Dopamine
Inhibitory Postsynaptic Potentials
Mesencephalon
121 Citations (Scopus)

Crystal structure and association behaviour of the GluR2 amino-terminal domain

Jin, R., Singh, S. K., Gu, S., Furukawa, H., Sobolevsky, A. I., Zhou, J., Jin, Y. & Gouaux, E., Jun 17 2009, In : EMBO Journal. 28, 12, p. 1812-1823 12 p.

Research output: Contribution to journalArticle

AMPA Receptors
Crystal structure
Ligand-Gated Ion Channels
Ionotropic Glutamate Receptors
Kainic Acid Receptors
476 Citations (Scopus)

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

Kawate, T., Michel, J. C., Birdsong, W. T. & Gouaux, E., Jul 30 2009, In : Nature. 460, 7255, p. 592-598 7 p.

Research output: Contribution to journalArticle

Ion Channels
Adenosine Triphosphate
Cations
Ion Channel Gating
Physiological Phenomena
3 Citations (Scopus)

Crystal structures of catalytic and regulatory subunits of rat protein kinase CK2

Zhou, W. H., Qin, X. H., Yan, X. J., Xie, X. Q., Li, L., Fang, S. S., Long, J. F., Adelman, J., Tang, W. J. & Shen, Y. Q., Jan 2009, In : Chinese Science Bulletin. 54, 2, p. 220-226 7 p.

Research output: Contribution to journalArticle

Casein Kinase II
Conformations
Rats
Crystal structure
Plasticity
168 Citations (Scopus)

Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex

Giorgio, V., Bisetto, E., Soriano, M. E., Dabbeni-Sala, F., Basso, E., Petronilli, V., Forte, M., Bernardi, P. & Lippe, G., Dec 4 2009, In : Journal of Biological Chemistry. 284, 49, p. 33982-33988 7 p.

Research output: Contribution to journalArticle

Mitochondrial Proton-Translocating ATPases
Adenosine Triphosphate
Mitochondria
Enzyme activity
Enzymes
92 Citations (Scopus)

Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury

Wang, X., Carlsson, Y., Basso, E., Zhu, C., Rousset, C. I., Rasola, A., Johansson, B. R., Blomgren, K., Mallard, C., Bernardi, P., Forte, M. & Hagberg, H., Feb 25 2009, In : Journal of Neuroscience. 29, 8, p. 2588-2596 9 p.

Research output: Contribution to journalArticle

Brain Injuries
Cell Death
Brain
Caspases
Permeability
84 Citations (Scopus)

Direct actions of carbenoxolone on synaptic transmission and neuronal membrane properties

Tovar, K. R., Maher, B. J. & Westbrook, G., Aug 2009, In : Journal of Neurophysiology. 102, 2, p. 974-978 5 p.

Research output: Contribution to journalArticle

Carbenoxolone
Synaptic Transmission
Membranes
Excitatory Postsynaptic Potentials
Gap Junctions
47 Citations (Scopus)

ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells

Obara, Y., Yamauchi, A., Takehara, S., Nemoto, W., Takahashi, M., Stork, P. & Nakahata, N., Aug 28 2009, In : Journal of Biological Chemistry. 284, 35, p. 23564-23573 10 p.

Research output: Contribution to journalArticle

PC12 Cells
Tyrosine 3-Monooxygenase
Nerve Growth Factor
Stabilization
Phosphorylation
43 Citations (Scopus)

Experience-dependent maturation of the glomerular microcircuit

Maher, B. J., McGinley, M. J. & Westbrook, G., Sep 29 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 39, p. 16865-16870 6 p.

Research output: Contribution to journalArticle

Gap Junctions
Dendrites
Sensory Deprivation
Membranes
Excitatory Postsynaptic Potentials
87 Citations (Scopus)

External tufted cells drive the output of olfactory bulb glomeruli

De Jan, D. S., Hirnet, D., Westbrook, G. & Charpak, S., Feb 18 2009, In : Journal of Neuroscience. 29, 7, p. 2043-2052 10 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Olfactory Nerve
Population
Patch-Clamp Techniques
Transgenic Mice
73 Citations (Scopus)

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

Palma, E., Tiepolo, T., Angelin, A., Sabatelli, P., Maraldi, N. M., Basso, E., Forte, M., Bernardip, P. & Bonaldo, P., 2009, In : Human Molecular Genetics. 18, 11, p. 2024-2031 8 p.

Research output: Contribution to journalArticle

Collagen
Permeability
Apoptosis
Muscles
Muscular Dystrophies
164 Citations (Scopus)

Genetic deficit of SK3 and IK1 channels disrupts the endothelium-deerived hyperpolarizing factor vasodilator pathway and causes hypertension

Brähler, S., Kaistha, A., Schmidt, V. J., Wölfle, S. E., Busch, C., Kaistha, B. P., Kacik, M., Hasenau, A. L., Grgic, I., Si, H., Bond, C. T., Adelman, J., Wulff, H., De Wit, C., Hoyer, J. & Köhler, R., May 5 2009, In : Circulation. 119, 17, p. 2323-2332 10 p.

Research output: Contribution to journalArticle

Vasodilator Agents
Endothelium
Hypertension
Blood Pressure
Vasodilation
148 Citations (Scopus)

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

Sano, R., Annunziata, I., Patterson, A., Moshiach, S., Gomero, E., Opferman, J., Forte, M. & d'Azzo, A., Nov 13 2009, In : Molecular Cell. 36, 3, p. 500-511 12 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Mitochondria
Apoptosis
Membranes
Organelles
52 Citations (Scopus)

Hemichannel-mediated and pH-based feedback from horizontal cells to cones in the vertebrate retina

Fahrenfort, I., Steijaert, M., Sjoerdsma, T., Vickers, E., Ripps, H., van Asselt, J., Endeman, D., Klooster, J., Numan, R., ten Eikelder, H., Von Gersdorff, H. & Kamermans, M., Jun 30 2009, In : PLoS One. 4, 6, e6090.

Research output: Contribution to journalArticle

cones (retina)
retina
Vertebrates
Retina
Cones