Research Output 1987 2019

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2012
280 Citations (Scopus)

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

Hattori, M. & Gouaux, E., May 10 2012, In : Nature. 484, 7397, p. 207-212 6 p.

Research output: Contribution to journalArticle

Ion Channels
Adenosine Triphosphate
Ion Channel Gating
Binding Sites
Physiological Phenomena
24 Citations (Scopus)

Morphine desensitization and cellular tolerance are distinguished in rat locus ceruleus neurons

Levitt, E. S. & Williams, J., Nov 2012, In : Molecular Pharmacology. 82, 5, p. 983-992 10 p.

Research output: Contribution to journalArticle

Locus Coeruleus
Morphine
Neurons
Protein Kinase C
Protein Phosphatase 1
13 Citations (Scopus)

Neuroligin-1 Overexpression in Newborn Granule Cells In Vivo

Schnell, E., Bensen, A. L., Washburn, E. K. & Westbrook, G., Oct 22 2012, In : PLoS One. 7, 10, e48045.

Research output: Contribution to journalArticle

synapse
Synapses
granules
neonates
Dendritic Spines
1 Citation (Scopus)

Neuroscience: Promiscuous vesicles

Williams, J., Oct 11 2012, In : Nature. 490, 7419, p. 178-179 2 p.

Research output: Contribution to journalArticle

GABA Plasma Membrane Transport Proteins
Corpus Striatum
Dopaminergic Neurons
Neurosciences
gamma-Aminobutyric Acid
21 Citations (Scopus)

Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression

Phillips, R. S., Cleary, D. R., Nalwalk, J. W., Arttamangkul, S., Hough, L. B. & Heinricher, M., Nov 1 2012, In : Journal of Neurophysiology. 108, 9, p. 2393-2404 12 p.

Research output: Contribution to journalArticle

Respiratory Insufficiency
Opioid Analgesics
Neurons
Pain
Analgesics
12 Citations (Scopus)

Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals

Vickers, E., Kim, M. H., Vigh, J. & Von Gersdorff, H., Aug 22 2012, In : Journal of Neuroscience. 32, 34, p. 11688-11699 12 p.

Research output: Contribution to journalArticle

Retinal Bipolar Cells
Light
Ocular Adaptation
Goldfish
Synapses
33 Citations (Scopus)

Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ

Kim, S., Ma, L., Jensen, K. L., Kim, M. M., Bond, C. T., Adelman, J. & Yu, C. R., Sep 2012, In : Nature Neuroscience. 15, 9, p. 1236-1244 9 p.

Research output: Contribution to journalArticle

Vomeronasal Organ
Potassium Channels
Chloride Channels
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Potassium
5 Citations (Scopus)

Patch-clamp capacitance measurements and Ca2+ imaging at single nerve terminals in retinal slices

Kim, M. H., Vickers, E. & Von Gersdorff, H., 2012, In : Journal of Visualized Experiments. 59, p. 1-6 6 p., e3345.

Research output: Contribution to journalArticle

Capacitance measurement
Clamping devices
Neurons
Neurotransmitter Agents
Carisoprodol
40 Citations (Scopus)

Regulation of microRNA-375 by cAMP in pancreatic-βcells

Keller, D. M., Clark, E. A. & Goodman, R., Jun 2012, In : Molecular Endocrinology. 26, 6, p. 989-999 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Cyclic AMP-Dependent Protein Kinases
Insulin
Glucose
Insulinoma
8 Citations (Scopus)

Short-term field stimulation mimics synaptic maturation of hippocampal synapses

Bagley, E. E. & Westbrook, G., Apr 2012, In : Journal of Physiology. 590, 7, p. 1641-1654 14 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Synapses
Hippocampus
Anisomycin
Developmental Genes
30 Citations (Scopus)

SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons

Deignan, J., Luján, R., Bond, C., Riegel, A., Watanabe, M., Williams, J., Maylie, J. & Adelman, J., Aug 16 2012, In : Neuroscience. 217, p. 67-76 10 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Apamin
Action Potentials
Calcium-Activated Potassium Channels
Immunoelectron Microscopy
43 Citations (Scopus)

SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells

Ohtsuki, G., Piochon, C., Adelman, J. & Hansel, C., Jul 12 2012, In : Neuron. 75, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

Purkinje Cells
Dendrites
Apamin
Excitatory Postsynaptic Potentials
Carisoprodol
235 Citations (Scopus)

Small-conductance Ca 2+-activated K + channels: Form and function

Adelman, J., Maylie, J. & Sah, P., 2012, In : Annual Review of Physiology. 74, p. 245-269 25 p.

Research output: Contribution to journalArticle

Macromolecular Substances
Neurons
Casein Kinase II
Protein Phosphatase 2
Neuronal Plasticity
157 Citations (Scopus)

Structural plasticity and dynamic selectivity of acid-sensing ion channelspider toxin complexes

Baconguis, I. & Gouaux, E., Sep 20 2012, In : Nature. 489, 7416, p. 400-405 6 p.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Ions
Acids
Physiological Phenomena
Nociception
77 Citations (Scopus)

Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

Wang, H., Elferich, J. & Gouaux, E., Feb 2012, In : Nature Structural and Molecular Biology. 19, 2, p. 212-219 8 p.

Research output: Contribution to journalArticle

Plasma Membrane Neurotransmitter Transport Proteins
Membranes
Binding Sites
Selenomethionine
Dimyristoylphosphatidylcholine
31 Citations (Scopus)

Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue

Wang, H. & Gouaux, E., Sep 2012, In : EMBO Reports. 13, 9, p. 861-866 6 p.

Research output: Contribution to journalArticle

Plasma Membrane Neurotransmitter Transport Proteins
Clomipramine
Substrates
Binding Sites
X-Rays
18 Citations (Scopus)
Membrane Potentials
Action Potentials
Neurons
Temperature
Brain Stem
30 Citations (Scopus)

Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold

Wimmer, R. D., Astori, S., Bond, C. T., Rovó, Z., Chatton, J. Y., Adelman, J., Franken, P. & Lüthi, A., Oct 3 2012, In : Journal of Neuroscience. 32, 40, p. 13917-13928 12 p.

Research output: Contribution to journalArticle

Arousal
Sleep
Eye Movements
Thalamic Nuclei
Conservation of Natural Resources
69 Citations (Scopus)

Thyroid hormone drives fetal cardiomyocyte maturation

Chattergoon, N., Giraud, G., Louey, S., Stork, P., Fowden, A. L. & Thornburg, K., Jan 2012, In : FASEB Journal. 26, 1, p. 397-408 12 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Cardiac Myocytes
Cyclin D1
Cells
Thyronines
298 Citations (Scopus)

X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

Krishnamurthy, H. & Gouaux, E., Jan 26 2012, In : Nature. 481, 7382, p. 469-474 6 p.

Research output: Contribution to journalArticle

Plasma Membrane Neurotransmitter Transport Proteins
X-Rays
Sodium
Aminobutyrates
Bacterial Structures
7 Citations (Scopus)

Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery

Walogorsky, M., Mongeon, R., Wen, H., Nelson, N. R., Urban, J. M., Ono, F., Mandel, G. & Brehm, P., Oct 23 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 43, p. 17711-17716 6 p.

Research output: Contribution to journalArticle

Congenital Myasthenic Syndromes
Zebrafish
Mutation
Muscle Weakness
Cholinergic Receptors
2011
55 Citations (Scopus)

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

Bell, A., Komarov, A., Hajnóczky, G., Bernardi, P., Bourdette, D. & Forte, M., Mar 2011, In : European Journal of Neuroscience. 33, 5, p. 831-842 12 p.

Research output: Contribution to journalArticle

Permeability
Neurons
Mitochondria
Time-Lapse Imaging
Mitochondrial Proteins
25 Citations (Scopus)

Allosteric modulation of retinal GABA receptors by ascorbic acid

Calero, C. I., Vickers, E., Cid, G. M., Aguayo, L. G., Von Gersdorff, H. & Calvo, D. J., Jun 29 2011, In : Journal of Neuroscience. 31, 26, p. 9672-9682 11 p.

Research output: Contribution to journalArticle

GABA Receptors
Ascorbic Acid
gamma-Aminobutyric Acid
GABA-A Receptors
Retina
26 Citations (Scopus)

Amino terminal domains of the NMDA receptor are organized as local heterodimers

Lee, C. H. & Gouaux, E., 2011, In : PLoS One. 6, 4, e19180.

Research output: Contribution to journalArticle

aspartic acid
N-Methyl-D-Aspartate Receptors
Dimers
Cysteine
cysteine
11 Citations (Scopus)

An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses

Mongeon, R., Walogorsky, M., Urban, J., Mandel, G., Ono, F. & Brehm, P., Sep 2011, In : Journal of General Physiology. 138, 3, p. 353-366 14 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Zebrafish
Synapses
Muscles
Nicotinic Receptors
300 Citations (Scopus)

A role for glia in the progression of Rett-syndrome

Lioy, D. T., Garg, S. K., Monaghan, C. E., Raber, J., Foust, K. D., Kaspar, B. K., Hirrlinger, P. G., Kirchhoff, F., Bissonnette, J. M., Ballas, N. & Mandel, G., Jul 28 2011, In : Nature. 475, 7357, p. 497-500 4 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
Neuroglia
Neurons
Astrocytes
43 Citations (Scopus)

A role for Myosin VI in the localization of axonal proteins

Lewis, T. L., Mao, T. & Arnold, D. B., Mar 2011, In : PLoS Biology. 9, 3, e1001021.

Research output: Contribution to journalArticle

myosin
Myosins
Dendrites
Axons
Protein Transport
46 Citations (Scopus)

Axonal GABAA receptors increase cerebellar granule cell excitability and synaptic activity

Pugh, J. R. & Jahr, C., Jan 12 2011, In : Journal of Neuroscience. 31, 2, p. 565-574 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Axons
Interneurons
gamma-Aminobutyric Acid
Carisoprodol
7 Citations (Scopus)

BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast

Juhásová, B., Mentel, M., Bhatia-Kiššová, I., Zeman, I., Kolarov, J., Forte, M. & Polčic, P., Sep 2 2011, In : FEBS Letters. 585, 17, p. 2709-2713 5 p.

Research output: Contribution to journalArticle

Yeast
bcl-2-Associated X Protein
Yeasts
Cell death
bcl-2 Homologous Antagonist-Killer Protein
4 Citations (Scopus)

Bipolar cells in the vertebrate retina: From form to function

Nawy, S. & Von Gersdorff, H., Jan 2011, In : Visual Neuroscience. 28, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Retinal Bipolar Cells
Retinal Cone Photoreceptor Cells
Amacrine Cells
Goldfish
Presynaptic Terminals
70 Citations (Scopus)

Ca2+-dependent enhancement of release by subthreshold somatic depolarization

Christie, J. M., Chiu, D. N. & Jahr, C., Jan 2011, In : Nature Neuroscience. 14, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Carisoprodol
Axons
Interneurons
Photons
Cerebellum
17 Citations (Scopus)

Distribution of extracellular glutamate in the neuropil of hippocampus

Herman, M. A., Nahir, B. & Jahr, C., Nov 1 2011, In : PLoS One. 6, 11, e26501.

Research output: Contribution to journalArticle

Neuropil
hippocampus
glutamates
Glutamic Acid
Hippocampus
46 Citations (Scopus)

Early developmental actions of endocrine disruptors on the hypothalamus, hippocampus, and cerebral cortex

Parent, A. S., Naveau, E., Gerard, A., Bourguignon, J. P. & Westbrook, G., Jul 2011, In : Journal of Toxicology and Environmental Health - Part B: Critical Reviews. 14, 5-7, p. 328-345 18 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cerebral Cortex
Hypothalamus
Hippocampus
Polychlorinated Biphenyls
29 Citations (Scopus)

Light-evoked lateral gabaergic inhibition at single bipolar cell synaptic terminals is driven by distinct retinal microcircuits

Vigh, J., Vickers, E. & Von Gersdorff, H., Nov 2 2011, In : Journal of Neuroscience. 31, 44, p. 15884-15893 10 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Amacrine Cells
Light
Vertebrate Photoreceptor Cells
Goldfish
30 Citations (Scopus)

Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway

Gantz, S. C., Ford, C. P., Neve, K. & Williams, J., Aug 31 2011, In : Journal of Neuroscience. 31, 35, p. 12629-12637 9 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Substantia Nigra
Neurons
Dopamine
Rett Syndrome
13 Citations (Scopus)

Loss of olfactory cell adhesion molecule reduces the synchrony of mitral cell activity in olfactory glomeruli

Borisovska, M., Mcginley, M. J., Bensen, A. & Westbrook, G., Apr 2011, In : Journal of Physiology. 589, 8, p. 1927-1941 15 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Cell Adhesion Molecules
Knockout Mice
Synapses
Olfactory Receptor Neurons
9 Citations (Scopus)

Membrane and synaptic properties of pyramidal neurons in the anterior olfactory nucleus

McGinley, M. J. & Westbrook, G., Apr 2011, In : Journal of Neurophysiology. 105, 4, p. 1444-1453 10 p.

Research output: Contribution to journalArticle

Synaptic Membranes
Pyramidal Cells
Synapses
Neurons
Action Potentials
101 Citations (Scopus)

MiR-132 mediates the integration of newborn neurons into the adult dentate gyrus

Luikart, B. W., Bensen, A. L., Washburn, E. K., Perederiy, J. V., Su, K. G., Li, Y., Kernie, S. G., Parada, L. F. & Westbrook, G., 2011, In : PLoS One. 6, 5, e19077.

Research output: Contribution to journalArticle

Dentate Gyrus
MicroRNAs
microRNA
Neurons
neonates
28 Citations (Scopus)

Mitochondrial calcium and its regulation in neurodegeneration induced by oxidative stress

Bell, A., Bourdette, D. & Forte, M., Aug 2011, In : European Journal of Neuroscience. 34, 3, p. 437-447 11 p.

Research output: Contribution to journalArticle

Oxidative Stress
Calcium
Neurons
Permeability
Mitochondria
17 Citations (Scopus)

NMDA receptor agonists fail to alter release from cerebellar basket cells

Pugh, J. R. & Jahr, C., Nov 16 2011, In : Journal of Neuroscience. 31, 46, p. 16550-16555 6 p.

Research output: Contribution to journalArticle

Iontophoresis
N-Methyl-D-Aspartate Receptors
Calcium
Presynaptic Receptors
Axons
89 Citations (Scopus)

Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons

Matsui, A. & Williams, J., Nov 30 2011, In : Journal of Neuroscience. 31, 48, p. 17729-17735 7 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Mesencephalon
Synapses
gamma-Aminobutyric Acid
Opioid Analgesics
41 Citations (Scopus)

Optogenetic photochemical control of designer K+ channels in mammalian neurons

Fortin, D. L., Dunn, T. W., Fedorchak, A., Allen, D., Montpeti, R., Banghart, M. R., Trauner, D., Adelman, J. & Kramer, R. H., Jul 2011, In : Journal of Neurophysiology. 106, 1, p. 488-496 9 p.

Research output: Contribution to journalArticle

Optogenetics
Ion Channels
Cysteine
Neurons
Light
27 Citations (Scopus)

Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons

Wu, W., Adelman, J. & Maylie, J., Feb 16 2011, In : Journal of Neuroscience. 31, 7, p. 2638-2648 11 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Estrogens
Hormones
Membranes
Action Potentials
658 Citations (Scopus)

Principles of activation and permeation in an anion-selective Cys-loop receptor

Hibbs, R. E. & Gouaux, E., Jun 2 2011, In : Nature. 474, 7349, p. 54-60 7 p.

Research output: Contribution to journalArticle

Cysteine Loop Ligand-Gated Ion Channel Receptors
Anions
Ivermectin
Picrotoxin
Synaptic Transmission
44 Citations (Scopus)

Properties of Ca 2+ transport in mitochondria of Drosophila melanogaster

Von Stockum, S., Basso, E., Petronilli, V., Sabatelli, P., Forte, M. & Bernardi, P., Dec 2 2011, In : Journal of Biological Chemistry. 286, 48, p. 41163-41170 8 p.

Research output: Contribution to journalArticle

Mitochondria
Drosophila melanogaster
Mammals
Permeability
Ruthenium Red
85 Citations (Scopus)

Pten knockdown in vivo increases excitatory drive onto dentate granule cells

Luikart, B. W., Schnell, E., Washburn, E. K., Bensen, A. L., Tovar, K. R. & Westbrook, G., Mar 16 2011, In : Journal of Neuroscience. 31, 11, p. 4345-4354 10 p.

Research output: Contribution to journalArticle

Dendritic Spines
Phosphoric Monoester Hydrolases
Young Adult
Hippocampus
Chromosomes, Human, Pair 10
5 Citations (Scopus)

Reconstitution of interactions of Murine gammaherpesvirus 68 M11 with Bcl-2 family proteins in yeast

Juhásová, B., Bhatia-Kiššová, I., Polčicová, K., Mentel, M., Forte, M. & Polčic, P., Apr 22 2011, In : Biochemical and Biophysical Research Communications. 407, 4, p. 783-787 5 p.

Research output: Contribution to journalArticle

Fungal Proteins
Yeast
Apoptosis
BH3 Interacting Domain Death Agonist Protein
bcl-2 Homologous Antagonist-Killer Protein
56 Citations (Scopus)

Recovery from short-term depression and facilitation is ultrafast and ca dependent at auditory hair cell synapses

Cho, S., Li, G. L. & Von Gersdorff, H., Apr 13 2011, In : Journal of Neuroscience. 31, 15, p. 5682-5692 11 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Synapses
Membrane Potentials
Synaptic Vesicles
Egtazic Acid
51 Citations (Scopus)

Recovery from μ-opioid receptor desensitization after chronic treatment with morphine and methadone

Quillinan, N., Lau, E. K., Virk, M., Von Zastrow, M. & Williams, J., Mar 23 2011, In : Journal of Neuroscience. 31, 12, p. 4434-4443 10 p.

Research output: Contribution to journalArticle

Methadone
Opioid Receptors
Morphine
Arrestin
Opioid Analgesics
38 Citations (Scopus)

Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development

Mandel, G., Fiondella, C. G., Covey, M. V., Lu, D. D., LoTurco, J. J. & Ballas, N., Oct 4 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 40, p. 16789-16794 6 p.

Research output: Contribution to journalArticle

Transcriptional Silencer Elements
Transcription Factors
Neurogenesis
Classical Lissencephalies and Subcortical Band Heterotopias
Phenotype