Research Output 1987 2019

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2013
16 Citations (Scopus)

Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure

Birdsong, W. T., Arttamangkul, S., Clark, M. J., Cheng, K., Rice, K. C., Traynor, J. R. & Williams, J., Feb 27 2013, In : Journal of Neuroscience. 33, 9, p. 4118-4127 10 p.

Research output: Contribution to journalArticle

Opioid Receptors
GTP-Binding Proteins
Arrestin
Pertussis Toxin
Opioid Analgesics
8 Citations (Scopus)

Macrocircuits for sound localization use leaky coincidence detectors and specialized synapses

Portfors, C. V. & Von Gersdorff, H., Jun 5 2013, In : Neuron. 78, 5, p. 755-757 3 p.

Research output: Contribution to journalArticle

Sound Localization
Synapses
Ear
Neurons
28 Citations (Scopus)
Lipoylation
Interneurons
Somatostatin
MicroRNAs
Enzymes
39 Citations (Scopus)

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

Su, K., Bourdette, D. & Forte, M., 2013, In : Frontiers in Physiology. 4 JUL, Article 169.

Research output: Contribution to journalArticle

Multiple Sclerosis
Plague
Demyelinating Diseases
Immunosuppressive Agents
Oxidation-Reduction
23 Citations (Scopus)

Neural injury alters proliferation and integration of adult-generated neurons in the dentate gyrus

Perederiy, J. V., Luikart, B. W., Washburn, E. K., Schnell, E. & Westbrook, G., Mar 13 2013, In : Journal of Neuroscience. 33, 11, p. 4754-4767 14 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Dendritic Spines
Neurons
Wounds and Injuries
Perforant Pathway

Neuroscience: Faster than kiss-and-run

Cho, S. & Von Gersdorff, H., 2013, In : Nature. 504, 7479, p. 220-221 2 p.

Research output: Contribution to journalArticle

neurology
cytology
biochemistry
Neurology
Neurosciences
4 Citations (Scopus)

Novel Dicarboxylate Selectivity in an Insect Glutamate Transporter Homolog

Wang, H., Rascoe, A. M., Holley, D. C., Gouaux, E. & Kavanaugh, M. P., Aug 7 2013, In : PLoS One. 8, 8, e70947.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Culicidae
glutamates
Dicarboxylic Acids
Insects
35 Citations (Scopus)

N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence

Wang, Z., Liu, Y., Takahashi, M., Van Hook, K., Kampa-Schittenhelm, K. M., Sheppard, B., Sears, R., Stork, P. & Lopez, C., Jan 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 312-317 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Guanosine Triphosphate
Oncogenes
ras Proteins
Neoplasms
44 Citations (Scopus)

Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology

Nguyen, M. V. C., Felice, C. A., Du, F., Covey, M. V., Robinson, J. K., Mandel, G. & Ballas, N., 2013, In : Journal of Neuroscience. 33, 48, p. 18764-18774 11 p.

Research output: Contribution to journalArticle

Rett Syndrome
Oligodendroglia
Myelin Proteins
Hindlimb
Neuroglia
118 Citations (Scopus)

Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex

Hooks, B. M., Mao, T., Gutnisky, D. A., Yamawaki, N., Svoboda, K. & Shepherd, G. M. G., Jan 9 2013, In : Journal of Neuroscience. 33, 2, p. 748-760 13 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Motor Cortex
Neurons
Ventral Thalamic Nuclei
Prefrontal Cortex
10 Citations (Scopus)

Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses

Wu, W., Bryant, D. N., Dorsa, D., Adelman, J. & Maylie, J., 2013, In : Journal of Neuroscience. 33, 41, p. 16158-16169 12 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Synapses
Hormones
Therapeutics
Aptitude
42 Citations (Scopus)

Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity

Johnson, S. L., Kuhn, S., Franz, C., Ingham, N., Furness, D. N., Knipper, M., Steel, K. P., Adelman, J., Holley, M. C. & Marcotti, W., May 21 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 21, p. 8720-8725 6 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Auditory Hair Cells
Synapses
Action Potentials
Calcium Signaling
25 Citations (Scopus)

Protein kinase a-dependent phosphorylation of Rap1 regulates its membrane localization and cell migration

Takahashi, M., Dillon, T. J., Liu, C., Kariya, Y., Wang, Z. & Stork, P., Sep 27 2013, In : Journal of Biological Chemistry. 288, 39, p. 27712-27723 12 p.

Research output: Contribution to journalArticle

Phosphorylation
Protein Kinases
Cell Movement
Monomeric GTP-Binding Proteins
Membranes
18 Citations (Scopus)

Rapid structural change in synaptosomal-associated protein 25 (SNAP25) precedes the fusion of single vesicles with the plasma membrane in live chromaffin cells

Zhao, Y., Fang, Q., Herbst, A. D., Berberian, K. N., Almers, W. & Lindau, M., Aug 27 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. 14249-14254 6 p.

Research output: Contribution to journalArticle

Synaptosomal-Associated Protein 25
Chromaffin Cells
Fluorescence Resonance Energy Transfer
SNARE Proteins
Cell Membrane
16 Citations (Scopus)
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Protein Kinases
Chemical activation
Cells
311 Citations (Scopus)

Regulation of μ-opioid receptors: Desensitization, phosphorylation, internalization, and tolerance

Williams, J., Ingram, S., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J. & Christie, M. J., 2013, In : Pharmacological Reviews. 65, 1, p. 223-254 32 p.

Research output: Contribution to journalArticle

Opioid Receptors
Phosphorylation
Opioid Analgesics
Pain
Endocytosis
19 Citations (Scopus)
Ocular Paraneoplastic Syndromes
Retinal Bipolar Cells
retinal diseases
electroretinography
autoantibodies
24 Citations (Scopus)

Single Ca2+ channels and exocytosis at sensory synapses

Kim, M. H., Li, G. L. & Von Gersdorff, H., Jul 2013, In : Journal of Physiology. 591, 13, p. 3167-3178 12 p.

Research output: Contribution to journalArticle

Exocytosis
Synapses
Ear
Photoreceptor Cells
Synaptic Vesicles
40 Citations (Scopus)

Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Gantz, S. C., Bunzow, J. R. & Williams, J., Jun 5 2013, In : Neuron. 78, 5, p. 807-812 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Physiological Phenomena
Ligand-Gated Ion Channels
Inhibitory Postsynaptic Potentials
GTP-Binding Proteins
78 Citations (Scopus)

Structural basis for action by diverse antidepressants on biogenic amine transporters

Wang, H., Goehring, A., Wang, K. H., Penmatsa, A., Ressler, R. & Gouaux, E., 2013, In : Nature. 503, 7474, p. 141-145 5 p.

Research output: Contribution to journalArticle

Biogenic Amines
Antidepressive Agents
Serotonin Uptake Inhibitors
Tricyclic Antidepressive Agents
Pharmacology
20 Citations (Scopus)

Structural plasticity in the dentate gyrus- Revisiting a classic injury model

Perederiy, J. V. & Westbrook, G., Jan 27 2013, In : Frontiers in Neural Circuits. JAN

Research output: Contribution to journalArticle

Dentate Gyrus
Perforant Pathway
Wounds and Injuries
Neurogenesis
Brain
17 Citations (Scopus)

Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources

Wen, H., Hubbard, J. M., Rakela, B., Linhoff, M. W., Mandel, G. & Brehm, P., Dec 24 2013, In : eLife. 2013, 2, e01206.

Research output: Contribution to journalArticle

Synaptic Transmission
Calcium
Synapses
Q-Type Calcium Channels
P-Type Calcium Channels
106 Citations (Scopus)

Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome

Garg, S. K., Lioy, D. T., Cheval, H., McGann, J. C., Bissonnette, J. M., Murtha, M. J., Foust, K. D., Kaspar, B. K., Bird, A. & Mandel, G., 2013, In : Journal of Neuroscience. 33, 34, p. 13612-13620 9 p.

Research output: Contribution to journalArticle

Rett Syndrome
Microcephaly
X-Linked Genes
Brain Diseases
Nervous System Diseases
100 Citations (Scopus)

Triheteromeric NMDA receptors at hippocampal synapses

Tovar, K. R., McGinley, M. J. & Westbrook, G., May 22 2013, In : Journal of Neuroscience. 33, 21, p. 9150-9160 11 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Synapses
Neurotransmitter Receptor
Neurons
Pharmacology
27 Citations (Scopus)
Acid Sensing Ion Channels
Ligand-Gated Ion Channels
Adenosine Triphosphate
Purinergic P2X4 Receptors
Ion Channels
308 Citations (Scopus)

X-ray structure of dopamine transporter elucidates antidepressant mechanism

Penmatsa, A., Wang, K. H. & Gouaux, E., 2013, In : Nature. 503, 7474, p. 85-90 6 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Antidepressive Agents
Nortriptyline
Neurotransmitter Agents
X-Rays
14 Citations (Scopus)

Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission

Wen, H., Linhoff, M. W., Hubbard, J. M., Nelson, N. R., Stensland, D., Dallman, J., Mandel, G. & Brehm, P., Apr 24 2013, In : Journal of Neuroscience. 33, 17, p. 7384-7392 9 p.

Research output: Contribution to journalArticle

Conotoxins
Zebrafish
Calcium Channels
Anura
Organism Cloning
2012
8 Citations (Scopus)

Acetylcholine receptor gating in a zebrafish model for slow-channel syndrome

Walogorsky, M., Mongeon, R., Wen, H., Mandel, G. & Brehm, P., Jun 6 2012, In : Journal of Neuroscience. 32, 23, p. 7941-7948 8 p.

Research output: Contribution to journalArticle

Quinidine
Cholinergic Receptors
Zebrafish
Mutation
Acetylcholine
110 Citations (Scopus)

A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening

Hattori, M., Hibbs, R. E. & Gouaux, E., Aug 8 2012, In : Structure. 20, 8, p. 1293-1299 7 p.

Research output: Contribution to journalArticle

Gel Chromatography
Membrane Proteins
Protein Stability
Fluorescence
Purinergic P2X4 Receptors
12 Citations (Scopus)

Amino-terminal ligands prolong NMDA receptor- mediated EPSCs

Tovar, K. R. & Westbrook, G., Jun 6 2012, In : Journal of Neuroscience. 32, 23, p. 8065-8073 9 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Zinc
Ligands
Neurons
Neurotransmitter Receptor

An introduction to a symposium dedicated to the scientific achievements of Roger Nicoll

Jahr, C., Perkel, D. & Sah, P., May 2012, In : Journal of Physiology. 590, 10, p. 2201-2202 2 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Synaptic Transmission
Hippocampus
31 Citations (Scopus)

Astrocytes conspire with neurons during progression of neurological disease

McGann, J. C., Lioy, D. T. & Mandel, G., Oct 2012, In : Current Opinion in Neurobiology. 22, 5, p. 850-858 9 p.

Research output: Contribution to journalArticle

Astrocytes
Disease Progression
Neurons
Rett Syndrome
Oligodendroglia
531 Citations (Scopus)

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

Madisen, L., Mao, T., Koch, H., Zhuo, J. M., Berenyi, A., Fujisawa, S., Hsu, Y. W. A., Garcia, A. J., Gu, X., Zanella, S., Kidney, J., Gu, H., Mao, Y., Hooks, B. M., Boyden, E. S., Buzsáki, G., Ramirez, J. M., Jones, A. R., Svoboda, K., Han, X. & 2 others, Turner, E. E. & Zeng, H., May 2012, In : Nature Neuroscience. 15, 5, p. 793-802 10 p.

Research output: Contribution to journalArticle

Optogenetics
Transgenic Mice
Light
Halorhodopsins
Parvalbumins
11 Citations (Scopus)

Ca2+ influx and neurotransmitter release at ribbon synapses

Cho, S. & Von Gersdorff, H., Sep 2012, In : Cell Calcium. 52, 3-4, p. 208-216 9 p.

Research output: Contribution to journalArticle

Synapses
Neurotransmitter Agents
Exocytosis
SNARE Proteins
Clathrin
34 Citations (Scopus)

Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach

Cambronne, X., Shen, R., Auer, P. L. & Goodman, R., Dec 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 50, p. 20473-20478 6 p.

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
MicroRNAs
Proto-Oncogene Proteins c-crk
Zonula Occludens-1 Protein
Prosencephalon
6 Citations (Scopus)

Connexin 39.9 protein is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish

Hirata, H., Wen, H., Kawakami, Y., Naganawa, Y., Ogino, K., Yamada, K., Saint-Amant, L., Low, S. E., Cui, W. W., Zhou, W., Sprague, S. M., Asakawa, K., Muto, A., Kawakami, K. & Kuwada, J. Y., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1080-1089 10 p.

Research output: Contribution to journalArticle

Connexins
Zebrafish
Muscle
Gap Junctions
Chemical activation
2 Citations (Scopus)

Corrigendum to "An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling" [YMCNE (2010) 146-156]

Impey, S., Davare, M., Lesiak, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T., Goodman, R. & Wayman, G. A., Feb 2012, In : Molecular and Cellular Neuroscience. 49, 2, p. 250 1 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Dentate gyrus neurogenesis, integration and microRNAs

Luikart, B. W., Perederiy, J. V. & Westbrook, G., Feb 14 2012, In : Behavioural Brain Research. 227, 2, p. 348-355 8 p.

Research output: Contribution to journalArticle

Neurogenesis
Dentate Gyrus
MicroRNAs
Neurons
Gene Expression
16 Citations (Scopus)

Desensitization and trafficking of μ-opioid receptors in locus ceruleus neurons: Modulation by kinases

Arttamangkul, S., Lau, E. K., Lu, H. W. & Williams, J., Mar 2012, In : Molecular Pharmacology. 81, 3, p. 348-355 8 p.

Research output: Contribution to journalArticle

Methionine Enkephalin
Locus Coeruleus
Opioid Receptors
G-Protein-Coupled Receptor Kinases
Phosphotransferases
25 Citations (Scopus)

Developmental profile of SK2 channel expression and function in CA1 neurons

Ballesteros-Merino, C., Lin, M., Wu, W., Ferrandiz-Huertas, C., Cabañero, M. J., Watanabe, M., Fukazawa, Y., Shigemoto, R., Maylie, J., Adelman, J. & Luján, R., Jun 2012, In : Hippocampus. 22, 6, p. 1467-1480 14 p.

Research output: Contribution to journalArticle

Apamin
Pyramidal Cells
Excitatory Postsynaptic Potentials
Hippocampus
Spine
9 Citations (Scopus)
Sodium-Calcium Exchanger
Axons
Actins
Reactive Oxygen Species
Oxidative Stress
13 Citations (Scopus)
Oxidation-Reduction
Mitochondria
Reactive Oxygen Species
Neurons
Neurodegenerative Diseases
22 Citations (Scopus)

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis

Su, K. G., Savino, C., Marracci, G., Chaudhary, P., Yu, X., Morris, B., Galipeau, D., Giorgio, M., Forte, M. & Bourdette, D., Feb 2012, In : European Journal of Neuroscience. 35, 3-4, p. 562-571 10 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Protein Isoforms
Autoimmune Experimental Encephalomyelitis
Reactive Oxygen Species
Cell Death
26 Citations (Scopus)

GPER1/GPR30 Activation Improves Neuronal Survival Following Global Cerebral Ischemia Induced by Cardiac Arrest in Mice

Kosaka, Y., Quillinan, N., Bond, C. T., Traystman, R. J., Hurn, P. D. & Herson, P. S., Dec 2012, In : Translational Stroke Research. 3, 4, p. 500-507 8 p.

Research output: Contribution to journalArticle

Induced Heart Arrest
Brain Ischemia
Estrogens
Estrogen Receptors
Small-Conductance Calcium-Activated Potassium Channels
25 Citations (Scopus)

Increasing SK2 channel activity impairs associative learning

McKay, B. M., Matthew Oh, M., Galvez, R., Burgdorf, J., Kroes, R. A., Weiss, C., Adelman, J., Moskal, J. R. & Disterhoft, J. F., Aug 1 2012, In : Journal of Neurophysiology. 108, 3, p. 863-870 8 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Hippocampus
Learning
Small-Conductance Calcium-Activated Potassium Channels
Biomarkers
34 Citations (Scopus)

Insights into transport mechanism from LeuT engineered to transport tryptophan

Piscitelli, C. L. & Gouaux, E., Jan 4 2012, In : EMBO Journal. 31, 1, p. 228-235 8 p.

Research output: Contribution to journalArticle

Plasma Membrane Neurotransmitter Transport Proteins
Tryptophan
Binding Sites
Ligands
Functional analysis
106 Citations (Scopus)

MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain

Nguyen, M. V. C., Du, F., Felice, C. A., Shan, X., Nigam, A., Mandel, G., Robinson, J. K. & Ballas, N., Jul 18 2012, In : Journal of Neuroscience. 32, 29, p. 10021-10034 14 p.

Research output: Contribution to journalArticle

Anatomy
Rett Syndrome
Methyl-CpG-Binding Protein 2
Brain
Proteins
16 Citations (Scopus)
Thyroid Hormones
Cardiac Myocytes
Sheep
Pregnancy
Thyronines
33 Citations (Scopus)

Modulating Neuromodulation by Receptor Membrane Traffic in the Endocytic Pathway

von Zastrow, M. & Williams, J., Oct 4 2012, In : Neuron. 76, 1, p. 22-32 11 p.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
Endocytosis
Membranes
Neurotransmitter Agents
Therapeutics
16 Citations (Scopus)

Modulation of endothelial SK3 channel activity by Ca2+-dependent caveolar trafficking

Lin, M. T., Adelman, J. & Maylie, J., Aug 1 2012, In : American Journal of Physiology - Cell Physiology. 303, 3, p. 318-327 10 p.

Research output: Contribution to journalArticle

Membrane Potentials
Endothelial Cells
Cell Membrane
Calcium-Activated Potassium Channels
Caveolae