Research Output 1987 2020

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2016
7 Citations (Scopus)

Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation

Du, F., Nguyen, M. V. C., Karten, A., Felice, C. A., Mandel, G. & Ballas, N., May 1 2016, In : Human Molecular Genetics. 25, 9, p. 1690-1702 13 p., ddw038.

Research output: Contribution to journalArticle

Rett Syndrome
Brain
Methyl-CpG-Binding Protein 2
Phenotype
X-Linked Genes
41 Citations (Scopus)

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Hornick, N. I., Doron, B., Abdelhamed, S., Huan, J., Harrington, C. C., Shen, R., Cambronne, X., Verghese, S. C. & Kurre, P., Sep 6 2016, In : Science Signaling. 9, 444, ra88.

Research output: Contribution to journalArticle

Exosomes
Hematopoiesis
MicroRNAs
Acute Myeloid Leukemia
Hematopoietic Stem Cells
50 Citations (Scopus)

Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM

Zhao, Y., Chen, S., Yoshioka, C., Baconguis, I. & Gouaux, E., Jul 1 2016, In : Nature. 536, 7614, p. 108-111 4 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
AMPA Receptors
Proteins
Ligands
Ion Channels
101 Citations (Scopus)

Biosensor reveals multiple sources for mitochondrial NAD+

Cambronne, X., Stewart, M. L., Kim, D., Jones-Brunette, A. M., Morgan, R. K., Farrens, D., Cohen, M. & Goodman, R., Jun 17 2016, In : Science. 352, 6292, p. 1474-1477 4 p.

Research output: Contribution to journalArticle

Biosensing Techniques
NAD
Sirtuins
Mitochondria
Enzymes
8 Citations (Scopus)

Calcium Release from Stores Inhibits GIRK

Kramer, P. F. & Williams, J., Dec 20 2016, In : Cell Reports. 17, 12, p. 3246-3255 10 p.

Research output: Contribution to journalArticle

Calcium
Neurons
Dopaminergic Neurons
Substantia Nigra
Calmodulin
13 Citations (Scopus)

Cell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation

Barrett, R. M., Liu, H. W., Jin, H., Goodman, R. & Cohen, M., Jun 17 2016, In : ACS Chemical Biology. 11, 6, p. 1532-1536 5 p.

Research output: Contribution to journalArticle

Puromycin
Proteome
Cells
Tissue
Enzymes
4 Citations (Scopus)

Early exposure to Aroclor 1254 in vivo disrupts the functional synaptic development of newborn hippocampal granule cells

Parent, A. S., Pinson, A., Woods, N., Chatzi, C., Vaaga, C. E., Bensen, A., Gérard, A., Thome, J. P., Bourguignon, J. P. & Westbrook, G., 2016, (Accepted/In press) In : European Journal of Neuroscience.

Research output: Contribution to journalArticle

Chlorodiphenyl (54% Chlorine)
Polychlorinated Biphenyls
Newborn Infant
Neurogenesis
Neurons
11 Citations (Scopus)

Endothelial SK3 channel-associated ca2+ microdomains modulate blood pressure

Yap, F. C., Weber, D. S., Taylor, M. S., Townsley, M. I., Comer, B. S., Maylie, J., Adelman, J. & Lin, M. T., May 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 9, p. H1151-H1163

Research output: Contribution to journalArticle

Endothelium
Blood Pressure
Vasodilation
Mesenteric Arteries
Blood Vessels
4 Citations (Scopus)

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells

Obara, Y., Nagasawa, R., Nemoto, W., Pellegrino, M. J., Takahashi, M., Habecker, B., Stork, P., Ichiyanagi, O., Ito, H., Tomita, Y., Ishii, K. & Nakahata, N., Mar 1 2016, In : Cellular Signalling. 28, 3, p. 177-189 13 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Tyrosine 3-Monooxygenase
Catecholamines
Homeostasis
Pheochromocytoma
43 Citations (Scopus)

Fast, Temperature-Sensitive and Clathrin-Independent Endocytosis at Central Synapses

Delvendahl, I., Vyleta, N. P., Von Gersdorff, H. & Hallermann, S., May 4 2016, In : Neuron. 90, 3, p. 492-498 7 p.

Research output: Contribution to journalArticle

Clathrin
Endocytosis
Synapses
Temperature
Membranes
3 Citations (Scopus)

Fatigue in rapsyn-deficient zebrafish reflects defective transmitter release

Wen, H., Hubbard, J. M., Wang, W. C. & Brehm, P., Oct 19 2016, In : Journal of Neuroscience. 36, 42, p. 10870-10882 13 p.

Research output: Contribution to journalArticle

Muscle Weakness
Zebrafish
Fatigue
Fishes
Motor Neurons
12 Citations (Scopus)

IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons

Wang, K., Mateos-Aparicio, P., Hönigsperger, C., Raghuram, V., Wu, W., Ridder, M. C., Sah, P., Maylie, J., Storm, J. F. & Adelman, J., Jan 14 2016, In : eLife. 5, JANUARY2016, e11206.

Research output: Contribution to journalArticle

Pyramidal Cells
Neurons
Calcium-Activated Potassium Channels
Action Potentials
Aging of materials
81 Citations (Scopus)

Mechanism of NMDA Receptor Inhibition and Activation

Zhu, S., Stein, R. A., Yoshioka, C., Lee, C. H., Goehring, A., McHaourab, H. S. & Gouaux, E., Apr 21 2016, In : Cell. 165, 3, p. 704-714 11 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Chemical activation
Ligands
Ion Channels
Dimers
4 Citations (Scopus)

Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function

Kim, G., Luján, R., Schwenk, J., Kelley, M. H., Aguado, C., Watanabe, M., Fakler, B., Maylie, J. & Adelman, J., Feb 12 2016, In : eLife. 5, FEBRUARY2016, e12637.

Research output: Contribution to journalArticle

Scaffolds
Membrane Proteins
Membranes
Synaptic Membranes
Long-Term Potentiation
55 Citations (Scopus)

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

Ma, Z., Stork, W. T., Bergles, D. E. & Freeman, M., 2016, In : Nature. 539, 7629, p. 428-432 5 p.

Research output: Contribution to journalArticle

Astrocytes
Neurotransmitter Agents
Octopamine
Tyramine
Dopaminergic Neurons
8 Citations (Scopus)

Nonequivalent release sites govern synaptic depression

Wen, H., McGinley, M. J., Mandel, G. & Brehm, P., Jan 19 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 3, p. E378-E386

Research output: Contribution to journalArticle

Synapses
Depression
Motor Neurons
Zebrafish
Catalytic Domain
20 Citations (Scopus)

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Roy, S., Šileikyte, J., Neuenswander, B., Hedrick, M. P., Chung, T. D. Y., Aubé, J., Schoenen, F. J., Forte, M. & Bernardi, P., Feb 4 2016, In : ChemMedChem. 11, 3, p. 283-288 6 p.

Research output: Contribution to journalArticle

Mitochondria
Pharmacokinetics
Ion Channels
Swelling
Permeability
4 Citations (Scopus)

Optogenetic Control of Mouse Outer Hair Cells

Wu, T., Ramamoorthy, S., Wilson, T., Chen, F., Porsov, E., Subhash, H., Foster, S., Zhang, Y., Omelchenko, I., Bateschell, M., Wang, L., Brigande, J., Jiang, Z-G., Mao, T. & Nuttall, A., Jan 19 2016, In : Biophysical Journal. 110, 2, p. 493-502 10 p.

Research output: Contribution to journalArticle

Outer Auditory Hair Cells
Optogenetics
Light
Cochlea
Cations
11 Citations (Scopus)

Parallel processing of afferent olfactory sensory information

Vaaga, C. E. & Westbrook, G., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Olfactory Receptor Neurons
Olfactory Bulb
Olfactory Nerve
Axons
Glutamic Acid
10 Citations (Scopus)

PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis

Huang, J. Y., Wang, K., Vermehren-Schmaedick, A., Adelman, J. & Cohen, M., Jan 4 2016, In : Scientific Reports. 6, 18512.

Research output: Contribution to journalArticle

Morphogenesis
Adenosine Diphosphate
Poly(ADP-ribose) Polymerases
Dendrites
Bacterial Toxins
21 Citations (Scopus)

Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction

Carter, B. C. & Jahr, C., Jul 11 2016, (Accepted/In press) In : Nature Neuroscience.

Research output: Contribution to journalArticle

Presynaptic Receptors
N-Methyl-D-Aspartate Receptors
Photons
Somatosensory Cortex
Pyramidal Cells
8 Citations (Scopus)

Postsynaptic Plasticity Triggered by Ca2+-Permeable AMPA Receptor Activation in Retinal Amacrine Cells

Kim, M. H. & Von Gersdorff, H., Feb 3 2016, In : Neuron. 89, 3, p. 507-520 14 p.

Research output: Contribution to journalArticle

Amacrine Cells
AMPA Receptors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Dendrites
Ocular Adaptation
8 Citations (Scopus)

Protein kinase A-independent Ras protein activation cooperates with Rap1 protein to mediate activation of the extracellular signal-regulated kinases (ERK) by cAMP

Li, Y., Dillon, T. J., Takahashi, M., Earley, K. T. & Stork, P., Oct 7 2016, In : Journal of Biological Chemistry. 291, 41, p. 21584-21595 12 p.

Research output: Contribution to journalArticle

ras Proteins
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Chemical activation
14 Citations (Scopus)
Permeability
Screening
Molecules
Pathology
Assays
9 Citations (Scopus)

SK channels and calmodulin

Adelman, J., Jan 1 2016, In : Channels. 10, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Calmodulin
Ion Channels
Ions
Calmodulin-Binding Proteins
Gymnastics
23 Citations (Scopus)

The REST remodeling complex protects genomic integrity during embryonic neurogenesis

Nechiporuk, T., McGann, J., Mullendorff, K., Hsieh, J., Wurst, W., Floss, T. & Mandel, G., Jan 8 2016, In : eLife. 5, JANUARY2016, e09584.

Research output: Contribution to journalArticle

Neurogenesis
Genes
S Phase
Chromatin
Tumor Suppressor Protein p53
8 Citations (Scopus)

Thermostabilization, expression, purification, and crystallization of the human serotonin transporter bound to S-citalopram

Coleman, J. A., Green, E. M. & Gouaux, E., Nov 27 2016, In : Journal of Visualized Experiments. 2016, 117, e54792.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Citalopram
Crystallization
Antibodies
Purification
8 Citations (Scopus)
Thiouracil
Gene Expression
Messenger RNA
uracil phosphoribosyltransferase
Neurons
199 Citations (Scopus)

X-ray structures and mechanism of the human serotonin transporter

Coleman, J. A., Green, E. M. & Gouaux, E., Apr 21 2016, In : Nature. 532, 7599, p. 334-339 6 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Antidepressive Agents
X-Rays
Allosteric Site
Citalopram
68 Citations (Scopus)

X-ray structures define human P2X 3 receptor gating cycle and antagonist action

Mansoor, S. E., Lü, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E. & Gouaux, E., Sep 14 2016, In : Nature. 538, 7623, p. 66-71 6 p.

Research output: Contribution to journalArticle

X-Rays
Receptors, Tumor Necrosis Factor, Member 25
Ions
Cardiovascular System
Ion Channels
2015
14 Citations (Scopus)

Agonist binding and desensitization of the μ-opioid receptor is modulated by phosphorylation of the C-terminal tail domain

Birdsong, W. T., Arttamangkul, S., Bunzow, J. R. & Williams, J., Oct 1 2015, In : Molecular Pharmacology. 88, 4, p. 816-824 9 p.

Research output: Contribution to journalArticle

Opioid Receptors
Phosphorylation
Arrestin
Psychologic Desensitization
G-Protein-Coupled Receptors
21 Citations (Scopus)

A High-Resolution Imaging Approach to Investigate Chromatin Architecture in Complex Tissues

Linhoff, M. W., Garg, S. K. & Mandel, G., Sep 24 2015, In : Cell. 163, 1, p. 246-255 10 p.

Research output: Contribution to journalArticle

Chromatin
Tissue
Imaging techniques
Heterochromatin
Neurons
3 Citations (Scopus)

Apamin boosting of synaptic potentials in CaV2.3 R-type Ca2+ channel null mice

Wang, K., Kelley, M. H., Wu, W., Adelman, J. & Maylie, J., Sep 29 2015, In : PLoS One. 10, 9, e0139332.

Research output: Contribution to journalArticle

Apamin
Synaptic Potentials
Excitatory Postsynaptic Potentials
Neurons
Pyramidal Cells
9 Citations (Scopus)

Applying superresolution localization-based microscopy to neurons

Zhong, H., May 1 2015, In : Synapse. 69, 5, p. 283-294 12 p.

Research output: Contribution to journalArticle

Microscopy
Neurons
Neurosciences
Brain
Light
9 Citations (Scopus)

Cocaine Decreases Metabotropic Glutamate Receptor mGluR1 Currents in Dopamine Neurons by Activating mGluR5

Kramer, P. F. & Williams, J., Apr 1 2015, In : Neuropsychopharmacology. 40, 10, p. 2418-2424 7 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Dopaminergic Neurons
Cocaine
Injections
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
16 Citations (Scopus)

Commentary: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore

Bernardi, P. & Forte, M., 2015, In : Frontiers in Physiology. 6, NOV, 320.

Research output: Contribution to journalArticle

Mitochondria
Cell Death
mitochondrial permeability transition pore
16 Citations (Scopus)

Depression of serotonin synaptic transmission by the dopamine Precursor L-DOPA

Gantz, S. C., Levitt, E. S., Llamosas, N., Neve, K. & Williams, J., 2015, In : Cell Reports. 12, 6, p. 944-954 11 p.

Research output: Contribution to journalArticle

Synaptic Transmission
Dopamine
Serotonin
Inhibitory Postsynaptic Potentials
Neurons
26 Citations (Scopus)

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

Roy, S., Šileikyte, J., Schiavone, M., Neuenswander, B., Argenton, F., Aubé, J., Hedrick, M. P., Chung, T. D. Y., Forte, M., Bernardi, P. & Schoenen, F. J., Oct 1 2015, In : ChemMedChem. 10, 10, p. 1655-1671 17 p.

Research output: Contribution to journalArticle

Isoxazoles
Muscular Dystrophies
Zebrafish
Cell death
Cell Death
20 Citations (Scopus)

Distinct regulation of dopamine D2S and D2L autoreceptor signaling by calcium

Gantz, S. C., Robinson, B. G., Buck, D. C., Bunzow, J. R., Neve, R. L., Williams, J. & Neve, K., Aug 26 2015, In : eLife. 4, AUGUST2015, e09358.

Research output: Contribution to journalArticle

Autoreceptors
Calcium Signaling
Dopamine
Calcium
Protein Isoforms
9 Citations (Scopus)

Does PKC activation increase the homologous desensitization of μ opioid receptors?

Arttamangkul, S., Birdsong, W. & Williams, J., 2015, In : British Journal of Pharmacology. 172, 2, p. 583-592 10 p.

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Muscarine
Phorbol Esters
Staurosporine
43 Citations (Scopus)

F-ATPase of drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release

Von Stockum, S., Giorgio, V., Trevisan, E., Lippe, G., Glick, G. D., Forte, M., Da-Rè, C., Checchetto, V., Mazzotta, G., Costa, R., Szabò, I. & Bernardi, P., Feb 20 2015, In : Journal of Biological Chemistry. 290, 8, p. 4537-4544 8 p.

Research output: Contribution to journalArticle

Mitochondria
Drosophila melanogaster
Drosophila
Adenosine Triphosphatases
Calcium-Transporting ATPases
25 Citations (Scopus)

Functional integration of adult-born hippocampal neurons after traumatic brain injury

Villasana, L., Kim, K. N., Westbrook, G. & Schnell, E., Jan 1 2015, In : eNeuro. 2, 5, e0056-15.2015.

Research output: Contribution to journalArticle

Neurons
Neurogenesis
Pro-Opiomelanocortin
Traumatic Brain Injury
Wounds and Injuries
190 Citations (Scopus)

Glycine receptor mechanism elucidated by electron cryo-microscopy

Du, J., Lü, W., Wu, S., Cheng, Y. & Gouaux, E., Oct 8 2015, In : Nature. 526, 7572, p. 224-229 6 p.

Research output: Contribution to journalArticle

Glycine Receptors
Cryoelectron Microscopy
Strychnine
Glycine
Ivermectin
8 Citations (Scopus)

Localized hypoxia within the subgranular zone determines the early survival of newborn hippocampal granule cells

Chatzi, C., Schnell, E. & Westbrook, G., Oct 17 2015, In : eLife. 4, OCTOBER2015, e08722.

Research output: Contribution to journalArticle

Cell death
Stem cells
Glycine
Neurons
Byproducts
36 Citations (Scopus)

Memory formation and retention are affected in adult miR-132/212 knockout mice

Hernandez-Rapp, J., Smith, P. Y., Filali, M., Goupil, C., Planel, E., Magill, S. T., Goodman, R. & Hébert, S. S., Jul 1 2015, In : Behavioural Brain Research. 287, p. 15-26 12 p.

Research output: Contribution to journalArticle

Knockout Mice
Neurodegenerative Diseases
Neuronal Plasticity
Brain-Derived Neurotrophic Factor
Memory Disorders
39 Citations (Scopus)

MiR-218 is essential to establish motor neuron fate as a downstream effector of Isl1-Lhx3

Thiebes, K. P., Nam, H., Cambronne, X., Shen, R., Glasgow, S. M., Cho, H. H., Kwon, J. S., Goodman, R., Lee, J., Lee, S. & Lee, S-K., Jul 27 2015, In : Nature Communications. 6, 7718.

Research output: Contribution to journalArticle

effectors
Motor Neurons
neurons
Neurons
Gene Regulatory Networks
164 Citations (Scopus)

Neurotransmitter and psychostimulant recognition by the dopamine transporter

Wang, K. H., Penmatsa, A. & Gouaux, E., May 21 2015, In : Nature. 521, 7552, p. 322-327 6 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Cocaine
Neurotransmitter Agents
Biogenic Amines
Binding Sites
17 Citations (Scopus)

Synaptic Vesicle Exocytosis at the Dendritic Lobules of an Inhibitory Interneuron in the Mammalian Retina

Balakrishnan, V., Puthussery, T., Kim, M. H., Taylor, W. & Von Gersdorff, H., Aug 5 2015, In : Neuron. 87, 3, p. 564-576 13 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Exocytosis
Interneurons
Amacrine Cells
Synapses
5 Citations (Scopus)

The corepressor Rcor1 is essential for normal myeloerythroid lineage differentiation

Yao, H., Goldman, D., Fan, G., Mandel, G. & Fleming, W., Nov 1 2015, In : Stem Cells. 33, 11, p. 3304-3314 11 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Lymphoid Progenitor Cells
Monocytes
B-Lymphocytes
Hematopoietic Stem Cells
7 Citations (Scopus)

The effect of PKCα on the light response of rod bipolar cells in the mouse retina

Xiong, W-H., Pang, J. J., Pennesi, M., Duvoisin, R., Wu, S. M. & Morgans, C., 2015, In : Investigative Ophthalmology and Visual Science. 56, 8, p. 4961-4974 14 p.

Research output: Contribution to journalArticle

Protein Kinase C
Retina
Light
Protein Kinase C-alpha
Patch-Clamp Techniques