Research Output 1987 2020

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2018
11 Citations (Scopus)

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapyinduced degeneration

Liu, H. W., Smith, C. B., Schmidt, M. S., Cambronne, X., Cohen, M., Migaud, M. E., Brenner, C. & Goodman, R., Oct 16 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 42, p. 10654-10659 6 p.

Research output: Contribution to journalArticle

Nicotinamide Mononucleotide
Nerve Degeneration
NAD
Pharmacology
Nicotinamidase
10 Citations (Scopus)

Preferential targeting of lateral entorhinal inputs onto newly integrated granule cells

Woods, N. I., Vaaga, C. E., Chatzi, C., Adelson, J. D., Collie, M. F., Perederiy, J. V., Tovar, K. R. & Westbrook, G., Jun 27 2018, In : Journal of Neuroscience. 38, 26, p. 5843-5853 11 p.

Research output: Contribution to journalArticle

Perforant Pathway
Entorhinal Cortex
Axons
Synapses
Hippocampus
1 Citation (Scopus)

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect

Rauen, K. A., Schoyer, L., Schill, L., Stronach, B., Albeck, J., Andresen, B. S., Cavé, H., Ellis, M., Fruchtman, S. M., Gelb, B. D., Gibson, C. C., Gripp, K., Hefner, E., Huang, W. Y. C., Itkin, M., Kerr, B., Linardic, C. M., McMahon, M., Oberlander, B., Perlstein, E. & 17 others, Ratner, N., Rogers, L., Schenck, A., Shankar, S., Shvartsman, S., Stevenson, D. A., Stites, E. C., Stork, P., Sun, C., Therrien, M., Ullian, E. M., Widemann, B. C., Yeh, E., Zampino, G., Zenker, M., Timmer, W. & McCormick, F., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A. e40632.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Neoplasms
Musculoskeletal Abnormalities
Skin Abnormalities
Eye Abnormalities
3 Citations (Scopus)

Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan

Clements, R. & Wright, K., Oct 15 2018, In : Developmental Biology. 442, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

Dystroglycans
Optic Chiasm
Retinal Ganglion Cells
Axons
Extracellular Matrix
3 Citations (Scopus)

Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins

Jackman, S., Chen, C. H., Chettih, S. N., Neufeld, S. Q., Drew, I. R., Agba, C. K., Flaquer, I., Stefano, A. N., Kennedy, T. J., Belinsky, J. E., Roberston, K., Beron, C. C., Sabatini, B. L., Harvey, C. D. & Regehr, W. G., Mar 20 2018, In : Cell Reports. 22, 12, p. 3351-3361 11 p.

Research output: Contribution to journalArticle

Optogenetics
Fibroins
Silk
Viruses
Proteins
1 Citation (Scopus)

SK2 Channels Associate With mGlu Receptors and CaV2.1 Channels in Purkinje Cells

Luján, R., Aguado, C., Ciruela, F., Arus, X. M., Martín-Belmonte, A., Alfaro-Ruiz, R., Martínez-Gómez, J., de la Ossa, L., Watanabe, M., Adelman, J., Shigemoto, R. & Fukazawa, Y., Sep 19 2018, In : Frontiers in Cellular Neuroscience. 12, 311.

Research output: Contribution to journalArticle

Purkinje Cells
Macromolecular Substances
Post-Synaptic Density
Calcium-Activated Potassium Channels
Dendritic Spines
23 Citations (Scopus)

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Coleman, J. A. & Gouaux, E., Feb 1 2018, In : Nature Structural and Molecular Biology. 25, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Antidepressive Agents
Binding Sites
Serotonin Agents
Fluvoxamine
9 Citations (Scopus)

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

Ge, J., Elferich, J., Goehring, A., Zhao, H., Schuck, P. & Gouaux, E., Aug 2 2018, In : eLife. 7, e38770.

Research output: Contribution to journalArticle

Stereocilia
Membranes
Audition
Deafness
Cadherins
9 Citations (Scopus)

Structure of the human epithelial sodium channel by cryo-electron microscopy

Noreng, S., Bharadwaj, A., Posert, R., Yoshioka, C. & Baconguis, I., Sep 25 2018, In : eLife. 7

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Cryoelectron Microscopy
Thumb
Electron microscopy
Fingers
4 Citations (Scopus)

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

Navratna, V., Tosh, D. K., Jacobson, K. A. & Gouaux, E., Jul 1 2018, In : PLoS One. 13, 7, e0200085.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
dopamine
Purification
transporters
Conformations
28 Citations (Scopus)

The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH

Antoniel, M., Jones, K., Antonucci, S., Spolaore, B., Fogolari, F., Petronilli, V., Giorgio, V., Carraro, M., Di Lisa, F., Forte, M., Szabó, I., Lippe, G. & Bernardi, P., Feb 1 2018, In : EMBO Reports. 19, 2, p. 257-268 12 p.

Research output: Contribution to journalArticle

Diethyl Pyrocarbonate
Oligomycins
Protein Subunits
Histidine
Permeability
3 Citations (Scopus)

Trajectory analysis unveils Reelin’s role in the directed migration of granule cells in the dentate gyrus

Wang, S., Brunne, B., Zhao, S., Chai, X., Li, J., Lau, J., Failla, A. V., Zobiak, B., Sibbe, M., Westbrook, G., Lutz, D. & Frotscher, M., Jan 3 2018, In : Journal of Neuroscience. 38, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Cell Movement
Neurons
Neurologic Mutant Mice
Pro-Opiomelanocortin
9 Citations (Scopus)

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

Farley, J. E., Burdett, T. C., Barria, R., Neukomm, L. J., Kenna, K. P., Landers, J. E. & Freeman, M., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1358-1363 6 p.

Research output: Contribution to journalArticle

Axons
Carrier Proteins
Transcription Factors
Wounds and Injuries
Sensory Receptor Cells
89 Citations (Scopus)

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Patriarchi, T., Cho, J. R., Merten, K., Howe, M. W., Marley, A., Xiong, W-H., Folk, R. W., Broussard, G. J., Liang, R., Jang, M. J., Zhong, H., Dombeck, D., von Zastrow, M., Nimmerjahn, A., Gradinaru, V., Williams, J. & Tian, L., May 31 2018, (Accepted/In press) In : Science. p. 1-14 14 p.

Research output: Contribution to journalArticle

Dopamine
Optogenetics
Learning
Melatonin
Neuropeptides
2017
37 Citations (Scopus)

Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM

Chen, S., Zhao, Y., Wang, Y., Shekhar, M., Tajkhorshid, E. & Gouaux, E., 2017, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

AMPA Receptors
Chemical activation
Proteins
Quisqualic Acid
Kainic Acid
5 Citations (Scopus)

A Gradient in Synaptic Strength and Plasticity among Motoneurons Provides a Peripheral Mechanism for Locomotor Control

Wang, W. C. & Brehm, P., Feb 6 2017, In : Current Biology. 27, 3, p. 415-422 8 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Motor Neurons
motor neurons
Plasticity
Muscle
19 Citations (Scopus)

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

Sun, W., Hansen, K. B. & Jahr, C., Apr 5 2017, In : Neuron. 94, 1, p. 58-64.e3

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Glutamic Acid
Up-Regulation
Central Nervous System
NR2B NMDA receptor
1 Citation (Scopus)

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

Ligases
Biotin
ras Proteins
Cells
Prenylation

Assessment of mutations in KCNN2 and ZNF135 to patient neurological symptoms

Raghuram, V., Weber, S., Raber, J., Chen, D. H., Bird, T. D., Maylie, J. & Adelman, J., 2017, In : NeuroReport. 28, 7, p. 375-379 5 p.

Research output: Contribution to journalArticle

Mutation
Nonsense Codon
Genes
Exome
Calcium-Activated Potassium Channels
10 Citations (Scopus)

Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development

O'Sullivan, M. L., Puñal, V. M., Kerstein, P. C., Brzezinski, J. A., Glaser, T., Wright, K. & Kay, J. N., Oct 1 2017, In : GLIA. 65, 10, p. 1697-1716 20 p.

Research output: Contribution to journalArticle

Ganglia
Astrocytes
Axons
Retinal Ganglion Cells
Retina
16 Citations (Scopus)

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Lu, T. Y., MacDonald, J. M., Neukomm, L. J., Sheehan, A. E., Bradshaw, R., Logan, M. & Freeman, M., Feb 6 2017, In : Nature Communications. 8, 14355.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 4
axons
degeneration
Neuroglia
Axons
61 Citations (Scopus)

Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transition

Giorgio, V., Burchell, V., Schiavone, M., Bassot, C., Minervini, G., Petronilli, V., Argenton, F., Forte, M., Tosatto, S., Lippe, G. & Bernardi, P., Jul 1 2017, In : EMBO Reports. 18, 7, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Permeability
Adenosine Triphosphate
Cell Death
Cell death
Catalytic Domain
13 Citations (Scopus)

Ca2+-permeable AMPARs mediate glutamatergic transmission and excitotoxic damage at the hair cell ribbon synapse

Sebe, J. Y., Cho, S., Sheets, L., Rutherford, M. A., Von Gersdorff, H. & Raible, D. W., Jun 21 2017, In : Journal of Neuroscience. 37, 25, p. 6162-6175 14 p.

Research output: Contribution to journalArticle

Synapses
Cochlea
Rana catesbeiana
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Zebrafish
12 Citations (Scopus)

Cholinergic interneurons underlie spontaneous dopamine release in nucleus accumbens

Yorgason, J. T., Zeppenfeld, D. M. & Williams, J., Feb 22 2017, In : Journal of Neuroscience. 37, 8, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Interneurons
Cholinergic Agents
Dopamine
Cocaine
2 Citations (Scopus)

Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors

Robinson, B. G., Condon, A. F., Radl, D., Borrelli, E., Williams, J. & Neve, K., Nov 20 2017, In : eLife. 6, e31924.

Research output: Contribution to journalArticle

Autoreceptors
Cocaine
Neurons
Plasticity
Dopamine
65 Citations (Scopus)

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journalArticle

KATP Channels
Glyburide
Adenosine Triphosphate
Hypoglycemic Agents
Conformations
50 Citations (Scopus)

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

Lü, W., Du, J., Goehring, A. & Gouaux, E., Mar 24 2017, In : Science. 355, 6331, eaal3729.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Ion Channel Gating
Ion Channels
Electron Microscopy
9 Citations (Scopus)

Desensitized D2 autoreceptors are resistant to trafficking

Robinson, B. G., Bunzow, J. R., Grimm, J. B., Lavis, L. D., Dudman, J. T., Brown, J., Neve, K. & Williams, J., Dec 1 2017, In : Scientific Reports. 7, 1, 4728.

Research output: Contribution to journalArticle

Autoreceptors
Dopaminergic Neurons
Dopamine
Locus Coeruleus
Opioid Receptors
10 Citations (Scopus)

Distinct actions of voltage-activated Ca2+ channel block on spontaneous release at excitatory and inhibitory central synapses

Tsintsadze, T., Williams, C. L., Weingarten, D. J., Von Gersdorff, H. & Smith, S., Apr 19 2017, In : Journal of Neuroscience. 37, 16, p. 4301-4310 10 p.

Research output: Contribution to journalArticle

Synapses
Calcium Channels
Calcium Channel Blockers
Synaptic Transmission
Brain Stem
3 Citations (Scopus)

Distinct temporal filters in mitral cells and external tufted cells of the olfactory bulb

Vaaga, C. E. & Westbrook, G., Oct 1 2017, In : Journal of Physiology. 595, 19, p. 6349-6362 14 p.

Research output: Contribution to journalArticle

Olfactory Bulb
Odorant Receptors
Neurons
Olfactory Receptor Neurons
Olfactory Nerve
3 Citations (Scopus)

Dystroglycan maintains inner limiting membrane integrity to coordinate retinal development

Clements, R., Turk, R., Campbell, K. P. & Wright, K., Aug 30 2017, In : Journal of Neuroscience. 37, 35, p. 8559-8574 16 p.

Research output: Contribution to journalArticle

Dystroglycans
Membranes
Neuroepithelial Cells
Neuronal Plasticity
Muscular Dystrophies
12 Citations (Scopus)

Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments

Chiu, D. N. & Jahr, C., Mar 14 2017, In : Cell Reports. 18, 11, p. 2576-2583 8 p.

Research output: Contribution to journalArticle

Nucleus Accumbens
Glutamic Acid
Amino Acid Transport Systems
Excitatory Amino Acids
Extracellular Space
17 Citations (Scopus)

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Tillo, S. E., Xiong, W-H., Takahashi, M., Miao, S., Andrade, A. L., Fortin, D. A., Yang, G., Qin, M., Smoody, B. F., Stork, P. & Zhong, H., Apr 18 2017, In : Cell Reports. 19, 3, p. 617-629 13 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Catalytic Domain
Membranes
Substrates
Protein Kinase C
15 Citations (Scopus)

miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock

Mendoza-Viveros, L., Chiang, C. K., Ong, J. L. K., Hegazi, S., Cheng, A. H., Bouchard-Cannon, P., Fana, M., Lowden, C., Zhang, P., Bothorel, B., Michniewicz, M. G., Magill, S. T., Holmes, M. M., Goodman, R., Simonneaux, V., Figeys, D. & Cheng, H. Y. M., Apr 18 2017, In : Cell Reports. 19, 3, p. 505-520 16 p.

Research output: Contribution to journalArticle

Circadian Clocks
Suprachiasmatic Nucleus
Neurons
Clocks
Dendritic Spines
7 Citations (Scopus)

Modulating synaptic NMDA receptors

Tovar, K. R. & Westbrook, G., Jan 1 2017, In : Neuropharmacology. 112, p. 29-33 5 p.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
N-Methyl-D-Aspartate Receptors
Ligands
Ionotropic Glutamate Receptors
Behavior Therapy
9 Citations (Scopus)

Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus

Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K. & Shi, S. H., Mar 29 2017, In : Nature Neuroscience. 20, 4, p. 516-528 13 p.

Research output: Contribution to journalArticle

Thalamus
Organizations
Cognition
Thalamic Nuclei
Hedgehogs
12 Citations (Scopus)

Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP

Takahashi, M., Li, Y., Dillon, T. J. & Stork, P., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1449-1461 13 p.

Research output: Contribution to journalArticle

Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Chemical activation
3 Citations (Scopus)

Phosphorylation of the C-Raf N region promotes Raf dimerization

Takahashi, M., Li, Y., Dillon, T. J., Kariya, Y. & Stork, P., Oct 1 2017, In : Molecular and Cellular Biology. 37, 19, e00132-17.

Research output: Contribution to journalArticle

Dimerization
Phosphorylation
Extracellular Signal-Regulated MAP Kinases
Serine
Tyrosine
11 Citations (Scopus)

Presynaptic gain control by endogenous cotransmission of dopamine and GABA in the olfactory bulb

Vaaga, C. E., Yorgason, J. T., Williams, J. & Westbrook, G., Mar 1 2017, In : Journal of Neurophysiology. 117, 3, p. 1163-1170 8 p.

Research output: Contribution to journalArticle

Olfactory Bulb
gamma-Aminobutyric Acid
Dopamine
Interneurons
Axons
12 Citations (Scopus)

REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation- differentiation balance in the developing brain

Monaghan, C. E., Nechiporuk, T., Jeng, S., McWeeney, S., Wang, J., Rosenfeld, M. G. & Mandel, G., Jan 17 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. E406-E415

Research output: Contribution to journalArticle

Co-Repressor Proteins
Insulinoma
Brain
Transcription Factors
Neurons
11 Citations (Scopus)

Short-term depression of sprouted mossy fiber synapses from adult-born granule cells

Hendricks, W. D., Chen, Y., Bensen, A. L., Westbrook, G. & Schnell, E., Jun 7 2017, In : Journal of Neuroscience. 37, 23, p. 5722-5735 14 p.

Research output: Contribution to journalArticle

Synapses
Status Epilepticus
Optogenetics
Pilocarpine
Temporal Lobe Epilepsy
18 Citations (Scopus)

Site-directed RNA repair of endogenous Mecp2 RNA in neurons

Sinnamon, J. R., Kim, S. Y., Corson, G. M., Song, Z., Nakai, H., Adelman, J. & Mandel, G., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. E9395-E9402

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
RNA
Neurons
RNA Editing
7 Citations (Scopus)

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Jongbloets, B. C., Lemstra, S., Schellino, R., Broekhoven, M. H., Parkash, J., Hellemons, A. J. C. G. M., Mao, T., Giacobini, P., Van Praag, H., De Marchis, S., Ramakers, G. M. J. & Pasterkamp, R. J., Mar 10 2017, In : Nature Communications. 8, 14666.

Research output: Contribution to journalArticle

Neurogenesis
Dentate Gyrus
Brain
brain
Parahippocampal Gyrus
17 Citations (Scopus)

The coupling between Ca2+ channels and the exocytotic Ca2+ sensor at hair cell ribbon synapses varies tonotopically along the mature cochlea

Johnson, S. L., Olt, J., Cho, S., Von Gersdorff, H. & Marcotti, W., Mar 1 2017, In : Journal of Neuroscience. 37, 9, p. 2471-2484 14 p.

Research output: Contribution to journalArticle

Cochlea
Synapses
Exocytosis
Buffers
Gerbillinae
14 Citations (Scopus)

The secreted neurotrophin spätzle 3 promotes glial morphogenesis and supports neuronal survival and function

Coutinho-Budd, J. C., Sheehan, A. E. & Freeman, M., Oct 15 2017, In : Genes and Development. 31, 20, p. 2023-2038 16 p.

Research output: Contribution to journalArticle

Neurotrophin 3
Morphogenesis
Neuroglia
Neurons
Central Nervous System

Tuning auditory synapses for resilience, reliability and precision

Lujan, B. & Von Gersdorff, H., Feb 1 2017, In : Journal of Physiology. 595, 3, p. 621-622 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Two-color, one-photon uncaging of glutamate and GABA

Passlick, S., Kramer, P. F., Richers, M. T., Williams, J. & Ellis-Davies, G. C. R., Nov 1 2017, In : PLoS One. 12, 11, e0187732.

Research output: Contribution to journalArticle

Photolysis
Photons
glutamates
gamma-Aminobutyric Acid
Glutamic Acid
2 Citations (Scopus)

Whole genome sequencing-based mapping and candidate identification of mutations from fixed zebrafish tissue

Sanchez, N. E., Harty, B. L., O'Reilly-Pol, T., Ackerman, S. D., Herbert, A. L., Holmgren, M., Johnson, S. L., Gray, R. S. & Monk, K., Oct 1 2017, In : G3: Genes, Genomes, Genetics. 7, 10, p. 3415-3425 11 p.

Research output: Contribution to journalArticle

Zebrafish
Genome
Tissue Fixation
Mutation
In Situ Hybridization
2016
83 Citations (Scopus)

A comprehensive excitatory input map of the striatum reveals novel functional organization

Hunnicutt, B. J., Jongbloets, B. C., Birdsong, W. T., Gertz, K. J., Zhong, H. & Mao, T., Nov 28 2016, In : eLife. 5, November2016, e19103.

Research output: Contribution to journalArticle

Corpus Striatum
Thalamus
Optogenetics
Basal Ganglia
Experiments
22 Citations (Scopus)

Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells

Grasselli, G., He, Q., Wan, V., Adelman, J., Ohtsuki, G. & Hansel, C., Mar 22 2016, In : Cell Reports. 14, 11, p. 2546-2553 8 p.

Research output: Contribution to journalArticle

Purkinje Cells
Apamin
Plasticity
Learning
Neurons