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2018

Influences: Sodium channel excitement

Mandel, G., Aug 1 2018, In : Journal of General Physiology. 150, 8, p. 1047-1049 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Light-Controlled Lipid Interaction and Membrane Organization in Photolipid Bilayer Vesicles

Urban, P., Pritzl, S. D., Konrad, D. B., Frank, J. A., Pernpeintner, C., Roeske, C. R., Trauner, D. & Lohmüller, T., Nov 6 2018, In : Langmuir. 34, 44, p. 13368-13374 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1 G93A mouse model of amyotrophic lateral sclerosis

Peters, O. M., Lewis, E. A., Osterloh, J. M., Weiss, A., Salameh, J. S., Metterville, J., Brown, R. H. & Freeman, M. R., Jan 1 2018, In : Human molecular genetics. 27, 21, p. 3761-3771 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mechanism of NMDA receptor channel block by MK-801 and memantine

Song, X., Jensen, M. O., Jogini, V., Stein, R. A., Lee, C. H., McHaourab, H. S., Shaw, D. E. & Gouaux, E., Apr 26 2018, In : Nature. 556, 7702, p. 515-519 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

Jalali-Yazdi, F., Chowdhury, S., Yoshioka, C. & Gouaux, E., Nov 29 2018, In : Cell. 175, 6, p. 1520-1532.e15

Research output: Contribution to journalArticle

18 Scopus citations

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

Giera, S., Luo, R., Ying, Y., Ackerman, S. D., Jeong, S. J., Stoveken, H. M., Folts, C. J., Welsh, C. A., Tall, G. G., Stevens, B., Monk, K. R. & Piao, X., May 29 2018, In : eLife. 7, e33385.

Research output: Contribution to journalArticle

22 Scopus citations

Mutations in dock1 disrupt early Schwann cell development

Cunningham, R. L., Herbert, A. L., Harty, B. L., Ackerman, S. D. & Monk, K. R., Aug 8 2018, In : Neural Development. 13, 1, 17.

Research output: Contribution to journalArticle

1 Scopus citations

Neuronal activity induces glutathione metabolism gene expression in astrocytes

McGann, J. C. & Mandel, G., Sep 1 2018, In : GLIA. 66, 9, p. 2024-2039 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Optical control of L-type Ca 2+ channels using a diltiazem photoswitch

Fehrentz, T., Huber, F. M. E., Hartrampf, N., Bruegmann, T., Frank, J. A., Fine, N. H. F., Malan, D., Danzl, J. G., Tikhonov, D. B., Sumser, M., Sasse, P., Hodson, D. J., Zhorov, B. S., Klöcker, N. & Trauner, D., Aug 1 2018, In : Nature Chemical Biology. 14, 8, p. 764-767 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapyinduced degeneration

Liu, H. W., Smith, C. B., Schmidt, M. S., Cambronne, X., Cohen, M., Migaud, M. E., Brenner, C. & Goodman, R., Oct 16 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 42, p. 10654-10659 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Preferential targeting of lateral entorhinal inputs onto newly integrated granule cells

Woods, N. I., Vaaga, C. E., Chatzi, C., Adelson, J. D., Collie, M. F., Perederiy, J. V., Tovar, K. R. & Westbrook, G., Jun 27 2018, In : Journal of Neuroscience. 38, 26, p. 5843-5853 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect

Rauen, K. A., Schoyer, L., Schill, L., Stronach, B., Albeck, J., Andresen, B. S., Cavé, H., Ellis, M., Fruchtman, S. M., Gelb, B. D., Gibson, C. C., Gripp, K., Hefner, E., Huang, W. Y. C., Itkin, M., Kerr, B., Linardic, C. M., McMahon, M., Oberlander, B., Perlstein, E. & 17 others, Ratner, N., Rogers, L., Schenck, A., Shankar, S., Shvartsman, S., Stevenson, D. A., Stites, E. C., Stork, P., Sun, C., Therrien, M., Ullian, E. M., Widemann, B. C., Yeh, E., Zampino, G., Zenker, M., Timmer, W. & McCormick, F., Jan 1 2018, (Accepted/In press) In : American Journal of Medical Genetics, Part A. e40632.

Research output: Contribution to journalArticle

3 Scopus citations

Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan

Clements, R. & Wright, K., Oct 15 2018, In : Developmental Biology. 442, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins

Jackman, S., Chen, C. H., Chettih, S. N., Neufeld, S. Q., Drew, I. R., Agba, C. K., Flaquer, I., Stefano, A. N., Kennedy, T. J., Belinsky, J. E., Roberston, K., Beron, C. C., Sabatini, B. L., Harvey, C. D. & Regehr, W. G., Mar 20 2018, In : Cell Reports. 22, 12, p. 3351-3361 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

SK2 Channels Associate With mGlu Receptors and CaV2.1 Channels in Purkinje Cells

Luján, R., Aguado, C., Ciruela, F., Arus, X. M., Martín-Belmonte, A., Alfaro-Ruiz, R., Martínez-Gómez, J., de la Ossa, L., Watanabe, M., Adelman, J. P., Shigemoto, R. & Fukazawa, Y., Sep 19 2018, In : Frontiers in Cellular Neuroscience. 12, 311.

Research output: Contribution to journalArticle

1 Scopus citations

Structural basis for recognition of diverse antidepressants by the human serotonin transporter

Coleman, J. A. & Gouaux, E., Feb 1 2018, In : Nature Structural and Molecular Biology. 25, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

Ge, J., Elferich, J., Goehring, A., Zhao, H., Schuck, P. & Gouaux, E., Aug 2 2018, In : eLife. 7, e38770.

Research output: Contribution to journalArticle

10 Scopus citations

Structure of the human epithelial sodium channel by cryo-electron microscopy

Noreng, S., Bharadwaj, A., Posert, R., Yoshioka, C. & Baconguis, I., Sep 25 2018, In : eLife. 7

Research output: Contribution to journalArticle

23 Scopus citations

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

Navratna, V., Tosh, D. K., Jacobson, K. A. & Gouaux, E., Jul 1 2018, In : PLoS One. 13, 7, e0200085.

Research output: Contribution to journalArticle

6 Scopus citations

The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH

Antoniel, M., Jones, K., Antonucci, S., Spolaore, B., Fogolari, F., Petronilli, V., Giorgio, V., Carraro, M., Di Lisa, F., Forte, M., Szabó, I., Lippe, G. & Bernardi, P., Feb 1 2018, In : EMBO Reports. 19, 2, p. 257-268 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Trajectory analysis unveils Reelin’s role in the directed migration of granule cells in the dentate gyrus

Wang, S., Brunne, B., Zhao, S., Chai, X., Li, J., Lau, J., Failla, A. V., Zobiak, B., Sibbe, M., Westbrook, G. L., Lutz, D. & Frotscher, M., Jan 3 2018, In : Journal of Neuroscience. 38, 1, p. 137-148 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

Farley, J. E., Burdett, T. C., Barria, R., Neukomm, L. J., Kenna, K. P., Landers, J. E. & Freeman, M. R., Feb 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 6, p. 1358-1363 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Patriarchi, T., Cho, J. R., Merten, K., Howe, M. W., Marley, A., Xiong, W. H., Folk, R. W., Broussard, G. J., Liang, R., Jang, M. J., Zhong, H., Dombeck, D., von Zastrow, M., Nimmerjahn, A., Gradinaru, V., Williams, J. T. & Tian, L., Jun 29 2018, In : Science. 360, 6396, eaat4422.

Research output: Contribution to journalArticle

123 Scopus citations
2017

Activation and Desensitization Mechanism of AMPA Receptor-TARP Complex by Cryo-EM

Chen, S., Zhao, Y., Wang, Y., Shekhar, M., Tajkhorshid, E. & Gouaux, E., 2017, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

46 Scopus citations

A Gradient in Synaptic Strength and Plasticity among Motoneurons Provides a Peripheral Mechanism for Locomotor Control

Wang, W. C. & Brehm, P., Feb 6 2017, In : Current Biology. 27, 3, p. 415-422 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties

Sun, W., Hansen, K. B. & Jahr, C., Apr 5 2017, In : Neuron. 94, 1, p. 58-64.e3

Research output: Contribution to journalArticle

22 Scopus citations

Analysis of K-Ras interactions by biotin ligase tagging

Ritchie, C., Mack, A., Harper, L., Alfadhli, A., Stork, P. J. S., Nan, X. & Barklis, E., Jul 1 2017, In : Cancer Genomics and Proteomics. 14, 4, p. 225-239 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Assessment of mutations in KCNN2 and ZNF135 to patient neurological symptoms

Raghuram, V., Weber, S., Raber, J., Chen, D. H., Bird, T. D., Maylie, J. & Adelman, J. P., Jan 1 2017, In : NeuroReport. 28, 7, p. 375-379 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development

O'Sullivan, M. L., Puñal, V. M., Kerstein, P. C., Brzezinski, J. A., Glaser, T., Wright, K. M. & Kay, J. N., Oct 2017, In : GLIA. 65, 10, p. 1697-1716 20 p.

Research output: Contribution to journalArticle

17 Scopus citations

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Lu, T. Y., MacDonald, J. M., Neukomm, L. J., Sheehan, A. E., Bradshaw, R., Logan, M. A. & Freeman, M. R., Feb 6 2017, In : Nature communications. 8, 14355.

Research output: Contribution to journalArticle

18 Scopus citations

Ca2+ binding to F-ATP synthase β subunit triggers the mitochondrial permeability transition

Giorgio, V., Burchell, V., Schiavone, M., Bassot, C., Minervini, G., Petronilli, V., Argenton, F., Forte, M., Tosatto, S., Lippe, G. & Bernardi, P., Jul 1 2017, In : EMBO Reports. 18, 7, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

76 Scopus citations

Ca2+-permeable AMPARs mediate glutamatergic transmission and excitotoxic damage at the hair cell ribbon synapse

Sebe, J. Y., Cho, S., Sheets, L., Rutherford, M. A., Von Gersdorff, H. & Raible, D. W., Jun 21 2017, In : Journal of Neuroscience. 37, 25, p. 6162-6175 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Cholinergic interneurons underlie spontaneous dopamine release in nucleus accumbens

Yorgason, J. T., Zeppenfeld, D. M. & Williams, J., Feb 22 2017, In : Journal of Neuroscience. 37, 8, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors

Robinson, B. G., Condon, A. F., Radl, D., Borrelli, E., Williams, J. T. & Neve, K. A., Nov 20 2017, In : eLife. 6, e31924.

Research output: Contribution to journalArticle

3 Scopus citations

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Martin, G. M., Yoshioka, C., Rex, E. A., Fay, J. F., Xie, Q., Whorton, M., Chen, J. Z. & Shyng, S-L., Jan 16 2017, In : eLife. 6, e24149.

Research output: Contribution to journalArticle

72 Scopus citations

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

Lü, W., Du, J., Goehring, A. & Gouaux, E., Mar 24 2017, In : Science. 355, 6331, eaal3729.

Research output: Contribution to journalArticle

57 Scopus citations

Desensitized D2 autoreceptors are resistant to trafficking

Robinson, B. G., Bunzow, J. R., Grimm, J. B., Lavis, L. D., Dudman, J. T., Brown, J., Neve, K. & Williams, J., Dec 1 2017, In : Scientific Reports. 7, 1, 4728.

Research output: Contribution to journalArticle

12 Scopus citations

Distinct actions of voltage-activated Ca2+ channel block on spontaneous release at excitatory and inhibitory central synapses

Tsintsadze, T., Williams, C. L., Weingarten, D. J., Von Gersdorff, H. & Smith, S., Apr 19 2017, In : Journal of Neuroscience. 37, 16, p. 4301-4310 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Distinct temporal filters in mitral cells and external tufted cells of the olfactory bulb

Vaaga, C. E. & Westbrook, G. L., Oct 1 2017, In : Journal of Physiology. 595, 19, p. 6349-6362 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Dystroglycan maintains inner limiting membrane integrity to coordinate retinal development

Clements, R., Turk, R., Campbell, K. P. & Wright, K., Aug 30 2017, In : Journal of Neuroscience. 37, 35, p. 8559-8574 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Extracellular Glutamate in the Nucleus Accumbens Is Nanomolar in Both Synaptic and Non-synaptic Compartments

Chiu, D. N. & Jahr, C., Mar 14 2017, In : Cell Reports. 18, 11, p. 2576-2583 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination

Ghidinelli, M., Poitelon, Y., Shin, Y. K., Ameroso, D., Williamson, C., Ferri, C., Pellegatta, M., Espino, K., Mogha, A., Monk, K., Podini, P., Taveggia, C., Nave, K. A., Wrabetz, L., Park, H. T. & Feltri, M. L., Jun 21 2017, In : PLoS Biology. 15, 6, e2001408.

Research output: Contribution to journalArticle

14 Scopus citations

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates

Tillo, S. E., Xiong, W-H., Takahashi, M., Miao, S., Andrade, A. L., Fortin, D. A., Yang, G., Qin, M., Smoody, B. F., Stork, P. & Zhong, H., Apr 18 2017, In : Cell Reports. 19, 3, p. 617-629 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles

Pernpeintner, C., Frank, J. A., Urban, P., Roeske, C. R., Pritzl, S. D., Trauner, D. & Lohmüller, T., Apr 25 2017, In : Langmuir. 33, 16, p. 4083-4089 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

miR-132/212 Modulates Seasonal Adaptation and Dendritic Morphology of the Central Circadian Clock

Mendoza-Viveros, L., Chiang, C. K., Ong, J. L. K., Hegazi, S., Cheng, A. H., Bouchard-Cannon, P., Fana, M., Lowden, C., Zhang, P., Bothorel, B., Michniewicz, M. G., Magill, S. T., Holmes, M. M., Goodman, R. H., Simonneaux, V., Figeys, D. & Cheng, H. Y. M., Apr 18 2017, In : Cell Reports. 19, 3, p. 505-520 16 p.

Research output: Contribution to journalArticle

17 Scopus citations

Modulating synaptic NMDA receptors

Tovar, K. R. & Westbrook, G., Jan 1 2017, In : Neuropharmacology. 112, p. 29-33 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ontogenetic establishment of order-specific nuclear organization in the mammalian thalamus

Shi, W., Xianyu, A., Han, Z., Tang, X., Li, Z., Zhong, H., Mao, T., Huang, K. & Shi, S. H., Mar 29 2017, In : Nature Neuroscience. 20, 4, p. 516-528 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Optical control of GPR40 signalling in pancreatic β-cells

Frank, J. A., Yushchenko, D. A., Fine, N. H. F., Duca, M., Citir, M., Broichhagen, J., Hodson, D. J., Schultz, C. & Trauner, D., Jan 1 2017, In : Chemical Science. 8, 11, p. 7604-7610 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Phosphorylation of Rap1 by cAMP-dependent protein kinase (PKA) creates a binding site for KSR to sustain ERK activation by cAMP

Takahashi, M., Li, Y., Dillon, T. J. & Stork, P., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1449-1461 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

Phosphorylation of the C-Raf N region promotes Raf dimerization

Takahashi, M., Li, Y., Dillon, T. J., Kariya, Y. & Stork, P., Oct 1 2017, In : Molecular and Cellular Biology. 37, 19, e00132-17.

Research output: Contribution to journalArticle

5 Scopus citations