Vaccine and Gene Therapy Institute

Research output

Research output per year 1989 2006 2007 2008 2010 2011 2012 2013 2014 2015 2017 2018 2019 2020 2021 2022 2023 2024

• 697 Article
• 82 Review article
• 34 Comment/debate
• 25 Chapter
• 27 More
  • 10 Short survey
  • 8 Letter
  • 7 Editorial
  • 1 Conference contribution
  • 1 Foreword/postscript

Research output per year

Research output per year

Search results

• 2024

  Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine

  MacMillen, Z., Hatzakis, K., Simpson, A., Shears, M. J., Watson, F., Erasmus, J. H., Khandhar, A. P., Wilder, B., Murphy, S. C., Reed, S. G., Davie, J. W. & Avril, M., Dec 2024, In: npj Vaccines. 9, 1, 12.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Malaria Vaccines 100%
  • Sporozoites 97%
  • Vaccines 54%
  • Immunization 24%
  • Radiation 21%

• CD4^dimCD8^brightT cells are inversely associated with neuro-inflammatory markers among people with HIV

  Albalawi, Y. A., Shull, T., Virdi, A. K., Subra, C., Mitchell, J., Slike, B. M., Jian, N., Krebs, S. J., Sacdalan, C., Ratnaratorn, N., Hsu, D. C., Phanuphak, N., Spudich, S., Trautmann, L. & Al-Harthi, L., Jan 1 2024, In: AIDS. 38, 1, p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebrospinal Fluid 100%
  • HIV 79%
  • T-Lymphocytes 35%
  • Neopterin 19%
  • Biomarkers 18%

• Induction of somatic cell haploidy by premature cell division

  Mikhalchenko, A., Gutierrez, N. M., Frana, D., Safaei, Z., Van Dyken, C., Li, Y., Ma, H., Koski, A., Liang, D., Lee, S. G., Amato, P. & Mitalipov, S., Mar 2024, In: Science Advances. 10, 10, eadk9001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Haploidy 100%
  • Cell Division 75%
  • Genome 53%
  • Meiosis 45%
  • Oocytes 37%

• SIV Infection Is Associated with Transient Acute-Phase Steatosis in Hepatocytes In Vivo

  Derby, N., Biswas, S., Yusova, S., Luevano-Santos, C., Pacheco, M. C., Meyer, K. A., Johnson, B. I., Fischer, M., Fancher, K. A., Fisher, C., Abraham, Y. M., McMahon, C. J., Lutz, S. S., Smedley, J. V., Burwitz, B. J. & Sodora, D. L., Feb 2024, In: Viruses. 16, 2, 296.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hepatocytes 100%
  • Liver 61%
  • Infections 56%
  • Macaca 49%
  • Cholesterol 32%

• Virology—the path forward

  Rasmussen, A. L., Gronvall, G. K., Lowen, A. C., Goodrum, F., Alwine, J., Andersen, K. G., Anthony, S. J., Baines, J., Banerjee, A., Broadbent, A. J., Brooke, C. B., Campos, S. K., Caposio, P., Casadevall, A., Chan, G. C., Cliffe, A. R., Collins-McMillen, D., Connell, N., Damania, B., Daugherty, M. D., & 58 othersDebbink, K., Dermody, T. S., DiMaio, D., Duprex, W. P., Emerman, M., Galloway, D. A., Garry, R. F., Goldstein, S. A., Greninger, A. L., Hartman, A. L., Hogue, B. G., Horner, S. M., Hotez, P. J., Jung, J. U., Kamil, J. P., Karst, S. M., Laimins, L., Lakdawala, S. S., Landais, I., Letko, M., Lindenbach, B., Liu, S. L., Luftig, M., McFadden, G., Mehle, A., Morrison, J., Moscona, A., Mühlberger, E., Munger, J., Münger, K., Murphy, E., Neufeldt, C. J., Nikolich, J. Z., O'Connor, C. M., Pekosz, A., Permar, S. R., Pfeiffer, J. K., Popescu, S. V., Purdy, J. G., Racaniello, V. R., Rice, C. M., Runstadler, J. A., Sapp, M. J., Scott, R. S., Smith, G. A., Sorrell, E. M., Speranza, E., Streblow, D., Tibbetts, S. A., Toth, Z., Van Doorslaer, K., Weiss, S. R., White, E. A., White, T. M., Wobus, C. E., Worobey, M., Yamaoka, S. & Yurochko, A., Jan 2024, In: Journal of virology. 98, 1

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  1 Scopus citations

• Virology—the path forward

  Rasmussen, A. L., Gronvall, G. K., Lowen, A. C., Goodrum, F., Alwine, J., Andersen, K. G., Anthony, S. J., Baines, J., Banerjee, A., Broadbent, A. J., Brooke, C. B., Campos, S. K., Caposio, P., Casadevall, A., Chan, G. C., Cliffe, A. R., Collins-McMillen, D., Connell, N., Damania, B., Daugherty, M. D., & 58 othersDebbink, K., Dermody, T. S., DiMaio, D., Duprex, W. P., Emerman, M., Galloway, D. A., Garry, R. F., Goldstein, S. A., Greninger, A. L., Hartman, A. L., Hogue, B. G., Horner, S. M., Hotez, P. J., Jung, J. U., Kamil, J. P., Karst, S. M., Laimins, L., Lakdawala, S. S., Landais, I., Letko, M., Lindenbach, B., Liu, S. L., Luftig, M., McFadden, G., Mehle, A., Morrison, J., Moscona, A., Mühlberger, E., Munger, J., Münger, K., Murphy, E., Neufeldt, C. J., Nikolich, J. Z., O'Connor, C. M., Pekosz, A., Permar, S. R., Pfeiffer, J. K., Popescu, S. V., Purdy, J. G., Racaniello, V. R., Rice, C. M., Runstadler, J. A., Sapp, M. J., Scott, R. S., Smith, G. A., Sorrell, E. M., Speranza, E., Streblow, D., Tibbetts, S. A., Toth, Z., Van Doorslaer, K., Weiss, S. R., White, E. A., White, T. M., Wobus, C. E., Worobey, M., Yamaoka, S. & Yurochko, A., Mar 2024, In: Journal of virology. 98, 3

  Research output: Contribution to journal › Review article › peer-review
• 2023

  Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology

  Streblow, D. N., Hirsch, A. J., Stanton, J. J., Lewis, A. D., Colgin, L., Hessell, A. J., Kreklywich, C. N., Smith, J. L., Sutton, W. F., Chauvin, D., Woo, J., Bimber, B. N., LeBlanc, C. N., Acharya, S. N., O’Roak, B. J., Sardar, H., Sajadi, M. M., Tehrani, Z. R., Walter, M. R., Martinez-Sobrido, L., & 15 othersKobie, J. J., Reader, R. J., Olstad, K. J., Hobbs, T. R., Saphire, E. O., Schendel, S. L., Carnahan, R. H., Knoch, J., Branco, L. M., Crowe, J. E., Van Rompay, K. K. A., Lovalenti, P., Vu Truong, T., Forthal, D. N. & Haigwood, N. L., Dec 2023, In: Nature communications. 14, 1, 7062.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • pathology 93%
  • antibodies 91%
  • Macaca 86%

• Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques

  Wu, H. L., Busman-Sahay, K., Weber, W. C., Waytashek, C. M., Boyle, C. D., Bateman, K. B., Reed, J. S., Hwang, J. M., Shriver-Munsch, C., Swanson, T., Northrup, M., Armantrout, K., Price, H., Robertson-LeVay, M., Uttke, S., Kumar, M. R., Fray, E. J., Taylor-Brill, S., Bondoc, S., Agnor, R., & 23 othersJunell, S. L., Legasse, A. W., Moats, C., Bochart, R. M., Sciurba, J., Bimber, B. N., Sullivan, M. N., Dozier, B., MacAllister, R. P., Hobbs, T. R., Martin, L. D., Panoskaltsis-Mortari, A., Colgin, L. M. A., Siliciano, R. F., Siliciano, J. D., Estes, J. D., Smedley, J. V., Axthelm, M. K., Meyers, G., Maziarz, R. T., Burwitz, B. J., Stanton, J. J. & Sacha, J. B., Jul 11 2023, In: Immunity. 56, 7, p. 1649-1663.e5

  Research output: Contribution to journal › Article › peer-review

  • Macaca 100%
  • Allogeneic Cells 96%
  • Hematopoietic Stem Cell Transplantation 95%
  • Stem Cell Transplantation 93%
  • Immunity 73%
  6 Scopus citations

• An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8⁺ T cell magnitude and short-lived differentiation status

  RV254/SEARCH010 & RV304/SEARCH013, Sep 13 2023, In: Cell Host and Microbe. 31, 9, p. 1494-1506.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-lymphocytes 100%
  • therapeutics 85%
  • Maintenance 76%
  • HIV 75%
  • T-Lymphocytes 67%
  3 Scopus citations

• A Small Molecule RIG-I Agonist Serves as an Adjuvant to Induce Broad Multifaceted Influenza Virus Vaccine Immunity

  Hemann, E. A., Knoll, M. L., Wilkins, C. R., Subra, C., Green, R., García-Sastre, A., Thomas, P. G., Trautmann, L., Ireton, R. C., Loo, Y. M. & Gale, M., May 1 2023, In: Journal of Immunology. 210, 9, p. 1247-1256 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Influenza Vaccines 100%
  • Tretinoin 90%
  • Influenza A virus 77%
  • Immunity 71%
  • Interferon Regulatory Factor-3 51%
  2 Scopus citations

• Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease

  Erickson, M. A., Logsdon, A. F., Rhea, E. M., Hansen, K. M., Holden, S. J., Banks, W. A., Smith, J. L., German, C., Farr, S. A., Morley, J. E., Weaver, R. R., Hirsch, A. J., Kovac, A., Kontsekova, E., Baumann, K. K., Omer, M. A. & Raber, J., Mar 2023, In: Brain, Behavior, and Immunity. 109, p. 251-268 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Blood-Brain Barrier 65%
  • Cognitive Dysfunction 55%
  • Alzheimer Disease 52%
  • Transcytosis 45%
  9 Scopus citations

• Brain volumetrics differ by Fiebig stage in acute HIV infection

  Bolzenius, J., Sacdalan, C., Ndhlovu, L. C., Sailasuta, N., Trautmann, L., Tipsuk, S., Crowell, T. A., Suttichom, D., Colby, D. J., Phanuphak, N., Chan, P., Premeaux, T., Kroon, E., Vasan, S., Hsu, D. C., Valcour, V., Ananworanich, J., Robb, M. L., Ake, J. A., Pohl, K. M., & 3 othersSriplienchan, S., Spudich, S. & Paul, R., May 1 2023, In: AIDS. 37, 6, p. 861-869 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Putamen 100%
  • HIV Infections 98%
  • Nucleus Accumbens 96%
  • Globus Pallidus 78%
  • HIV 61%
  1 Scopus citations

• Chronic immune activation and gut barrier dysfunction is associated with neuroinflammation in ART-suppressed SIV+ rhesus macaques

  Byrnes, S. J., Busman-Sahay, K., Angelovich, T. A., Younger, S., Taylor-Brill, S., Nekorchuk, M., Bondoc, S., Dannay, R., Terry, M., Cochrane, C. R., Jenkins, T. A., Roche, M., Deleage, C., Bosinger, S. E., Paiardini, M., Brew, B. J., Estes, J. D. & Churchill, M. J., Mar 2023, In: PLoS pathogens. 19, 3, e1011290.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Macaca mulatta 100%
  • frontal lobe 80%
  • digestive system 77%
  • Frontal Lobe 67%
  • Neurocognitive Disorders 65%
  3 Scopus citations

• Correction: Tracking the Luminal Exposure and Lymphatic Drainage Pathways of Intravaginal and Intrarectal Inocula Used in Nonhuman Primate Models of HIV Transmission

  Smedley, J., Turkbey, B., Bernardo, M. L., Del Prete, G. Q., Estes, J. D., Griffiths, G. L., Kobayashi, H., Choyke, P. L., Lifson, J. D. & Keele, B. F., Jul 2023, In: PloS one. 18, 7 July, e0288566.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Primates 100%
  • Drainage 90%
  • HIV 73%
  • Animals 53%
  • Antiparasitic Agents 48%

• Editorial: Preclinical macaque models of viral diseases

  Smedley, J., 2023, In: Frontiers in immunology. 14, 1331774.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Erratum: Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques (PLoS Pathogens (2021) 17:5 (e1009565) DOI: 10.1371/journal.ppat.1009565)

  Bochart, R. M., Busman-Sahay, K., Bondoc, S., Morrow, D. W., Ortiz, A. M., Fennessey, C. M., Fischer, M. B., Shiel, O., Swanson, T., Shriver-Munsch, C. M., Crank, H. B., Armantrout, K. M., Barber-Axthelm, A. M., Langner, C., Moats, C., Labriola, C. S., MacAllister, R., Axthelm, M. K., Brenchley, J. M., Keele, B. F., & 3 othersEstes, J. D., Hansen, S. G. & Smedley, J. V., Apr 2023, In: PLoS pathogens. 19, 4 April, e1011343.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Combined Modality Therapy 100%
  • Macaca mulatta 84%
  • gastrointestinal system 76%
  • fenbendazole 75%
  • inflammation 72%

• Establishing the normal range of sperm DNA fragmentation index (% DFI) for rhesus macaques

  Burch, F. C., Leung, P. Y., McDonald, E., Jensen, J., Mishler, E., Piekarski, N., Mendes, C. M., Sylwester, A. & Hanna, C. B., Dec 2023, In: Scientific Reports. 13, 1, 20016.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Fragmentation 100%
  • Macaca mulatta 98%
  • Spermatozoa 86%
  • Reference Values 74%
  • Chromatin 41%

• First pilot study of maternal spindle transfer for the treatment of repeated in vitro fertilization failures in couples with idiopathic infertility

  Costa-Borges, N., Nikitos, E., Späth, K., Miguel-Escalada, I., Ma, H., Rink, K., Coudereau, C., Darby, H., Koski, A., Van Dyken, C., Mestres, E., Papakyriakou, E., De Ziegler, D., Kontopoulos, G., Mantzavinos, T., Vasilopoulos, I., Grigorakis, S., Prokopakis, T., Dimitropoulos, K., Polyzos, P., & 6 othersVlachos, N., Kostaras, K., Mitalipov, S., Calderón, G., Psathas, P. & Wells, D., Jun 2023, In: Fertility and sterility. 119, 6, p. 964-973 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Fertilization in Vitro 100%
  • Infertility 86%
  • Mitochondrial DNA 78%
  • Mothers 59%
  • Mitochondrial Replacement Therapy 37%
  16 Scopus citations

• Genome sequencing of Pakistani families with male infertility identifies deleterious genotypes in SPAG6, CCDC9, TKTL1, TUBA3C, and M1AP

  Khan, M. R., Akbari, A., Nicholas, T. J., Castillo-Madeen, H., Ajmal, M., Haq, T. U., Laan, M., Quinlan, A. R., Ahuja, J. S., Shah, A. A. & Conrad, D. F., 2023, (Accepted/In press) In: Andrology.

  Research output: Contribution to journal › Article › peer-review

  • Male Infertility 100%
  • Whole Genome Sequencing 67%
  • Genotype 62%
  • Genome 59%
  • Whole Exome Sequencing 34%

• HCMV UL8 interaction with β-catenin and DVL2 regulates viral reactivation in CD34⁺ hematopoietic progenitor cells

  Dirck, A., Diggins, N. L., Crawford, L. B., Perez, W. D., Parkins, C. J., Struthers, H. H., Turner, R., Pham, A. H., Mitchell, J., Papen, C. R., Malouli, D., Hancock, M. H. & Caposio, P., Oct 2023, In: Journal of virology. 97, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • catenins 100%
  • Human betaherpesvirus 5 89%
  • hematopoietic stem cells 83%
  • Catenins 75%
  • Cytomegalovirus 59%

• Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA

  Archin, N., Bar, K. J., Burdo, T., Caskey, M., Chahroudi, A., Farzan, M., Ho, Y. C., Jones, R. B., Kearney, M., Kuritzkes, D., Margolis, D., Martinez-Picado, J., Okoye, A., Salgado, M. & Stevenson, M., Mar 2023, In: Journal of Virus Eradication. 9, 1, 100315.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • persistence 100%
  • HIV 78%
  • Education 71%
  • Research Personnel 39%
  • Literacy 33%
  4 Scopus citations

• HIV rapidly targets a diverse pool of CD4⁺ T cells to establish productive and latent infections

  Gantner, P., Buranapraditkun, S., Pagliuzza, A., Dufour, C., Pardons, M., Mitchell, J. L., Kroon, E., Sacdalan, C., Tulmethakaan, N., Pinyakorn, S., Robb, M. L., Phanuphak, N., Ananworanich, J., Hsu, D., Vasan, S., Trautmann, L., Fromentin, R. & Chomont, N., Mar 14 2023, In: Immunity. 56, 3, p. 653-668.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HIV 100%
  • T-Lymphocytes 89%
  • Infections 69%
  • Proviruses 37%
  • Phenotype 34%
  25 Scopus citations

• Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection

  Zarrella, K., Longmire, P., Zeltzer, S., Collins-McMillen, D., Hancock, M., Buehler, J., Reitsma, J. M., Terhune, S. S., Nelson, J. A. & Goodrum, F., Jun 2023, In: PLoS pathogens. 19, 6 June, e1011185.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human betaherpesvirus 5 100%
  • STAT1 Transcription Factor 93%
  • Cytomegalovirus 66%
  • Viral Genome 57%
  • phosphorylation 46%
  3 Scopus citations

• Identification of Vancomycin Resistance in Methicillin-resistant Staphylococcus aureus in two macaque species and decolonization and long-term prevention of recolonization in Cynomolgus Macaques (Macaca fascicularis)

  Bochart, R. M., Armantrout, K., Crank, H., Tonelli, R., Shriver-Munsch, C., Swanson, T., Fischer, M., Wu, H., Axthelm, M., Sacha, J. & Smedley, J. V., 2023, In: Frontiers in immunology. 14, 1244637.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vancomycin Resistance 100%
  • Macaca fascicularis 84%
  • Macaca 77%
  • Methicillin-Resistant Staphylococcus aureus 70%
  • Vancomycin 58%

• In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

  Jensen, B. E. O., Knops, E., Cords, L., Lübke, N., Salgado, M., Busman-Sahay, K., Estes, J. D., Huyveneers, L. E. P., Perdomo-Celis, F., Wittner, M., Gálvez, C., Mummert, C., Passaes, C., Eberhard, J. M., Münk, C., Hauber, I., Hauber, J., Heger, E., De Clercq, J., Vandekerckhove, L., & 16 othersBergmann, S., Dunay, G. A., Klein, F., Häussinger, D., Fischer, J. C., Nachtkamp, K., Timm, J., Kaiser, R., Harrer, T., Luedde, T., Nijhuis, M., Sáez-Cirión, A., Schulze zur Wiesch, J., Wensing, A. M. J., Martinez-Picado, J. & Kobbe, G., Mar 2023, In: Nature medicine. 29, 3, p. 583-587 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoietic Stem Cell Transplantation 100%
  • HIV-1 81%
  • Antigen 78%
  • Antigens 19%
  • T-Lymphocyte Subsets 16%
  46 Scopus citations

• Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein

  Powers, J. M., Lyski, Z. L., Weber, W. C., Denton, M., Streblow, M. M., Mayo, A. T., Haese, N. N., Nix, C. D., Rodríguez-Santiago, R., Alvarado, L. I., Rivera-Amill, V., Messer, W. B. & Streblow, D. N., Mar 2023, In: PLoS neglected tropical diseases. 17, 3, e0011154.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chikungunya Fever 100%
  • Heterophile Antibodies 95%
  • Broadly Neutralizing Antibodies 94%
  • Alphavirus 92%
  • Glycoproteins 57%
  3 Scopus citations

• Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis)

  Hansen, F., Vučak, M., Nichols, J., Hughes, J., Bane, S., Camiolo, S., da Silva Filipe, A., Ostermann, E., Staliunaite, L., Chan, B., Mauch, T., Sogoba, N., Streblow, D. N., Voigt, S., Oestereich, L., Ehlers, B., Redwood, A. J., Feldmann, H., Brune, W., Rosenke, K., & 2 othersJarvis, M. A. & Davison, A. J., 2023, In: Journal of General Virology. 104, 8, 001873.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Murinae 100%
  • Cytomegalovirus 65%
  • Genome 44%
  • Viruses 44%
  • Lassa virus 30%
  1 Scopus citations

• Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV

  Hansen, S. G., Womack, J. L., Perez, W., Schmidt, K. A., Marshall, E., Iyer, R. F., Rubeor, H. C., Otero, C. E., Taher, H., Burgt, N. H. V., Barfield, R., Randall, K. T., Morrow, D., Hughes, C. M., Selseth, A. N., Gilbride, R. M., Ford, J. C., Caposio, P., Tarantal, A. F., Chan, C., & 5 othersMalouli, D., Barry, P. A., Permar, S. R., Picker, L. J. & Fruh, K., Mar 22 2023, In: JCI Insight. 8, 6, 164692.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytomegalovirus 100%
  • T-Lymphocytes 62%
  • Gene Expression 60%
  • Macaca mulatta 52%
  • Major Histocompatibility Complex 51%
  4 Scopus citations

• Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation

  Munks, M. W., Rott, K., Nesterenko, P. A., Smart, S. M., Williams, V., Tatum, A., Xu, G., Smith, T., Murray, S. E. & Hill, A. B., Jan 2023, In: PLoS pathogens. 19, 1, e1010351.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Economic Inflation 91%
  • Drive 84%
  • endothelial cells 83%
  • T-lymphocytes 74%
  • Endothelial Cells 60%
  4 Scopus citations

• Limitations of gene editing assessments in human preimplantation embryos

  Liang, D., Mikhalchenko, A., Ma, H., Marti Gutierrez, N., Chen, T., Lee, Y., Park, S. W., Tippner-Hedges, R., Koski, A., Darby, H., Li, Y., Van Dyken, C., Zhao, H., Wu, K., Zhang, J., Hou, Z., So, S., Han, J., Park, J., Kim, C. J., & 20 othersZong, K., Gong, J., Yuan, Y., Gu, Y., Shen, Y., Olson, S. B., Yang, H., Battaglia, D., O’Leary, T., Krieg, S. A., Lee, D. M., Wu, D. H., Duell, P. B., Kaul, S., Kim, J. S., Heitner, S. B., Kang, E., Chen, Z. J., Amato, P. & Mitalipov, S., Dec 2023, In: Nature communications. 14, 1, 1219.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • editing 100%
  • Gene Editing 84%
  • embryos 83%
  • genes 80%
  • Blastocyst 78%
  8 Scopus citations

• Marked skewing of entire T-cell memory compartment occurs only in a minority of CMV-infected individuals and is unrelated to the degree of memory subset skewing among CMV-specific T-cells

  Fuhrmann, S., Reus, B., Frey, O., Pera, A., Picker, L. J. & Kern, F., 2023, In: Frontiers in immunology. 14, 1258339.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Memory 100%
  • T-Lymphocytes 84%
  • T-Lymphocyte Subsets 41%
  • Infections 28%
  • Antigens 18%

• Mass spectrometry analysis of gut tissue in acute SIV-infection in rhesus macaques identifies early proteome alterations preceding the interferon inflammatory response

  Berard, A. R., Hensley-McBain, T., Noël-Romas, L., Birse, K., Abou, M., Westmacott, G., McCorrister, S., Smedley, J., Klatt, N. R. & Burgener, A. D., Dec 2023, In: Scientific Reports. 13, 1, 690.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Macaca mulatta 100%
  • Proteome 99%
  • Interferons 87%
  • Mass Spectrometry 85%
  • Infections 45%
  1 Scopus citations

• Mayaro virus pathogenesis and immunity in rhesus macaques

  Weber, W. C., Labriola, C. S., Kreklywich, C. N., Ray, K., Haese, N. N., Andoh, T. F., Denton, M., Medica, S., Streblow, M. M., Smith, P. P., Mizuno, N., Frias, N., Fisher, M. B., Barber-Axthelm, A. M., Chun, K., Uttke, S., Whitcomb, D., Defilippis, V., Rakshe, S., Fei, S. S., & 3 othersAxthelm, M. K., Smedley, J. V. & Streblow, D. N., Nov 2023, In: PLoS neglected tropical diseases. 17, 11, e0011742.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • immunity 100%
  • Macaca mulatta 92%
  • activation 86%
  • Alphavirus Infections 74%
  • Immunity 72%

• Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques

  Viox, E. G., Hoang, T. N., Upadhyay, A. A., Nchioua, R., Hirschenberger, M., Strongin, Z., Tharp, G. K., Pino, M., Nguyen, K., Harper, J. L., Gagne, M., Marciano, S., Boddapati, A. K., Pellegrini, K. L., Pradhan, A., Tisoncik-Go, J., Whitmore, L. S., Karunakaran, K. A., Roy, M., Kirejczyk, S., & 22 othersCurran, E. H., Wallace, C., Wood, J. S., Connor-Stroud, F., Voigt, E. A., Monaco, C. M., Gordon, D. E., Kasturi, S. P., Levit, R. D., Gale, M., Vanderford, T. H., Silvestri, G., Busman-Sahay, K., Estes, J. D., Vaccari, M., Douek, D. C., Sparrer, K. M. J., Johnson, R. P., Kirchhoff, F., Schreiber, G., Bosinger, S. E. & Paiardini, M., Jul 2023, In: Science Immunology. 8, 85, adg0033.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Interferon Type I 92%
  • Macaca mulatta 81%
  • Inflammation 45%
  4 Scopus citations

• Molecular basis for maternal inheritance of human mitochondrial DNA

  Lee, W., Zamudio-Ochoa, A., Buchel, G., Podlesniy, P., Marti Gutierrez, N., Puigròs, M., Calderon, A., Tang, H. Y., Li, L., Mikhalchenko, A., Koski, A., Trullas, R., Mitalipov, S. & Temiakov, D., Oct 2023, In: Nature genetics. 55, 10, p. 1632-1639 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Maternal Inheritance 100%
  • Mitochondrial DNA 82%
  • Spermatozoa 73%
  • Mitochondria 43%
  • mitochondrial transcription factor A 20%
  4 Scopus citations

• MRNA vaccine against fibroblast activation protein ameliorates murine models of inflammatory arthritis

  Zhang, X., Jozic, A., Song, P., Xu, Q., Shi, X., Wang, H., Bishop, L., Struthers, H. M., Rutledge, J., Chen, S., Xu, F., Hancock, M. H., Zhu, D., Sahay, G. & Chu, C. Q., Jun 1 2023, In: Rheumatology and Immunology Research. 4, 2, p. 90-97 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Experimental Arthritis 100%
  • Arthritis 74%
  • Vaccines 63%
  • Fibroblasts 62%
  • Nanoparticles 42%
  2 Scopus citations

• Programming cytomegalovirus as an HIV vaccine

  Picker, L. J., Lifson, J. D., Gale, M., Hansen, S. G. & Früh, K., Apr 2023, In: Trends in Immunology. 44, 4, p. 287-304 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • AIDS Vaccines 100%
  • Cytomegalovirus 76%
  • T-Lymphocytes 47%
  • Simian Immunodeficiency Virus 39%
  • Primates 14%
  13 Scopus citations

• Prolonged experimental CD4⁺ T-cell depletion does not cause disease progression in SIV-infected African green monkeys

  Le Hingrat, Q., Sette, P., Xu, C., Rahmberg, A. R., Tarnus, L., Annapureddy, H., Kleinman, A., Brocca-Cofano, E., Sivanandham, R., Sivanandham, S., He, T., Capreri, D. J., Ma, D., Estes, J. D., Brenchley, J. M., Apetrei, C. & Pandrea, I., Dec 2023, In: Nature communications. 14, 1, 979.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chlorocebus aethiops 100%
  • monkeys 99%
  • progressions 81%
  • depletion 63%
  • Disease Progression 58%
  2 Scopus citations

• Protective effect of pre-existing natural immunity in a nonhuman primate reinfection model of congenital cytomegalovirus infection

  Moström, M. J., Yu, S., Tran, D., Saccoccio, F. M., Versoza, C. J., Malouli, D., Mirza, A., Valencia, S., Gilbert, M., Blair, R. V., Hansen, S., Barry, P., Früh, K., Jensen, J. D., Pfeifer, S. P., Kowalik, T. F., Permar, S. R. & Kaur, A., Oct 2023, In: PLoS pathogens. 19, 10 October, e1011646.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytomegalovirus infections 100%
  • Cytomegalovirus Infections 66%
  • innate immunity 61%
  • protective effect 58%
  • Primates 56%
  1 Scopus citations

• Proximity-dependent mapping of the HCMV US28 interactome identifies RhoGEF signaling as a requirement for efficient viral reactivation

  Medica, S., Crawford, L. B., Denton, M., Min, C. K., Jones, T. A., Alexander, T., Parkins, C. J., Diggins, N. L., Streblow, G. J., Mayo, A. T., Kreklywich, C. N., Smith, P., Jeng, S., McWeeney, S., Hancock, M. H., Yurochko, A., Cohen, M. S., Caposio, P. & Streblow, D. N., Oct 2023, In: PLoS pathogens. 19, 10 October, e1011682.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rho Guanine Nucleotide Exchange Factors 100%
  • Human betaherpesvirus 5 97%
  • Cytomegalovirus 64%
  • hematopoietic stem cells 60%
  • Virus Latency 60%

• Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

  Angelovich, T. A., Cochrane, C. R., Zhou, J., Tumpach, C., Byrnes, S. J., Jamal Eddine, J., Waring, E., Busman-Sahay, K., Deleage, C., Jenkins, T. A., Hearps, A. C., Turville, S., Gorry, P. R., Lewin, S. R., Brew, B. J., Estes, J. D., Roche, M. & Churchill, M. J., Oct 2023, In: Annals of Neurology. 94, 4, p. 798-802 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proviruses 100%
  • HIV 52%
  • White Matter 41%
  • Brain 37%
  • DNA 17%
  7 Scopus citations

• Relationship of maternal cytomegalovirus-specific antibody responses and viral load to vertical transmission risk following primary maternal infection in a rhesus macaque model

  Otero, C. E., Barfield, R., Scheef, E., Nelson, C. S., Rodgers, N., Wang, H. Y., Moström, M. J., Manuel, T. D., Sass, J., Schmidt, K., Taher, H., Papen, C., Sprehe, L., Kendall, S., Davalos, A., Barry, P. A., Früh, K., Pollara, J., Malouli, D., Chan, C., & 2 othersKaur, A. & Permar, S. R., Oct 2023, In: PLoS pathogens. 19, 10 October, e1011378.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cytomegalovirus 100%
  • viral load 83%
  • amniotic fluid 80%
  • Macaca mulatta 75%
  • antibody formation 71%
  1 Scopus citations

• Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4⁺ and CD8⁺ T cells

  Dubé, M., Tastet, O., Dufour, C., Sannier, G., Brassard, N., Delgado, G. G., Pagliuzza, A., Richard, C., Nayrac, M., Routy, J. P., Prat, A., Estes, J. D., Fromentin, R., Chomont, N. & Kaufmann, D. E., Sep 13 2023, In: Cell Host and Microbe. 31, 9, p. 1507-1522.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • T-lymphocytes 100%
  • therapeutics 85%
  • HIV 75%
  • T-Lymphocytes 67%
  • transcription (genetics) 40%
  6 Scopus citations

• Stabilization of the human cytomegalovirus UL136p33 reactivation determinant overcomes the requirement for UL135 for replication in hematopoietic cells

  Moy, M. A., Collins-McMillen, D., Crawford, L., Parkins, C., Zeltzer, S., Caviness, K., Zaidi, S. S. A., Caposio, P. & Goodrum, F., Aug 2023, In: Journal of virology. 97, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Human betaherpesvirus 5 100%
  • hematopoietic stem cells 93%
  • Cytomegalovirus 66%
  • Hematopoietic Stem Cells 66%
  • Viruses 26%

• T helper 1 effector memory CD4⁺ T cells protect the skin from poxvirus infection

  Harbour, J. C., Abdelbary, M., Schell, J. B., Fancher, S. P., McLean, J. J., Nappi, T. J., Liu, S., Nice, T. J., Xia, Z., Früh, K. & Nolz, J. C., May 30 2023, In: Cell Reports. 42, 5, 112407.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poxviridae Infections 100%
  • Effector 63%
  • Interferons 42%
  • T-Lymphocytes 36%
  • Major Histocompatibility Complex 35%
  1 Scopus citations

• Therapeutic neutralizing monoclonal antibody administration protects against lethal yellow fever virus infection

  Ricciardi, M. J., Rust, L. N., Nuria, P. L., Yusova, S., Biswas, S., Webb, G. M., Gonzalez-Nieto, L., Voigt, T. B., Louw, J. J., Laurino, F. D., DiBello, J. R., Raué, H. P., Barber-Axthelm, A. M., Chun, K., Uttke, S., Raphael, L. M. S., Yrizarry-Medina, A., Rosen, B. C., Agnor, R., Gao, L., & 13 othersLabriola, C., Axthelm, M., Smedley, J., Julander, J. G., Bonaldo, M. C., Walker, L. M., Messaoudi, I., Slifka, M. K., Burton, D. R., Kallas, E. G., Sacha, J. B., Watkins, D. I. & Burwitz, B. J., Mar 29 2023, In: Science translational medicine. 15, 689, eade5795.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Yellow fever virus 100%
  • Neutralizing Antibodies 67%
  • Virus Diseases 49%
  • Monoclonal Antibodies 49%
  • Disease Outbreaks 14%
  1 Scopus citations

• Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication

  Pinkevych, M., Docken, S. S., Okoye, A. A., Fennessey, C. M., Del Prete, G. Q., Pino, M., Harper, J. L., Betts, M. R., Paiardini, M., Keele, B. F. & Davenport, M. P., Oct 2023, In: PLoS pathogens. 19, 10 October, e1011660.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • therapeutics 100%
  • viral load 74%
  • infection 67%
  • HIV infections 47%
  • T-lymphocytes 29%
  2 Scopus citations

• Viral miRNA regulation of host gene expression

  Diggins, N. L. & Hancock, M. H., Sep 15 2023, In: Seminars in Cell and Developmental Biology. 146, p. 2-19 18 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Gene Expression Regulation 100%
  • MicroRNAs 78%
  • Viruses 30%
  • Immune Evasion 9%
  • Small Untranslated RNA 9%
  10 Scopus citations

• Virology under the Microscope-a Call for Rational Discourse

  Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 othersCameron, C., Campos, S., Caposio, P., Chan, G., Cliffe, A., Coffin, J., Collins, K., Damania, B., Daugherty, M., Debbink, K., DeCaprio, J., Dermody, T., Dikeakos, J., DiMaio, D., Dinglasan, R., Duprex, W. P., Dutch, R., Elde, N., Emerman, M., Enquist, L., Fane, B., Fernandez-Sesma, A., Flenniken, M., Frappier, L., Frieman, M., Frueh, K., Gack, M., Gaglia, M., Gallagher, T., Galloway, D., García-Sastre, A., Geballe, A., Glaunsinger, B., Goff, S., Greninger, A., Hancock, M., Harris, E., Heaton, N., Heise, M., Heldwein, E., Hogue, B., Horner, S., Hutchinson, E., Hyser, J., Jackson, W., Kalejta, R., Kamil, J., Karst, S., Kirchhoff, F., Knipe, D., Kowalik, T., Lagunoff, M., Laimins, L., Langlois, R., Lauring, A., Lee, B., Leib, D., Liu, S. L., Longnecker, R., Lopez, C., Luftig, M., Lund, J., Manicassamy, B., McFadden, G., McIntosh, M., Mehle, A., Miller, W. A., Mohr, I., Moody, C., Moorman, N., Moscona, A., Mounce, B., Munger, J., Münger, K., Murphy, E., Naghavi, M., Nelson, J., Neufeldt, C., Nikolich, J., O'Connor, C., Ono, A., Orenstein, W., Ornelles, D., Ou, J. H., Parker, J., Parrish, C., Pekosz, A., Pellett, P., Pfeiffer, J., Plemper, R., Polyak, S., Purdy, J., Pyeon, D., Quinones-Mateu, M., Renne, R., Rice, C., Schoggins, J., Roller, R., Russell, C., Sandri-Goldin, R., Sapp, M., Schang, L., Schmid, S., Schultz-Cherry, S., Semler, B., Shenk, T., Silvestri, G., Simon, V., Smith, G., Smith, J., Spindler, K., Stanifer, M., Subbarao, K., Sundquist, W., Suthar, M., Sutton, T., Tai, A., Tarakanova, V., tenOever, B., Tibbetts, S., Tompkins, S., Toth, Z., van Doorslaer, K., Vignuzzi, M., Wallace, N., Walsh, D., Weekes, M., Weinberg, J., Weitzman, M., Weller, S., Whelan, S., White, E., Williams, B., Wobus, C., Wong, S. & Yurochko, A., Jan 2023, In: mBio. 14, 1

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Virology 100%
  • SARS Virus 45%
  • Viruses 20%
  • Pandemics 16%
  • Administrative Personnel 15%
  1 Scopus citations

• Virology under the Microscope—a Call for Rational Discourse

  Goodrum, F., Lowen, A. C., Lakdawala, S., Alwine, J., Casadevall, A., Imperiale, M. J., Atwood, W., Avgousti, D., Baines, J., Banfield, B., Banks, L., Bhaduri-McIntosh, S., Bhattacharya, D., Blanco-Melo, D., Bloom, D., Boon, A., Boulant, S., Brandt, C., Broadbent, A., Brooke, C., & 136 othersCameron, C., Campos, S., Caposio, P., Chan, G., Cliffe, A., Coffin, J., Collins, K., Damania, B., Daugherty, M., Debbink, K., DeCaprio, J., Dermody, T., Dikeakos, J., DiMaio, D., Dinglasan, R., Duprex, W. P., Dutch, R., Elde, N., Emerman, M., Enquist, L., Fane, B., Fernandez-Sesma, A., Flenniken, M., Frappier, L., Frieman, M., Frueh, K., Gack, M., Gaglia, M., Gallagher, T., Galloway, D., García-Sastre, A., Geballe, A., Glaunsinger, B., Goff, S., Greninger, A., Hancock, M., Harris, E., Heaton, N., Heise, M., Heldwein, E., Hogue, B., Horner, S., Hutchinson, E., Hyser, J., Jackson, W., Kalejta, R., Kamil, J., Karst, S., Kirchhoff, F., Knipe, D., Kowalik, T., Lagunoff, M., Laimins, L., Langlois, R., Lauring, A., Lee, B., Leib, D., Liu, S. L., Longnecker, R., Lopez, C., Luftig, M., Lund, J., Manicassamy, B., McFadden, G., McIntosh, M., Mehle, A., Miller, W. A., Mohr, I., Moody, C., Moorman, N., Moscona, A., Mounce, B., Munger, J., Münger, K., Murphy, E., Naghavi, M., Nelson, J., Neufeldt, C., Nikolich, J., O'Connor, C., Ono, A., Orenstein, W., Ornelles, D., Ou, J. H., Parker, J., Parrish, C., Pekosz, A., Pellett, P., Pfeiffer, J., Plemper, R., Polyak, S., Purdy, J., Pyeon, D., Quinones-Mateu, M., Renne, R., Rice, C., Schoggins, J., Roller, R., Russell, C., Sandri-Goldin, R., Sapp, M., Schang, L., Schmid, S., Schultz-Cherry, S., Semler, B., Shenk, T., Silvestri, G., Simon, V., Smith, G., Smith, J., Spindler, K., Stanifer, M., Subbarao, K., Sundquist, W., Suthar, M., Sutton, T., Tai, A., Tarakanova, V., tenOever, B., Tibbetts, S., Tompkins, S., Toth, Z., van Doorslaer, K., Vignuzzi, M., Wallace, N., Walsh, D., Weekes, M., Weinberg, J., Weitzman, M., Weller, S., Whelan, S., White, E., Williams, B., Wobus, C., Wong, S. & Yurochko, A., Apr 2023, In: mSphere. 8, 2

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Virology 100%
  • SARS Virus 45%
  • Viruses 20%
  • Pandemics 16%
  • Administrative Personnel 15%
  1 Scopus citations