Research Cores and Shared Resources

Research output

Research output per year 2009 2016 2017 2018 2020 2022 2023 2024

• 80 Article
• 3 Comment/debate
• 1 Letter
• 1 Review article

Research output per year

Research output per year

Search results

• 2024

  Chenodeoxycholic acid (CDCA) treatment during pregnancy in women with cerebrotendinous xanthomatosis (CTX): Lessons learned from 19 pregnancies

  Zaccai, T. C. F., Hassin-Baer, S., Kfir, N. C., Duell, P. B., Neerhof, M., Sloma, R., Roitman, M., Kisanuki, Y. Y., Verrips, A. & DeBarber, A. E., May 2024, In: Genetics in Medicine. 26, 5, 101086.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Effect of PCSK9 inhibition on plasma levels of small dense low density lipoprotein-cholesterol and 7-ketocholesterol

  Mahmood, T., Miles, J. R., Minnier, J., Tavori, H., DeBarber, A. E., Fazio, S. & Shapiro, M. D., Jan 1 2024, In: Journal of clinical lipidology. 18, 1, p. e50-e58

  Research output: Contribution to journal › Article › peer-review

  • 7-ketocholesterol 100%
  • oxidized low density lipoprotein 61%
  • LDL Cholesterol 55%
  • Oxysterols 50%
  • Cholesterol 19%

• Influence of the storage conditions of embryo culture media on mouse development

  Davenport, M., Wang, Y. & Fedorov, L. M., 2024, (Accepted/In press) In: In Vitro Cellular and Developmental Biology - Animal.

  Research output: Contribution to journal › Article › peer-review

• Living with Cerebrotendinous Xanthomatosis: Patient, Caregiver, and Expert Perspectives

  Steiner, R. D., DeBarber, A., Larson, A., Blanchard, B., Laurie, S., Odedara, N., Rosengrant, H. & Dutta, R., Feb 2024, In: Advances in Therapy. 41, 2, p. 467-475 9 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Multiple Isomers of Photolumazine V Bind MR1 and Differentially Activate MAIT Cells

  Krawic, J. R., Ladd, N. A., Cansler, M., McMurtrey, C., Devereaux, J., Worley, A., Ahmed, T., Froyd, C., Kulicke, C. A., Swarbrick, G., Nilsen, A., Lewinsohn, D. M., Adams, E. J. & Hildebrand, W., Mar 15 2024, In: Journal of Immunology. 212, 6, p. 933-940 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mucosal-Associated Invariant T Cells 100%
  • Mycobacterium smegmatis 55%
  • Hydroxyl Radical 43%
  • Ligands 28%
  • Histocompatibility Antigens Class I 23%
• 2023

  Author Correction: The amniotic fluid proteome changes across gestation in humans and rhesus macaques (Scientific Reports, (2023), 13, 1, (17039), 10.1038/s41598-023-44125-3)

  Shorey-Kendrick, L. E., Crosland, B. A., Spindel, E. R., McEvoy, C. T., Wilmarth, P. A., Reddy, A. P., Zientek, K. D., Roberts, V. H. J., D’Mello, R. J., Ryan, K. S., Olyaei, A. F., Hagen, O. L., Drake, M. G., McCarty, O. J. T., Scottoline, B. P. & Lo, J. O., Dec 2023, In: Scientific Reports. 13, 1, 17640.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Amniotic Fluid 100%
  • Macaca mulatta 97%
  • Proteome 96%
  • Pregnancy 55%

• Characterization of extracellular matrix deposited by segmental trabecular meshwork cells

  Raghunathan, V. K., Nartey, A., Dhamodaran, K., Baidouri, H., Staverosky, J. A., Keller, K. E., Zientek, K., Reddy, A., Acott, T. & Vranka, J. A., Sep 2023, In: Experimental Eye Research. 234, 109605.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Trabecular Meshwork 100%
  • Extracellular Matrix 63%
  • Steroids 15%
  • Pressure 13%
  • Ocular Hypertension 13%
  2 Scopus citations

• Divergent metabolic programmes control two populations of MAIT cells that protect the lung

  Riffelmacher, T., Paynich Murray, M., Wientjens, C., Chandra, S., Cedillo-Castelán, V., Chou, T. F., McArdle, S., Dillingham, C., Devereaux, J., Nilsen, A., Brunel, S., Lewinsohn, D. M., Hasty, J., Seumois, G., Benedict, C. A., Vijayanand, P. & Kronenberg, M., Jun 2023, In: Nature Cell Biology. 25, 6, p. 877-891 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mucosal-Associated Invariant T Cells 100%
  • Lung 32%
  • Population 23%
  • Interleukin-7 Receptor alpha Subunit 16%
  • Mitochondria 12%
  4 Scopus citations

• Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity

  Zheng, T. J., Kohs, T. C. L., Mueller, P. A., Pang, J., Reitsma, S. E., Parra-Izquierdo, I., Melrose, A. R., Yang, L., Choi, J., Zientek, K. D., Sviridov, D. O., Larson, M. K., Williams, C. D., Pamir, N., Shatzel, J. J., Reddy, A. P., Kievit, P., Remaley, A. T., Stevens, J. F., Hinds, M. T., & 2 othersMcCarty, O. J. T. & Aslan, J. E., Apr 25 2023, In: Blood Advances. 7, 8, p. 1366-1378 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Platelet Aggregation Inhibitors 100%
  • oxidized low density lipoprotein 88%
  • Protein-Tyrosine Kinases 80%
  • platelet membrane glycoprotein VI 75%
  • Blood Platelets 68%
  5 Scopus citations

• Gait Abnormalities and Aberrant D2 Receptor Expression and Signaling in Mice Carrying the Human Pathogenic Mutation DRD2I212F

  Rodriguez-Contreras, D., Gong, S., Lebowitz, J. J., Fedorov, L. M., Asad, N., Dore, T. M., Phillips, T. J., Ford, C. P., Williams, J. T. & Neve, K. A., Mar 1 2023, In: Molecular pharmacology. 103, 3, p. 188-198 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Gait 100%
  • Mutation 58%
  • Dopamine 35%
  • Hyperkinesis 29%
  • Sulpiride 27%
  1 Scopus citations

• GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner

  Xu, Y., Zhang, W. H., Allen, E. M., Fedorov, L. M., Barnes, A. P., Qian, Z. Y., Bah, T. M., Li, Y., Wang, R. K., Shangraw, R. E. & Alkayed, N. J., Oct 2023, In: Translational Stroke Research. 14, 5, p. 766-775 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stroke 100%
  • Capillaries 62%
  • Brain Injuries 47%
  • Knockout Mice 44%
  • Perfusion 36%
  9 Scopus citations

• Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation

  Munks, M. W., Rott, K., Nesterenko, P. A., Smart, S. M., Williams, V., Tatum, A., Xu, G., Smith, T., Murray, S. E. & Hill, A. B., Jan 2023, In: PLoS pathogens. 19, 1, e1010351.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Economic Inflation 91%
  • Drive 84%
  • endothelial cells 83%
  • T-lymphocytes 74%
  • Endothelial Cells 60%
  4 Scopus citations

• Micelle-Formulated Juglone Effectively Targets Pancreatic Cancer and Remodels the Tumor Microenvironment

  Shah, V. M., Rizvi, S., Smith, A., Tsuda, M., Krieger, M., Pelz, C., MacPherson, K., Eng, J., Chin, K., Munks, M. W., Daniel, C. J., Al-Fatease, A., Yardimci, G. G., Langer, E. M., Brody, J. R., Sheppard, B. C., Alani, A. W. G. & Sears, R. C., Dec 2023, In: Pharmaceutics. 15, 12, 2651.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • juglone 100%
  • Juglone 89%
  • Micelles 68%
  • Tumor Microenvironment 59%
  • Pancreatic Neoplasms 54%
  1 Scopus citations

• MicroRNA137-loaded lipid nanoparticles regulate synaptic proteins in the prefrontal cortex

  Palumbo, M. C., Gautam, M., Sonneborn, A., Kim, K., Wilmarth, P. A., Reddy, A. P., Shi, X., Marks, D. L., Sahay, G., Abbas, A. I. & Janowsky, A., Oct 4 2023, In: Molecular Therapy. 31, 10, p. 2975-2990 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Prefrontal Cortex 100%
  • Nanoparticles 97%
  • Lipid 76%
  • Lipids 72%
  • Nanoparticle 54%
  1 Scopus citations

• MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer

  Doha, Z. O., Wang, X., Calistri, N. L., Eng, J., Daniel, C. J., Ternes, L., Kim, E. N., Pelz, C., Munks, M., Betts, C., Kwon, S., Bucher, E., Li, X., Waugh, T., Tatarova, Z., Blumberg, D., Ko, A., Kirchberger, N., Pietenpol, J. A., Sanders, M. E., & 9 othersLanger, E. M., Dai, M. S., Mills, G., Chin, K., Chang, Y. H., Coussens, L. M., Gray, J. W., Heiser, L. M. & Sears, R. C., Dec 2023, In: Nature communications. 14, 1, 5665.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • Triple Negative Breast Neoplasms 72%
  • breast 63%
  • tumors 57%
  • cancer 56%
  3 Scopus citations

• Proteomic profiling of retina and retinal pigment epithelium combined embryonic tissue to facilitate ocular disease gene discovery

  Aryal, S., Anand, D., Huang, H., Reddy, A. P., Wilmarth, P. A., David, L. L. & Lachke, S. A., Jul 2023, In: Human genetics. 142, 7, p. 927-947 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Retinal Pigment Epithelium 100%
  • Genetic Association Studies 92%
  • Eye Diseases 90%
  • Proteomics 79%
  • Retina 75%

• TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function

  Okhovat, M., VanCampen, J., Nevonen, K. A., Harshman, L., Li, W., Layman, C. E., Ward, S., Herrera, J., Wells, J., Sheng, R. R., Mao, Y., Ndjamen, B., Lima, A. C., Vigh-Conrad, K. A., Stendahl, A. M., Yang, R., Fedorov, L., Matthews, I. R., Easow, S. A., Chan, D. K., & 6 othersJan, T. A., Eichler, E. E., Rugonyi, S., Conrad, D. F., Ahituv, N. & Carbone, L., Dec 2023, In: Nature communications. 14, 1, 8111.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Domain Boundary 100%
  • characterization 37%
  • Retroelements 29%
  • Chromatin Immunoprecipitation Sequencing 29%
  • Genes 27%
  2 Scopus citations

• The amniotic fluid proteome changes across gestation in humans and rhesus macaques

  Shorey-Kendrick, L. E., Crosland, B. A., Spindel, E. R., McEvoy, C. T., Wilmarth, P. A., Reddy, A. P., Zientek, K. D., Roberts, V. H. J., D’Mello, R. J., Ryan, K. S., Olyaei, A. F., Hagen, O. L., Drake, M. G., McCarty, O. J. T., Scottoline, B. P. & Lo, J. O., Dec 2023, In: Scientific Reports. 13, 1, 17039.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amniotic Fluid 100%
  • Macaca mulatta 97%
  • Proteome 96%
  • Pregnancy 55%
  • Fetal Development 19%
  1 Scopus citations

• Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models

  Deleeuw, V., Carlson, E., Renard, M., Zientek, K. D., Wilmarth, P. A., Reddy, A. P., Manalo, E. C., Tufa, S. F., Keene, D. R., Olbinado, M., Stampanoni, M., Kanki, S., Yanagisawa, H., Mosquera, L. M., Sips, P., De Backer, J. & Sakai, L. Y., Nov 2023, In: Matrix Biology. 123, p. 17-33 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Thoracic Aortic Aneurysm 100%
  • Aortic Diseases 71%
  • Aneurysm 67%
  • Microdissection 49%
  • Rupture 32%
  2 Scopus citations
• 2022

  A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target

  Martín-Acosta, P., Meng, Q., Klimek, J., Reddy, A. P., David, L., Petrie, S. K., Li, B. X. & Xiao, X., May 2022, In: Acta Pharmaceutica Sinica B. 12, 5, p. 2406-2416 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • betulinic acid 100%
  • Tropomyosin 84%
  • Triterpenes 26%
  • Cytoskeleton 21%
  • Phenotype 12%
  3 Scopus citations

• ANKRD24 organizes TRIOBP to reinforce stereocilia insertion points

  Krey, J. F., Liu, C., Belyantseva, I. A., Bateschell, M., Dumont, R. A., Goldsmith, J., Chatterjee, P., Morrill, R. S., Fedorov, L. M., Foster, S., Kim, J., Nuttall, A., Jones, S. M., Choi, D., Friedman, T., Ricci, A. J., Zhao, B. & Barr-Gillespie, P. G., Apr 4 2022, In: Journal of Cell Biology. 221, 4, e202109134.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stereocilia 100%
  • Ankyrin Repeat 32%
  • Normal Distribution 26%
  • Recovery of Function 24%
  • Hearing Loss 21%
  5 Scopus citations

• Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination

  Mammel, A. E., Delgado, K. C., Chin, A. L., Condon, A. F., Hill, J. Q., Aicher, S. A., Wang, Y., Fedorov, L. M. & Robinson, F. L., Apr 15 2022, In: Human molecular genetics. 31, 8, p. 1216-1229 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Charcot-Marie-Tooth Disease 100%
  • Schwann Cells 82%
  • Axons 64%
  • Peripheral Nervous System 40%
  • Myelin Sheath 38%
  2 Scopus citations

• Effects of ex vivo blood anticoagulation and preanalytical processing time on the proteome content of platelets

  Tassi Yunga, S., Gower, A. J., Melrose, A. R., Fitzgerald, M. K., Rajendran, A., Lusardi, T. A., Armstrong, R. J., Minnier, J., Jordan, K. R., McCarty, O. J. T., David, L. L., Wilmarth, P. A., Reddy, A. P. & Aslan, J. E., Jun 2022, In: Journal of Thrombosis and Haemostasis. 20, 6, p. 1437-1450 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteome 100%
  • Blood Platelets 74%
  • Edetic Acid 16%
  • Extracellular Traps 15%
  • Anticoagulants 14%
  12 Scopus citations

• In-Depth Mass Spectrometry-Based Proteomics of Formalin-Fixed, Paraffin-Embedded Tissues with a Spatial Resolution of 50-200 μm

  Nwosu, A. J., Misal, S. A., Truong, T., Carson, R. H., Webber, K. G. I., Axtell, N. B., Liang, Y., Johnston, S. M., Virgin, K. L., Smith, E. G., Thomas, G. V., Morgan, T., Price, J. C. & Kelly, R. T., Sep 2 2022, In: Journal of Proteome Research. 21, 9, p. 2237-2245 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Formaldehyde 100%
  • Paraffin 99%
  • Proteomics 98%
  • Mass Spectrometry 96%
  • Protein 44%
  9 Scopus citations

• Mucus secretions from a conditionally reprogrammed primary endocervical cell culture

  Park, D., Reddy, A., Wilmarth, P. A., Jensen, J. & Han, L., May 2022, In: F and S Science. 3, 2, p. 159-165 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Primary Cell Culture 100%
  • Mucus 87%
  • Macaca mulatta 34%
  • Proteins 30%
  • Tandem Mass Spectrometry 18%
  1 Scopus citations

• Proteomic analysis distinguishes extracellular vesicles produced by cancerous versus healthy pancreatic organoids

  Buenafe, A. C., Dorrell, C., Reddy, A. P., Klimek, J. & Marks, D. L., Dec 2022, In: Scientific Reports. 12, 1, 3556.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Extracellular Vesicles 89%
  • Proteomics 70%
  • Adenocarcinoma 33%
  • 6,6'-(ethylenebis(oxyethyleneimino))bis(17-cyclopropylmethyl)-4,5-epoxymorphinan-3,14-diol 19%
  14 Scopus citations

• Proteomic profiling of concurrently isolated primary microvascular endothelial cells, pericytes, and vascular smooth muscle cells from adult mouse heart

  Cao, Z., Minnier, J., Liu, L., Scott, K. L. L., Reddy, A. P., Wilmarth, P. A., David, L. L., Barnes, A. P., Grafe, M. R., Kaul, S., Alkayed, N. J. & Davis, C. M., Dec 2022, In: Scientific Reports. 12, 1, 8835.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pericytes 100%
  • Vascular Smooth Muscle 80%
  • Proteomics 74%
  • Smooth Muscle Myocytes 71%
  • Endothelial Cells 60%
  4 Scopus citations

• The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

  Sjostrom, M., Zhao, S. G., Levy, S., Zhang, M., Ning, Y., Shrestha, R., Lundberg, A., Herberts, C., Foye, A., Aggarwal, R., Hua, J. T., Li, H., Bergamaschi, A., Maurice-Dro, C., Maheshwari, A., Chen, S., Ng, S. W. S., Ye, W., Petricca, J., Fraser, M., & 44 othersChesner, L., Perry, M. D., Moreno-Rodrigue, T., Chen, W. S., Alumkal, J. J., Chou, J., Morgans, A. K., Beer, T. M., Thomas, G. V., Gleave, M., Lloyd, P., Phillips, T., McCarthy, E., Haffner, M. C., Zoubeidi, A., Annala, M., Reiter, R. E., Rettig, M. B., Witte, O. N., Fong, L., Bose, R., Huang, F. W., Luo, J., Bjartell, A., Lang, J. M., Mahajan, N. P., Lara, P. N., Evans, C. P., Tran, P. T., Posadas, E. M., He, C., Cui, X. L., Huang, J., Zwart, W., Gilbert, L. A., Maher, C. A., Boutros, P. C., Chi, K. N., Ashworth, A., Small, E. J., He, H. H., Wyatt, A. W., Quigley, D. A. & Feng, F. Y., Nov 1 2022, In: Cancer Research. 82, 21, p. 3888-3902 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 5-hydroxymethylcytosine 100%
  • Prostatic Neoplasms 52%
  • 5-Methylcytosine 26%
  • DNA Sequence Analysis 18%
  • Biomarkers 18%
  18 Scopus citations

• Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity

  Westbrook, T. C., Guan, X., Rodansky, E., Flores, D., Liu, C. J., Udager, A. M., Patel, R. A., Haffner, M. C., Hu, Y. M., Sun, D., Beer, T. M., Foye, A., Aggarwal, R., Quigley, D. A., Youngren, J. F., Ryan, C. J., Gleave, M., Wang, Y., Huang, J., Coleman, I., & 17 othersMorrissey, C., Nelson, P. S., Evans, C. P., Lara, P., Reiter, R. E., Witte, O., Rettig, M., Wong, C. K., Weinstein, A. S., Uzunangelov, V., Stuart, J. M., Thomas, G. V., Feng, F. Y., Small, E. J., Yates, J. A., Xia, Z. & Alumkal, J. J., Dec 2022, In: Nature communications. 13, 1, 5345.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enzalutamide 100%
  • MDV 3100 98%
  • Plastic Property 77%
  • determinants 70%
  • tumors 63%
  11 Scopus citations
• 2021

  Cabozantinib and dasatinib synergize to induce tumor regression in non-clear cell renal cell carcinoma

  Lue, H. W., Derrick, D. S., Rao, S., Van Gaest, A., Cheng, L., Podolak, J., Lawson, S., Xue, C., Garg, D., White, R., Ryan, C. W., Drake, J. M., Ritz, A., Heiser, L. M. & Thomas, G. V., May 18 2021, In: Cell Reports Medicine. 2, 5, 100267.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cabozantinib 100%
  • cabozantinib 81%
  • Dasatinib 69%
  • Renal Cell Carcinoma 48%
  • EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinase) Inhibitor 40%
  5 Scopus citations

• Characterization of parp6 function in knockout mice and patients with developmental delay

  Vermehren-Schmaedick, A., Huang, J. Y., Levinson, M., Pomaville, M. B., Reed, S., Bellus, G. A., Gilbert, F., Keren, B., Heron, D., Haye, D., Janello, C., Makowski, C., Danhauser, K., Fedorov, L. M., Haack, T. B., Wright, K. M. & Cohen, M. S., Jun 2021, In: Cells. 10, 6, 1289.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(ADPribose) 100%
  • Developmental 88%
  • Knockout Mice 66%
  • Mutation 61%
  • Neurons 45%
  6 Scopus citations

• Comparing endocervical mucus proteome of humans and rhesus macaques

  Han, L., Park, D., Reddy, A., Wilmarth, P. A. & Jensen, J. T., Jul 2021, In: Proteomics - Clinical Applications. 15, 4, 2100023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mucus 100%
  • Macaca mulatta 98%
  • Proteome 98%
  • Protein 38%
  • Primates 29%
  7 Scopus citations

• Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis

  Höflinger, P., Hauser, S., Yutuc, E., Hengel, H., Griffiths, L., Radelfahr, F., Howell, O. W., Wang, Y., Connor, S. L., Duell, P. B., DeBarber, A. E., Martus, P., Lütjohann, D., Griffiths, W. J. & Schöls, L., 2021, In: Journal of lipid research. 62, 100078.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebrotendinous Xanthomatosis 100%
  • Chenodeoxycholic Acid 83%
  • Cerebrospinal Fluid 52%
  • Metabolic 49%
  • Metabolite 42%
  12 Scopus citations

• New Scalable Synthetic Routes to ELQ-300, ELQ-316, and Other Antiparasitic Quinolones

  Pou, S., Dodean, R. A., Frueh, L., Liebman, K. M., Gallagher, R. T., Jin, H., Jacobs, R. T., Nilsen, A., Stuart, D. R., Doggett, J. S., Riscoe, M. K. & Winter, R. W., Aug 20 2021, In: Organic Process Research and Development. 25, 8, p. 1841-1852 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Ullmann Reaction 100%
  • Vacuum Distillation 99%
  • Quinolone 90%
  • Reaction Step 77%
  • Protecting Group 74%
  7 Scopus citations

• Platelet proteome dynamics in hibernating 13-lined ground squirrels

  Cooper, S., Wilmarth, P. A., Cunliffe, J. M., Klimek, J., Pang, J., Yunga, S. T., Minnier, J., Reddy, A., David, L. & Aslan, J. E., Nov 2021, In: Physiological genomics. 53, 11, p. 473-485 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sciuridae 100%
  • Proteome 71%
  • Blood Platelets 53%
  • Torpor 41%
  • Cold Temperature 22%
  8 Scopus citations
• 2020

  Copy number loss of 17q22 is associated with enzalutamide resistance and poor prognosis in metastatic castration-resistant prostate cancer

  Guan, X., Sun, D., Lu, E., Urrutia, J. A., Reiter, R. E., Rettig, M., Evans, C. P., Lara, P., Gleave, M., Beer, T. M., Thomas, G. V., Huang, J., Aggarwal, R. R., Quigley, D. A., Foye, A., Chen, W. S., Youngren, J., Weinstein, A. S., Stuart, J. M., Feng, F. Y., & 3 othersSmall, E. J., Xia, Z. & Alumkal, J. J., Sep 2020, In: Clinical Cancer Research. 26, 17, p. 4616-4624 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MDV 3100 100%
  • Castration 75%
  • Prostatic Neoplasms 53%
  • Whole Genome Sequencing 17%
  • RNA Sequence Analysis 16%
  10 Scopus citations

• Down-regulation of ADRB2 expression is associated with small cell neuroendocrine prostate cancer and adverse clinical outcomes in castration-resistant prostate cancer

  Kwon, D. H., Zhang, L., Quigley, D. A., Foye, A., Chen, W. S., Wong, C. K., Feng, F. Y., Bailey, A., Huang, J., Stuart, J. M., Friedl, V., Weinstein, A. S., Beer, T. M., Alumkal, J. J., Rettig, M., Gleave, M., Lara, P. N., Thomas, G. V., Li, P., Lui, A., & 2 othersSmall, E. J. & Aggarwal, R. R., Dec 2020, In: Urologic Oncology: Seminars and Original Investigations. 38, 12, p. 931.e9-931.e16

  Research output: Contribution to journal › Article › peer-review

  • Neuroendocrine Cells 100%
  • Castration 87%
  • Prostatic Neoplasms 62%
  • Down-Regulation 55%
  • Survival 43%
  3 Scopus citations

• Equivalence of human and bovine dentin matrix molecules for dental pulp regeneration: proteomic analysis and biological function

  Horsophonphong, S., Sercia, A., França, C. M., Tahayeri, A., Reddy, A. P., Wilmarth, P. A., Surarit, R., Smith, A. J., Ferracane, J. L. & Bertassoni, L. E., Nov 2020, In: Archives of Oral Biology. 119, 104888.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dental Pulp 100%
  • Dentin 82%
  • Proteomics 72%
  • Regeneration 66%
  • Cattle 63%
  8 Scopus citations

• MS/MS in silico subtraction-based proteomic profiling as an approach to facilitate disease gene discovery: application to lens development and cataract

  Aryal, S., Anand, D., Hernandez, F. G., Weatherbee, B. A. T., Huang, H., Reddy, A. P., Wilmarth, P. A., David, L. L. & Lachke, S. A., Feb 1 2020, In: Human genetics. 139, 2, p. 151-184 34 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Association Studies 100%
  • Proteome 98%
  • Crystallins 91%
  • Lenses 89%
  • Computer Simulation 88%
  12 Scopus citations

• Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial

  Zhang, Z., Garzotto, M., Davis, E. W., Mori, M., Stoller, W. A., Farris, P. E., Wong, C. P., Beaver, L. M., Thomas, G. V., Williams, D. E., Dashwood, R. H., Hendrix, D. A., Ho, E. & Shannon, J., Jan 2 2020, In: Nutrition and Cancer. 72, 1, p. 74-87 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sulforafan 100%
  • Brassica 93%
  • Biological Availability 62%
  • Prostate 57%
  • Histone Deacetylases 48%
  40 Scopus citations

• The DNA methylation landscape of advanced prostate cancer

  Zhao, S. G., Chen, W. S., Li, H., Foye, A., Zhang, M., Sjöström, M., Aggarwal, R., Playdle, D., Liao, A., Alumkal, J. J., Das, R., Chou, J., Hua, J. T., Barnard, T. J., Bailey, A. M., Chow, E. D., Perry, M. D., Dang, H. X., Yang, R., Moussavi-Baygi, R., & 49 othersZhang, L., Alshalalfa, M., Laura Chang, S., Houlahan, K. E., Shiah, Y. J., Beer, T. M., Thomas, G., Chi, K. N., Gleave, M., Zoubeidi, A., Reiter, R. E., Rettig, M. B., Witte, O., Yvonne Kim, M., Fong, L., Spratt, D. E., Morgan, T. M., Bose, R., Huang, F. W., Li, H., Chesner, L., Shenoy, T., Goodarzi, H., Asangani, I. A., Sandhu, S., Lang, J. M., Mahajan, N. P., Lara, P. N., Evans, C. P., Febbo, P., Batzoglou, S., Knudsen, K. E., He, H. H., Huang, J., Zwart, W., Costello, J. F., Luo, J., Tomlins, S. A., Wyatt, A. W., Dehm, S. M., Ashworth, A., Gilbert, L. A., Boutros, P. C., Farh, K., Chinnaiyan, A. M., Maher, C. A., Small, E. J., Quigley, D. A. & Feng, F. Y., Aug 1 2020, In: Nature genetics. 52, 8, p. 778-789 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA Methylation 100%
  • Methylation 91%
  • Prostatic Neoplasms 80%
  • Whole Exome Sequencing 60%
  • Whole Genome Sequencing 58%
  173 Scopus citations

• Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance

  Alumkal, J. J., Sun, D., Lu, E., Beer, T. M., Thomas, G. V., Latour, E., Aggarwal, R., Cetnar, J., Ryan, C. J., Tabatabaei, S., Bailey, S., Turina, C. B., Quigley, D. A., Guan, X., Foye, A., Youngren, J. F., Urrutia, J., Huangi, J., Weinstein, A. S., Friedl, V., & 11 othersRettig, M., Reiter, R. E., Spratt, D. E., Gleav, M., Evans, C. P., Stuart, J. M., Chen, Y., Feng, F. Y., Small, E. J., Witte, O. N. & Xia, Z., Jun 2 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 22, p. 12315-12323 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MDV 3100 100%
  • Androgen Receptors 73%
  • Prostate-Specific Antigen 55%
  • Castration 45%
  • Prostatic Neoplasms 32%
  71 Scopus citations
• 2019

  Genomic Drivers of Poor Prognosis and Enzalutamide Resistance in Metastatic Castration-resistant Prostate Cancer(Figure presented.)

  Chen, W. S., Aggarwal, R., Zhang, L., Zhao, S. G., Thomas, G. V., Beer, T. M., Quigley, D. A., Foye, A., Playdle, D., Huang, J., Lloyd, P., Lu, E., Sun, D., Guan, X., Rettig, M., Gleave, M., Evans, C. P., Youngren, J., True, L., Lara, P., & 8 othersKothari, V., Xia, Z., Chi, K. N., Reiter, R. E., Maher, C. A., Feng, F. Y., Small, E. J. & Alumkal, J. J., Nov 2019, In: European Urology. 76, 5, p. 562-571 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • MDV 3100 100%
  • Castration 75%
  • Prostatic Neoplasms 53%
  • Catenins 53%
  • Whole Genome Sequencing 29%
  90 Scopus citations

• MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer

  Nickols, N. G., Nazarian, R., Zhao, S. G., Tan, V., Uzunangelov, V., Xia, Z., Baertsch, R., Neeman, E., Gao, A. C., Thomas, G. V., Howard, L., De Hoedt, A. M., Stuart, J., Goldstein, T., Chi, K., Gleave, M. E., Graff, J. N., Beer, T. M., Drake, J. M., Evans, C. P., & 11 othersAggarwal, R., Foye, A., Feng, F. Y., Small, E. J., Aronson, W. J., Freedland, S. J., Witte, O. N., Huang, J., Alumkal, J. J., Reiter, R. E. & Rettig, M. B., Dec 1 2019, In: Prostate Cancer and Prostatic Diseases. 22, 4, p. 531-538 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Castration 100%
  • Mitogen-Activated Protein Kinase Kinases 98%
  • Prostatic Neoplasms 71%
  • trametinib 21%
  • Phosphotransferases 16%
  65 Scopus citations

• Prevalence of Cerebrotendinous Xanthomatosis among Patients Diagnosed with Acquired Juvenile-Onset Idiopathic Bilateral Cataracts

  Freedman, S. F., Brennand, C., Chiang, J., Debarber, A., Del Monte, M. A., Duell, P. B., Fiorito, J. & Marshall, R., Nov 2019, In: JAMA ophthalmology. 137, 11, p. 1312-1316 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebrotendinous Xanthomatosis 100%
  • Cataract 56%
  • Cholestanols 49%
  • Cholestanol 43%
  • Urine 14%
  23 Scopus citations

• Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

  Stafford, A. M., Reed, C., Baba, H., Walter, N. A. R., Mootz, J. R. K., Williams, R. W., Neve, K. A., Fedorov, L. M., Janowsky, A. J. & Phillips, T. J., Jul 2019, In: eLife. 8, e46472.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methamphetamine 100%
  • Genes 30%
  • Trace amine-associated receptor 1 17%
  • Hot Temperature 14%
  • Chromosomes, Human, Pair 10 12%
  22 Scopus citations

• Whole-genome and transcriptional analysis of treatment-emergent small-cell neuroendocrine prostate cancer demonstrates intraclass heterogeneity

  Aggarwal, R. R., Quigley, D. A., Huang, J., Zhang, L., Beer, T. M., Rettig, M. B., Reiter, R. E., Gleave, M. E., Thomas, G. V., Foye, A., Playdle, D., Lloyd, P., Chi, K. N., Evans, C. P., Lara, P. N., Feng, F. Y., Alumkal, J. J. & Small, E. J., Jun 1 2019, In: Molecular Cancer Research. 17, 6, p. 1235-1240 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Cells 100%
  • Neuroendocrine Carcinoma 76%
  • Small Cell Carcinoma 71%
  • Prostatic Neoplasms 62%
  • Genome 53%
  43 Scopus citations
• 2018

  Biomechanical rigidity and quantitative proteomics analysis of segmental regions of the trabecular meshwork at physiologic and elevated pressures

  Vranka, J. A., Staverosky, J. A., Reddy, A. P., Wilmarth, P. A., David, L. L., Acott, T. S., Russell, P. & Raghunathan, V. K., Jan 2018, In: Investigative Ophthalmology and Visual Science. 59, 1, p. 246-259 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Trabecular Meshwork 100%
  • Proteomics 68%
  • Pressure 48%
  • Elastic Modulus 37%
  • Extracellular Matrix Proteins 35%
  51 Scopus citations

• Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: A multi-institutional prospective study

  Aggarwal, R., Huang, J., Alumkal, J. J., Zhang, L., Feng, F. Y., Thomas, G. V., Weinstein, A. S., Friedl, V., Zhang, C., Witte, O. N., Lloyd, P., Gleave, M., Evans, C. P., Youngren, J., Beer, T. M., Rettig, M., Wong, C. K., True, L., Foye, A., Playdle, D., & 11 othersRyan, C. J., Lara, P., Chi, K. N., Uzunangelov, V., Sokolov, A., Newton, Y., Beltran, H., Demichelis, F., Rubin, M. A., Stuart, J. M. & Small, E. J., Aug 20 2018, In: Journal of Clinical Oncology. 36, 24, p. 2492-2503 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Cells 100%
  • Prostatic Neoplasms 62%
  • Prospective Studies 50%
  • Castration 21%
  • Androgen Receptors 15%
  433 Scopus citations

• Coordinated responses to individual tumor antigens by IgG antibody and CD8+ T cells following cancer vaccination

  Hulett, T. W., Jensen, S. M., Wilmarth, P. A., Reddy, A. P., Ballesteros-Merino, C., Afentoulis, M. E., Dubay, C., David, L. L. & Fox, B. A., Apr 5 2018, In: Journal for immunotherapy of cancer. 6, 1, 27.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Antigens 100%
  • Vaccination 75%
  • Immunoglobulin G 70%
  • T-Lymphocytes 58%
  • Antibodies 52%
  15 Scopus citations