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2015

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Lovera, J., Ramos, A., Devier, D., Garrison, V., Kovner, B., Reza, T., Koop, D., Rooney, W., Foundas, A. & Bourdette, D., Nov 15 2015, In : Journal of the Neurological Sciences. 358, 1-2, p. 46-52 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data

Schrodi, S. J., DeBarber, A., He, M., Ye, Z., Peissig, P., Van Wormer, J. J., Haws, R., Brilliant, M. H. & Steiner, R. D., Jun 1 2015, In : Human genetics. 134, 6, p. 659-669 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rapid communication: 17 b-estradiol increases persistent Na+ current and excitability of AVPV/PeN kiss1 neurons in female mice

Zhang, C., Bosch, M. A., Qiu, J., Rønnekleiv, O. K. & Kelly, M. J., Jan 1 2015, In : Molecular Endocrinology. 29, 4, p. 518-527 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane

Schifferer, M., Feng, S., Stein, F., Tischer, C. & Schultz, C., May 29 2015, In : Bioorganic and Medicinal Chemistry. 23, 12, p. 2862-2867 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of the paraventricular nucleus of the hypothalamus in the sympathoexcitatory effects of leptin

Shi, Z., Li, B. & Brooks, V. L., Nov 1 2015, In : Hypertension. 66, 5, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Selective inhibition of PARP10 using a chemical genetics strategy

Morgan, R. K., Carter-O'Connell, I. & Cohen, M. S., Nov 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 21, p. 4770-4773 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Spontaneous activity does not predict morphological type in cerebellar interneurons

Haar, S., Givon-Mayo, R., Barmack, N. H., Yakhnitsa, V. & Donchin, O., Jan 28 2015, In : Journal of Neuroscience. 35, 4, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Xie, F., Li, B. X., Alkayed, N. J. & Xiao, X., Jan 2 2015, In : Synthetic Communications. 45, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias

Gardner, R. T., Wang, L., Lang, B. T., Cregg, J. M., Dunbar, C. L., Woodward, W. R., Silver, J., Ripplinger, C. M. & Habecker, B. A., Feb 2015, In : Nature communications. 6, 6235.

Research output: Contribution to journalArticle

39 Scopus citations

Temperature differentially facilitates spontaneous but not evoked glutamate release from cranial visceral primary afferents

Fawley, J. A., Hofmann, M. E., Largent-Milnes, T. M. & Andresen, M. C., May 20 2015, In : PloS one. 10, 5, e0127764.

Research output: Contribution to journalArticle

8 Scopus citations

The chemistry and pharmacology of privileged pyrroloquinazolines

Chao, B., Li, B. X. & Xiao, X., Apr 1 2015, In : MedChemComm. 6, 4, p. 510-520 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

The effect of PKCα on the light response of rod bipolar cells in the mouse retina

Xiong, W. H., Pang, J. J., Pennesi, M. E., Duvoisin, R. M., Wu, S. M. & Morgans, C. W., 2015, In : Investigative Ophthalmology and Visual Science. 56, 8, p. 4961-4974 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction

Navarro, V. M., Bosch, M. A., León, S., Simavli, S., True, C., Pinilla, L., Carroll, R. S., Seminara, S. B., Tena-Sempere, M., Rønnekleiv, O. K. & Kaiser, U. B., Feb 1 2015, In : Endocrinology. 156, 2, p. 627-637 11 p.

Research output: Contribution to journalArticle

50 Scopus citations

The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development

Kang, X., Lu, Z., Cui, C., Deng, M., Fan, Y., Dong, B., Han, X., Xie, F., Tyner, J. W., Coligan, J. E., Collins, R. H., Xiao, X., You, M. J. & Zhang, C. C., May 5 2015, In : Nature Cell Biology. 17, 5, p. 665-677 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

TRPM3 expression in mouse retina

Brown, R. L., Xiong, W. H., Peters, J. H., Tekmen-Clark, M., Strycharska-Orczyk, I., Reed, B. T., Morgans, C. W. & Duvoisin, R. M., Feb 13 2015, In : PloS one. 10, 2, e0117615.

Research output: Contribution to journalArticle

10 Scopus citations

Voriconazole, an antifungal triazol that causes visual side effects, is an inhibitor of TRPM1 and TRPM3 channels

Xiong, W. H., Lane Brown, R., Reed, B., Burke, N. S., Duvoisin, R. M. & Morgans, C. W., Feb 2015, In : Investigative Ophthalmology and Visual Science. 56, 2, p. 1367-1373 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2014

A blood test for cerebrotendinous xanthomatosis with potential for disease detection in newborns

DeBarber, A. E., Luo, J., Star-Weinstock, M., Purkayastha, S., Geraghty, M. T., Chiang, J., Merkens, L. S., Pappu, A. S. & Steiner, R. D., Jan 1 2014, In : Journal of lipid research. 55, 1, p. 146-154 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema

Trojanek, J. B., Cobos-Correa, A., Diemer, S., Kormann, M., Schubert, S. C., Zhou-Suckow, Z., Agrawal, R., Duerr, J., Wagner, C. J., Schatterny, J., Hirtz, S., Sommerburg, O., Hartl, D., Schultz, C. & Mall, M. A., Nov 1 2014, In : American journal of respiratory cell and molecular biology. 51, 5, p. 709-720 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner

Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N. & Raber, J., Apr 1 2014, In : Neurobiology of Disease. 64, p. 150-162 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Aqueous cigarette smoke extract induces a voltage-dependent inhibition of CFTR expressed in Xenopus oocytes

Moran, A. R., Norimatsu, Y., Dawson, D. C. & MacDonald, K. D., Feb 1 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 3, p. L284-L291

Research output: Contribution to journalArticle

13 Scopus citations

A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease

Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L. & Kaye, J., 2014, In : Journal of Alzheimer's Disease. 38, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

124 Scopus citations

A rapidly reversible chemical dimerizer system to study lipid signaling in living cells

Feng, S., Laketa, V., Stein, F., Rutkowska, A., MacNamara, A., Depner, S., Klingmüller, U., Saez-Rodriguez, J. & Schultz, C., Jun 23 2014, In : Angewandte Chemie - International Edition. 53, 26, p. 6720-6723 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

A useful multi-analyte blood test for cerebrotendinous xanthomatosis

DeBarber, A. E., Luo, J., Giugliani, R., Souza, C. F. M., Chiang, J. P. W., Merkens, L. S., Pappu, A. S. & Steiner, R. D., Jun 2014, In : Clinical Biochemistry. 47, 9, p. 860-863 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

A US perspective on newborn screening: A powerful tool for prevention

DeBarber, A. E. & Steiner, R. D., Nov 1 2014, In : Expert Opinion on Orphan Drugs. 2, 11, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Capsaicin-responsive corneal afferents do not contain TRPV1 at their central terminals in trigeminal nucleus caudalis in rats

Hegarty, D. M., Hermes, S. M., Largent-Milnes, T. M. & Aicher, S. A., Nov 1 2014, In : Journal of Chemical Neuroanatomy. 61, p. 1-12 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cell death in the central division of the medial preoptic nucleus of male and female lamb fetuses

Reddy, R. C., Scheldrup, M., Meaker, M., Stormshak, F., Estill, C. T. & Roselli, C. E., Mar 20 2014, In : Brain research. 1554, p. 21-28 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders

Kalinichev, M., Le Poul, E., Boléa, C., Girard, F., Campo, B., Fonsi, M., Royer-Urios, I., Browne, S. E., Uslaner, J. M., Davis, M. J., Raber, J., Duvoisin, R., Bate, S. T., Reynolds, I. J., Poli, S. & Celanire, S., Sep 2014, In : Journal of Pharmacology and Experimental Therapeutics. 350, 3, p. 495-505 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Corneal pain activates a trigemino-parabrachial pathway in rats

Aicher, S. A., Hegarty, D. M. & Hermes, S. M., Mar 6 2014, In : Brain research. 1550, p. 18-26 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators protect G551D but not Δf508 CFTR from thermal instability

Liu, X. & Dawson, D. C., Sep 9 2014, In : Biochemistry. 53, 35, p. 5613-5618 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Differential content of vesicular glutamate transporters in subsets of vagal afferents projecting to the nucleus tractus solitarii in the rat

Hermes, S. M., Colbert, J. F. & Aicher, S. A., Feb 15 2014, In : Journal of Comparative Neurology. 522, 3, p. 642-653 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Engineering the substrate specificity of ADP-ribosyltransferases for identifying direct protein targets

Carter-O'Connell, I., Jin, H., Morgan, R. K., David, L. L. & Cohen, M. S., Apr 9 2014, In : Journal of the American Chemical Society. 136, 14, p. 5201-5204 4 p.

Research output: Contribution to journalArticle

57 Scopus citations

External QX-314 inhibits evoked cranial primary afferent synaptic transmission independent of TRPV1

Hofmann, M. E., Largent-Milnes, T. M., Fawley, J. A. & Andresen, M. C., Dec 1 2014, In : Journal of neurophysiology. 112, 11, p. 2697-2706 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

FRET-based and other fluorescent proteinase probes

Hu, H. Y., Gehrig, S., Reither, G., Subramanian, D., Mall, M. A., Plettenburg, O. & Schultz, C., Feb 1 2014, In : Biotechnology Journal. 9, 2, p. 266-281 16 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetically encoded fluorescent indicator for imaging NAD+/NADH ratio changes in different cellular compartments

Bilan, D. S., Matlashov, M. E., Gorokhovatsky, A. Y., Schultz, C., Enikolopov, G. & Belousov, V. V., Mar 1 2014, In : Biochimica et Biophysica Acta - General Subjects. 1840, 3, p. 951-957 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels

Qiu, J., Zhang, C., Borgquist, A., Nestor, C. C., Smith, A. W., Bosch, M. A., Ku, S., Wagner, E. J., Rønnekleiv, O. K. & Kelly, M. J., Apr 1 2014, In : Cell Metabolism. 19, 4, p. 682-693 12 p.

Research output: Contribution to journalArticle

85 Scopus citations

Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size

Guo, C., Chen, X., Song, H., Maynard, M. A., Zhou, Y., Lobanov, A. V., Gladyshev, V. N., Ganis, J. J., Wiley, D., Jugo, R. H., Lee, N. Y., Castroneves, L. A., Zon, L. I., Scanlan, T. S., Feldman, H. A. & Huang, S. A., Oct 1 2014, In : Endocrinology. 155, 10, p. 4069-4080 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

In vivo imaging of mouse tumors by a lipidated cathepsin S substrate

Hu, H. Y., Vats, D., Vizovisek, M., Kramer, L., Germanier, C., Wendt, K. U., Rudin, M., Turk, B., Plettenburg, O. & Schultz, C., Jul 14 2014, In : Angewandte Chemie - International Edition. 53, 29, p. 7669-7673 5 p.

Research output: Contribution to journalArticle

40 Scopus citations

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosislike lung disease

Gehrig, S., Duerr, J., Weitnauer, M., Wagner, C. J., Graeber, S. Y., Schatterny, J., Hirtz, S., Belaaouaj, A., Dalpke, A. H., Schultz, C. & Mall, M. A., May 1 2014, In : American journal of respiratory and critical care medicine. 189, 9, p. 1082-1092 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Leptin stimulates sympathetic axon outgrowth

Pellegrino, M. J., McCully, B. H. & Habecker, B. A., Apr 30 2014, In : Neuroscience Letters. 566, p. 1-5 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels

Carta, M., Lanore, F., Rebola, N., Szabo, Z., Da Silva, S. V., Lourenço, J., Verraes, A., Nadler, A., Schultz, C., Blanchet, C. & Mulle, C., Feb 19 2014, In : Neuron. 81, 4, p. 787-799 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Minimal tags for rapid dual-color live-cell labeling and super-resolution microscopy

Nikic̈, I., Plass, T., Schraidt, O., Szymański, J., Briggs, J. A. G., Schultz, C. & Lemke, E. A., Feb 17 2014, In : Angewandte Chemie - International Edition. 53, 8, p. 2245-2249 5 p.

Research output: Contribution to journalArticle

168 Scopus citations

Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation

Cassaglia, P. A., Shi, Z., Li, B., Reis, W. L., Clute-Reinig, N. M., Stern, J. E. & Brooks, V. L., Apr 1 2014, In : Journal of Physiology. 592, 7, p. 1655-1675 21 p.

Research output: Contribution to journalArticle

22 Scopus citations

Novel type of prodrug activation through a long-range O,N-acyl transfer: A case of water-soluble CREB inhibitor

Li, B. X., Xie, F., Fan, Q., Barnhart, K. M., Moore, C. E., Rheingold, A. L. & Xiao, X., Oct 9 2014, In : ACS Medicinal Chemistry Letters. 5, 10, p. 1104-1109 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons

Largent-Milnes, T. M., Hegarty, D. M., Aicher, S. A. & Andresen, M. C., Jun 1 2014, In : Journal of neurophysiology. 111, 11, p. 2222-2231 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

PIP3 induces the recycling of receptor tyrosine kinases

Laketa, V., Zarbakhsh, S., Traynor-Kaplan, A., MacNamara, A., Subramanian, D., Putyrski, M., Mueller, R., Nadler, A., Mentel, M., Saez-Rodriguez, J., Pepperkok, R. & Schultz, C., Jan 14 2014, In : Science signaling. 7, 308, ra5.

Research output: Contribution to journalArticle

15 Scopus citations

Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis

Reversi, A., Loeser, E., Subramanian, D., Schultz, C. & De Renzis, S., 2014, In : Journal of Cell Biology. 205, 3, p. 395-408 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Prenatal influence of an androgen agonist and antagonist on the differentiation of the ovine sexually dimorphic nucleus in male and female lamb fetuses

Roselli, C. E., Reddy, R. C., Estill, C. T., Scheldrup, M., Meaker, M., Stormshak, F. & Montilla, H. J., Dec 1 2014, In : Endocrinology. 155, 12, p. 5000-5010 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome

Colak, D., Zaninovic, N., Cohen, M. S., Rosenwaks, Z., Yang, W. Y., Gerhardt, J., Disney, M. D. & Jaffrey, S. R., Jan 1 2014, In : Science. 343, 6174, p. 1002-1005 4 p.

Research output: Contribution to journalArticle

157 Scopus citations

Proof of Concept of the Electrochemical Sensing of 3-Iodothyronamine (T1AM) and Thyronamine (T0AM)

Gonçalves, L. M., Moreira, M. M., Azevedo, C. F., Valente, I. M., Sousa, J. C., Scanlan, T. S., Compton, R. G. & Rodrigues, J. A., Oct 1 2014, In : ChemElectroChem. 1, 10, p. 1623-1626 4 p.

Research output: Contribution to journalArticle

2 Scopus citations