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2016

Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias

Gardner, R. T., Ripplinger, C. M., Myles, R. C. & Habecker, B. A., Feb 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 2, e001359.

Research output: Contribution to journalArticle

23 Scopus citations

Myocardial infarction causes transient cholinergic transdifferentiation of cardiac sympathetic nerves via gp130

Olivas, A., Gardner, R. T., Wang, L., Ripplinger, C. M., Woodward, W. R. & Habecker, B. A., Jan 13 2016, In : Journal of Neuroscience. 36, 2, p. 479-488 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Optogenetic stimulation of arcuate nucleus kiss1 neurons reveals a steroid-dependent glutamatergic input to POMC and AgRP neurons in male mice

Nestor, C. C., Qiu, J., Padilla, S. L., Zhang, C., Bosch, M. A., Fan, W., Aicher, S. A., Palmiter, R. D., Rønnekleiv, O. K. & Kelly, M. J., Jun 2016, In : Molecular Endocrinology. 30, 6, p. 630-644 15 p.

Research output: Contribution to journalArticle

33 Scopus citations

PARP6 is a Regulator of Hippocampal Dendritic Morphogenesis

Huang, J. Y., Wang, K., Vermehren-Schmaedick, A., Adelman, J. P. & Cohen, M. S., Jan 4 2016, In : Scientific Reports. 6, 18512.

Research output: Contribution to journalArticle

12 Scopus citations

Photoswitchable diacylglycerols enable optical control of protein kinase C

Frank, J. A., Yushchenko, D. A., Hodson, D. J., Lipstein, N., Nagpal, J., Rutter, G. A., Rhee, J. S., Gottschalk, A., Brose, N., Schultz, C. & Trauner, D., Sep 1 2016, In : Nature Chemical Biology. 12, 9, p. 755-762 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium

Jia, J., Davis, C. M., Zhang, W., Edin, M. L., Jouihan, S., Jia, T., Bradbury, J. A., Graves, J. P., DeGraff, L. M., Lee, C. R., Ronnekleiv, O., Wang, R., Xu, Y., Zeldin, D. C. & Alkayed, N. J., May 1 2016, In : Experimental Neurology. 279, p. 75-85 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells

Mitton, B., Chae, H. D., Hsu, K., Dutta, R., Aldana-Masangkay, G., Ferrari, R., Davis, K., Tiu, B. C., Kaul, A., Lacayo, N., Dahl, G., Xie, F., Li, B. X., Breese, M. R., Landaw, E. M., Nolan, G., Pellegrini, M., Romanov, S., Xiao, X. & Sakamoto, K. M., Dec 1 2016, In : Leukemia. 30, 12, p. 2302-2311 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Sobetirome prodrug esters with enhanced blood–brain barrier permeability

Placzek, A. T., Ferrara, S. J., Hartley, M. D., Sanford-Crane, H. S., Meinig, J. M. & Scanlan, T. T., Nov 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 22, p. 5842-5854 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

Systemic Inhibition of CREB is Well-tolerated in vivo

Li, B. X., Gardner, R., Xue, C., Qian, Z. D., Xie, F., Thomas, G., Kazmierczak, S. S., Habecker, B. & Xiao, X., Oct 3 2016, In : Scientific Reports. 6, 34513.

Research output: Contribution to journalArticle

10 Scopus citations

The degradation of mitomycin C under various storage methods

Kinast, R. M., Akula, K. K., De Barber, A., Barker, G. T., Gardiner, S. K., Whitson, E. & Mansberger, S. L., 2016, In : Journal of Glaucoma. 25, 6, p. 477-481 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Translational neurocardiology: preclinical models and cardioneural integrative aspects

Ardell, J. L., Andresen, M., Armour, J. A., Billman, G. E., Chen, P. S., Foreman, R. D., Herring, N., O'Leary, D. S., Sabbah, H. N., Schultz, H. D., Sunagawa, K. & Zucker, I. H., Jul 15 2016, In : Journal of Physiology. 594, 14, p. 3877-3909 33 p.

Research output: Contribution to journalArticle

43 Scopus citations

Update on newborn dried bloodspot testing for cerebrotendinous xanthomatosis: An available high-throughput liquid-chromatography tandem mass spectrometry method

Bleyle, L., Huidekoper, H. H., Vaz, F. M., Singh, R., Steiner, R. D. & De Barber, A., Jun 1 2016, In : Molecular Genetics and Metabolism Reports. 7, p. 11-15 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Vanilloids selectively sensitize thermal glutamate release from TRPV1 expressing solitary tract afferents

Hofmann, M. E. & Andresen, M. C., Oct 2 2016, In : Neuropharmacology. 101, p. 401-411 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Varicellazoster virus activates CREB, and inhibition of the pCREB-p300/CBP interaction inhibits viral replication in vitro and skin pathogenesis in vivo

François, S., Sen, N., Mitton, B., Xiao, X., Sakamoto, K. M. & Arvin, A., 2016, In : Journal of Virology. 90, 19, p. 8686-8697 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

A Clickable Aminooxy Probe for Monitoring Cellular ADP-Ribosylation

Morgan, R. K. & Cohen, M. S., Aug 21 2015, In : ACS chemical biology. 10, 8, p. 1778-1784 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development

Cunningham, D., DeBarber, A. E., Bir, N., Binkley, L., Merkens, L. S., Steiner, R. D. & Herman, G. E., May 15 2015, In : Human molecular genetics. 24, 10, p. 2808-2825 18 p., ddv042.

Research output: Contribution to journalArticle

15 Scopus citations

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer

Alumkal, J. J., Slottke, R., Schwartzman, J., Cherala, G., Munar, M., Graff, J. N., Beer, T. M., Ryan, C. W., Koop, D. R., Gibbs, A., Gao, L., Flamiatos, J. F., Tucker, E., Kleinschmidt, R. & Mori, M., Apr 1 2015, In : Investigational New Drugs. 33, 2, p. 480-489 10 p.

Research output: Contribution to journalArticle

79 Scopus citations

Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes

Appadurai, V., DeBarber, A., Chiang, P. W., Patel, S. B., Steiner, R. D., Tyler, C. & Bonnen, P. E., Jan 1 2015, In : Molecular Genetics and Metabolism. 116, 4, p. 298-304 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

A single-cell model of PIP3 dynamics using chemical dimerization

Macnamara, A., Stein, F., Feng, S., Schultz, C. & Saez-Rodriguez, J., May 29 2015, In : Bioorganic and Medicinal Chemistry. 23, 12, p. 2868-2876 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Climbing Fibers Mediate Vestibular Modulation of Both “Complex” and “Simple Spikes” in Purkinje Cells

Barmack, N. H. & Yakhnitsa, V., Oct 1 2015, In : Cerebellum. 14, 5, p. 597-612 16 p.

Research output: Contribution to journalArticle

3 Scopus citations

Denervation of the lacrimal gland leads to corneal hypoalgesia in a novel rat model of aqueous dry eye disease

Aicher, S. A., Hermes, S. M. & Hegarty, D. M., Oct 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 11, p. 6981-6989 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

DOTAM Derivatives as Active Cartilage-Targeting Drug Carriers for the Treatment of Osteoarthritis

Hu, H. Y., Lim, N. H., Ding-Pfennigdorff, D., Saas, J., Wendt, K. U., Ritzeler, O., Nagase, H., Plettenburg, O., Schultz, C. & Nazare, M., Mar 18 2015, In : Bioconjugate Chemistry. 26, 3, p. 383-388 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of testosterone on neuronal morphology and neuritic growth of fetal lamb hypothalamus-preoptic area and cerebral cortex in primary culture

Reddy, R. C., Amodei, R., Estill, C. T., Stormshak, F., Meaker, M. & Roselli, C. E. R., Jun 8 2015, In : PloS one. 10, 6

Research output: Contribution to journalArticle

7 Scopus citations

Engineering the glutamate transporter homologue GltPh using protein semisynthesis

Focke, P. J., Annen, A. W. & Valiyaveetil, F. I., Mar 3 2015, In : Biochemistry. 54, 8, p. 1694-1702 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Highly Stable trans-Cyclooctene Amino Acids for Live-Cell Labeling

Hoffmann, J. E., Plass, T., Nikic, I., Aramburu, I. V., Koehler, C., Gillandt, H., Lemke, E. A. & Schultz, C., Aug 1 2015, In : Chemistry - A European Journal. 21, 35, p. 12266-12270 5 p.

Research output: Contribution to journalArticle

31 Scopus citations

Hypothalamic Paraventricular and Arcuate Nuclei Contribute to Elevated Sympathetic Nerve Activity in Pregnant Rats: Roles of Neuropeptide Y and α-Melanocyte-Stimulating Hormone

Shi, Z., Cassaglia, P. A., Gotthardt, L. C. & Brooks, V. L., Dec 1 2015, In : Hypertension. 66, 6, p. 1191-1198 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity

Xie, F., Li, B. X., Kassenbrock, A., Xue, C., Wang, X., Qian, D. Z., Sears, R. C. & Xiao, X., Jun 25 2015, In : Journal of Medicinal Chemistry. 58, 12, p. 5075-5087 13 p.

Research output: Contribution to journalArticle

36 Scopus citations
11 Scopus citations

Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach

Carter-O'Connell, I., Jin, H., Morgan, R. K., Zaja, R., David, L., Ahel, I. & Cohen, M., Jul 22 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

33 Scopus citations

Incorporation of non-canonical amino acids

Leisle, L., Valiyaveetil, F., Mehl, R. A. & Ahern, C. A., Oct 1 2015, In : Advances in Experimental Medicine and Biology. 869, p. 119-151 33 p.

Research output: Contribution to journalArticle

8 Scopus citations

In vivo visualization of osteoarthritic hypertrophic lesions

Hu, H. Y., Lim, N. H., Juretschke, H. P., Ding-Pfennigdorff, D., Florian, P., Kohlmann, M., Kandira, A., Peter Von Kries, J., Saas, J., Rudolphi, K. A., Wendt, K. U., Nagase, H., Plettenburg, O., Nazare, M. & Schultz, C., Jan 1 2015, In : Chemical Science. 6, 11, p. 6256-6261 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ion-binding properties of a K+ channel selectivity filter in different conformations

Liu, S., Focke, P. J., Matulef, K., Bian, X., Moënne-Loccoz, P., Valiyaveetil, F. I. & Lockless, S. W., Dec 8 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 49, p. 15096-15100 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Kisspeptin and gonadotropin-releasing hormone neuronal excitability: Molecular mechanisms driven by 17β-estradiol

Rønnekleiv, O. K., Zhang, C., Bosch, M. A. & Kelly, M. J., Nov 10 2015, In : Neuroendocrinology. 102, 3, p. 184-193 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: Role of oestrogen

Shi, Z. & Brooks, V. L., Apr 1 2015, In : Journal of Physiology. 593, 7, p. 1633-1647 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Live-cell STED microscopy with genetically encoded biosensor

Mishina, N. M., Mishin, A. S., Belyaev, Y., Bogdanova, E. A., Lukyanov, S., Schultz, C. & Belousov, V. V., May 13 2015, In : Nano Letters. 15, 5, p. 2928-2932 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Localization and expression of GABA transporters in the suprachiasmatic nucleus

Moldavan, M., Cravetchi, O., Williams, M., Irwin, R. P., Aicher, S. & Allen, C., 2015, (Accepted/In press) In : European Journal of Neuroscience.

Research output: Contribution to journalArticle

13 Scopus citations

Look carefully to the heels! A potentially treatable cause of spastic paraplegia

Saute, J. A., Giugliani, R., Merkens, L. S., Chiang, J. P. W., DeBarber, A. E. & de Souza, C. F. M., Jan 1 2015, In : Journal of inherited metabolic disease. 38, 2, p. 363-364 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation

Neuillé, M., Morgans, C. W., Cao, Y., Orhan, E., Michiels, C., Sahel, J. A., Audo, I., Duvoisin, R. M., Martemyanov, K. A. & Zeitz, C., Aug 1 2015, In : European Journal of Neuroscience. 42, 3, p. 1966-1975 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

New synthetic routes to thyroid hormone analogs: d6-sobetirome, 3H-sobetirome, and the antagonist NH-3

Placzek, A. T. & Scanlan, T. S., Jul 25 2015, In : Tetrahedron. 71, 35, p. 5946-5951 6 p., 26767.

Research output: Contribution to journalArticle

11 Scopus citations

Obesity-induced increases in sympathetic nerve activity: Sex matters

Brooks, V. L., Shi, Z., Holwerda, S. W. & Fadel, P. J., Jan 1 2015, In : Autonomic Neuroscience: Basic and Clinical. 187, p. 18-26 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Polyphenon E, non-futile at neuroprotection in multiple sclerosis but unpredictably hepatotoxic: Phase I single group and phase II randomized placebo-controlled studies

Lovera, J., Ramos, A., Devier, D., Garrison, V., Kovner, B., Reza, T., Koop, D., Rooney, W., Foundas, A. & Bourdette, D., Nov 15 2015, In : Journal of the Neurological Sciences. 358, 1-2, p. 46-52 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Prevalence estimation for monogenic autosomal recessive diseases using population-based genetic data

Schrodi, S. J., DeBarber, A., He, M., Ye, Z., Peissig, P., Van Wormer, J. J., Haws, R., Brilliant, M. H. & Steiner, R. D., Jun 1 2015, In : Human genetics. 134, 6, p. 659-669 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rapid communication: 17 b-estradiol increases persistent Na+ current and excitability of AVPV/PeN kiss1 neurons in female mice

Zhang, C., Bosch, M. A., Qiu, J., Rønnekleiv, O. K. & Kelly, M. J., Jan 1 2015, In : Molecular Endocrinology. 29, 4, p. 518-527 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Reversible chemical dimerizer-induced recovery of PIP2 levels moves clathrin to the plasma membrane

Schifferer, M., Feng, S., Stein, F., Tischer, C. & Schultz, C., May 29 2015, In : Bioorganic and Medicinal Chemistry. 23, 12, p. 2862-2867 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Role of the paraventricular nucleus of the hypothalamus in the sympathoexcitatory effects of leptin

Shi, Z., Li, B. & Brooks, V. L., Nov 1 2015, In : Hypertension. 66, 5, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Selective inhibition of PARP10 using a chemical genetics strategy

Morgan, R. K., Carter-O'Connell, I. & Cohen, M. S., Nov 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 21, p. 4770-4773 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Spontaneous activity does not predict morphological type in cerebellar interneurons

Haar, S., Givon-Mayo, R., Barmack, N. H., Yakhnitsa, V. & Donchin, O., Jan 28 2015, In : Journal of Neuroscience. 35, 4, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Synthesis of 14,15-EET from Arachidonic Acid Using Urea-Hydrogen Peroxide as the Oxidant

Xie, F., Li, B. X., Alkayed, N. J. & Xiao, X., Jan 2 2015, In : Synthetic Communications. 45, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias

Gardner, R. T., Wang, L., Lang, B. T., Cregg, J. M., Dunbar, C. L., Woodward, W. R., Silver, J., Ripplinger, C. M. & Habecker, B. A., Feb 2015, In : Nature communications. 6, 6235.

Research output: Contribution to journalArticle

37 Scopus citations

Temperature differentially facilitates spontaneous but not evoked glutamate release from cranial visceral primary afferents

Fawley, J. A., Hofmann, M. E., Largent-Milnes, T. M. & Andresen, M. C., May 20 2015, In : PloS one. 10, 5, e0127764.

Research output: Contribution to journalArticle

8 Scopus citations