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2018

Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14)

Carter-O'Connell, I., Vermehren-Schmaedick, A., Jin, H., Morgan, R. K., David, L. & Cohen, M., Oct 19 2018, In : ACS Chemical Biology. 13, 10, p. 2841-2848 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis

Duell, P., Salen, G., Eichler, F. S., De Barber, A., Connor, S. L., Casaday, L., Jayadev, S., Kisanuki, Y., Lekprasert, P., Malloy, M. J., Ramdhani, R. A., Ziajka, P. E., Quinn, J., Su, K. G., Geller, A. S., Diffenderfer, M. R. & Schaefer, E. J., Jan 1 2018, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

18 Scopus citations

Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons

Stincic, T. L., Ronnekleiv, O. & Kelly, M., Jan 1 2018, (Accepted/In press) In : Hormones and Behavior.

Research output: Contribution to journalArticle

6 Scopus citations

Early prenatal androgen exposure reduces testes size and sperm concentration in sheep without altering neuroendocrine differentiation and masculine sexual behavior

Scully, C. M., Estill, C. T., Amodei, R., McKune, A., Gribbin, K. P., Meaker, M., Stormshak, F. & Roselli, C., Jan 1 2018, In : Domestic Animal Endocrinology. 62, p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effects of sub-chronic MPTP exposure on behavioral and cognitive performance and the microbiome of wild-type and mGlu8 knockout female and male mice

Torres, E. R. S., Akinyeke, T., Stagaman, K., Duvoisin, R., Meshul, C. K., Sharpton, T. J. & Raber, J., Jul 18 2018, In : Frontiers in Behavioral Neuroscience. 12, 140.

Research output: Contribution to journalArticle

5 Scopus citations

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis

Dittrich, A. S., Kühbandner, I., Gehrig, S., Rickert-Zacharias, V., Twigg, M., Wege, S., Taggart, C. C., Herth, F., Schultz, C. & Mall, M. A., Jan 1 2018, In : European Respiratory Journal. 51, 3, 1701910.

Research output: Contribution to journalArticle

13 Scopus citations

Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion

Hauke, S., Keutler, K., Phapale, P., Yushchenko, D. A. & Schultz, C., Oct 1 2018, In : Diabetes. 67, 10, p. 1986-1998 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Estradiol drives the anorexigenic activity of proopiomelanocortin neurons in female mice

Stincic, T. L., Grachev, P., Bosch, M. A., Rønnekleiv, O. K. & Kelly, M. J., Jul 1 2018, In : eNeuro. 5, 4, e0103-18.2018.

Research output: Contribution to journalArticle

4 Scopus citations

Estradiol protects proopiomelanocortin neurons against insulin resistance

Qiu, J., Bosch, M. A., Meza, C., Navarro, U. V., Nestor, C. C., Wagner, E. J., Ronnekleiv, O. & Kelly, M., Feb 1 2018, In : Endocrinology. 159, 2, p. 647-664 18 p.

Research output: Contribution to journalArticle

18 Scopus citations

Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

Qiu, J., Rivera, H. M., Bosch, M. A., Padilla, S. L., Stincic, T. L., Palmiter, R. D., Kelly, M. & Ronnekleiv, O., Aug 6 2018, In : eLife. 7, e35656.

Research output: Contribution to journalArticle

13 Scopus citations

Hypothalamic-Pituitary-Thyroid Axis Perturbations in Male Mice by CNS-Penetrating Thyromimetics

Ferrara, S. J., Bourdette, D. & Scanlan, T. T., Jul 1 2018, In : Endocrinology. 159, 7, p. 2733-2740 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma

Abdel-Khalik, J., Crick, P. J., Yutuc, E., DeBarber, A. E., Duell, P. B., Steiner, R. D., Laina, I., Wang, Y. & Griffiths, W. J., Oct 2018, In : Biochimie. 153, p. 86-98 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Intravenous Fish Oil and Pediatric Intestinal Failure–Associated Liver Disease: Changes in Plasma Phytosterols, Cytokines, and Bile Acids and Erythrocyte Fatty Acids

Calkins, K. L., DeBarber, A., Steiner, R. D., Flores, M. J., Grogan, T. R., Henning, S. M., Reyen, L. & Venick, R. S., Mar 2018, In : Journal of Parenteral and Enteral Nutrition. 42, 3, p. 633-641 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor

Infield, D. T., Matulef, K., Galpin, J. D., Lam, K., Tajkhorshid, E., Ahern, C. A. & Valiyaveetil, F., Dec 1 2018, In : Nature Communications. 9, 1, 5055.

Research output: Contribution to journalArticle

2 Scopus citations
5 Scopus citations

MRI Verification of a 10–20 Targeting Protocol Used During Transcranial Magnetic Stimulation Sessions for Tinnitus

Theodoroff, S., Stevens, A., McMillan, G., Pettersson, D., Woodward, W. & Folmer, R. L., Feb 21 2018, (Accepted/In press) In : Brain Topography. p. 1-10 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Newborn screening for cerebrotendinous xanthomatosis is the solution for early identification and treatment

De Barber, A., Kalfon, L., Fedida, A., Fleisher Sheffer, V., Ben Haroush, S., Chasnyk, N., Shuster Biton, E., Mandel, H., Jeffries, K., Shinwell, E. S. & Falik-Zaccai, T. C., Nov 1 2018, In : Journal of Lipid Research. 59, 11, p. 2214-2222 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapyinduced degeneration

Liu, H. W., Smith, C. B., Schmidt, M. S., Cambronne, X., Cohen, M., Migaud, M. E., Brenner, C. & Goodman, R., Oct 16 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 42, p. 10654-10659 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Rational Design of Cell-Active Inhibitors of PARP10

Morgan, R. K., Kirby, I. T., Vermehren-Schmaedick, A., Rodriguez, K. & Cohen, M., Jan 1 2018, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

2 Scopus citations

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., Heras, V., Velasco, I., Dieguez, C., Pinilla, L., Gaytan, F., Nogueiras, R., Bosch, M. A., Ronnekleiv, O., Lomniczi, A., Ojeda, S. & Tena-Sempere, M., Dec 1 2018, In : Nature Communications. 9, 1, 4194.

Research output: Contribution to journalArticle

11 Scopus citations

Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis

Jiang, M., Yan, Y., Yang, K., Liu, Z., Qi, J., Zhou, H., Qian, N., Zhou, Q., Wang, T., Xu, X., Xiao, X. & Deng, L., Jan 1 2018, (Accepted/In press) In : Journal of Cellular and Molecular Medicine.

Research output: Contribution to journalArticle

2 Scopus citations

Sobetirome and its Amide Prodrug Sob-AM2 Exert Thyromimetic Actions in Mct8-Deficient Brain

Bárez-López, S., Hartley, M. D., Grijota-Martínez, C., Scanlan, T. T. & Guadaño-Ferraz, A., Sep 1 2018, In : Thyroid. 28, 9, p. 1211-1220 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structure-Activity Relationships of Central Nervous System Penetration by Fatty Acid Amide Hydrolase (FAAH)-Targeted Thyromimetic Prodrugs

Meinig, J. M., Ferrara, S. J., Banerji, T., Banerji, T., Sanford-Crane, H. S., Bourdette, D. & Scanlan, T. T., Jan 1 2018, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

T 3 induces both markers of maturation and aging in pancreatic b-cells

Aguayo-Mazzucato, C., Lee, T. B., Matzko, M., DiIenno, A., Rezanejad, H., Ramadoss, P., Scanlan, T., Zavacki, A. M., Larsen, P. R., Hollenberg, A., Colton, C., Sharma, A. & Bonner-Weir, S., Jul 2018, In : Diabetes. 67, 7, p. 1322-1331 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

The 3rd World Conference on Kisspeptin, “Kisspeptin 2017: Brain and Beyond”: Unresolved questions, challenges and future directions for the field

Lehman, M. N., Coolen, L. M., Steiner, R. A., Neal-Perry, G., Wang, L., Moenter, S. M., Moore, A. M., Goodman, R. L., Yeo, S. H., Padilla, S. L., Kauffman, A. S., Garcia, J., Kelly, M. J., Clarkson, J., Radovick, S., Babwah, A. V., Leon, S., Tena-Sempere, M., Comninos, A. N., Seminara, S. & 6 others, Dhillo, W. S., Levine, J., Terasawa, E., Negron, A., Navarro, V. M. & Herbison, A. E., May 2018, In : Journal of Neuroendocrinology. 30, 5, e12600.

Research output: Contribution to journalArticle

4 Scopus citations

Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

Yu, G., Tzouvelekis, A., Wang, R., Herazo-Maya, J. D., Ibarra, G. H., Srivastava, A., De Castro, J. P. W., Deiuliis, G., Ahangari, F., Woolard, T., Aurelien, N., Drigo, R. A. E., Gan, Y., Graham, M., Liu, X., Homer, R. J., Scanlan, T. T., Mannam, P., Lee, P. J., Herzog, E. L. & 2 others, Bianco, A. C. & Kaminski, N., Jan 1 2018, In : Nature Medicine. 24, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

67 Scopus citations

Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences

Bayles, R. G., Olivas, A., Denfeld, Q., Woodward, W., Fei, S. S., Gao, L. & Habecker, B., Dec 1 2018, In : Scientific Reports. 8, 1, 8963.

Research output: Contribution to journalArticle

3 Scopus citations

Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility

Parrish, D. C., Francis Stuart, S. D., Olivas, A., Wang, L., Nykjaer, A., Ripplinger, C. M. & Habecker, B. A., Mar 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 3, p. H415-H423

Research output: Contribution to journalArticle

3 Scopus citations

TRPCing around the hypothalamus

Kelly, M., Qiu, J. & Ronnekleiv, O., Jan 1 2018, (Accepted/In press) In : Frontiers in Neuroendocrinology.

Research output: Contribution to journalArticle

2 Scopus citations

Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway

Komegae, E. N., Farmer, D. G. S., Brooks, V., McKinley, M. J., McAllen, R. M. & Martelli, D., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

24 Scopus citations
2017

AgRP to Kiss1 neuron signaling links nutritional state and fertility

Padilla, S. L., Qiu, J., Nestor, C. C., Zhang, C., Smith, A. W., Whiddon, B. B., Ronnekleiv, O., Kelly, M. & Palmiter, R. D., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2413-2418 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria

Frueh, L., Li, Y., Mather, M. W., Li, Q., Pou, S., Nilsen, A., Winter, R. W., Forquer, I. P., Pershing, A. M., Xie, L. H., Smilkstein, M. J., Caridha, D., Koop, D., Campbell, R. F., Sciotti, R. J., Kreishman-Deitrick, M., Kelly, J. X., Vesely, B., Vaidya, A. B. & Riscoe, M., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 728-735 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

A newborn screening method for cerebrotendinous xanthomatosis using bile alcohol glucuronides and metabolite ratios

Vaz, F. M., Bootsma, A. H., Kulik, W., Verrips, A., Wevers, R. A., Schielen, P. C., De Barber, A. & Huidekoper, H. H., May 1 2017, In : Journal of Lipid Research. 58, 5, p. 1002-1007 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Arcuate neuropeptide y inhibits sympathetic nerve activity via multiple neuropathways

Shi, Z., Madden, C. C. & Brooks, V., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2868-2880 13 p.

Research output: Contribution to journalArticle

12 Scopus citations

A thyroid hormone-based strategy for correcting the biochemical abnormality in X-linked adrenoleukodystrophy

Hartley, M. D., Kirkemo, L. L., Banerji, T. & Scanlan, T. T., May 1 2017, In : Endocrinology. 158, 5, p. 1328-1338 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Autoantibodies in Melanoma-Associated Retinopathy Recognize an Epitope Conserved Between TRPM1 and TRPM3

Duvoisin, R., Haley, T. L., Ren, G., Strycharska-Orczyk, I., Bonaparte, J. P. & Morgans, C., May 1 2017, In : Investigative ophthalmology & visual science. 58, 5, p. 2732-2738 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cerebrotendinous xanthomatosis: Early diagnosis on the basis of juvenile cataracts

Tibrewal, S., Duell, P., De Barber, A. & Loh, A., Jan 1 2017, (Accepted/In press) In : Journal of AAPOS.

Research output: Contribution to journalArticle

4 Scopus citations

Cervical vagus nerve stimulation augments spontaneous discharge in second-and higher-order sensory neurons in the rat nucleus of the solitary tract

Beaumont, E., Campbell, R. P., Andresen, M., Scofield, S., Singh, K., Libbus, I., Kenknight, B. H., Snyder, L. & Cantrell, N., Aug 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H354-H367

Research output: Contribution to journalArticle

5 Scopus citations
4 Scopus citations

Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines

Chao, B., Li, B. X. & Xiao, X., Jul 15 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 14, p. 3107-3110 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dynasore blocks evoked release while augmenting spontaneous synaptic transmission from primary visceral afferents

Hofmann, M. E. & Andresen, M., Mar 1 2017, In : PLoS One. 12, 3, e0174915.

Research output: Contribution to journalArticle

2 Scopus citations

Elevated serum tetrac in graves disease: Potential pathogenic role in thyroid-associated ophthalmopathy

Fernando, R., Placzek, E., Reese, E. A., Placzek, A. T., Schwartz, S., Trierweiler, A., Niziol, L. M., Raychaudhuri, N., Atkins, S., Scanlan, T. T. & Smith, T. J., Mar 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 3, p. 776-785 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Endogenous opioids regulate moment-to-moment neuronal communication and excitability

Winters, B. L., Gregoriou, G. C., Kissiwaa, S. A., Wells, O. A., Medagoda, D. I., Hermes, S. M., Burford, N. T., Alt, A., Aicher, S. & Bagley, E. E., Mar 22 2017, In : Nature Communications. 8, 14611.

Research output: Contribution to journalArticle

14 Scopus citations

Endosomal phosphatidylinositol 3-phosphate promotes gephyrin clustering and GABAergic neurotransmission at inhibitory postsynapses

Papadopoulos, T., Rhee, H. J., Subramanian, D., Paraskevopoulou, F., Mueller, R., Schultz, C., Brose, N., Rhee, J. S. & Betz, H., Jan 27 2017, In : Journal of Biological Chemistry. 292, 4, p. 1160-1177 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration

Ferrara, S. J., Meinig, J. M., Placzek, A. T., Banerji, T., McTigue, P., Hartley, M. D., Sanford-Crane, H. S., Banerji, T., Bourdette, D. & Scanlan, T. T., May 15 2017, In : Bioorganic and Medicinal Chemistry. 25, 10, p. 2743-2753 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Fos expression in the olfactory pathway of high- and low-sexually performing rams exposed to urine from estrous or ovariectomized ewes

Mirto, A. J., Austin, K. J., Uthlaut, V. A., Roselli, C. & Alexander, B. M., Jan 1 2017, In : Applied Animal Behaviour Science. 186, p. 22-28 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

GLP-1R signaling directly activates arcuate nucleus kisspeptin action in brain slices but does not rescue luteinizing hormone inhibition in ovariectomized mice during negative energy balance

Heppner, K. M., Baquero, A. F., Bennett, C. M., Lindsley, S. R., Kirigiti, M. A., Bennett, B., Bosch, M. A., Mercer, A. J., Ronnekleiv, O., True, C., Grove, K. & Smith, M. S., Jan 5 2017, In : eNeuro. 4, 1, e0198.

Research output: Contribution to journalArticle

9 Scopus citations

Implication of thyroid hormone signaling in neural crest cells migration: Evidence from thyroid hormone receptor beta knockdown and NH3 antagonist studies

Bronchain, O. J., Chesneau, A., Monsoro-Burq, A. H., Jolivet, P., Paillard, E., Scanlan, T. S., Demeneix, B. A., Sachs, L. M. & Pollet, N., Jan 5 2017, In : Molecular and Cellular Endocrinology. 439, p. 233-246 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration

Ma, H., Yang, F., Butler, M. R., Belcher, J., Redmond, T. M., Placzek, A. T., Scanlan, T. T. & Ding, X. Q., Aug 1 2017, In : FASEB Journal. 31, 8, p. 3425-3438 14 p.

Research output: Contribution to journalArticle

5 Scopus citations